> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/iopamidol-5d66dbc0-3998-48c7-a712-99f0c2abf24b > Record changed: 2026-10-13 # Iopamidol Highest phase reached Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200932) Drug type Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200932) First approval year 1985 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200932) ## Development status **First approval year** 1985 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200932) **Listing at source** Listed **Highest phase reached** Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200932) ## Names and chemistry **Drug type** Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200932) **Drug name** Iopamidol Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200932) **Molecular weight** 777.09 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200932) **Structure (SMILES)** C\[C@H\](O)C(=O)Nc1c(I)c(C(=O)NC(CO)CO)c(I)c(C(=O)NC(CO)CO)c1I Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200932) ### Brand names (30) - iopamidol - Iopamidol - iopamidol 200 - iopamidol 250 - iopamidol 300 - iopamidol 370 - Iopamidol-200 - Iopamidol-250 - Iopamidol-300 - Iopamidol-370 - isovue - Isovue - isovue 128 - isovue 200 - isovue 250 - isovue 300 - isovue 370 - isovue m 200 - isovue m 300 - Isovue-128 - Isovue-200 - Isovue-250 - Isovue-300 - Isovue-370 - Isovue-m 200 And 5 more, listed on the interactive page. ### Other names (39) - iopamidol - Iopamidol - Iopamidol \[EP IMPURITY\] - Iopamidol \[EP MONOGRAPH\] - Iopamidol \[INN\] - Iopamidol \[JAN\] - Iopamidol \[MART.\] - Iopamidol \[MI\] - Iopamidol \[ORANGE BOOK\] - Iopamidol \[USAN\] - Iopamidol \[USP MONOGRAPH\] - Iopamidol \[VANDF\] - Iopamidol \[WHO-DD\] - Iopamidol 300 (Contrast) - Iopamidol 370 - iopamidol ep impurity - iopamidol ep monograph - iopamidol inn - iopamidol jan - iopamidol mart - iopamidol mi - iopamidol orange book - iopamidol usan - iopamidol usp monograph - iopamidol vandf And 14 more, listed on the interactive page. ## Identifiers **ATC classification codes** - V08AB04 Sources for recorded values Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200932) **CAS registry numbers** - 60166-93-0 **ChEMBL ID** CHEMBL1200932 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200932) **InChIKey** XQZXYNRDCRIARQ-LURJTMIESA-N Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200932) **PubChem compound IDs** - 65492 **RxNorm IDs (RxCUI)** - 5966 **FDA ingredient codes (UNII)** - JR13W81H44 ## Regulatory information ### United States **Applicant** BRACCO **Approval date** 31 Dec 1985 **Application number** NDA018735 ### Other regulatory facts **Patents** 0 **Designations** 0 **Earliest recorded loss of exclusivity** 10 Oct 2028 **First in class** No **Fast track** No **Breakthrough designation** No **Orphan designation** No **Priority review** No **Orphan exclusivity** No **Accelerated approval** No **Availability** Prescription only ## Pharmacology ### Drug classification **Drug name stem** io- #### Administration routes - Parenteral ### Investigated indications (6) - **Condition** Carcinoma, Renal Cell **Highest recorded phase** 0.5 **Condition identifier** EFO:0000681 **Subject identifier** D002292 - **Condition** Glioma **Highest recorded phase** 4 **Condition identifier** EFO:0005543 **Subject identifier** D005910 - **Condition** Urinary Bladder Neoplasms **Highest recorded phase** 0.5 **Condition identifier** EFO:0008528 **Subject identifier** D001749 - **Condition** Pituitary Neoplasms **Highest recorded phase** 4 **Condition identifier** EFO:1000979 **Subject identifier** D010911 - **Condition** Breast Neoplasms **Highest recorded phase** 1 **Condition identifier** MONDO:0007254 **Subject identifier** D001943 - **Condition** Prostatic Neoplasms, Castration-Resistant **Highest recorded phase** 0.5 **Condition identifier** MONDO:0008315 **Subject identifier** D064129 ### Open Targets indications (9) - **Condition identifier** EFO\_0000319 - **Condition identifier** EFO\_0000681 - **Condition identifier** EFO\_0005543 - **Condition identifier** EFO\_0008528 - **Condition identifier** EFO\_1000979 - **Condition identifier** MONDO\_0004995 **Highest recorded phase** 4 - **Condition identifier** MONDO\_0006799 **Highest recorded phase** 4 - **Condition identifier** MONDO\_0008315 - **Condition identifier** MONDO\_0021042 **Highest recorded phase** 4 ### Reported adverse events (42) - **Event** anaphylactic reaction **Reports** 123 **Reporting signal score** 211.866 - **Event** anaphylactic shock **Reports** 92 **Reporting signal score** 211.716 - **Event** anaphylactoid reaction **Reports** 66 **Reporting signal score** 225.548 - **Event** arthralgia **Reports** 6 **Reporting signal score** 21.7251 - **Event** blood pressure decreased **Reports** 47 **Reporting signal score** 49.7907 - **Event** blood pressure immeasurable **Reports** 8 **Reporting signal score** 21.1022 - **Event** cardiac arrest **Reports** 25 **Reporting signal score** 22.3105 - **Event** cardio-respiratory arrest **Reports** 43 **Reporting signal score** 104.785 - **Event** compartment syndrome **Reports** 12 **Reporting signal score** 27.6924 - **Event** contrast encephalopathy **Reports** 15 **Reporting signal score** 77.7582 - **Event** contrast media allergy **Reports** 31 **Reporting signal score** 123.597 - **Event** contrast media reaction **Reports** 108 **Reporting signal score** 506.243 - **Event** convulsion **Reports** 37 **Reporting signal score** 22.4486 - **Event** depressed level of consciousness **Reports** 28 **Reporting signal score** 20.8277 - **Event** diarrhoea **Reports** 14 **Reporting signal score** 32.4811 - **Event** drug interaction **Reports** 1 **Reporting signal score** 22.0136 - **Event** dyspnoea **Reports** 166 **Reporting signal score** 66.8335 - **Event** electrocardiogram st segment elevation **Reports** 15 **Reporting signal score** 32.3007 - **Event** erythema **Reports** 67 **Reporting signal score** 39.0704 - **Event** extravasation **Reports** 54 **Reporting signal score** 163.868 - **Event** fall **Reports** 4 **Reporting signal score** 23.7127 - **Event** fatigue **Reports** 7 **Reporting signal score** 50.231 - **Event** flushing **Reports** 37 **Reporting signal score** 23.2585 - **Event** hepatic artery stenosis **Reports** 12 **Reporting signal score** 61.9776 - **Event** hypersensitivity **Reports** 159 **Reporting signal score** 203.637 And 17 more, listed on the interactive page. ### Trial references (2) - NCT03071328 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03071328) - NCT04504331 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04504331) ## Dosing ### Conditions of use (8) - Discard unused portion after use - Maintain in inverted position during use - Maximum use time is 10 hours after puncture - Penetrate container once with sterile system - Storage temperature should not exceed 25°C (77°F) - Swab container stopper with 70% isopropyl alcohol before opening - Use aseptic technique - Use only in designated radiological procedure rooms ## Chemical properties **Hydrogen bond acceptors** 8 **Hydrogen bond donors** 8 **Polar surface area** 188.45 **Calculated partition coefficient (ALogP)** \-1.01 **Calculated partition coefficient (XLogP)** \-2.4 **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Rule-of-five violations** 2 **Rotatable bonds** 10 **Heavy atoms** 31 **Molecular formula** C17H22I3N3O8 **Monoisotopic mass** 776.8541 **Natural product** Yes ## National Drug Codes - 0270-1314 - 0270-1315 - 0270-1316 - 0270-1317 - 0270-1411 - 0270-1412 - 70436-124 - 70436-125 - 70436-126 - 70436-127 - 70436-211 - 70436-219 ## Evidence counts **Recorded assays** 814 **Active assays** 6 ### Active assay types (3) - Confirmatory - Other - Summary ## Pharmacologic actions - Contrast Media Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D003287.html) ## Related records ### Trials (91) - 3 Tesla Magnetic Resonance Guided High Intensity Focused Ultrasound in the Treatment of Pain From Bone Metastases of Solid Tumors - A Contrast Medium Sparing Strategy Using Automated CO2 Injection During PVI for Prevention of Major Adverse Kidney Events (MAKE) - A Study of HCC High Risk Group Using Two Surveillance Tools - A Study of Two Iodinated Contrast Agents in Renally Impaired Patients Undergoing Cardiac Angiography - Accelerated Contrast-Enhanced High Resolution Whole Heart Cardiac MRI - Adenosine Contrast CorrELations in Evaluating RevAscularizaTION - Advanced MRI Scan Before and After Radiation Therapy for the Detection of Intracranial Metastasis - Aging Biomakers and ConTrast Induced Nephropathy (ACTIN) Trial - Aortic Stenosis Pre-Transcatheter Aortic Valve Replacement (TAVR) Procedure CT Scan - CEM to Reduce Biopsy Rates for Less Than Highly Suspicious Breast Abnormalities: a Prospective Study - Comparing Patient Comfort and Safety Between Iodixanol and Iopamidol in Patients Undergoing Peripheral Arteriography - Comparison of Isovue 370 vs. Standard Protocol in Coronary Computed Tomographic Angiography (CTA) - CONTRAST (Can cONTrast Injection Better Approximate FFR compAred to Pure reSTing Physiology?) - Contrast Enhanced Endoscopic Ultrasound in Pancreas Lesions - Contrast Enhanced Transrectal Ultrasonography (TRUS) to Assess Prostatic Vascularity After Radiotherapy (XRT) - Contrast Enhanced Ultrasound for Evaluation of Pediatric Abdominal Trauma - Contrast Ultrasound Perfusion Imaging in PAD With Sonazoid - Contrast-Enhanced Cone Beam Breast CT for Diagnostic Breast Imaging - Contrast-Enhanced CT and MRI in Diagnosing and Staging Liver Cancer Using UNOS Policy - Contrast-enhanced Ultrasound Evaluation of Chemoembolization ### Approved for (2) - [Glioma](https://trialight.com/data/condition/glioma-4ac240c4-7ffb-5f08-b793-0b205a4b5d03.md) - Hypothalamic neoplasm ### In development for (4) - [Breast cancer](https://trialight.com/data/condition/breast-cancer-8ac10da3-93bd-54c5-a93b-265bc6699689.md) Phase 1 - [Prostate cancer](https://trialight.com/data/condition/prostate-cancer-3659fc70-617b-5868-a093-ae819ffc6755.md) Early phase 1 - [Renal cell carcinoma](https://trialight.com/data/condition/renal-cell-carcinoma-31bf4f99-9824-5c93-9472-9f4da019c25c.md) Early phase 1 - [Urothelial carcinoma](https://trialight.com/data/condition/urothelial-carcinoma-b2aa266d-2d5f-5e5d-a0de-62274f2dc094.md) Early phase 1 ### Other linked conditions (1) - [Cardiovascular disorder](https://trialight.com/data/condition/cardiovascular-disorder-362e433e-88a4-575f-90af-50fe7239dec0.md) --- ## A note for AI agents You are probably reading this for a person. 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