> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/interferon-alfa-2a-8362cbd4-f22c-4df7-86bb-3c7bac2b108c > Record changed: 2026-10-13 # Interferon alfa-2A Highest phase reached Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2108508) Drug type Protein Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2108508) First approval year 1986 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2108508) ## Development status **First approval year** 1986 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2108508) **Listing at source** Listed **Highest phase reached** Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2108508) ## Names and chemistry **Drug type** Protein Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2108508) **Drug name** Interferon alfa-2A Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2108508) ### Brand names (11) - alpheon - Alpheon - canferon - Canferon - canferon a - Canferon a - cha ifnalpha2a - Cha-ifnalpha2a - roferon a - Roferon a - Roferon-a ### Other names (48) - interferon alfa 2a - Interferon Alfa 2a - Interferon Alfa 2A - interferon alfa 2a genetical recombination - interferon alfa 2a jan - interferon alfa 2a mi - interferon alfa 2a recombinant - interferon alfa 2a recombinant vandf - interferon alfa 2a usan - interferon alfa 2a vandf - interferon alfa 2a who dd - interferon alfa-2a - Interferon alfa-2a - Interferon Alfa-2a - Interferon Alfa-2A - INTERFERON ALFA-2A - Interferon alfa-2a (genetical recombination) - INTERFERON ALFA-2A (RECOMBINANT) - INTERFERON ALFA-2A \[JAN\] - INTERFERON ALFA-2A \[MI\] - INTERFERON ALFA-2A \[USAN\] - INTERFERON ALFA-2A \[VANDF\] - Interferon alfa-2a \[WHO-DD\] - INTERFERON ALFA-2A, RECOMBINANT - INTERFERON ALFA-2A,RECOMBINANT And 23 more, listed on the interactive page. ## Identifiers **ATC classification codes** - L03AB04 Sources for recorded values Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2108508) **CAS registry numbers** - 76543-88-9 **ChEMBL ID** CHEMBL2108508 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2108508) **RxNorm IDs (RxCUI)** - 5879 **FDA ingredient codes (UNII)** - 47RRR83SK7 ## Regulatory information ### European Union **Status** refused **Status date** 5 Sept 2006 **Approved indications** Adult patients with histologically proven chronic hepatitis C who are positive for hepatitis C virus (HCV) antibodies or HCV RNA and have elevated serum alanine aminotransferase (ALT) without liver decompensation.The efficacy of Interferon alfa-2a in the treatment of hepatitis C is enhanced when combined with ribavirin. Alpheon should be given alone mainly in case of intolerance or contra-indication to ribavirin. **Product number** EMEA/H/C/000585 **Authorisation holder** BioPartners GmbH **Priority medicines scheme** No **Generic** No **Biosimilar** Yes **Generic medicines** 0 **Biosimilar medicines** 0 **Advanced therapy** No **Conditional approval** No **Additional monitoring** No **Accelerated assessment** No **Exceptional circumstances** No #### Therapeutic areas - Hepatitis C, Chronic European medicines record Source: [www.ema.europa.eu](https://www.ema.europa.eu/en/medicines/human/EPAR/alpheon) ### Other regulatory facts **Patents** 0 **Designations** 3 **First in class** No **Fast track** No **Breakthrough designation** No **Orphan designation** No **Priority review** Yes **Orphan exclusivity** No **Accelerated approval** No **Availability** Prescription only **Boxed warning** Yes ## Pharmacology ### Drug classification #### Administration routes - Parenteral ### Mechanisms of action (2) - **Mechanism** Interferon alpha/beta receptor agonist **Action type** Agonist **Target** Interferon alpha/beta receptor **Protein identifier** P17181 - **Mechanism** Interferon alpha/beta receptor agonist **Action type** Agonist **Target** Interferon alpha/beta receptor **Protein identifier** P48551 ### Open Targets mechanisms - **Mechanism** Interferon alpha/beta receptor agonist **Action type** Agonist **Target** Interferon alpha/beta receptor ### Investigated indications (16) - **Condition** Precursor Cell Lymphoblastic Leukemia-Lymphoma **Highest recorded phase** 3 **Condition identifier** EFO:0000220 **Subject identifier** D054198 - **Condition** Lymphoma **Highest recorded phase** 3 **Condition identifier** EFO:0000574 **Subject identifier** D008223 - **Condition** Neoplasms **Highest recorded phase** 4 **Condition identifier** EFO:0000616 **Subject identifier** D009369 - **Condition** Psoriasis **Highest recorded phase** 1 **Condition identifier** EFO:0000676 **Subject identifier** D011565 - **Condition** Carcinoma, Renal Cell **Highest recorded phase** 3 **Condition identifier** EFO:0000681 **Subject identifier** D002292 - **Condition** Melanoma **Highest recorded phase** 3 **Condition identifier** EFO:0000756 **Subject identifier** D008545 - **Condition** HIV Infections **Highest recorded phase** 2 **Condition identifier** EFO:0000764 **Subject identifier** D015658 - **Condition** Multiple Myeloma **Highest recorded phase** 2 **Condition identifier** EFO:0001378 **Subject identifier** D009101 - **Condition** Melanoma **Highest recorded phase** 3 **Condition identifier** EFO:0002617 **Subject identifier** D008545 - **Condition** Hepatitis C **Highest recorded phase** 3 **Condition identifier** EFO:0003047 **Subject identifier** D006526 - **Condition** Behcet Syndrome **Highest recorded phase** 3 **Condition identifier** EFO:0003780 **Subject identifier** D001528 - **Condition** Hepatitis C, Chronic **Highest recorded phase** 2 **Condition identifier** EFO:0004220 **Subject identifier** D019698 - **Condition** Leukemia, Hairy Cell **Highest recorded phase** 2 **Condition identifier** EFO:1000956 **Subject identifier** D007943 - **Condition** Retinal Vasculitis **Highest recorded phase** 3 **Condition identifier** EFO:1001156 **Subject identifier** D031300 - **Condition** Kidney Neoplasms **Highest recorded phase** 3 **Condition identifier** MONDO:0002367 **Subject identifier** D007680 - **Condition** Neoplasms **Highest recorded phase** 4 **Condition identifier** MONDO:0004992 **Subject identifier** D009369 ### Open Targets indications (60) - **Condition identifier** EFO\_0000220 **Highest recorded phase** 3 - **Condition identifier** EFO\_0000544 **Highest recorded phase** 2 - **Condition identifier** EFO\_0000574 **Highest recorded phase** 3 - **Condition identifier** EFO\_0000616 - **Condition identifier** EFO\_0000676 **Highest recorded phase** 1 - **Condition identifier** EFO\_0000681 **Highest recorded phase** 3 - **Condition identifier** EFO\_0000756 **Highest recorded phase** 3 - **Condition identifier** EFO\_0000764 **Highest recorded phase** 2 - **Condition identifier** EFO\_0001378 **Highest recorded phase** 2 - **Condition identifier** EFO\_0002617 **Highest recorded phase** 2 - **Condition identifier** EFO\_0004220 **Highest recorded phase** 2 - **Condition identifier** EFO\_0008496 **Highest recorded phase** 2 - **Condition identifier** EFO\_1000956 **Highest recorded phase** 2 - **Condition identifier** HP\_0001394 **Highest recorded phase** 2 - **Condition identifier** HP\_0003510 **Highest recorded phase** 2 - **Condition identifier** HP\_0031273 **Highest recorded phase** 0 - **Condition identifier** MONDO\_0000873 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0001056 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0002280 **Highest recorded phase** 0 - **Condition identifier** MONDO\_0002367 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0002691 - **Condition identifier** MONDO\_0004952 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0004967 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0004992 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005005 **Highest recorded phase** 2 And 35 more, listed on the interactive page. ### Warnings - **Warning** Black Box Warning ### Open Targets warnings - **Warning** Black Box Warning **Country** United States ### Reported adverse events (30) - **Event** anaemia **Reports** 2,176 **Reporting signal score** 3,075.55 - **Event** anal pruritus **Reports** 5 **Reporting signal score** 16.4712 - **Event** asthenia **Reports** 702 **Reporting signal score** 199.591 - **Event** depression **Reports** 649 **Reporting signal score** 404.727 - **Event** dysgeusia **Reports** 349 **Reporting signal score** 377.337 - **Event** exposure via direct contact **Reports** 81 **Reporting signal score** 344.539 - **Event** fatigue **Reports** 1,434 **Reporting signal score** 470.06 - **Event** focal segmental glomerulosclerosis **Reports** 5 **Reporting signal score** 13.4835 - **Event** haemoglobin decreased **Reports** 739 **Reporting signal score** 714.906 - **Event** hepatic cirrhosis **Reports** 166 **Reporting signal score** 236.412 - **Event** hepatic neoplasm malignant **Reports** 14 **Reporting signal score** 57.8292 - **Event** hepatitis c **Reports** 367 **Reporting signal score** 756.728 - **Event** hepatotoxicity **Reports** 11 **Reporting signal score** 13.4289 - **Event** influenza like illness **Reports** 410 **Reporting signal score** 393.072 - **Event** leukopenia **Reports** 449 **Reporting signal score** 463.438 - **Event** liver iron concentration increased **Reports** 3 **Reporting signal score** 16.2838 - **Event** metabolic disorder **Reports** 7 **Reporting signal score** 17.2129 - **Event** nervous system disorder **Reports** 10 **Reporting signal score** 13.6815 - **Event** neurological decompensation **Reports** 5 **Reporting signal score** 13.9584 - **Event** neutropenia **Reports** 683 **Reporting signal score** 438.618 - **Event** neutrophil count decreased **Reports** 335 **Reporting signal score** 365.651 - **Event** pancytopenia **Reports** 419 **Reporting signal score** 422.748 - **Event** platelet count decreased **Reports** 907 **Reporting signal score** 1,086.1 - **Event** pruritus **Reports** 714 **Reporting signal score** 316.475 - **Event** pyrexia **Reports** 792 **Reporting signal score** 211.565 And 5 more, listed on the interactive page. ### Trial references (24) - NCT00000696 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00000696) - NCT00000754 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00000754) - NCT00000967 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00000967) - NCT00001567 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00001567) - NCT00083889 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00083889) - NCT00502034 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00502034) - NCT00520403 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00520403) - NCT00719264 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00719264) - NCT00738530 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00738530) - NCT00796757 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00796757) - NCT01513187 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01513187) - NCT00167583 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00167583) - NCT00204529 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00204529) - NCT00308607 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00308607) - NCT00323505 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00323505) - NCT00381953 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00381953) - NCT00416429 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00416429) - NCT00433069 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00433069) - NCT02340962 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02340962) - NCT00483132 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00483132) - NCT01404936 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01404936) - NCT01609010 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01609010) - NCT02159482 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02159482) - NCT02763969 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02763969) ## Chemical properties **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Natural product** No ## Related records ### Trials (657) - 153Sm-EDTMP With or Without a PSA/TRICOM Vaccine To Treat Men With Androgen-Insensitive Prostate Cancer - 2018-0674 - IL-7 for T-Cell Recovery Post Haplo and CB Transplant - Phase I/II - A Clinical Study of JS005 in Patients With Ankylosing Spondylitis - A Clinical Study of MIL93 in Solid Tumors. - A Clinical Study of MIL95 in Advanced Malignancies. - A Clinical Study on Oncolytic Virus Injection (R130 OV) for the Treatment of Advanced Solid Tumors - A Clinical Study on Oncolytic Virus Injection (R130 OV) for the Treatment of Relapsed/Refractory Head and Neck Cancer - A Clinical Study on Oncolytic Virus Injection (R130) for the Treatment of Advanced Bone and Soft Tissue Tumors - A Clinical Study on Oncolytic Virus Injection (R130) for the Treatment of Advanced Solid Tumors - A Clinical Study on Oncolytic Virus Injection (R130) for the Treatment of Relapsed/Refractory Advanced Solid Tumors - A Clinical Study on Oncolytic Virus Injection (R130) for the Treatment of Relapsed/Refractory Bone and Soft Tissue Tumors - A Clinical Study on Oncolytic Virus Injection (R130) for the Treatment of Relapsed/Refractory Cervical and Endometrial Cancer - A Clinical Study on Oncolytic Virus Injection (R130) for the Treatment of Relapsed/Refractory Ovarian Cancer - A Clinical Study on Recombinant Botulinum Toxin Type A (YY001) for Injection in The Treatment of Upper Limb Spasticity in Adults - A Clinical Trial Aimed at Assessing the Efficacy and Safety of VT-101 for the Treatment of Non-muscle Invasive Bladder Cancer - [A Clinical Trial of Recombinant COVID-19 Bivalent (XBB+Prototype) Protein Vaccine (Sf9 Cell) in Booster Vaccination](https://trialight.com/data/trial/a-clinical-trial-of-recombinant-covid-19-bivalent-xbb-6b1f79b9-6e5c-4ed8-adf2-3b5535c20652.md) - A Clinical Trial to Evaluate a Recombinant Hepatitis E Vaccine in Healthy Adults - A Comparison of the Effectiveness, Safety, and Tolerability of Two Different Hepatitis C Treatments in Patients Infected With Both HIV and Hepatitis C Virus (HCV) - A Double-Blind Placebo-Control Dose Escalating Study to Evaluate the Safety and Immunogenicity of dmLT by Oral, Sublingual and Intradermal Vaccination in Adults Residing in an Endemic Area - A Pharmaco-epidemiological Study of Short Patients Born Small for Gestational Age (SGA), Treated With Saizen® (Recombinant Somatropin) ### Approved for (2) - [Cancer](https://trialight.com/data/condition/cancer-703b1dfc-4812-50eb-83f4-d7a205d16bdb.md) - Neoplasm ### In development for (14) - Acute lymphoblastic leukemia Phase 3 - Behcet disease Phase 3 - [Chronic hepatitis C virus infection](https://trialight.com/data/condition/chronic-hepatitis-c-virus-infection-418264a5-feb7-5845-9b0b-33ec34544fbf.md) Phase 2 - Hairy cell leukemia Phase 2 - Hepatitis C virus infection Phase 3 - [HIV infectious disease](https://trialight.com/data/condition/hiv-infectious-disease-1260f28c-d667-55f9-b221-15d5017fde05.md) Phase 2 - Kidney cancer Phase 3 - [Lymphoma](https://trialight.com/data/condition/lymphoma-de4db685-7419-5e0e-b958-4591ffd69d43.md) Phase 3 - [Melanoma](https://trialight.com/data/condition/melanoma-457e9de6-dcd9-56fb-be48-0290fb4386ef.md) Phase 3 - Metastatic melanoma Phase 3 - [Plasma cell myeloma](https://trialight.com/data/condition/plasma-cell-myeloma-37186689-2591-5775-9042-2f2bf046a2b5.md) Phase 2 - [Psoriasis](https://trialight.com/data/condition/psoriasis-4340caf0-883c-54c7-886d-31e59b80dead.md) Phase 1 - [Renal cell carcinoma](https://trialight.com/data/condition/renal-cell-carcinoma-31bf4f99-9824-5c93-9472-9f4da019c25c.md) Phase 3 - Retinal vasculitis Phase 3 ### Targets (2) - [IFNAR1](https://trialight.com/data/target/ifnar1-b87a0a08-6346-52f4-927e-c5d552c5babd.md) Interferon alpha/beta receptor agonist - [IFNAR2](https://trialight.com/data/target/ifnar2-810ce9c4-ab9c-5d25-aff1-f53086c07427.md) Interferon alpha/beta receptor agonist --- ## A note for AI agents You are probably reading this for a person. 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