> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/irinotecan-sucrosofate-66c3ee1a-3027-4788-891f-b941309b8241
> Record changed: 2026-11-04

# Irinotecan sucrosofate

Highest phase reached

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314381)

Drug type

Small molecule

Source: [gsrs.ncats.nih.gov](https://gsrs.ncats.nih.gov/ginas/app/beta/substances/OL741S3N8B)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314381)

## Names and chemistry

**Drug type**

Small molecule

Source: [gsrs.ncats.nih.gov](https://gsrs.ncats.nih.gov/ginas/app/beta/substances/OL741S3N8B)

**Drug name**

Irinotecan sucrosofate

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314381)

**Molecular weight**

3,329.56

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314381)

**Structure (SMILES)**

CCc1c2c(nc3ccc(OC(=O)N4CCC(N5CCCCC5)CC4)cc13)-c1cc3c(c(=O)n1C2)COC(=O)\[C@\]3(O)CC.CCc1c2c(nc3ccc(OC(=O)N4CCC(N5CCCCC5)CC4)cc13)-c1cc3c(c(=O)n1C2)COC(=O)\[C@\]3(O)CC.CCc1c2c(nc3ccc(OC(=O)N4CCC(N5CCCCC5)CC4)cc13)-c1cc3c(c(=O)n1C2)COC(=O)\[C@\]3(O)CC.CCc1c2c(nc3ccc(OC(=O)N4CCC(N5CCCCC5)CC4)cc13)-c1cc3c(c(=O)n1C2)COC(=O)\[C@\]3(O)CC.O=S(=O)(O)OC\[C@H\]1O\[C@@\](COS(=O)(=O)O)(O\[C@H\]2O\[C@H\](COS(=O)(=O)O)\[C@@H\](OS(=O)(=O)O)\[C@H\](OS(=O)(=O)O)\[C@H\]2OS(=O)(=O)O)\[C@@H\](OS(=O)(=O)O)\[C@@H\]1OS(=O)(=O)O

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314381)

### Other names (12)

- irinotecan sucrosofate
- Irinotecan sucrosofate
- Irinotecan Sucrosofate
- IRINOTECAN SUCROSOFATE \[USAN\]
- Irinotecan sucrosofate \[WHO-DD\]
- irinotecan sucrosofate usan
- irinotecan sucrosofate who dd
- mm 398
- MM-398
- pep 02
- PEP-02
- pep02

## Identifiers

**CAS registry numbers**

- 1361317-83-0

**ChEMBL ID**

CHEMBL5314381

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314381)

**InChIKey**

BCPSLKYBXGKPIW-RTXWKGGWSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314381)

**PubChem compound IDs**

- 76964235

**FDA ingredient codes (UNII)**

- OL741S3N8B

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Drug classification

**Drug name stem**

\-tecan

### Mechanisms of action

- **Mechanism**  
DNA topoisomerase I inhibitor

**Action type**  
Inhibitor

**Target**  
DNA topoisomerase 1

**Protein identifier**  
P11387

### Open Targets mechanisms

- **Mechanism**  
DNA topoisomerase I inhibitor

**Action type**  
Inhibitor

**Target**  
DNA topoisomerase 1

### Investigated indications (5)

- **Condition**  
Neoplasms

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000616

**Subject identifier**  
D009369
- **Condition**  
Pancreatic Neoplasms

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0002618

**Subject identifier**  
D010190
- **Condition**  
Rectal Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
EFO:1000657

**Subject identifier**  
D012004
- **Condition**  
Neoplasms

**Highest recorded phase**  
1

**Condition identifier**  
MONDO:0004992

**Subject identifier**  
D009369
- **Condition**  
Colorectal Neoplasms

**Highest recorded phase**  
1

**Condition identifier**  
MONDO:0005575

**Subject identifier**  
D015179

### Open Targets indications (17)

- **Condition identifier**  
EFO\_0003860

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_1000359

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_1001480

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0001056

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0002158

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0003219

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005036

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005070

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005184

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0005192

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005575

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0006047

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0006519

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0008170

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0009831

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0015686

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0021040

**Highest recorded phase**  
3

### Reported adverse events (36)

- **Event**  
abdominal pain

**Reports**  
349

**Reporting signal score**

114.509
- **Event**  
alopecia

**Reports**  
223

**Reporting signal score**

121.526
- **Event**  
anaemia

**Reports**  
518

**Reporting signal score**

303.38
- **Event**  
bone marrow failure

**Reports**  
138

**Reporting signal score**

152.844
- **Event**  
cholinergic syndrome

**Reports**  
34

**Reporting signal score**

107.176
- **Event**  
colorectal cancer metastatic

**Reports**  
62

**Reporting signal score**

206.339
- **Event**  
decreased appetite

**Reports**  
437

**Reporting signal score**

317.979
- **Event**  
dehydration

**Reports**  
289

**Reporting signal score**

163.275
- **Event**  
dermatitis acneiform

**Reports**  
86

**Reporting signal score**

179.622
- **Event**  
diarrhoea

**Reports**  
1,643

**Reporting signal score**  
1,415.08
- **Event**  
disease progression

**Reports**  
739

**Reporting signal score**  
1,181.56
- **Event**  
epistaxis

**Reports**  
185

**Reporting signal score**

132.179
- **Event**  
febrile neutropenia

**Reports**  
435

**Reporting signal score**

570.852
- **Event**  
gastrointestinal toxicity

**Reports**  
79

**Reporting signal score**

171.785
- **Event**  
general physical health deterioration

**Reports**  
214

**Reporting signal score**

154.885
- **Event**  
haematotoxicity

**Reports**  
110

**Reporting signal score**

193.853
- **Event**  
headache

**Reports**  
82

**Reporting signal score**

109.656
- **Event**  
hypertension

**Reports**  
408

**Reporting signal score**

215.822
- **Event**  
intestinal obstruction

**Reports**  
111

**Reporting signal score**

108.632
- **Event**  
leukopenia

**Reports**  
331

**Reporting signal score**

395.033
- **Event**  
malignant neoplasm progression

**Reports**  
284

**Reporting signal score**

302.542
- **Event**  
metastases to liver

**Reports**  
142

**Reporting signal score**

265.622
- **Event**  
metastases to lung

**Reports**  
74

**Reporting signal score**

120.989
- **Event**  
mucosal inflammation

**Reports**  
284

**Reporting signal score**

463.529
- **Event**  
myelosuppression

**Reports**  
104

**Reporting signal score**

162.77

And 11 more, listed on the interactive page.

### Trial references (6)

- NCT01494506  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01494506)
- NCT02551991  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02551991)
- NCT02631733  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02631733)
- NCT02640365  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02640365)
- NCT02785068  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02785068)
- NCT04009876  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04009876)

## Chemical properties

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Heavy atoms**

227

**Molecular formula**

C144H174N16O59S8

**Monoisotopic mass**

3326.8872715

**Natural product**

No

## Related records

### Trials (80)

- 2nd-line Therapy With Nal-IRI After Gem/Nab-pac in Advanced Pancreatic Cancer - Predictive Role of 1st-line Therapy
- A Dose Escalation Study of MM-398 Plus Irinotecan in Patients With Unresectable Advanced Cancer
- A Phase II Study of Irinotecan Liposome Plus Fruquintinib and Sintilimab in Second-Line PD-L1-Positive Advanced Gastric Cancer
- A PhaseⅠ/Ⅱ Study of Simmitinib or Irinotecan Liposomes Combined With DP303c in Gastric Adenocarcinoma or Gastroesophageal Junction Adenocarcinoma
- A Randomized Controlled Study Comparing the Safety and Efficacy of Irinotecan Hydrochloride Liposome Injection Combined With Temozolomide and Vincristine (NALIRI-VT) Versus Irinotecan Combined With Temozolomide and Vincristine (VIT) in Patients With Advanced Ewing's Sarcoma
- A Study Comparing BL-B01D1 With Treatment of Physician's Choice in Patients With Locally Advanced or Metastatic Biliary Tract Cancer After Failure of Platinum-based Chemotherapy(PANKU-BTC01)
- A Study Evaluating the Efficacy of 5-FU + NALIRI and 5-FU + NALIRINOX for PDAC (NALPAC)
- A Study of BBI608 in Combination With Standard Chemotherapies in Adult Patients With Pancreatic Cancer
- A Study of BL-M07D1 Versus Physician's Choice of Chemotherapy in Patients With HER2-expressing Locally Advanced or Metastatic Biliary Tract Cancer After Platinum-containing Chemotherapy Failure
- A Study of Irinotecan Hydrochloride Liposome in Combination With 5-FU/LV in Advanced Solid Tumors
- A Study of Nal-IRI With 5-FU, Levofolinic Acid and Oxaliplatin in Patients With Resectable Pancreatic Cancer
- A Study of NALIRIFOX in Combination With Radiation Therapy in People With Pancreatic Ductal Adenocarcinoma (PDAC)
- A Study of PEP02 in Combination With 5-fluorouracil (5-FU) and Leucovorin (LV) in Advanced Solid Tumors
- [A Study to Compare Onivyde Manufactured at Two Different Production Sites in Adult Participants With Advanced Cancer in the Pancreas](https://trialight.com/data/trial/a-study-to-compare-onivyde-manufactured-at-two-different-827c28ba-0328-4e9f-a2e3-8eccd9c2ac66.md)
- Adebrelimab Combined with Irinotecan Liposomes, 5-FU, CF ± Lenvatinib As First-line Treatment for Advanced ICC
- AZD0901 in Participants With Advanced Solid Tumours Expressing Claudin18.2
- Basal-like PDAC Treated With Gemcitabine, Erlotinib, and Nab-paclitaxel
- BrUOG 329 Onivyde & Metronomic Temozolomide in Recurrent Glioblastoma
- Chemotherapy and Surgical Resection in Patients With Hepatic Oligometastatic Adenocarcinoma of the Pancreas
- Clinical Study of Irinotecan Hydrochloride Liposome Combined With Capecitabine for Second-line Treatment in Patients With Advanced or Metastatic Biliary Tract Carcinoma

### In development for (15)

- [Cancer](https://trialight.com/data/condition/cancer-703b1dfc-4812-50eb-83f4-d7a205d16bdb.md) Phase 1
- [Colorectal cancer](https://trialight.com/data/condition/colorectal-cancer-09c643cf-146c-5e27-a5b7-3c891b3368c2.md) Phase 1
- Exocrine pancreatic carcinoma Phase 3
- [Fallopian tube cancer](https://trialight.com/data/condition/fallopian-tube-cancer-b95d05ee-41d5-565a-87e1-041170b88760.md) Phase 2
- [Gastric adenocarcinoma](https://trialight.com/data/condition/gastric-adenocarcinoma-6bb74a55-7ba6-53e3-a113-22296a84d6ae.md) Phase 2
- [Gastric cancer](https://trialight.com/data/condition/gastric-cancer-3c1e2785-2672-5b3e-afce-9335f684c159.md) Phase 1
- [Gastroesophageal junction adenocarcinoma](https://trialight.com/data/condition/gastroesophageal-junction-adenocarcinoma-de7e280e-cbd1-5266-a5dd-dda00261a706.md) Phase 2
- [Malignant pancreatic neoplasm](https://trialight.com/data/condition/malignant-pancreatic-neoplasm-5dd0b53e-5962-50ea-a2e5-cf2444bd0485.md) Phase 3
- [Neoplasm](https://trialight.com/data/condition/neoplasm-2a973797-359b-5982-907e-98f9b7c1a284.md) Phase 1
- [Ovarian cancer](https://trialight.com/data/condition/ovarian-cancer-f64f2018-55a5-553a-8960-76cb4906aa17.md) Phase 2
- [Pancreatic adenocarcinoma](https://trialight.com/data/condition/pancreatic-adenocarcinoma-fd65444c-0bc5-53ed-8c6a-62d9809145d0.md) Phase 3
- [Pancreatic ductal adenocarcinoma](https://trialight.com/data/condition/pancreatic-ductal-adenocarcinoma-77c1c5a8-638b-51d0-b18e-2c881b8902e5.md) Phase 3
- [Pancreatic neoplasm](https://trialight.com/data/condition/pancreatic-neoplasm-de300cc3-339a-5c06-97d8-2d9155fc3a7b.md) Phase 3
- Primary peritoneal carcinoma Phase 2
- Rectal cancer Phase 2

### Targets (1)

- [TOP1](https://trialight.com/data/target/top1-efb273d0-ed4a-5281-9372-90a0abb25f90.md) DNA topoisomerase I inhibitor

---

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