> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/imipenem-f7af1694-45a9-4315-b812-d17767d1ad0f > Record changed: 2026-10-13 # Imipenem Highest phase reached Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL43708) Drug type Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL43708) First approval year 1985 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL43708) ## Development status **First approval year** 1985 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL43708) **Listing at source** Listed **Highest phase reached** Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL43708) ## Names and chemistry **Drug type** Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL43708) **Drug name** Imipenem Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL43708) **Molecular weight** 317.37 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL43708) **Structure (SMILES)** C\[C@@H\](O)\[C@H\]1C(=O)N2C(C(=O)O)=C(SCCNC=N)C\[C@H\]12.O Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL43708) ### Brand names (4) - imipenem component of primaxin - Imipenem component of primaxin - imipenem component of recarbrio - Imipenem component of recarbrio ### Other names (40) - h2o - H2O - imipemide - Imipemide - imipenem - Imipenem - IMIPENEM \[MART.\] - IMIPENEM \[ORANGE BOOK\] - IMIPENEM \[USAN\] - IMIPENEM \[USP MONOGRAPH\] - IMIPENEM \[VANDF\] - imipenem hydrate - Imipenem hydrate - IMIPENEM HYDRATE \[JAN\] - imipenem hydrate jan - imipenem mart - imipenem monohydrate - Imipenem monohydrate - Imipenem monohydrate (h2o) - IMIPENEM MONOHYDRATE \[EP MONOGRAPH\] - IMIPENEM MONOHYDRATE \[MI\] - IMIPENEM MONOHYDRATE \[USP-RS\] - Imipenem monohydrate \[WHO-DD\] - imipenem monohydrate ep monograph - imipenem monohydrate h2o And 15 more, listed on the interactive page. ## Identifiers **ChEMBL ID** CHEMBL43708 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL43708) **InChIKey** GSOSVVULSKVSLQ-JJVRHELESA-N Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL43708) **FDA ingredient codes (UNII)** - 71OTZ9ZE0A ### CAS registry numbers (2) - 64221-86-9 - 74431-23-5 ### PubChem compound IDs (2) - 5282372 - 168341515 ### RxNorm IDs (RxCUI) (2) - 5690 - 2184135 ## Regulatory information ### United States **Applicant** MERCK **Approval date** 26 Nov 1985 **Application number** NDA050587 ### Other regulatory facts **First in class** No **Orphan designation** No **Availability** Prescription only ## Pharmacology ### Drug classification **Pharmacology name** imipenem **Type** Synthetic organic **Drug name stem** \-penem **Approval recorded by Guide to Pharmacology** Yes #### Administration routes - Parenteral ### Mechanisms of action (7) - **Mechanism** Bacterial penicillin-binding protein inhibitor **Action type** Inhibitor **Target** Bacterial penicillin-binding protein **Protein identifier** P02918 - **Mechanism** Bacterial penicillin-binding protein inhibitor **Action type** Inhibitor **Target** Bacterial penicillin-binding protein **Protein identifier** P02919 - **Mechanism** Bacterial penicillin-binding protein inhibitor **Action type** Inhibitor **Target** Bacterial penicillin-binding protein **Protein identifier** P08506 - **Mechanism** Bacterial penicillin-binding protein inhibitor **Action type** Inhibitor **Target** Bacterial penicillin-binding protein **Protein identifier** P0AD65 - **Mechanism** Bacterial penicillin-binding protein inhibitor **Action type** Inhibitor **Target** Bacterial penicillin-binding protein **Protein identifier** P0AD68 - **Mechanism** Bacterial penicillin-binding protein inhibitor **Action type** Inhibitor **Target** Bacterial penicillin-binding protein **Protein identifier** P0AEB2 - **Mechanism** Bacterial penicillin-binding protein inhibitor **Action type** Inhibitor **Target** Bacterial penicillin-binding protein **Protein identifier** P24228 ### Open Targets mechanisms - **Mechanism** Bacterial penicillin-binding protein inhibitor **Action type** Inhibitor **Target** Bacterial penicillin-binding protein ### DrugCentral mechanisms - **Action type** Inhibitor **Gene symbol** mrcA|mrcB|dacC|mrdA|ftsI|dacA|dacB **Protein identifier** P02918|P02919|P08506|P0AD65|P0AD68|P0AEB2|P24228 **Organism** Escherichia coli (strain K12) ### Investigated indications (15) - **Condition** Endocarditis **Highest recorded phase** 4 **Condition identifier** EFO:0000465 **Subject identifier** D004696 - **Condition** Infections **Highest recorded phase** 4 **Condition identifier** EFO:0000544 **Subject identifier** D007239 - **Condition** Intraabdominal Infections **Highest recorded phase** 4 **Condition identifier** EFO:0000544 **Subject identifier** D059413 - **Condition** Bacterial Infections **Highest recorded phase** 3 **Condition identifier** EFO:0000771 **Subject identifier** D001424 - **Condition** Hematologic Neoplasms **Highest recorded phase** 2 **Condition identifier** EFO:0001642 **Subject identifier** D019337 - **Condition** Osteomyelitis **Highest recorded phase** 0.5 **Condition identifier** EFO:0003102 **Subject identifier** D010019 - **Condition** Urinary Tract Infections **Highest recorded phase** 4 **Condition identifier** EFO:0003103 **Subject identifier** D014552 - **Condition** Pneumonia **Highest recorded phase** 4 **Condition identifier** EFO:0003106 **Subject identifier** D011014 - **Condition** Lung Diseases **Highest recorded phase** 2 **Condition identifier** EFO:0003818 **Subject identifier** D008171 - **Condition** Pyelonephritis **Highest recorded phase** 3 **Condition identifier** EFO:1001141 **Subject identifier** D011704 - **Condition** Pneumonia, Bacterial **Highest recorded phase** 3 **Condition identifier** EFO:1001272 **Subject identifier** D018410 - **Condition** Enterobacteriaceae Infections **Highest recorded phase** 3 **Condition identifier** EFO:1001313 **Subject identifier** D004756 - **Condition** Pneumonia, Ventilator-Associated **Highest recorded phase** 3 **Condition identifier** EFO:1001865 **Subject identifier** D053717 - **Condition** Sepsis **Highest recorded phase** 4 **Condition identifier** HP:0100806 **Subject identifier** D018805 - **Condition** Hematologic Neoplasms **Highest recorded phase** 2 **Condition identifier** MONDO:0044881 **Subject identifier** D019337 ### Open Targets indications (27) - **Condition identifier** EFO\_0000465 - **Condition identifier** EFO\_0000544 - **Condition identifier** EFO\_0000544 **Highest recorded phase** 4 - **Condition identifier** EFO\_0000771 - **Condition identifier** EFO\_0001642 - **Condition identifier** EFO\_0003102 - **Condition identifier** EFO\_0003103 - **Condition identifier** EFO\_0003106 - **Condition identifier** EFO\_0006834 - **Condition identifier** EFO\_1001272 **Highest recorded phase** 3 - **Condition identifier** EFO\_1001313 **Highest recorded phase** 3 - **Condition identifier** EFO\_1001865 **Highest recorded phase** 3 - **Condition identifier** HP\_0002783 - **Condition identifier** HP\_0100523 **Highest recorded phase** 3 - **Condition identifier** HP\_0100806 - **Condition identifier** HP\_0100806 **Highest recorded phase** 4 - **Condition identifier** MONDO\_0003529 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0004652 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0005002 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005025 **Highest recorded phase** 4 - **Condition identifier** MONDO\_0005113 **Highest recorded phase** 4 - **Condition identifier** MONDO\_0005229 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005249 **Highest recorded phase** 4 - **Condition identifier** MONDO\_0006939 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0021678 And 2 more, listed on the interactive page. ### Reported adverse events (43) - **Event** acinetobacter infection **Reports** 8 **Reporting signal score** 24.3753 - **Event** acute generalised exanthematous pustulosis **Reports** 25 **Reporting signal score** 42.1407 - **Event** agranulocytosis **Reports** 28 **Reporting signal score** 31.1487 - **Event** clostridium difficile colitis **Reports** 25 **Reporting signal score** 43.2231 - **Event** clostridium test positive **Reports** 11 **Reporting signal score** 29.703 - **Event** convulsion **Reports** 137 **Reporting signal score** 224.791 - **Event** cytolytic hepatitis **Reports** 14 **Reporting signal score** 24.2895 - **Event** deafness **Reports** 25 **Reporting signal score** 31.9375 - **Event** dermatitis exfoliative **Reports** 21 **Reporting signal score** 39.078 - **Event** dizziness **Reports** 11 **Reporting signal score** 27.9537 - **Event** drug rash with eosinophilia and systemic symptoms **Reports** 21 **Reporting signal score** 44.896 - **Event** drug reaction with eosinophilia and systemic symptoms **Reports** 37 **Reporting signal score** 40.0061 - **Event** drug resistance **Reports** 62 **Reporting signal score** 106.707 - **Event** electrocardiogram qt prolonged **Reports** 54 **Reporting signal score** 62.9446 - **Event** enterococcus test positive **Reports** 12 **Reporting signal score** 44.8451 - **Event** eosinophilia **Reports** 62 **Reporting signal score** 121.16 - **Event** epilepsy **Reports** 38 **Reporting signal score** 43.9806 - **Event** fall **Reports** 4 **Reporting signal score** 27.6891 - **Event** fatigue **Reports** 11 **Reporting signal score** 49.406 - **Event** fungaemia **Reports** 15 **Reporting signal score** 49.959 - **Event** geotrichum infection **Reports** 6 **Reporting signal score** 27.1308 - **Event** grand mal convulsion **Reports** 28 **Reporting signal score** 46.8687 - **Event** granulomatosis with polyangiitis **Reports** 11 **Reporting signal score** 35.6771 - **Event** headache **Reports** 12 **Reporting signal score** 35.2199 - **Event** hepatic cytolysis **Reports** 15 **Reporting signal score** 33.0684 And 18 more, listed on the interactive page. ### Trial references (33) - NCT00080496 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00080496) - NCT00707239 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00707239) - NCT02493764 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02493764) - NCT05204563 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05204563) - NCT00236834 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00236834) - NCT00445094 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00445094) - NCT01379157 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01379157) - NCT03177720 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03177720) - NCT01381549 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01381549) - NCT01506271 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01506271) - NCT01659866 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01659866) - NCT01721408 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01721408) - NCT02971423 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02971423) - NCT00589693 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00589693) - NCT00690378 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00690378) - NCT01505634 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01505634) - NCT02321800 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02321800) - NCT02474706 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02474706) - NCT03543436 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03543436) - NCT05204368 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05204368) - NCT06059846 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06059846) - NCT02099240 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02099240) - NCT02452047 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02452047) - NCT04787562 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04787562) - NCT04801043 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04801043) And 8 more, listed on the interactive page. ## Dosing **Dose** 1.25 grams (imipenem 500 mg, cilastatin 500 mg, relebactam 250 mg) **Route** Intravenous **How often** Every 6 hours ## Chemical properties **Hydrogen bond acceptors** 5 **Hydrogen bond donors** 4 **Polar surface area** 113.72 **Calculated partition coefficient (ALogP)** \-0.18 **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Rule-of-five violations** 0 **Rotatable bonds** 7 **Heavy atoms** 21 **Molecular formula** C12H19N3O5S **Monoisotopic mass** 317.10454189 **Natural product** No ## National Drug Codes - 0006-3516 - 63323-322 - 63323-349 ## Evidence counts **Recorded assays** 138 **Active assays** 1 ### Active assay types - Other ## Related records ### Trials (65) - A De-Escalating Strategy for Antibiotic Treatment of Pneumonia in The Medical Intensive Care Unit (0787B-092) - A Randomized Controlled Trial Comparing Imipenem and Tigecycline Versus Imipenem and Tigecycline With GM-CSF for the Management of Spontaneous Bacterial Peritonitis Presenting With Septic Shock. - A Safety and Tolerability Study of Doripenem in Patients With Abdominal Infections or Pneumonia - A Single-Dose Study to Investigate the Pharmacokinetics of MK-7655 in Participants With Impaired Renal Function (MK-7655-005) - A Study of Efficacy and Safety of Intravenous Cefiderocol (S-649266) Versus Imipenem/Cilastatin in Complicated Urinary Tract Infections - [A Study of Oral Tebipenem Pivoxil Hydrobromide (TBP-PI-HBr) Compared to Intravenous Imipenem-cilastatin in Participants With Complicated Urinary Tract Infection (cUTI) or Acute Pyelonephritis (AP)](https://trialight.com/data/trial/a-study-of-oral-tebipenem-pivoxil-hydrobromide-tbp-pi-hbr-dab1abf3-cb71-4379-a9eb-6a9c4ae939d7.md) - A Study of the Safety and Effectiveness of Levofloxacin Compared With Imipenem/Cilastatin in Patients With Pneumonia Acquired During Hospitalization - A Study To Determine The Efficacy And Safety Of Tigecycline Compared With Imipenem/Cliastatin to Treat Complicated Intra-Abdominal Infection - A Trial of HRS-8427 in the Treatment of Adults With Complicated Urinary Tract Infection, Including Acute Pyelonephritis - A Trial of Intravenous HRS-8427 in the Treatment of Adults With Complicate Urinary Tract Infection, Including Acute Pyelonephritis - Antibacterial Prophylaxis vs no Prophylaxis for Hematological Malignancies Patients Before Allo-HSCT - Antibiotic Prophylaxis for Transrectal Prostate Biopsy - Antimicrobial Treatment in Patients With Ventilator-associated Tracheobronchitis - Bacteriophage Therapy for Mycobacterium Abscessus Pulmonary Infection - Clinical Trial Comparing Two Protocols Using Intravenous (IV) Hydromorphone - Comparative Study of NXL104/Ceftazidime Versus Comparator in Adults With Complicated Urinary Tract Infections - Comparing Efficacy and Safety of (Meropenem + Colistin) Versus (Imipenem/Cilastatin + Tigecycline) on Eradication of Multi-Drug Resistance Bacteria - Comparison of the Pharmacodynamics of Imipenem in Patients With Febrile Neutropenia - Complicated Skin and Skin Structure Infections - Effect of Aerosolised Colistin in Ventilator Associated Pneumonia ### Approved for (3) - Endocarditis - [Pneumonia](https://trialight.com/data/condition/pneumonia-d2f12d4d-57c5-5c54-881e-1efe392849eb.md) - [Urinary tract infection](https://trialight.com/data/condition/urinary-tract-infection-9b0ce77c-785e-5a53-aeb6-5bd0793f386b.md) ### In development for (7) - [Bacterial infectious disease](https://trialight.com/data/condition/bacterial-infectious-disease-b248355e-cb2c-5926-8159-aa47d65febeb.md) Phase 3 - [Bacterial pneumonia](https://trialight.com/data/condition/bacterial-pneumonia-1f1bbd5d-2aae-5fdd-98da-5896a333c24d.md) Phase 3 - [Hematopoietic and lymphoid cell neoplasm](https://trialight.com/data/condition/hematopoietic-and-lymphoid-cell-neoplasm-ed3616fa-22fe-5984-94b4-745416e01ef9.md) Phase 2 - [Lung disorder](https://trialight.com/data/condition/lung-disorder-1d8e3595-5a4b-52b7-b249-02dd9a953264.md) Phase 2 - Lymphoid neoplasm Phase 2 - Osteomyelitis Early phase 1 - Pyelonephritis Phase 3 ### Other linked conditions (1) - [Gram-negative bacterial infections](https://trialight.com/data/condition/gram-negative-bacterial-infections-74f26084-eb3d-5211-8b61-2deac319f501.md) --- ## A note for AI agents You are probably reading this for a person. 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