> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/ivermectin-92b3d34e-69c8-464b-98da-d0f165a74513 > Record changed: 2026-10-13 # Ivermectin Highest phase reached Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6067487) Drug type Unknown First approval year 1996 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6067487) ## Development status **First approval year** 1996 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6067487) **Listing at source** Listed **Highest phase reached** Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6067487) ## Names and chemistry **Drug type** Unknown **Drug name** Ivermectin Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6067487) ### Brand names (10) - heartguard - Heartguard - ivermectin - Ivermectin - sklice - Sklice - soolantra - Soolantra - stromectol - Stromectol ### Other names (133) - 22 23 dihydro c 076b1 - 22 23 dihydroabamectin - 22 23 dihydroavermectin b1 - 22 23 dihydroavermectin b1a - 22,23-dihydro c-076b1 - 22,23-dihydroabamectin - 22,23-dihydroavermectin b1 - 22,23-dihydroavermectin b1a - a mixture of avermectin a1a 5 o demethyl 22 23 dihydro component h2b1a and avermectin a1a 5 o demethyl 25 de 1 methylpropyl 22 23 dihydro 25 1 methylethyl component h2b1b - A MIXTURE OF AVERMECTIN A1A, 5-O-DEMETHYL-22,23-DIHYDRO-(COMPONENT H2B1A), AND AVERMECTIN A1A, 5-O-DEMETHYL-25-DE(1-METHYLPROPYL)-22,23-DIHYDRO-25-(1-METHYLETHYL)-(COMPONENT H2B1B) - a mixture of not less than 80 ivermectin component b1a and not more than 20 ivermectin component b1b - A MIXTURE OF NOT LESS THAN 80% IVERMECTIN COMPONENT B1A AND NOT MORE THAN 20% IVERMECTIN COMPONENT B1B - acarexx - Acarexx - albendazole and ivermectin - bimectin - Bimectin - bovinet - Bovinet - cardomec - Cardomec - cardotek 30 - Cardotek 30 - cd 5024 - CD-5024 And 108 more, listed on the interactive page. ## Identifiers **CAS registry numbers** - 70288-86-7 **ChEMBL ID** CHEMBL6067487 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6067487) **RxNorm IDs (RxCUI)** - 6069 **FDA ingredient codes (UNII)** - 8883YP2R6D ### ATC classification codes (2) - D11AX22 - P02CF01 Sources for recorded values Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6067487) ## Regulatory information ### United States **Applicant** MERCK SHARP DOHME **Approval date** 22 Nov 1996 **Application number** NDA050742 ### Other regulatory facts **Patents** 5 **Designations** 1 **Earliest recorded loss of exclusivity** 13 Mar 2034 **First in class** No **Fast track** No **Breakthrough designation** No **Orphan designation** No **Priority review** Yes **Orphan exclusivity** No **Accelerated approval** No **Availability** Over the counter ## Pharmacology ### Drug classification **Pharmacology name** ivermectin **Type** Synthetic organic **Drug name stem** \-ectin **Approval recorded by Guide to Pharmacology** Yes #### Administration routes - Oral - topical ### Mechanisms of action (5) - **Action** Irreversible agonist **Action type** IRREVERSIBLE\_AGONIST **Target** Glycine Receptor (All subtypes) **Gene symbol** Glycine Receptor (All subtypes) **Median affinity** 6.4 **Affinity units** pEC50 - **Mechanism** Glutamate-gated chloride channel modulator **Action type** MODULATOR **Target** Glutamate-gated chloride channel **Protein identifier** P91730 - **Mechanism** Glutamate-gated chloride channel modulator **Action type** MODULATOR **Target** Glutamate-gated chloride channel **Protein identifier** Q25634 - **Action** Positive **Action type** POSITIVE **Target** nicotinic acetylcholine receptor α7 subunit **Gene symbol** CHRNA7 **Protein identifier** P36544 **Median affinity** 5.1 **Affinity units** pEC50 - **Action** Positive **Action type** POSITIVE **Target** P2X7 **Gene symbol** P2RX7 **Protein identifier** Q99572 ### Open Targets mechanisms - **Mechanism** Glutamate-gated chloride channel modulator **Action type** MODULATOR **Target** Glutamate-gated chloride channel ### Investigated indications (23) - **Condition** Dermatitis, Atopic **Highest recorded phase** 2 **Condition identifier** EFO:0000274 **Subject identifier** D003876 - **Condition** Infections **Highest recorded phase** 1 **Condition identifier** EFO:0000544 **Subject identifier** D007239 - **Condition** Severe Acute Respiratory Syndrome **Highest recorded phase** 3 **Condition identifier** EFO:0000694 **Subject identifier** D045169 - **Condition** Malaria **Highest recorded phase** 3 **Condition identifier** EFO:0001068 **Subject identifier** D008288 - **Condition** Pneumonia **Highest recorded phase** 3 **Condition identifier** EFO:0003106 **Subject identifier** D011014 - **Condition** Acne Vulgaris **Highest recorded phase** 2 **Condition identifier** EFO:0003894 **Subject identifier** D000152 - **Condition** Severe Dengue **Highest recorded phase** 2 **Condition identifier** EFO:0004227 **Subject identifier** D019595 - **Condition** Leishmaniasis **Highest recorded phase** 0.5 **Condition identifier** EFO:0005044 **Subject identifier** D007896 - **Condition** Triple Negative Breast Neoplasms **Highest recorded phase** 1 **Condition identifier** EFO:0005537 **Subject identifier** D064726 - **Condition** Dengue **Highest recorded phase** 2 **Condition identifier** EFO:0005547 **Subject identifier** D003715 - **Condition** Elephantiasis, Filarial **Highest recorded phase** 3 **Condition identifier** EFO:0007272 **Subject identifier** D004605 - **Condition** Influenza, Human **Highest recorded phase** 3 **Condition identifier** EFO:0007328 **Subject identifier** D007251 - **Condition** Onchocerciasis, Ocular **Highest recorded phase** 2 **Condition identifier** EFO:0007398 **Subject identifier** D015827 - **Condition** Onchocerciasis **Highest recorded phase** 4 **Condition identifier** EFO:0007402 **Subject identifier** D009855 - **Condition** Strongyloidiasis **Highest recorded phase** 4 **Condition identifier** EFO:0007501 **Subject identifier** D013322 - **Condition** Trichuriasis **Highest recorded phase** 2 **Condition identifier** EFO:0007524 **Subject identifier** D014257 - **Condition** Blepharitis **Highest recorded phase** 3 **Condition identifier** EFO:0009536 **Subject identifier** D001762 - **Condition** Rosacea **Highest recorded phase** 4 **Condition identifier** EFO:1000760 **Subject identifier** D012393 - **Condition** Helminthiasis **Highest recorded phase** 4 **Condition identifier** EFO:1001342 **Subject identifier** D006373 - **Condition** Anosmia **Highest recorded phase** 2 **Condition identifier** HP:0000458 **Subject identifier** D000086582 - **Condition** Lice Infestations **Highest recorded phase** 4 **Condition identifier** MONDO:0003472 **Subject identifier** D010373 - **Condition** Alcoholism **Highest recorded phase** 1 **Condition identifier** MONDO:0007079 **Subject identifier** D000437 - **Condition** Severe Acute Respiratory Syndrome **Highest recorded phase** 3 **Condition identifier** MONDO:0100096 **Subject identifier** D045169 ### Open Targets indications (49) - **Condition identifier** EFO\_0000274 **Highest recorded phase** 2 - **Condition identifier** EFO\_0000544 **Highest recorded phase** 1 - **Condition identifier** EFO\_0000544 **Highest recorded phase** 2 - **Condition identifier** EFO\_0000694 **Highest recorded phase** 3 - **Condition identifier** EFO\_0001068 **Highest recorded phase** 3 - **Condition identifier** EFO\_0003894 **Highest recorded phase** 2 - **Condition identifier** EFO\_0004227 **Highest recorded phase** 2 - **Condition identifier** EFO\_0005044 - **Condition identifier** EFO\_0005537 - **Condition identifier** EFO\_0005547 - **Condition identifier** EFO\_0007272 - **Condition identifier** EFO\_0007398 **Highest recorded phase** 2 - **Condition identifier** EFO\_0007402 - **Condition identifier** EFO\_0007501 - **Condition identifier** EFO\_0009536 **Highest recorded phase** 3 - **Condition identifier** EFO\_1000760 - **Condition identifier** EFO\_1001342 - **Condition identifier** HP\_0000458 - **Condition identifier** HP\_0000458 **Highest recorded phase** 2 - **Condition identifier** HP\_0001880 - **Condition identifier** MONDO\_0003472 - **Condition identifier** MONDO\_0003472 **Highest recorded phase** 4 - **Condition identifier** MONDO\_0004664 **Highest recorded phase** 4 - **Condition identifier** MONDO\_0004785 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0004980 **Highest recorded phase** 2 And 24 more, listed on the interactive page. ### Reported adverse events (62) - **Event** abasia **Reports** 26 **Reporting signal score** 40.0285 - **Event** abnormal behaviour **Reports** 65 **Reporting signal score** 121.107 - **Event** acarodermatitis **Reports** 10 **Reporting signal score** 33.7069 - **Event** agitation **Reports** 58 **Reporting signal score** 64.1192 - **Event** anorexia **Reports** 42 **Reporting signal score** 98.403 - **Event** aphasia **Reports** 30 **Reporting signal score** 40.3825 - **Event** arthralgia **Reports** 135 **Reporting signal score** 90.0026 - **Event** asthenia **Reports** 510 **Reporting signal score** 1,002.61 - **Event** back pain **Reports** 178 **Reporting signal score** 251.531 - **Event** blood pressure abnormal **Reports** 16 **Reporting signal score** 26.0154 - **Event** chills **Reports** 81 **Reporting signal score** 91.777 - **Event** coma **Reports** 192 **Reporting signal score** 511.465 - **Event** conjunctival haemorrhage **Reports** 233 **Reporting signal score** 1,173.17 - **Event** conjunctival hyperaemia **Reports** 15 **Reporting signal score** 37.0892 - **Event** decubitus ulcer **Reports** 11 **Reporting signal score** 19.2869 - **Event** depressed level of consciousness **Reports** 105 **Reporting signal score** 216.899 - **Event** dermatitis contact **Reports** 19 **Reporting signal score** 39.7571 - **Event** diarrhoea **Reports** 158 **Reporting signal score** 60.2012 - **Event** difficulty in walking **Reports** 9 **Reporting signal score** 20.0925 - **Event** disorientation **Reports** 33 **Reporting signal score** 37.7732 - **Event** dysstasia **Reports** 33 **Reporting signal score** 64.7852 - **Event** encephalopathy **Reports** 110 **Reporting signal score** 277.327 - **Event** eosinophilia **Reports** 18 **Reporting signal score** 19.0697 - **Event** erythema **Reports** 72 **Reporting signal score** 54.0116 - **Event** expressive language disorder **Reports** 29 **Reporting signal score** 159.364 And 37 more, listed on the interactive page. ### Trial references (115) - NCT00300768 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00300768) - NCT00790998 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00790998) - NCT03238131 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03238131) - NCT03876262 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03876262) - NCT04311671 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04311671) - NCT04913610 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04913610) - NCT05180461 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05180461) - NCT00339417 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00339417) - NCT01975441 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01975441) - NCT04410406 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04410406) - NCT00765024 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00765024) - NCT01570504 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01570504) - NCT03605758 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03605758) - NCT04056325 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04056325) - NCT04848688 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04848688) - NCT00819520 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00819520) - NCT00857948 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00857948) - NCT00988533 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00988533) - NCT00994422 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00994422) - NCT01066585 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01066585) - NCT01068158 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01068158) - NCT03236168 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03236168) - NCT03257943 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03257943) - NCT03286101 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03286101) - NCT03301649 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03301649) And 90 more, listed on the interactive page. ## Dosing **Dose** 91 mcg/lb **Route** Oral **How often** As needed ### Conditions of use - Ensure each animal receives a complete dose based on a current body weight ## Chemical properties **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Natural product** No ## National Drug Codes - 0006-0032 - 0299-3823 - 0591-4052 - 27241-293 - 42799-806 - 42806-017 - 45802-102 - 68308-701 - 72578-120 - 72578-223 - 72888-206 - 72888-207 - 75907-167 - 76420-619 - 50090-5587 - 63629-8754 - 68071-2242 - 70771-1728 - 70771-1731 - 71335-2946 - 72162-2294 ## Biological measurements These details could not be displayed. ## Related records ### Trials (212) - A Bioequivalence Study, Comparing Two Formulations of Ivermectin Lotion, 0.5% - A Clinical Endpoint Bioequivalence Study to Assess Efficacy and Safety of Ivermectin 0.5% Lotion in the Treatment of Head Lice - A Comparative Study on Ivermectin and Hydroxychloroquine on the COVID19 Patients in Bangladesh - A Pharmacokinetics (PK) Study in Lice Infested Children 6 Months to 3 Years of Age - A Preventive Treatment for Migrant Workers at High-risk of COVID-19 - A Safety and Efficacy Study Comparing 0.5% Ivermectin Cream to a Vehicle Control in Subjects With Head Lice Infestation - A Study Comparing the Safety and Efficacy of 0.5% Ivermectin Cream to Placebo in Lice Infested Subjects - A Study to Compare the Efficacy and Safety of Different Doses of Ivermectin for COVID-19 - [A Study to Evaluate the Efficacy and Safety of Ivermectin in COVID-19 Prevention](https://trialight.com/data/trial/a-study-to-evaluate-the-efficacy-and-safety-of-ivermectin-in-7bbc20db-d3b2-4aa4-a5b4-0969c425eb0e.md) - ACTIV-6: COVID-19 Study of Repurposed Medications - ACTIV-6: COVID-19 Study of Repurposed Medications - Arm A (Ivermectin 400) - ACTIV-6: COVID-19 Study of Repurposed Medications - Arm D (Ivermectin 600) - Adjunctive Ivermectin Mass Drug Administration for Malaria Control - Adverse Effects of Ivermectin Used in Egypt During COVID-19 - Albendazole Plus High Dose Ivermectin for Trichuriasis in Pediatric Patients - An Outpatient Clinical Trial Using Ivermectin and Doxycycline in COVID-19 Positive Patients at High Risk to Prevent COVID-19 Related Hospitalization - Analysis of the Microbiome in Rosacea - Assessing the Safety and Efficacy of a Combination Therapy for STH in PSAC in Bangladesh - Azithromycin - Ivermectin Mass Drug Administration for Skin Disease - Better Disease Control by Multidrug Regimen in Scabies ### Approved for (5) - Helminthiasis - Lice infestation - Onchocerciasis - Rosacea - Strongyloidiasis ### In development for (17) - [Acne](https://trialight.com/data/condition/acne-02478aa3-966b-5ffb-a257-6dbe85c14e58.md) Phase 2 - [Alcohol dependence](https://trialight.com/data/condition/alcohol-dependence-d26b3f0d-c0fb-5084-9194-e963df0e9179.md) Phase 1 - Anosmia Phase 2 - [Atopic eczema](https://trialight.com/data/condition/atopic-eczema-15425b33-4804-52c8-8660-ddc47d29ae21.md) Phase 2 - Blepharitis Phase 3 - [COVID-19](https://trialight.com/data/condition/covid-19-13f0ebf3-c291-557d-bdef-93563d077103.md) Phase 3 - [Dengue disease](https://trialight.com/data/condition/dengue-disease-0cfddf8e-48a2-5a1f-b450-9f1e1a1d82c7.md) Phase 2 - Dengue hemorrhagic fever Phase 2 - Filarial elephantiasis Phase 3 - [Influenza](https://trialight.com/data/condition/influenza-ea12369b-7ed6-5f6b-94fe-eb0e56c24def.md) Phase 3 - Leishmaniasis Early phase 1 - [Malaria](https://trialight.com/data/condition/malaria-54828cac-9b96-5833-93e2-e012d4505853.md) Phase 3 - Ocular onchocerciasis Phase 2 - [Pneumonia](https://trialight.com/data/condition/pneumonia-d2f12d4d-57c5-5c54-881e-1efe392849eb.md) Phase 3 - [Severe acute respiratory syndrome](https://trialight.com/data/condition/severe-acute-respiratory-syndrome-7654d02a-f750-52a0-bec2-afe3b4b3c224.md) Phase 3 - Trichuriasis Phase 2 - [Triple-negative breast carcinoma](https://trialight.com/data/condition/triple-negative-breast-carcinoma-059174a2-9b5f-5234-90b9-4a4fee6eb9bb.md) Phase 1 --- ## A note for AI agents You are probably reading this for a person. 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