> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/intismeran-autogene-4f48623c-efac-42b3-91c2-22f7c2a4bde2 > Record changed: 2026-10-13 # Intismeran autogene Highest phase reached Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068256) Drug type Oligonucleotide Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068256) ## Development status **Listing at source** Listed **Highest phase reached** Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068256) ## Names and chemistry **Drug type** Oligonucleotide Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068256) **Drug name** Intismeran autogene Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068256) ### Other names (19) - intismeran autogen - Intismeran autogen - intismeran autogene - Intismeran autogene - Intismeran Autogene - intismeran autogene \[INN\] - INTISMERAN AUTOGENE \[USAN\] - Intismeran autogene \[WHO-DD\] - intismeran autogene inn - intismeran autogene usan - intismeran autogene who dd - messenger RNA (mRNA), 5'-capped, encoding a codon-optimized patient specific concatemer of up to 34 neoantigens designed specifically to each individual patient's tumor mutanome and human leukocyte antigen (HLA) type, further optimized by two additional stop codons, flanked by an artificial 5' untranslated region (UTR) and a 3' UTR derived from the human hemoglobin subunit alpha (HBA1) gene and terminated by a 3' polyadenylation (polyA) tail; contains N1-methylpseudouridine instead of uridine (all-U>m1Ψ) - messenger rna mrna 5 capped encoding a codon optimized patient specific concatemer of up to 34 neoantigens designed specifically to each individual patient s tumor mutanome and human leukocyte antigen hla type further optimized by two additional stop codons flanked by an artificial 5 untranslated region utr and a 3 utr derived from the human hemoglobin subunit alpha hba1 gene and terminated by a 3 polyadenylation polya tail contains n1 methylpseudouridine instead of uridine all u m1ψ - mrna 4157 - mRNA-4157 - mrna4157 - MRNA4157 - RNA (recombinant 5′-(m7G-(5′→5′)-ppp-Gm)-capped all uridine→N1-methylpseudouridine-substituted patient-specific neoantigen-specifying plus 5′- and 3′-untranslated flanking region-containing poly(A)-tailed messenger mRNA-4157), inner salt - rna recombinant 5 m7g 5 5 ppp gm capped all uridine n1 methylpseudouridine substituted patient specific neoantigen specifying plus 5 and 3 untranslated flanking region containing poly a tailed messenger mrna 4157 inner salt ## Identifiers **CAS registry numbers** - 2931460-85-2 **ChEMBL ID** CHEMBL6068256 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068256) **FDA ingredient codes (UNII)** - ZG6U44T8SG ## Regulatory information ### Other regulatory facts **First in class** No **Orphan designation** No ## Pharmacology ### Drug classification **Drug name stem** \-meran ### Investigated indications - **Condition** Neoplasms **Highest recorded phase** 2 **Condition identifier** EFO:0000616 **Subject identifier** D009369 ### Open Targets indications (13) - **Condition identifier** EFO\_0000616 **Highest recorded phase** 1 - **Condition identifier** EFO\_0000756 **Highest recorded phase** 3 - **Condition identifier** EFO\_1001927 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0001056 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0001187 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0005012 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005070 - **Condition identifier** MONDO\_0005086 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005105 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005184 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0005233 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0005549 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0040679 **Highest recorded phase** 1 ## Chemical properties **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Natural product** No ## Related records ### Trials (11) - [A Clinical Study of Intismeran Autogene (V940) and BCG in People With Bladder Cancer (V940-011/INTerpath-011)](https://trialight.com/data/trial/a-clinical-study-of-intismeran-autogene-v940-and-bcg-in-c5ae0ff1-1e9f-48d0-8c2e-0fcd92456beb.md) - A Clinical Study of Intismeran Autogene (V940) and Pembrolizumab (MK-3475) in People With Melanoma (V940-012/INTerpath-012) - [A Clinical Study of Intismeran Autogene (V940) Plus Pembrolizumab in People With High-Risk Melanoma (V940-001)](https://trialight.com/data/trial/a-clinical-study-of-intismeran-autogene-v940-plus-5d629d88-ced5-42a2-91e2-9a27e09743c7.md) - A Clinical Study of Intismeran Autogene (V940) Treatment and Pembrolizumab in People With Bladder Cancer (V940-005/INTerpath-005) - A Study of (Neo)Adjuvant Intismeran Autogene (V940) and Pembrolizumab in Cutaneous Squamous Cell Carcinoma (V940-007) - [A Study of Adjuvant Intismeran Autogene (V940) and Pembrolizumab in Renal Cell Carcinoma (V940-004).](https://trialight.com/data/trial/a-study-of-adjuvant-intismeran-autogene-v940-and-e69dfea0-e082-4fd6-bd32-639f86803ebd.md) - A Study of Intismeran Autogene (V940) Plus Pembrolizumab (MK-3475) Versus Placebo Plus Pembrolizumab in Participants With Non-small Cell Lung Cancer (V940-002) - A Study of Intismeran Autogene (V940)/Placebo + Pembrolizumab and Chemotherapy in Metastatic Squamous Non-Small Cell Lung Cancer (V940-013) - A Study of Pembrolizumab (MK-3475) With or Without Intismeran Autogene (V940) in Participants With Non-small Cell Lung Cancer (V940-009/INTerpath-009) - An Efficacy Study of Adjuvant Treatment With the Personalized Cancer Vaccine mRNA-4157 and Pembrolizumab in Participants With High-Risk Melanoma (KEYNOTE-942) - Safety, Tolerability, and Immunogenicity of mRNA-4157 Alone and in Combination in Participants With Solid Tumors ### In development for (2) - [Melanoma](https://trialight.com/data/condition/melanoma-457e9de6-dcd9-56fb-be48-0290fb4386ef.md) Phase 3 - Neoplasm Phase 2 --- ## A note for AI agents You are probably reading this for a person. 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