> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/iohexol-47b25ad2-29fc-48fb-abf6-c5a716efc8d8 > Record changed: 2026-11-04 # Iohexol Highest phase reached Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200455) Drug type Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200455) First approval year 1985 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200455) ## Development status **First approval year** 1985 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200455) **Listing at source** Listed **Highest phase reached** Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200455) ## Names and chemistry **Drug type** Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200455) **Drug name** Iohexol Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200455) **Molecular weight** 821.14 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200455) **Structure (SMILES)** CC(=O)N(CC(O)CO)c1c(I)c(C(=O)NCC(O)CO)c(I)c(C(=O)NCC(O)CO)c1I Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200455) ### Brand names (24) - exypaque - Exypaque - omnipaque - Omnipaque - omnipaque 12 - Omnipaque 12 - omnipaque 140 - Omnipaque 140 - omnipaque 180 - Omnipaque 180 - omnipaque 210 - Omnipaque 210 - omnipaque 240 - Omnipaque 240 - omnipaque 300 - Omnipaque 300 - omnipaque 350 - Omnipaque 350 - omnipaque 70 - Omnipaque 70 - omnipaque 9 - Omnipaque 9 - oraltag - Oraltag ### Other names (56) - 1 3 benzenedicarboxamide 5 acetyl 2 3 dihydroxypropyl amino n n bis 2 3 dihydroxypropyl 2 4 6 triiodo - 1,3-BENZENEDICARBOXAMIDE, 5-(ACETYL(2,3-DIHYDROXYPROPYL)AMINO)-N,N'-BIS(2,3-DIHYDROXYPROPYL)-2,4,6-TRIIODO - 15 40 ml of dye iohexol as contrast - Iodinated Contrast Agent (Omnipaque) - iodinated contrast agent omnipaque - iohexol - Iohexol - IOHEXOL - IOHEXOL \[EP IMPURITY\] - IOHEXOL \[EP MONOGRAPH\] - iohexol \[INN\] - IOHEXOL \[JAN\] - IOHEXOL \[MART.\] - IOHEXOL \[MI\] - IOHEXOL \[ORANGE BOOK\] - IOHEXOL \[USAN\] - IOHEXOL \[USP MONOGRAPH\] - IOHEXOL \[USP-RS\] - IOHEXOL \[VANDF\] - Iohexol \[WHO-DD\] - IOHEXOL \[WHO-IP\] - iohexol ep impurity - iohexol ep monograph - iohexol injection - Iohexol Injection And 31 more, listed on the interactive page. ## Identifiers **ATC classification codes** - V08AB02 Sources for recorded values Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200455) **CAS registry numbers** - 66108-95-0 **ChEMBL ID** CHEMBL1200455 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200455) **InChIKey** NTHXOOBQLCIOLC-UHFFFAOYSA-N Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200455) **PubChem compound IDs** - 3730 **RxNorm IDs (RxCUI)** - 5956 **FDA ingredient codes (UNII)** - 4419T9MX03 ## Regulatory information ### United States **Applicant** GE HEALTHCARE **Approval date** 26 Dec 1985 **Application number** NDA018956 ### Other regulatory facts **Patents** 0 **Designations** 0 **Earliest recorded loss of exclusivity** 26 Jul 2026 **First in class** No **Fast track** No **Breakthrough designation** No **Orphan designation** No **Priority review** No **Orphan exclusivity** No **Accelerated approval** No **Availability** Prescription only **Boxed warning** Yes ## Approval status **United States (FDA)** Approved ## Pharmacology ### Drug classification **Drug name stem** io- #### Administration routes - Oral - Parenteral - topical ### Investigated indications (9) - **Condition** Neoplasms **Highest recorded phase** 1 **Condition identifier** EFO:0000616 **Subject identifier** D009369 - **Condition** HIV Infections **Highest recorded phase** 1 **Condition identifier** EFO:0000764 **Subject identifier** D015658 - **Condition** Kidney Diseases **Highest recorded phase** 2 **Condition identifier** EFO:0003086 **Subject identifier** D007674 - **Condition** Myocardial Ischemia **Highest recorded phase** 3 **Condition identifier** EFO:1001375 **Subject identifier** D017202 - **Condition** Renal Insufficiency **Highest recorded phase** 1 **Condition identifier** HP:0000083 **Subject identifier** D051437 - **Condition** Acute Kidney Injury **Highest recorded phase** 2 **Condition identifier** HP:0001919 **Subject identifier** D058186 - **Condition** Neoplasms **Highest recorded phase** 1 **Condition identifier** MONDO:0004992 **Subject identifier** D009369 - **Condition** Breast Neoplasms **Highest recorded phase** 1 **Condition identifier** MONDO:0007254 **Subject identifier** D001943 - **Condition** Fabry Disease **Highest recorded phase** 1 **Condition identifier** MONDO:0010526 **Subject identifier** D000795 ### Open Targets indications (8) - **Condition identifier** EFO\_0000616 **Highest recorded phase** 1 - **Condition identifier** EFO\_0003086 **Highest recorded phase** 2 - **Condition identifier** EFO\_1001375 **Highest recorded phase** 3 - **Condition identifier** HP\_0000083 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0002492 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005147 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0005575 - **Condition identifier** MONDO\_0010526 **Highest recorded phase** 1 ### Warnings - **Warning** Black Box Warning **Effect** misuse ### Open Targets warnings - **Warning** Black Box Warning **Effect** misuse **Country** United States ### Reported adverse events (49) - **Event** anaphylactic reaction **Reports** 146 **Reporting signal score** 160.319 - **Event** anaphylactic shock **Reports** 105 **Reporting signal score** 169.231 - **Event** anaphylactoid reaction **Reports** 82 **Reporting signal score** 228.828 - **Event** anaphylactoid shock **Reports** 28 **Reporting signal score** 104.876 - **Event** blood pressure decreased **Reports** 105 **Reporting signal score** 106.711 - **Event** cardio-respiratory arrest **Reports** 36 **Reporting signal score** 52.5549 - **Event** chest discomfort **Reports** 134 **Reporting signal score** 113.106 - **Event** chills **Reports** 192 **Reporting signal score** 192.6 - **Event** contrast media allergy **Reports** 100 **Reporting signal score** 430.232 - **Event** contrast media reaction **Reports** 175 **Reporting signal score** 753.508 - **Event** cough **Reports** 169 **Reporting signal score** 61.5372 - **Event** diarrhoea **Reports** 32 **Reporting signal score** 77.4048 - **Event** drug reaction with eosinophilia and systemic symptoms **Reports** 59 **Reporting signal score** 50.1588 - **Event** dyspnoea **Reports** 437 **Reporting signal score** 206.879 - **Event** erythema **Reports** 435 **Reporting signal score** 632.414 - **Event** extravasation **Reports** 128 **Reporting signal score** 389.349 - **Event** eye pruritus **Reports** 50 **Reporting signal score** 72.2687 - **Event** eye swelling **Reports** 66 **Reporting signal score** 88.2167 - **Event** eyelid oedema **Reports** 43 **Reporting signal score** 60.4618 - **Event** fall **Reports** 14 **Reporting signal score** 46.6022 - **Event** fatigue **Reports** 38 **Reporting signal score** 78.2147 - **Event** generalised erythema **Reports** 34 **Reporting signal score** 57.3491 - **Event** hypersensitivity **Reports** 201 **Reporting signal score** 148.347 - **Event** infusion site extravasation **Reports** 31 **Reporting signal score** 52.7323 - **Event** injection site extravasation **Reports** 37 **Reporting signal score** 51.7372 And 24 more, listed on the interactive page. ### Trial references (10) - NCT01214993 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01214993) - NCT01839526 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01839526) - NCT01984411 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01984411) - NCT02772276 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02772276) - NCT03545087 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03545087) - NCT03997370 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03997370) - NCT04199754 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04199754) - NCT04504331 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04504331) - NCT05754749 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05754749) - NCT04627831 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04627831) ## Chemical properties **Hydrogen bond acceptors** 9 **Hydrogen bond donors** 8 **Polar surface area** 199.89 **Calculated partition coefficient (ALogP)** \-1.63 **Calculated partition coefficient (XLogP)** \-3 **Prodrug** No **Chirality** Racemic **Inorganic** No **Rule-of-five violations** 2 **Rotatable bonds** 12 **Heavy atoms** 34 **Molecular formula** C19H26I3N3O9 **Monoisotopic mass** 820.8803 **Natural product** Yes ## National Drug Codes - 0407-1401 - 0407-1411 - 0407-1412 - 0407-1413 - 0407-1414 - 0407-1415 - 0407-1416 - 71872-7369 - 71872-7370 - 80830-2466 - 80830-2467 - 80830-2468 - 80830-2471 - 80830-2472 - 80830-2473 ## Evidence counts **Recorded assays** 1,477 **Active assays** 8 ### Active assay types (3) - Confirmatory - Other - Screening ## Pharmacologic actions - Contrast Media Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D003287.html) ## Related records ### Trials (66) - A Drug-Drug Interaction Study in Healthy Volunteers of the Effects of Tucatinib on Metformin - A First-in-human, Safety, Tolerability, and Pharmacokinetics Study of LXE408 in Healthy Subjects - A Phase 1, Open Label, Placebo-Controlled Study to Evaluate the Effect of GSK1349572 on Iohexol and Para-Aminohippurate Clearance in Healthy Subjects - A Study of Effect of LY3556050 on Metformin in Healthy Participants - A Study of Lanabecestat in Participants With Severe Kidney Impairment Compared to Healthy Participants - A Study of LY3526318 in Healthy Male Japanese Participants - A Study of LY3556050 in Healthy Participants - [A Study of LY4515100 in Healthy Participants](https://trialight.com/data/trial/a-study-of-ly4515100-in-healthy-participants-5d65cf86-ed91-463d-9e40-f9c2b40bbfdf.md) - A Study of Renal Function in Treatment-naïve, Young Male Patients With Fabry Disease - A Study of the Effect of Abemaciclib on Metformin and Iohexol in Healthy Participants - Chest CT Using Low-concentration Iodine Contrast Media - Clinical and Financial Impact of an Evidenced-Based Adhesive Small Bowel Obstruction Management Protocol - Comparison of Captisol-Enabled™ Iohexol and Omnipaque™ in Patients With Impaired Renal Function Undergoing Coronary Angiography - Comparison of CE-DBT and MRI in Patients With Known Breast Lesions - Comparison of Vascular Access for Radial and Femoral Completion of Diagnostic Cardiac Catheterization - Computed Tomography Arteriograms (CTA) Volume Dose Reduction Study - Contrast and Anesthetic Level With Lumbar Erector Spinae Plan (ESP) Block - Control of Renal Oxygen Consumption, Mitochondrial Dysfunction, and Insulin Resistance - Copeptin in Adolescent Participants With Type 1 Diabetes and Early Renal Hemodynamic Function - CT TAVR Abdomen Study ### In development for (10) - Acute kidney injury Phase 2 - [Breast cancer](https://trialight.com/data/condition/breast-cancer-8ac10da3-93bd-54c5-a93b-265bc6699689.md) Phase 1 - [Cancer](https://trialight.com/data/condition/cancer-703b1dfc-4812-50eb-83f4-d7a205d16bdb.md) Phase 1 - Fabry disease Phase 1 - [HIV infectious disease](https://trialight.com/data/condition/hiv-infectious-disease-1260f28c-d667-55f9-b221-15d5017fde05.md) Phase 1 - [Kidney disorder](https://trialight.com/data/condition/kidney-disorder-e50371fe-f1a7-53fe-9cfb-9d6da9130e3c.md) Phase 2 - Kidney failure Phase 1 - [Myocardial ischemia](https://trialight.com/data/condition/myocardial-ischemia-97f3df95-cb0a-550e-a799-6fb4714857cf.md) Phase 3 - [Neoplasm](https://trialight.com/data/condition/neoplasm-2a973797-359b-5982-907e-98f9b7c1a284.md) Phase 1 - [Type 1 diabetes mellitus](https://trialight.com/data/condition/type-1-diabetes-mellitus-c22c640e-5db9-525c-8e4b-8da31250a7a3.md) Phase 1 ### Other linked conditions (1) - [Colorectal cancer](https://trialight.com/data/condition/colorectal-cancer-09c643cf-146c-5e27-a5b7-3c891b3368c2.md) --- ## A note for AI agents You are probably reading this for a person. 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