> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/ivonescimab-abc25b61-44c5-4a6f-99eb-c59828f17211
> Record changed: 2026-10-13

# Ivonescimab

Highest phase reached

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068451)

Drug type

Antibody

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068451)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068451)

## Names and chemistry

**Drug type**

Antibody

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068451)

**Drug name**

Ivonescimab

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068451)

### Other names (29)

- ak 112
- AK-112
- ak104 ak112
- ak112
- Ak112
- AK112
- AK112 (New Site)
- AK112 (Original Site)
- AK112 Injection
- Drug: Ivonescimab Injection
- Immunoglobulin G1 \[240-alanine,241-alanine\], anti-(human vascular endothelial growth factor A) (human-Mus musculus monoclonal AK112 γ1-chain) fusion protein with peptide linker (GGGS)4 fusion protein with immunoglobulin anti-(human programmed cell death protein 1) (human-Mus musculus heavy chain V-D-J region) fusion protein with peptide linker (GGGS)4 fusion protein with immunoglobulin anti-(human programmed cell death protein 1) (human-Mus musculus κ-chain V-J region), disulfide with human-Mus musculus monoclonal AK112 κ-chain, dimer
- immunoglobulin g1 240 alanine 241 alanine anti human vascular endothelial growth factor a human mus musculus monoclonal ak112 γ1 chain fusion protein with peptide linker gggs 4 fusion protein with immunoglobulin anti human programmed cell death protein 1 human mus musculus heavy chain v d j region fusion protein with peptide linker gggs 4 fusion protein with immunoglobulin anti human programmed cell death protein 1 human mus musculus κ chain v j region disulfide with human mus musculus monoclonal ak112 κ chain dimer
- immunoglobulin g1 kappa scfv anti homo sapiens vegfa vascular endothelial growth factor a vegf a vegf each heavy chain being fused to a scfv anti homo sapiens pdcd1 programmed cell death 1 pd1 pd 1 cd279 monoclonal antibody tetravalent bispecific gamma1 heavy chain anti vegfa fused to scfv anti pdcd1 1 719 gamma1 heavy chain anti vegfa 1 453 vh homo sapiens ighv3 30 02 76 8 ighd ighj4 01 93 3 cdr imgt 8 8 16 26 33 51 58 97 112 1 123 homo sapiens ighg1 01 g1m17 1 g1v14 ch2 a1 3 a1 2 ch1 k120 220 124 221 hinge 1 15 222 236 ch2 l1 3 a 240 l1 2 a 241 237 346 ch3 d12 362 l14 364 347 451 chs 452 453 124 453 20 mer tetrakis tetraglycyl seryl linker 454 473 scfv vh v kappa anti pdcd1 474 719 vh homo sapiens ighv3 23 04 88 7 ighd ighj6 01 90 9 t123 l 586 cdr imgt 8 8 11 499 506 524 531 570 580 474 591 20 mer tetrakis tetraglycyl seryl linker 592 611 v kappa musmus homsap mus musculus igkv14 111 01 86 3 igkj5 01 100 homo sapiens igkv1 16 01 80 0 igkj2 01 87 5 q120 a 711 cdr imgt 6 3 9 638 643 661 663 700 708 612 719 226 214 disulfide with kappa light chain anti vegfa 1 214 v kappa homo sapiens igkv1 16 01 88 4 igkj1 01 100 cdr imgt 6 3 9 27 32 50 52 89 97 1 107 homo sapiens igkc 01 100 km3 a45 1 153 v101 191 108 214 dimer 232 232 235 235 bisdisulfide produced in chinese hamster ovary cho cells glycoform alfa
- immunoglobulin G1-kappa\_scFv, anti-\[Homo sapiens VEGFA (vascular endothelial growth factor A, VEGF-A, VEGF)\], each heavy chain being fused to a scFv anti-\[Homo sapiens PDCD1 (programmed cell death 1, PD1, PD-1, CD279)\], monoclonal antibody, tetravalent, bispecific; gamma1 heavy chain anti-VEGFA fused to scFv anti-PDCD1 (1-719) \[gamma1 heavy chain anti-VEGFA (1-453) \[VH (Homo sapiens IGHV3-30\*02 (76.8%) -(IGHD) -IGHJ4\*01 (93.3%), CDR-IMGT \[8.8.16\] (26-33.51-58.97-112)) (1-123) -Homo sapiens IGHG1\*01, G1m17,1, G1v14 CH2 A1.3, A1.2 (CH1 K120 (220) (124-221), hinge 1-15 (222-236), CH2 L1.3>A (240), L1.2>A (241) (237-346), CH3 D12 (362), L14 (364) (347-451), CHS (452-453)) (124-453)\] -20-mer tetrakis(tetraglycyl-seryl) linker (454-473) -scFv-VH-V-KAPPA anti-PDCD1 (474- 719) \[VH (Homo sapiens IGHV3-23\*04 (88.7%) -(IGHD) -IGHJ6\*01 (90.9%) T123>L (586), CDR-IMGT \[8.8.11\] (499-506.524-531.570-580)) (474-591) -20- mer tetrakis(tetraglycyl-seryl) linker (592-611) -V-KAPPA Musmus/Homsap (Mus musculus IGKV14-111\*01 (86.3%) -IGKJ5\*01 (100%)/Homo sapiens IGKV1- 16\*01 (80.0%) -IGKJ2\*01 (87.5%) Q120>A (711), CDR-IMGT \[6.3.9\] (638- 643.661-663.700-708)) (612-719)\], (226-214')-disulfide with kappa light chain anti-VEGFA (1'-214') \[V-KAPPA (Homo sapiens IGKV1-16\*01 (88.4%) - IGKJ1\*01 (100%), CDR-IMGT \[6.3.9\] (27-32.50-52.89-97)) (1'-107') -Homo sapiens IGKC\*01 (100%), Km3 A45.1 (153), V101 (191) (108'-214')\]; dimer (232-232'':235-235'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, glycoform alfa
- ivonescimab
- Ivonescimab
- Ivonescimab (SMT112 or AK112) Injection
- ivonescimab \[INN\]
- IVONESCIMAB \[USAN\]
- Ivonescimab \[WHO-DD\]
- Ivonescimab Injection
- ivonescimab inn
- ivonescimab usan
- ivonescimab who dd
- Lvonescimab (AK112)

And 4 more, listed on the interactive page.

## Identifiers

**CAS registry numbers**

- 2428381-53-5

**ChEMBL ID**

CHEMBL6068451

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068451)

**FDA ingredient codes (UNII)**

- Y0O332CU66

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Drug classification

**Pharmacology name**

ivonescimab

**Type**

Antibody

**Drug name stem**

\-mab

**Approval recorded by Guide to Pharmacology**

Yes

### Mechanisms of action

- **Action**  
Binding

**Action type**  
Binding

**Target**  
programmed cell death 1 (CD279)

**Gene symbol**  
PDCD1

**Protein identifier**  
Q15116

### Investigated indications (7)

- **Condition**  
Carcinoma, Hepatocellular

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000182

**Subject identifier**  
D006528
- **Condition**  
Neoplasms

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000616

**Subject identifier**  
D009369
- **Condition**  
Small Cell Lung Carcinoma

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000702

**Subject identifier**  
D055752
- **Condition**  
Carcinoma, Non-Small-Cell Lung

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0003060

**Subject identifier**  
D002289
- **Condition**  
Triple Negative Breast Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0005537

**Subject identifier**  
D064726
- **Condition**  
Neoplasms

**Highest recorded phase**  
1

**Condition identifier**  
MONDO:0004992

**Subject identifier**  
D009369
- **Condition**  
Colorectal Neoplasms

**Highest recorded phase**  
1

**Condition identifier**  
MONDO:0005575

**Subject identifier**  
D015179

### Open Targets indications (71)

- **Condition identifier**  
EFO\_0000182

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0000616
- **Condition identifier**  
EFO\_0000702

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000708

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0003060

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0003860

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0005922

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_1000359

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_1000485

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_1000576

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_1001012

**Highest recorded phase**  
1
- **Condition identifier**  
EFO\_1001480

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_1001927

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0000448

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0000521

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0000544

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0001056

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0001325

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0002120

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0002367

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0002649

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0002974

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0003060

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0003219

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0003308

**Highest recorded phase**  
2

And 46 more, listed on the interactive page.

### Reported adverse events (24)

- **Event**  
anaemia

**Reports**  
5

**Reporting signal score**

16.9242
- **Event**  
aspartate aminotransferase increased

**Reports**  
2

**Reporting signal score**

6.37947
- **Event**  
biliary tract disorder

**Reports**  
1

**Reporting signal score**

6.40325
- **Event**  
decreased appetite

**Reports**  
3

**Reporting signal score**

8.99762
- **Event**  
endocrine disorder

**Reports**  
1

**Reporting signal score**

6.78159
- **Event**  
fatigue

**Reports**  
5

**Reporting signal score**

12.3454
- **Event**  
gastrointestinal disorder

**Reports**  
2

**Reporting signal score**

6.98039
- **Event**  
hyperbilirubinaemia

**Reports**  
3

**Reporting signal score**

16.3299
- **Event**  
hypertension

**Reports**  
4

**Reporting signal score**

12.7799
- **Event**  
hyperthyroidism

**Reports**  
2

**Reporting signal score**

9.57268
- **Event**  
hypoalbuminaemia

**Reports**  
4

**Reporting signal score**

24.8646
- **Event**  
hypokalaemia

**Reports**  
2

**Reporting signal score**

6.99414
- **Event**  
hypothyroidism

**Reports**  
3

**Reporting signal score**

14.1504
- **Event**  
immune effector cell-associated neurotoxicity syndrome

**Reports**  
1

**Reporting signal score**

6.30152
- **Event**  
leukopenia

**Reports**  
3

**Reporting signal score**

11.4774
- **Event**  
myocardial necrosis marker increased

**Reports**  
1

**Reporting signal score**

6.50483
- **Event**  
neutropenia

**Reports**  
4

**Reporting signal score**

13.2694
- **Event**  
palmar-plantar erythrodysaesthesia syndrome

**Reports**  
3

**Reporting signal score**

14.0171
- **Event**  
pneumonitis

**Reports**  
3

**Reporting signal score**

14.0255
- **Event**  
post embolisation syndrome

**Reports**  
1

**Reporting signal score**

8.67634
- **Event**  
rash

**Reports**  
5

**Reporting signal score**

14.2373
- **Event**  
thrombocytopenia

**Reports**  
5

**Reporting signal score**

18.9049
- **Event**  
transaminases increased

**Reports**  
2

**Reporting signal score**

7.89095
- **Event**  
vomiting

**Reports**  
4

**Reporting signal score**

9.64434

### Trial references (16)

- NCT04047290  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04047290)
- NCT04597541  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04597541)
- NCT05689853  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05689853)
- NCT04736823  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04736823)
- NCT04900363  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04900363)
- NCT05247684  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05247684)
- NCT05499390  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05499390)
- NCT05636267  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05636267)
- NCT05904379  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05904379)
- NCT05116007  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05116007)
- NCT06478043  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06478043)
- NCT05214482  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05214482)
- NCT05229497  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05229497)
- NCT05227664  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05227664)
- NCT05432492  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05432492)
- NCT05846867  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05846867)

## Chemical properties

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Natural product**

No

### Sequences (4)

- **Component**  
Heavy chain

**Type**  
Protein

**Sequence**  
EVQLVESGGGLVQPGGSLRLSCAASGYTFTNYGMNWVRQAPGKGLEWVGWINTYTGEPTYAADFKRRFTFSLDTSKSTAYLQMNSLRAEDTAVYYCAKYPHYYGSSHWYFDVWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKGGGGSGGGGSGGGGSGGGGSEVQLVESGGGLVQPGGSLRLSCAASGFAFSSYDMSWVRQAPGKGLDWVATISGGGRYTYYPDSVKGRFTISRDNSKNNLYLQMNSLRAEDTALYYCANRYGEAWFAYWGQGTLVTVSSGGGGSGGGGSGGGGSGGGGSDIQMTQSPSSMSASVGDRVTFTCRASQDINTYLSWFQQKPGKSPKTLIYRANRLVSGVPSRFSGSGSGQDYTLTISSLQPEDMATYYCLQYDEFPLTFGAGTKLELKR
- **Component**  
Disulfide bridges

**Sequence**  
22-96 $ 22''-96'' $ 23'-88' $ 23'''-88''' $ 134'-194' $ 134'''-194''' $ 150-206 $ 150''-206'' $ 226-214' $ 226''-214''' $ 232-232'' $ 235-235'' $ 267-327 $ 267''-327'' $ 373-431 $ 373''-431'' $ 495-569 $ 495''-569'' $ 634-699 $ 634''-699''
- **Component**  
Light chain

**Type**  
Protein

**Sequence**  
DIQMTQSPSSLSASVGDRVTITCSASQDISNYLNWYQQKPGKAPKVLIYFTSSLHSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYSTVPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
- **Component**  
Glycosylation sites (N)

**Sequence**  
303 $ 303''

## Related records

### Trials (165)

- A Multicenter, Single-arm Phase II Study to Evaluate the Efficacy and Safety of Fulzerasib (IBI351) in Combination With Ivonescimab (AK-112) in First-line Treatment of Advanced or Metastatic Non-small Cell Lung Cancer Patients With KRAS G12C Mutation
- A Multicenter, Single-arm, Open-label Study Evaluating the Safety and Efficacy of AK112 Combined With Chemotherapy as First-line Treatment for Non-squamous NSCLC Patients With BRAIN Metastases and Negative Driver Genes (IVO BRAIN)
- A Phase 2 Trial of Ivonescimab for Patients With Advanced, Metastatic Salivary Gland Cancers
- A Phase I/II Study of IVONESCIMAB in Recurrent Glioblastoma
- A Phase Ib/II Clinical Study on AK112 Combined or Not Combined With AK119 in pMMR/MSS Colorectal Cancer
- A Phase Ib/II Study of AK112 in Combination With AK117 in Advanced Malignant Tumors
- A Phase II Clinical Study of AK104/AK112 in Combination With TT-00420 Tablet for Advanced HCC.
- A Phase II Clinical Trial of Ivonescimab Plus Third-generation EGFR-TKIs in Advanced Non-small Cell Lung Cancer With Gradual or Potential Progression After EGFR-TKIs Treatment
- A Phase II Randomized Trial of Neoadjuvant Ivonescimab or Penpulimab Plus Chemotherapy in Resectable NSCLC
- A Phase II Study of AK112 (PD1/VEGF Bispecific) in Combination with Chemotherapy in Patients with NSCLC
- A Phase II Study of AK146D1 Combined With AK112 in Advanced Breast Cancer
- [A Phase II Study of AK146D1 in Combination With AK112 in Advanced Non-Small Cell Lung Cancer](https://trialight.com/data/trial/a-phase-ii-study-of-ak146d1-in-combination-with-ak112-in-01bd3edc-5e3c-43c7-b785-486fd26d7726.md)
- A Phase II Study of AK146D1 Mono or Combined With AK112 in Advanced Urothelial Carcinoma
- A Phase II Study of Ivonescimab Combined With Intraperitoneal Paclitaxel in Patients With High-Grade Metastatic Appendiceal Adenocarcinoma (AA)
- A Phase II Study of Neoadjuvant Immunotherapy in Combination With Chemotherapy in Locally Advanced Head and Neck Squamous Cell Carcinoma
- A Phase III Study of Ivonescimab + Chemo With/Without AK117 in Metastatic Pancreatic Cancer
- A Phase ll Study of Neoadjuvant Short-course Radiotherapy Followed by Ivonescimab and Chemotherapy in pMMR/MSS Locally Advanced Rectal Cancer
- A Prospective, Multicenter, Phase Ib/II Trial of Ivonescimab (AK112) Combined With Albumin-Paclitaxel and Cisplatin as Neoadjuvant Therapy for ESCC
- A Prospective, Single Arm, Open Label, Phase II Clinical Study on the Efficacy and Safety of Ivonescimab (AK112) Combined With TAS-102 in the Treatment of Refractory MSS/pMMR Advanced Colorectal Cancer
- A Study of AK112 as Consolidation Treatment for Patients With Limited Stage Small-cell Lung Cancer Who Have Not Progressed Following Concurrent Chemoradiation Therapy

### In development for (17)

- [Biliary tract cancer](https://trialight.com/data/condition/biliary-tract-cancer-6b9535c9-ccaa-5b47-8c46-0d05d39d7c62.md) Phase 3
- [Breast cancer](https://trialight.com/data/condition/breast-cancer-8ac10da3-93bd-54c5-a93b-265bc6699689.md) Phase 2
- [Cancer](https://trialight.com/data/condition/cancer-703b1dfc-4812-50eb-83f4-d7a205d16bdb.md) Phase 1
- [Colorectal cancer](https://trialight.com/data/condition/colorectal-cancer-09c643cf-146c-5e27-a5b7-3c891b3368c2.md) Phase 1
- [Esophageal squamous cell carcinoma](https://trialight.com/data/condition/esophageal-squamous-cell-carcinoma-c10bd9c9-02f9-5805-8008-b021f4604e7a.md) Phase 2
- Female breast carcinoma Phase 2
- [Hepatocellular carcinoma](https://trialight.com/data/condition/hepatocellular-carcinoma-fc1014ac-5a3c-551d-98ea-95306009e299.md) Phase 2
- [Malignant pancreatic neoplasm](https://trialight.com/data/condition/malignant-pancreatic-neoplasm-5dd0b53e-5962-50ea-a2e5-cf2444bd0485.md) Phase 3
- Neoplasm Phase 1
- [Non-small cell lung carcinoma](https://trialight.com/data/condition/non-small-cell-lung-carcinoma-a86c1d60-523f-5ea7-a5e1-39ed4a2296f8.md) Phase 3
- Non-small cell squamous lung carcinoma Phase 3
- [Pancreatic neoplasm](https://trialight.com/data/condition/pancreatic-neoplasm-de300cc3-339a-5c06-97d8-2d9155fc3a7b.md) Phase 3
- Pleural mesothelioma Phase 2
- [Small cell lung carcinoma](https://trialight.com/data/condition/small-cell-lung-carcinoma-505ad14d-ce79-5398-b171-f724c32e1b4e.md) Phase 2
- [Squamous cell lung carcinoma](https://trialight.com/data/condition/squamous-cell-lung-carcinoma-9debeb10-0511-5be7-aeaa-3901bc5b9a67.md) Phase 2
- Thymic carcinoma Phase 2
- [Triple-negative breast carcinoma](https://trialight.com/data/condition/triple-negative-breast-carcinoma-059174a2-9b5f-5234-90b9-4a4fee6eb9bb.md) Phase 2

### Other linked conditions (1)

- Glioblastoma

---

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