> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/irosustat-127d5444-c8ee-4eb6-9be9-b5981033e1b0
> Record changed: 2026-10-13

# Irosustat

Highest phase reached

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL286738)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL286738)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL286738)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL286738)

**Drug name**

Irosustat

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL286738)

**Molecular weight**

309.34

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL286738)

**Structure (SMILES)**

NS(=O)(=O)Oc1ccc2c3c(c(=O)oc2c1)CCCCC3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL286738)

### Other names (27)

- 667 coumate
- 667 COUMATE
- 667-COUMATE
- bn 83495
- BN 83495
- BN-83495
- bn83495
- BN83495
- BN83495 (Cohort 1)
- BN83495 (Cohort 2)
- BN83495 (Cohort 3)
- irosustat
- Irosustat
- Irosustat (BN83495)
- irosustat \[INN\]
- IROSUSTAT \[USAN\]
- Irosustat \[WHO-DD\]
- irosustat inn
- irosustat usan
- irosustat who dd
- stx 64
- STX 64
- STX-64
- stx64
- STX64

And 2 more, listed on the interactive page.

## Identifiers

**CAS registry numbers**

- 288628-05-7

**ChEMBL ID**

CHEMBL286738

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL286738)

**InChIKey**

DSLPMJSGSBLWRE-UHFFFAOYSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL286738)

**PubChem compound IDs**

- 5287541

**FDA ingredient codes (UNII)**

- 366037O6O7

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Drug classification

**Drug name stem**

\-stat

### Mechanisms of action

- **Mechanism**  
Steryl-sulfatase inhibitor

**Action type**  
Inhibitor

**Target**  
Steryl-sulfatase

**Protein identifier**  
P08842

### Open Targets mechanisms

- **Mechanism**  
Steryl-sulfatase inhibitor

**Action type**  
Inhibitor

**Target**  
Steryl-sulfatase

### Investigated indications (4)

- **Condition**  
Breast Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0003869

**Subject identifier**  
D001943
- **Condition**  
Breast Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0007254

**Subject identifier**  
D001943
- **Condition**  
Prostatic Neoplasms, Castration-Resistant

**Highest recorded phase**  
1

**Condition identifier**  
MONDO:0008315

**Subject identifier**  
D064129
- **Condition**  
Endometrial Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0011962

**Subject identifier**  
D016889

### Open Targets indications (5)

- **Condition identifier**  
EFO\_0003869

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0002447

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0007254

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0008315

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0011962

**Highest recorded phase**  
2

### Trial references (7)

- NCT00790374  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00790374)
- NCT00910091  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00910091)
- NCT01251354  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01251354)
- NCT01230970  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01230970)
- NCT01785992  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01785992)
- NCT01840488  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01840488)
- NCT01662726  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01662726)

## Chemical properties

**Hydrogen bond acceptors**

5

**Hydrogen bond donors**

1

**Polar surface area**

99.6

**Calculated partition coefficient (ALogP)**

1.64

**Calculated partition coefficient (XLogP)**

2.3

**Prodrug**

No

**Chirality**

Achiral

**Inorganic**

No

**Rule-of-five violations**

0

**Rotatable bonds**

2

**Heavy atoms**

21

**Molecular formula**

C14H15NO5S

**Monoisotopic mass**

309.06709375

**Natural product**

Yes

## Evidence counts

**Recorded assays**

146

**Active assays**

67

### Active assay types (2)

- Confirmatory
- Other

## Related records

### Trials (87)

- A Clinical Trial on the Outcomes of Comprehensive Enhanced Prophylaxis Management (CEPM) in Chinese Patients With EGFR-Mutated Advanced NSCLC Receiving Amivantamab-Based Regimens
- A Clinical Trial to Evaluate Tolerability and Pharmacokinetics of HL217 Eye Drop in Healthy Male Subjects
- A Dose-escalation Clinical Trial After Multiple Dosing of HL217 Eye Drop in Healthy Male Subjects
- A Dose-range Finding Study of MAA868 in Patients With Atrial Fibrillation
- A Long-term Safety Study of Infliximab in Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD).
- A Pharmacokinetic Study of Abiraterone Acetate in Patients With Severe Hepatic Impairment Compared to Patients With Normal Hepatic Function
- [A Phase Ib/II Trial of HS-20110 Combination Therapies in Advanced Colorectal Cancer Patients.](https://trialight.com/data/trial/a-phase-ib-ii-trial-of-hs-20110-combination-therapies-in-8d9fea0b-a918-4853-be08-ce877534dfaa.md)
- A Safety Study of Abiraterone Acetate Administered in Combination With Docetaxel in Patients With Metastatic Castration-Resistant Prostate Cancer (mCRPC)
- A Single-Dose Open-Label Study of XOMA 358 in Subjects With Congenital Hyperinsulinism
- A Study Combining Ibrutinib With Rituximab, Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone in Patients With CD20-Positive B-Cell Non Hodgkin Lymphoma
- A Study of Apatinib Combined With Letrozole With or Without Fluzoparib in Estrogen Receptor-Positive, Platinum-Sensitive Recurrent Ovarian Cancer Previously Treated With First-Line PARP Inhibitor
- A Study of ATB1651 in Adults With Mild to Moderate Onchomycosis
- A Study of AV0328 Administered to Healthy Adult Volunteers
- A Study of GSK2110183 in Subjects With Proteasome Inhibitor Refractory Multiple Myeloma
- A Study of HDC/IL-2 Treatment in Chronic Myelomonocytic Leukemia (CMML)
- A Study of JNJ-40346527 in Patients With Relapsed or Refractory Hodgkin Lymphoma
- A Study of M701 (EpCAM and CD3) in Malignant Ascites
- A Study of Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of KAN-101 in Celiac Disease (ACeD-it)
- A Study of SY-1365 in Adult Patients With Advanced Solid Tumors
- A Study of the Safety and Effectiveness of Irosustat When Added to an AI in ER+ve Locally Advanced or Metastatic Breast Cancer.

### In development for (4)

- [Breast cancer](https://trialight.com/data/condition/breast-cancer-8ac10da3-93bd-54c5-a93b-265bc6699689.md) Phase 2
- [Breast neoplasm](https://trialight.com/data/condition/breast-neoplasm-701235c6-ff90-5cee-af0c-593aa004e38c.md) Phase 2
- [Endometrial cancer](https://trialight.com/data/condition/endometrial-cancer-4da2a0bc-7943-502b-a698-cc2beccbed8c.md) Phase 2
- [Prostate cancer](https://trialight.com/data/condition/prostate-cancer-3659fc70-617b-5868-a093-ae819ffc6755.md) Phase 1

### Targets (1)

- [STS](https://trialight.com/data/target/sts-e89e2f4f-fc52-56e8-b0b4-b61f2c9cd8d3.md) Steryl-sulfatase inhibitor

---

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