> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/indapamide-38f48c91-8217-4462-9f68-aacc5047dd2a > Record changed: 2026-10-13 # Indapamide Highest phase reached Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL406) Drug type Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL406) First approval year 1983 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL406) ## Development status **First approval year** 1983 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL406) **Listing at source** Listed **Highest phase reached** Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL406) ## Names and chemistry **Drug type** Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL406) **Drug name** Indapamide Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL406) **Molecular weight** 365.84 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL406) **Structure (SMILES)** CC1Cc2ccccc2N1NC(=O)c1ccc(Cl)c(S(N)(=O)=O)c1 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL406) ### Brand names (30) - cardide sr - Cardide sr - ethibide xl - Ethibide xl - indapamide - Indapamide - indapamide component of br 1015 - Indapamide component of br-1015 - indaxa 2 5 - Indaxa 2.5 - indipam xl - Indipam xl - lozol - Lozol - mapemid xl - Mapemid xl - natrilix - Natrilix - natrilix sr - Natrilix sr - nindaxa 2 5 - Nindaxa 2.5 - opumide 2 5 - Opumide 2.5 - rawel xl And 5 more, listed on the interactive page. ### Other names (79) - allisartan 240mg indapamide 1 5mg - arifon - Arifon - bajaten - Bajaten - br 1015 component indapamide - BR-1015 component Indapamide - damide - Damide - fimasartan indapamide - flubest - Flubest - fludex - Fludex - fludin - Fludin - flupamid - Flupamid - indaflex - Indaflex - indamide - Indamide - indamol - Indamol - indapamida And 54 more, listed on the interactive page. ## Identifiers **ATC classification codes** - C03BA11 Sources for recorded values Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL406) **CAS registry numbers** - 26807-65-8 **ChEMBL ID** CHEMBL406 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL406) **InChIKey** NDDAHWYSQHTHNT-UHFFFAOYSA-N Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL406) **PubChem compound IDs** - 3702 **RxNorm IDs (RxCUI)** - 5764 **FDA ingredient codes (UNII)** - F089I0511L ## Regulatory information ### United States **Applicant** AZURITY **Approval date** 5 Jun 2025 **Application number** NDA219423 ### Other regulatory facts **Patents** 3 **Designations** 0 **Earliest recorded loss of exclusivity** 23 Jan 2038 **First in class** No **Fast track** No **Breakthrough designation** No **Orphan designation** No **Priority review** No **Orphan exclusivity** No **Accelerated approval** No **Availability** Prescription only ## Pharmacology ### Drug classification **Pharmacology name** indapamide **Type** Synthetic organic **Drug name stem** \-pamide **Approval recorded by Guide to Pharmacology** Yes #### Administration routes - Oral ### Mechanisms of action (2) - **Action** Binding **Action type** Binding **Target** N-Acylphosphatidylethanolamine-phospholipase D **Gene symbol** NAPEPLD **Protein identifier** Q6IQ20 **Median affinity** 6.24 **Affinity units** pKd - **Mechanism** Thiazide-sensitive sodium-chloride cotransporter inhibitor **Action type** Inhibitor **Target** Solute carrier family 12 member 3 **Protein identifier** P55017 ### Open Targets mechanisms - **Mechanism** Thiazide-sensitive sodium-chloride cotransporter inhibitor **Action type** Inhibitor **Target** Solute carrier family 12 member 3 ### DrugCentral mechanisms - **Action type** Inhibitor **Gene symbol** SLC12A3 **Protein identifier** P55017 **Organism** Homo sapiens **Target development level** Clinical ### Investigated indications (7) - **Condition** Cardiovascular Diseases **Highest recorded phase** 4 **Condition identifier** EFO:0000319 **Subject identifier** D002318 - **Condition** Heart Failure **Highest recorded phase** 4 **Condition identifier** EFO:0000373 **Subject identifier** D006333 - **Condition** Hypertension **Highest recorded phase** 4 **Condition identifier** EFO:0000537 **Subject identifier** D006973 - **Condition** Toxemia **Highest recorded phase** 4 **Condition identifier** EFO:0000668 **Subject identifier** D014115 - **Condition** Multiple Sclerosis, Chronic Progressive **Highest recorded phase** 2 **Condition identifier** EFO:0003840 **Subject identifier** D020528 - **Condition** Essential Hypertension **Highest recorded phase** 3 **Condition identifier** MONDO:0001134 **Subject identifier** D000075222 - **Condition** Diabetes Mellitus, Type 2 **Highest recorded phase** 3 **Condition identifier** MONDO:0005148 **Subject identifier** D003924 ### Open Targets indications (13) - **Condition identifier** EFO\_0000319 - **Condition identifier** EFO\_0000373 - **Condition identifier** EFO\_0000537 - **Condition identifier** EFO\_0000668 - **Condition identifier** EFO\_0003840 **Highest recorded phase** 2 - **Condition identifier** HP\_0000822 **Highest recorded phase** 4 - **Condition identifier** MONDO\_0001134 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0004995 **Highest recorded phase** 4 - **Condition identifier** MONDO\_0005009 **Highest recorded phase** 4 - **Condition identifier** MONDO\_0005044 **Highest recorded phase** 4 - **Condition identifier** MONDO\_0005081 **Highest recorded phase** 4 - **Condition identifier** MONDO\_0005148 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0005301 **Highest recorded phase** 2 ### Reported adverse events (39) - **Event** acute kidney injury **Reports** 284 **Reporting signal score** 397.878 - **Event** atrial fibrillation **Reports** 92 **Reporting signal score** 79.1547 - **Event** blood pressure abnormal **Reports** 26 **Reporting signal score** 41.0234 - **Event** blood sodium decreased **Reports** 42 **Reporting signal score** 69.6202 - **Event** bundle branch block right **Reports** 20 **Reporting signal score** 37.9614 - **Event** cardio-respiratory arrest **Reports** 26 **Reporting signal score** 41.1373 - **Event** circulatory collapse **Reports** 28 **Reporting signal score** 36.5505 - **Event** confusional state **Reports** 237 **Reporting signal score** 310.933 - **Event** congenital bladder anomaly **Reports** 12 **Reporting signal score** 56.8955 - **Event** conjoined twins **Reports** 20 **Reporting signal score** 114.196 - **Event** dehydration **Reports** 97 **Reporting signal score** 62.3957 - **Event** electrocardiogram qt prolonged **Reports** 55 **Reporting signal score** 51.7646 - **Event** eosinophilia **Reports** 32 **Reporting signal score** 34.9401 - **Event** fall **Reports** 175 **Reporting signal score** 87.9436 - **Event** glomerular filtration rate decreased **Reports** 25 **Reporting signal score** 37.488 - **Event** hyperkalaemia **Reports** 50 **Reporting signal score** 46.7547 - **Event** hypertensive angiopathy **Reports** 7 **Reporting signal score** 37.6243 - **Event** hypochloraemia **Reports** 30 **Reporting signal score** 105.441 - **Event** hypokalaemia **Reports** 390 **Reporting signal score** 1,043 - **Event** hypomagnesaemia **Reports** 100 **Reporting signal score** 240.575 - **Event** hyponatraemia **Reports** 730 **Reporting signal score** 2,207.94 - **Event** hyponatraemic seizure **Reports** 26 **Reporting signal score** 124.846 - **Event** hypoosmolar state **Reports** 9 **Reporting signal score** 42.3219 - **Event** hypotension **Reports** 159 **Reporting signal score** 96.1146 - **Event** intestinal malrotation **Reports** 14 **Reporting signal score** 61.2053 And 14 more, listed on the interactive page. ### Trial references (16) - NCT00122811 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00122811) - NCT00128518 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00128518) - NCT00295542 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00295542) - NCT01620788 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01620788) - NCT02710539 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02710539) - NCT02710552 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02710552) - NCT03246555 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03246555) - NCT03814109 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03814109) - NCT04455178 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04455178) - NCT04518293 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04518293) - NCT04518306 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04518306) - NCT05103332 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05103332) - NCT05110898 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05110898) - NCT00145925 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00145925) - NCT05013463 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05013463) - NCT05878561 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05878561) ## Dosing **Dose** 10 mg/1.25 mg/0.625 mg to 40 mg/5 mg/2.5 mg **Route** Oral **How often** Once daily ### Conditions of use (3) - Do not cut, crush, or chew tablets - May be taken with or without food - Swallow tablets whole ## Chemical properties **Hydrogen bond acceptors** 4 **Hydrogen bond donors** 2 **Polar surface area** 92.5 **Calculated partition coefficient (ALogP)** 2.08 **Calculated partition coefficient (XLogP)** 2.9 **Prodrug** No **Chirality** Racemic **Inorganic** No **Rule-of-five violations** 0 **Rotatable bonds** 3 **Heavy atoms** 24 **Molecular formula** C16H16ClN3O3S **Monoisotopic mass** 365.0600902 **Natural product** Yes ## National Drug Codes - 0228-2571 - 0228-2597 - 16571-875 - 16571-876 - 24338-001 - 24338-002 - 24338-003 - 51407-024 - 51407-025 - 62559-510 - 62559-511 - 72189-591 - 50090-7826 - 50090-7828 - 63629-1953 - 63629-1954 - 68788-7247 - 71335-1541 - 72162-1766 - 72162-1767 ## Evidence counts **Recorded assays** 3,182 **Active assays** 101 ### Active assay types (4) - Confirmatory - Other - Screening - Summary ## Pharmacologic actions - Antihypertensive Agents Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D000959.html) - Diuretics Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D004232.html) - Sodium Chloride Symporter Inhibitors Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D049993.html) ## Related records ### Trials (36) - A Comparison of Indapamide SR 1.5 mg With HCTZ 25 mg, in Combination With an ACE-inhibitor, in Patients With Mild to Moderate AHT and Type 2 DM - A Study to Evaluate the Efficacy and Safety of BR1015 Combination Therapy - Ambulatory Blood Pressure Monitoring in the Prediction of Cardiovascular Events and Effects of Chronotherapy - Bioequivalence Study of 8 mg Perindopril Tert-Butylamine / 2.5 mg Indapamide / 10 mg Amlodipine Tablets Versus 10 mg Perindopril Arginine / 2.5 mg Indapamide / 10 mg Amlodipine Film-Coated Tablets in Healthy Volunteers - Bioequivalence Study of 8 mg Perindopril Tert-butylamine / 2.5 mg Indapamide Tablets Versus 10 mg Perindopril Arginine / 2.5 mg Indapamide Film-coated Tablets in Healthy Volunteers - Bioequivalence Study of Perindopril /Amlodipine/Indapamide 8 mg (10 mg)/2.5 mg/10 mg Tablets in Healthy Volunteers Under Fasting Conditions - Comparison of Losartan Associated With Indapamide Versus Hyzaar® in the Hypertension Treatment - Effect of Genetic Polymorphisms of UGT on the PKs of Indapamide in Egyptians - Efficacy and Safety of GMRx2 Compared to Dual Combinations for the Treatment of Hypertension - Efficacy and Safety of GMRx2 Compared to Placebo for the Treatment of Hypertension - Efficacy and Safety of Leningrado 5 Association in the Treatment of Hypertension - Efficacy and Safety of Leningrado Association in the Treatment of Hypertension - Efficacy and Safety Study of the Fixed-dose Combination of Olmesartan + Indapamide When Compared to the Isolated Drugs in the Treatment of Hypertension. - Evaluating the Use of Oral Indapamide to Reduce Disabiltiy Progression in Progressive Multiple Sclerosis (MS) - Evaluation of the Antihypertensive effectIveness, Tolerability, and Adherence With Amlodipine/ Indapamide/ Perindopril Triple Single-pill Combination in Hypertensive Patients Without Concomitant Antihypertensive Therapy (TRIPTYCH) - Fimasartan in the Senior Subjects - Hydroxychloroquine and Indapamide in SPMS - IDEAL Study: Identification of the Determinants of the Efficacy of Arterial Blood Pressure Lowering Drugs - Indapamide and Chlorthalidone to Reduce Urine Supersaturation for Kidney Stone Prevention - Indapamide Versus Hydrochlorothiazide in Elderly Hypertensive Patients With Renal Insufficiency ### Approved for (4) - [Cardiovascular disorder](https://trialight.com/data/condition/cardiovascular-disorder-362e433e-88a4-575f-90af-50fe7239dec0.md) - Congestive heart failure - [Hypertensive disorder](https://trialight.com/data/condition/hypertensive-disorder-6d786557-b9e8-5afc-80f3-89a1995f9da5.md) - Preeclampsia ### In development for (3) - [Chronic progressive multiple sclerosis](https://trialight.com/data/condition/chronic-progressive-multiple-sclerosis-99de35e9-2d98-5ec1-815e-693482f47d80.md) Phase 2 - [Essential hypertension](https://trialight.com/data/condition/essential-hypertension-bd582df2-4596-58b0-aa00-37f10a4759d3.md) Phase 3 - [Type 2 diabetes mellitus](https://trialight.com/data/condition/type-2-diabetes-mellitus-98e14a90-bb06-5174-90c7-901a0a259fb9.md) Phase 3 ### Targets (1) - [SLC12A3](https://trialight.com/data/target/slc12a3-cceec06e-4f72-537b-8114-fa1f2ce1d13c.md) Thiazide-sensitive sodium-chloride cotransporter inhibitor --- ## A note for AI agents You are probably reading this for a person. 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