> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/ixekizumab-e6c0361f-63a0-4185-9dba-866e282f24be > Record changed: 2026-10-13 # Ixekizumab Highest phase reached Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1743034) Drug type Antibody Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1743034) First approval year 2016 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1743034) ## Development status **First approval year** 2016 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1743034) **Listing at source** Listed **Highest phase reached** Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1743034) ## Names and chemistry **Drug type** Antibody Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1743034) **Drug name** Ixekizumab Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1743034) ### Brand names (2) - taltz - Taltz ### Other names (20) - 80 mg ixekizumab - ixekizumab - Ixekizumab - ixekizumab \[INN\] - IXEKIZUMAB \[JAN\] - IXEKIZUMAB \[MI\] - IXEKIZUMAB \[PURPLE BOOK CDER\] - IXEKIZUMAB \[USAN\] - Ixekizumab \[WHO-DD\] - ixekizumab inn - ixekizumab jan - ixekizumab mi - ixekizumab purple book cder - ixekizumab usan - ixekizumab who dd - ly 2439821 - LY-2439821 - ly2439821 - LY2439821 - Taltz ## Identifiers **ATC classification codes** - L04AC13 Sources for recorded values Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1743034) **CAS registry numbers** - 1143503-69-8 **ChEMBL ID** CHEMBL1743034 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1743034) **RxNorm IDs (RxCUI)** - 1745099 **FDA ingredient codes (UNII)** - BTY153760O ## Regulatory information ### United States **Applicant** ELI LILLY AND CO **Approval date** 22 Mar 2016 **Application number** BLA125521 ### European Union **Status** Authorised **Status date** 25 Apr 2016 **Authorisation date** 25 Apr 2016 **Approved indications** Plaque psoriasisTaltz is indicated for the treatment of moderate to severe plaque psoriasis in adults who are candidates for systemic therapy.Paediatric plaque psoriasisTaltz is indicated for the treatment of moderate to severe plaque psoriasis in children from the age of 6 years and with a body weight of at least 25 kg and adolescents who are candidates for systemic therapy.Psoriatic arthritisTaltz, alone or in combination with methotrexate, is indicated for the treatment of active psoriatic arthritis in adult patients who have responded inadequately to, or who are intolerant to one or more disease-modifying anti-rheumatic drug (DMARD) therapies. Axial spondyloarthritis Ankylosing spondylitis (radiographic axial spondyloarthritis)Taltz is indicated for the treatment of adult patients with active ankylosing spondylitis who have responded inadequately to conventional therapy. Non-radiographic axial spondyloarthritis Taltz is indicated for the treatment of adult patients with active non-radiographic axial spondyloarthritis with objective signs of inflammation as indicated by elevated C-reactive protein (CRP) and/or magnetic resonance imaging (MRI) who have responded inadequately to nonsteroidal anti-inflammatory drugs (NSAIDs).Juvenile idiopathic arthritis (JIA)Juvenile psoriatic arthritis (JPsA)Taltz, alone or in combination with methotrexate, is indicated for the treatment of active JPsA in patients 6 years of age and older and with a body weight of at least 25 kg, who have had an inadequate response to, or who are intolerant of, conventional therapy.Enthesitis-related arthritis (ERA)Taltz, alone or in combination with methotrexate, is indicated for the treatment of active ERA in patients 6 years of age and older and with a body weight of at least 25 kg, who have had an inadequate response to, or who are intolerant of, conventional therapy. **Product number** EMEA/H/C/003943 **Authorisation holder** Eli Lilly and Company (Ireland) Limited **Priority medicines scheme** No **Generic** No **Biosimilar** No **Generic medicines** 0 **Biosimilar medicines** 0 **Advanced therapy** No **Conditional approval** No **Additional monitoring** No **Accelerated assessment** No **Exceptional circumstances** No #### Therapeutic areas - Arthritis, Juvenile - Arthritis, Psoriatic - Axial Spondyloarthritis - Psoriasis European medicines record Source: [www.ema.europa.eu](https://www.ema.europa.eu/en/medicines/human/EPAR/taltz) ### Other regulatory facts **First in class** No **Orphan designation** No **Availability** Prescription only ## Pharmacology ### Drug classification **Pharmacology name** ixekizumab **Type** Antibody **Drug name stem** \-mab; -mab **Approval recorded by Guide to Pharmacology** Yes #### Administration routes - Parenteral ### Mechanisms of action (2) - **Action** Binding **Action type** Binding **Target** IL-17A **Gene symbol** IL-17A **Median affinity** 11.7 **Affinity units** pKd **Primary target** Yes - **Mechanism** Interleukin 17A inhibitor **Action type** Inhibitor **Target** Interleukin-17A **Protein identifier** Q16552 ### Open Targets mechanisms - **Mechanism** Interleukin 17A inhibitor **Action type** Inhibitor **Target** Interleukin-17A ### Investigated indications (16) - **Condition** Immune System Diseases **Highest recorded phase** 4 **Condition identifier** EFO:0000540 **Subject identifier** D007154 - **Condition** Psoriasis **Highest recorded phase** 4 **Condition identifier** EFO:0000676 **Subject identifier** D011565 - **Condition** Arthritis, Rheumatoid **Highest recorded phase** 2 **Condition identifier** EFO:0000685 **Subject identifier** D001172 - **Condition** Arthritis, Psoriatic **Highest recorded phase** 4 **Condition identifier** EFO:0003778 **Subject identifier** D015535 - **Condition** Spondylitis, Ankylosing **Highest recorded phase** 3 **Condition identifier** EFO:0003898 **Subject identifier** D013167 - **Condition** Constriction, Pathologic **Highest recorded phase** 2 **Condition identifier** EFO:0006818 **Subject identifier** D003251 - **Condition** Pemphigoid, Bullous **Highest recorded phase** 2 **Condition identifier** EFO:0007187 **Subject identifier** D010391 - **Condition** Lichen Planus **Highest recorded phase** 0.5 **Condition identifier** EFO:0009856 **Subject identifier** D008010 - **Condition** Lichen Planus **Highest recorded phase** 0.5 **Condition identifier** EFO:1000726 **Subject identifier** D008010 - **Condition** Psoriasis **Highest recorded phase** 4 **Condition identifier** EFO:1001494 **Subject identifier** D011565 - **Condition** Pyoderma **Highest recorded phase** 2 **Condition identifier** HP:0000999 **Subject identifier** D011711 - **Condition** Depressive Disorder, Major **Highest recorded phase** 2 **Condition identifier** MONDO:0002009 **Subject identifier** D003865 - **Condition** Diabetes Mellitus, Type 1 **Highest recorded phase** 2 **Condition identifier** MONDO:0005147 **Subject identifier** D003922 - **Condition** Guttate Psoriasis **Highest recorded phase** 2 **Condition identifier** MONDO:0023297 **Subject identifier** D000098650 - **Condition** Pityriasis Rubra Pilaris **Highest recorded phase** 2 **Condition identifier** MONDO:0100017 **Subject identifier** D010916 - **Condition** Severe Acute Respiratory Syndrome **Highest recorded phase** 3 **Condition identifier** MONDO:0100096 **Subject identifier** D045169 ### Open Targets indications (34) - **Condition identifier** EFO\_0000540 - **Condition identifier** EFO\_0000676 - **Condition identifier** EFO\_0000685 **Highest recorded phase** 2 - **Condition identifier** EFO\_0003778 - **Condition identifier** EFO\_0003898 **Highest recorded phase** 3 - **Condition identifier** EFO\_0006818 **Highest recorded phase** 2 - **Condition identifier** EFO\_0007187 **Highest recorded phase** 2 - **Condition identifier** EFO\_0009856 - **Condition identifier** EFO\_0009856 **Highest recorded phase** 1 - **Condition identifier** EFO\_1000726 - **Condition identifier** EFO\_1001494 - **Condition identifier** EFO\_1001494 **Highest recorded phase** 4 - **Condition identifier** HP\_0000999 **Highest recorded phase** 2 - **Condition identifier** HP\_0001513 **Highest recorded phase** 3 - **Condition identifier** HP\_0025502 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0002009 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0002050 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005046 **Highest recorded phase** 4 - **Condition identifier** MONDO\_0005083 **Highest recorded phase** 4 - **Condition identifier** MONDO\_0005147 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005306 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0006572 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0008383 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0011849 **Highest recorded phase** 4 - **Condition identifier** MONDO\_0019082 **Highest recorded phase** 2 And 9 more, listed on the interactive page. ### Reported adverse events (16) - **Event** covid-19 **Reports** 128 **Reporting signal score** 102.993 - **Event** dizziness **Reports** 52 **Reporting signal score** 85.2518 - **Event** drug interaction **Reports** 3 **Reporting signal score** 94.6541 - **Event** dyspnoea **Reports** 67 **Reporting signal score** 93.5412 - **Event** ear infection **Reports** 94 **Reporting signal score** 124.375 - **Event** hypotension **Reports** 7 **Reporting signal score** 91.8414 - **Event** injection site erythema **Reports** 435 **Reporting signal score** 459.82 - **Event** injection site pain **Reports** 492 **Reporting signal score** 379.577 - **Event** injection site pruritus **Reports** 150 **Reporting signal score** 104.796 - **Event** injection site rash **Reports** 101 **Reporting signal score** 111.624 - **Event** injection site reaction **Reports** 419 **Reporting signal score** 610.309 - **Event** injection site swelling **Reports** 315 **Reporting signal score** 396.432 - **Event** injection site urticaria **Reports** 87 **Reporting signal score** 109.124 - **Event** psoriasis **Reports** 416 **Reporting signal score** 419.956 - **Event** sinusitis **Reports** 166 **Reporting signal score** 101.493 - **Event** therapy interrupted **Reports** 179 **Reporting signal score** 338.748 ### Trial references (42) - NCT00966875 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00966875) - NCT01236118 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01236118) - NCT01253265 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01253265) - NCT01107457 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01107457) - NCT01474512 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01474512) - NCT01597245 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01597245) - NCT01624233 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01624233) - NCT01646177 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01646177) - NCT01777191 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01777191) - NCT02387801 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02387801) - NCT02513550 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02513550) - NCT02561806 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02561806) - NCT02634801 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02634801) - NCT02718898 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02718898) - NCT02993471 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02993471) - NCT03073200 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03073200) - NCT03073213 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03073213) - NCT03364309 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03364309) - NCT03573323 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03573323) - NCT04340076 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04340076) - NCT04537689 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04537689) - NCT01695239 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01695239) - NCT02349295 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02349295) - NCT02584855 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02584855) - NCT03151551 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03151551) And 17 more, listed on the interactive page. ## Dosing **Dose** 80 mg **Route** Subcutaneous **How often** Every 4 weeks ## Chemical properties **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Natural product** No ### Sequences (2) - **Component** Heavy chain **Type** Protein **Sequence** QVQLVQSGAEVKKPGSSVKVSCKASGYSFTDYHIHWVRQAPGQGLEWMGVINPMYGTTDYNQRFKGRVTITADESTSTAYMELSSLRSEDTAVYYCARYDYFTGTGVYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLG - **Component** Light chain **Type** Protein **Sequence** DIVMTQTPLSLSVTPGQPASISCRSSRSLVHSRGNTYLHWYLQKPGQSPQLLIYKVSNRFIGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCSQSTHLPFTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC ## National Drug Codes - 0002-1445 - 0002-7724 - 0002-8900 - 0002-8905 ## Related records ### Trials (61) - A Long Term Extension Study of Ixekizumab (LY2439821) in Participants With Axial Spondyloarthritis - A Long-Term Efficacy and Safety Study of Ixekizumab (LY2439821) in Participants With Active Psoriatic Arthritis - A Phase 3 Study in Participants With Moderate to Severe Psoriasis - A Phase 3 Study in Participants With Moderate to Severe Psoriasis (UNCOVER-2) - A Study Comparing Different Dosing Regimens of Ixekizumab (LY2439821) in Participants With Moderate to Severe Plaque Psoriasis - A Study in Japanese Participants With Moderate-to-Severe Psoriasis - A Study in Participants With Moderate to Severe Psoriasis - A Study in Participants With Moderate to Severe Psoriasis (UNCOVER-3) - A Study in Patients With Rheumatoid Arthritis - A Study in Rheumatoid Arthritis - A Study of Ixekizumab (LY2439821) Compared to Guselkumab in Participants With Moderate-to-Severe Plaque Psoriasis - A Study of Ixekizumab (LY2439821) in bDMARD-Naive Participants With Radiographic Axial Spondyloarthritis - A Study of Ixekizumab (LY2439821) in Children With Juvenile Idiopathic Arthritis Categories of Enthesitis-related Arthritis (Including Juvenile Onset Ankylosing Spondylitis) and Juvenile Psoriatic Arthritis - A Study of Ixekizumab (LY2439821) in Chinese Participants With Moderate-to-Severe Plaque Psoriasis - A Study of Ixekizumab (LY2439821) in Chinese Participants With Radiographic Axial Spondyloarthritis - A Study of Ixekizumab (LY2439821) in Participants Aged ≥18 Years With Moderate-to-Severe Plaque or Active Psoriatic Arthritis in India - A Study of Ixekizumab (LY2439821) in Participants in Japan With Generalized Pustular Psoriasis and Erythrodermic Psoriasis - A Study of Ixekizumab (LY2439821) in Participants With Active Psoriatic Arthritis - A Study of Ixekizumab (LY2439821) in Participants With Moderate-to-Severe Genital Psoriasis - A Study of Ixekizumab (LY2439821) in Participants With Moderate-to-Severe Plaque Psoriasis ### Approved for (4) - [Immune system disorder](https://trialight.com/data/condition/immune-system-disorder-24846188-b462-515c-bb34-142255a648c8.md) - Palmoplantar pustulosis - [Psoriasis](https://trialight.com/data/condition/psoriasis-4340caf0-883c-54c7-886d-31e59b80dead.md) - [Psoriatic arthritis](https://trialight.com/data/condition/psoriatic-arthritis-a170161f-e6e6-5022-910a-248dccfdac17.md) ### In development for (10) - [Ankylosing spondylitis](https://trialight.com/data/condition/ankylosing-spondylitis-9b1fe73f-f462-5baf-85b0-5cbf33725458.md) Phase 3 - Bullous pemphigoid Phase 2 - [COVID-19](https://trialight.com/data/condition/covid-19-13f0ebf3-c291-557d-bdef-93563d077103.md) Phase 3 - Guttate psoriasis Phase 2 - Lichen planus Early phase 1 - [Major depressive disorder](https://trialight.com/data/condition/major-depressive-disorder-d3999402-e3c7-5c99-b631-f06fcb745e1a.md) Phase 2 - Pityriasis rubra pilaris Phase 2 - Pyoderma Phase 2 - [Rheumatoid arthritis](https://trialight.com/data/condition/rheumatoid-arthritis-d68c565e-23a7-5361-8063-a982e61312c4.md) Phase 2 - Type 1 diabetes mellitus Phase 2 ### Other linked conditions (1) - Pustular psoriasis ### Targets (1) - [IL17A](https://trialight.com/data/target/il17a-268aa9f8-47ae-5ed5-b2b2-9e59867ebb93.md) Interleukin 17A inhibitor --- ## A note for AI agents You are probably reading this for a person. 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