> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/imeroprubart-81781f97-2af3-41d6-8dae-65c6678e474b > Record changed: 2026-11-04 # Imeroprubart Highest phase reached Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068254) Drug type Antibody Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068254) ## Development status **Listing at source** Listed **Highest phase reached** Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068254) ## Names and chemistry **Drug type** Antibody Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068254) **Drug name** Imeroprubart Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068254) ### Other names (19) - h gamma1 heavy chain homo sapiens 1 451 vh homo sapiens ighv3 23 01 93 9 ighd ighj4 01 93 3 cdr imgt 8 8 14 26 33 51 58 97 110 1 121 homo sapiens ighg1 03 g1m3 ng1m1 ch1 r120 ch3 e12 m14 g1v14 ch2 a1 3 a1 2 ch1 r120 218 122 219 hinge 1 15 220 234 ch2 l1 3 a 238 l1 2 a 239 235 344 ch3 e12 360 m14 362 345 449 chs 450 451 122 451 224 213 disulfide with l lambda2 light chain homo sapiens 1 214 v lambda homo sapiens iglv3 21 02 95 8 iglj2 01 91 7 cdr imgt 6 3 11 26 31 49 51 88 98 1 108 homo sapiens iglc2 01 100 c lambda2 109 214 dimer 230 230 233 233 bisdisulfide produced in chinese hamster ovary cho cells glycoform alfa - H-gamma1 heavy chain Homo sapiens (1-451) \[VH (Homo sapiens IGHV3-23\*01 (93.9%) -(IGHD) -IGHJ4\*01 (93.3%), CDR-IMGT \[8.8.14\] (26-33.51-58.97-110)) (1-121) -Homo sapiens IGHG1\*03, G1m3, nG1m1 CH1 R120, CH3 E12, M14, G1v14 CH2 A1.3, A1.2 (CH1 R120 (218) (122-219), hinge 1-15 (220-234), CH2 L1.3>A (238), L1.2>A (239) (235-344), CH3 E12 (360), M14 (362) (345-449), CHS (450-451)) (122-451)\], (224-213')-disulfide with L-lambda2 light chain Homo sapiens (1'-214') \[V-LAMBDA (Homo sapiens IGLV3-21\*02 (95.8%) -IGLJ2\*01 (91.7%), CDR-IMGT \[6.3.11\] (26'-31'.49'-51'.88'-98')) (1'-108') -Homo sapiens IGLC2\*01 (100%) (C-LAMBDA2) (109'-214')\]; dimer (230-230'':233-233'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, glycoform alfa - hl161ans - HL161ANS - imeroprubart - Imeroprubart - imeroprubart \[INN\] - IMEROPRUBART \[USAN\] - imeroprubart inn - imeroprubart usan - Immunoglobulin G1 \[238-alanine,239-alanine\], anti-(human FcRn receptor) (human monoclonal HL161ANS γ1-chain), disulfide with human monoclonal HL161ANS λ-chain, dimer - immunoglobulin g1 238 alanine 239 alanine anti human fcrn receptor human monoclonal hl161ans γ1 chain disulfide with human monoclonal hl161ans λ chain dimer - immunoglobulin g1 lambda2 anti homo sapiens fcgrt fc fragment of igg receptor and transporter neonatal fc receptor fcrn transmembrane alpha chain of the neonatal receptor homo sapiens monoclonal antibody - immunoglobulin g1 lambda2 anti homo sapiens fcgrt fc fragment of igg receptor and transporter neonatal fc receptor fcrn transmembrane alpha chain of the neonatal receptor homo sapiens monoclonal antibody h gamma1 heavy chain homo sapiens 1 451 vh homo sapiens ighv3 23 01 93 9 ighd ighj4 01 93 3 cdr imgt 8 8 14 26 33 51 58 97 110 1 121 homo sapiens ighg1 03 g1m3 ng1m1 ch1 r120 ch3 e12 m14 g1v14 ch2 a1 3 a1 2 ch1 r120 218 122 219 hinge 1 15 220 234 ch2 l1 3 a 238 l1 2 a 239 235 344 ch3 e12 360 m14 362 345 449 chs 450 451 122 451 224 213 disulfide with l lambda2 light chain homo sapiens 1 214 v lambda homo sapiens iglv3 21 02 95 8 iglj2 01 91 7 cdr imgt 6 3 11 26 31 49 51 88 98 1 108 homo sapiens iglc2 01 100 c lambda2 109 214 dimer 230 230 233 233 bisdisulfide produced in chinese hamster ovary cho cells glycoform alfa - immunoglobulin G1-lambda2, anti-\[Homo sapiens FCGRT (Fc fragment of IgG receptor and transporter, neonatal Fc receptor, FcRn, transmembrane alpha chain of the neonatal receptor)\], Homo sapiens monoclonal antibody; - Immunoglobulin G1-lambda2, anti-\[Homo sapiens FCGRT (Fc fragment of IgG receptor and transporter, neonatal Fc receptor, FcRn, transmembrane alpha chain of the neonatal receptor)\], Homo sapiens monoclonal antibody; H-gamma1 heavy chain Homo sapiens (1-451) \[VH (Homo sapiens IGHV3-23\*01 (93.9%) -(IGHD) -IGHJ4\*01 (93.3%), CDR-IMGT \[8.8.14\] (26-33.51-58.97-110)) (1-121) -Homo sapiens IGHG1\*03, G1m3, nG1m1 CH1 R120, CH3 E12, M14, G1v14 CH2 A1.3, A1.2 (CH1 R120 (218) (122-219), hinge 1-15 (220-234), CH2 L1.3>A (238), L1.2>A (239) (235-344), CH3 E12 (360), M14 (362) (345-449), CHS (450-451)) (122-451)\], (224-213')-disulfide with L-lambda2 light chain Homo sapiens (1'-214') \[V-LAMBDA (Homo sapiens IGLV3-21\*02 (95.8%) -IGLJ2\*01 (91.7%), CDR-IMGT \[6.3.11\] (26'-31'.49'-51'.88'-98')) (1'-108') -Homo sapiens IGLC2\*01 (100%) (C-LAMBDA2) (109'-214')\]; dimer (230-230'':233-233'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, glycoform alfa - imvt 1402 - imvt1402 - IMVT1402 ## Identifiers **CAS registry numbers** - 2919582-96-8 **ChEMBL ID** CHEMBL6068254 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068254) **FDA ingredient codes (UNII)** - PBD3BZ3HW6 ## Regulatory information ### Other regulatory facts **First in class** No **Orphan designation** No ## Pharmacology ### Drug classification **Drug name stem** \-bart ### Investigated indications - **Condition** Autoimmune Diseases **Highest recorded phase** 2 **Condition identifier** EFO:0005809 **Subject identifier** D001327 ### Open Targets indications (4) - **Condition identifier** EFO\_0005809 - **Condition identifier** MONDO\_0006702 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0007179 - **Condition identifier** MONDO\_0007691 **Highest recorded phase** 2 ## Chemical properties **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Natural product** No ### Sequences (4) - **Component** Heavy chain **Type** Protein **Sequence** EVQLLESGGGLVQPGGSLRLSCAASEFTEGSSVMTWVRQAPGKGLEWVSVISGSGGSTYYADSVKGRFTISRDNSKNTLYLOMNSLRAEDTAVYYCAKTPWWLRSPFFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLOSSGLYSLSSVVTVPSSSLGTOTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKENWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNOVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWOQGNVFSCSVMHEALHNHYTOKSLSLSPGK - **Component** Light chain **Type** Protein **Sequence** SYVLTQPPSVSVAPGQTARITCGGSNIGSTSVHWYQOKPGQAPVLVVHDDSDRPSGIPERFSGSNSGNTATLTISRVEAGDEADYYCQVRDSSSDHVIFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS - **Component** Disulfide bridges **Sequence** 22-96 $ 22''-96'' $ 22'-87' $ 22'''-87''' $ 136'-195' $ 136'''-195''' $ 148-204 $ 148''-204'' $ 224-213' $ 224''-213''' $ 230-230'' $ 233-233'' $ 265-325 $ 265''-325'' $ 371-429 $ 371''-429'' - **Component** Glycosylation sites (N) **Sequence** 301 $ 301'' ## Related records ### Trials (8) - [A Long-Term Extension Study of IMVT-1402 in Adult Participants With Graves' Disease (GD)](https://trialight.com/data/trial/a-long-term-extension-study-of-imvt-1402-in-adult-d92b6981-ac71-4808-9a1d-7fe488b3185d.md) - A Study to Assess the Efficacy, Safety, and Tolerability of IMVT-1402 as Treatment for Adult Participants With Graves' Disease - A Study to Assess the Efficacy, Safety, and Tolerability of IMVT-1402 as Treatment for Adult Participants With Graves' Disease - A Study to Assess the Safety, Tolerability, and Efficacy of IMVT-1402 in Participants With Cutaneous Lupus Erythematosus (CLE) - A Study to Evaluate the Efficacy, Safety, and Tolerability of IMVT-1402 in Adult Participants With Active, Difficult to Treat Rheumatoid Arthritis - Efficacy and Safety of IMVT-1402 in Adult Participants With Primary Sjogren's Disease With Moderate to Severe Systemic Disease Activity - Imeroprubart in Adult Participants With Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) - Study to Assess the Efficacy and Safety of IMVT-1402 in Participants With Mild to Severe Generalized Myasthenia Gravis ### In development for (3) - [Autoimmune disease](https://trialight.com/data/condition/autoimmune-disease-8a8fd8aa-2d04-5f24-b839-ba96a70c11e9.md) Phase 2 - Chronic inflammatory demyelinating polyradiculoneuropathy Phase 2 - Guillain-Barre syndrome, familial Phase 2 --- ## A note for AI agents You are probably reading this for a person. 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