> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/idrebormilast-6c71185f-a9f9-4206-9abb-b2b01bfc7b28 > Record changed: 2026-11-04 # Idrebormilast Highest phase reached Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6056273) Drug type Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6056273) ## Development status **Listing at source** Listed **Highest phase reached** Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6056273) ## Names and chemistry **Drug type** Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6056273) **Drug name** Idrebormilast Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6056273) **Molecular weight** 327.19 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6056273) **Structure (SMILES)** CCCOc1cc(-c2cncc(\[C@@H\]3COB(O)C3)c2)ccc1OC Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6056273) ### Other names (15) - idrebormilast - Idrebormilast - idrebormilast \[INN\] - IDREBORMILAST \[USAN\] - idrebormilast inn - idrebormilast usan - pf 07038124 - pf 07038124 ointment - pf 07038124 who dd - Pf-07038124 - PF-07038124 - PF-07038124 \[WHO-DD\] - PF-07038124 ointment - pf07038124 - PF07038124 ## Identifiers **CAS registry numbers** - 2415085-44-6 **ChEMBL ID** CHEMBL6056273 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6056273) **InChIKey** KXVKOYCGACSUPP-INIZCTEOSA-N Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6056273) **PubChem compound IDs** - 148293990 **FDA ingredient codes (UNII)** - M6ZU548FWD ## Regulatory information ### Other regulatory facts **First in class** No **Orphan designation** No ## Pharmacology ### Drug classification **Pharmacology name** PF-07038124 **Type** Synthetic organic **Drug name stem** \-ast ### Mechanisms of action - **Action** Inhibition **Action type** Inhibitor **Target** phosphodiesterase 4B **Gene symbol** PDE4B **Protein identifier** Q07343 **Median affinity** 9.3 **Affinity units** pIC50 ### Investigated indications (2) - **Condition** Psoriasis **Highest recorded phase** 1 **Condition identifier** EFO:0000676 **Subject identifier** D011565 - **Condition** Dermatitis **Highest recorded phase** 1 **Condition identifier** HP:0011123 **Subject identifier** D003872 ### Open Targets indications (9) - **Condition identifier** EFO\_0000274 **Highest recorded phase** 2 - **Condition identifier** EFO\_0000676 **Highest recorded phase** 2 - **Condition identifier** EFO\_1001494 **Highest recorded phase** 2 - **Condition identifier** HP\_0011123 - **Condition identifier** MONDO\_0002406 - **Condition identifier** MONDO\_0004980 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005083 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0006608 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0008661 **Highest recorded phase** 2 ## Chemical properties **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Heavy atoms** 24 **Molecular formula** C18H22BNO4 **Monoisotopic mass** 327.1641883 **Natural product** No ## Evidence counts **Recorded assays** 3 **Active assays** 3 ### Active assay types - Confirmatory ## Related records ### Trials (6) - A Study To Determine The Safety, Tolerability, Skin Irritation Potential, And PK Following Topical Application Of PF-07038124 In Healthy Participants - [A Study to Learn About The Study Medicine (PF-07038124) In Patients With Mild To Moderate Atopic Dermatitis Or Mild To Severe Plaque Psoriasis.](https://trialight.com/data/trial/a-study-to-learn-about-the-study-medicine-pf-07038124-in-6d4ea358-764e-4585-b0e7-c3941c471c09.md) - PDE4 Inhibition in Seborrheic Dermatitis and Papulopustular Rosacea - Study of Efficacy, Safety and Tolerability of Crisaborole and PF-07038124 With and Without NBUVB in Vitiligo - Study To Assess Efficacy, Safety, Tolerability And Pharmacokinetics Of PF-07038124 Ointment In Participants With Atopic Dermatitis Or Plaque Psoriasis - Study to Evaluate the Safety, Local and Systemic Tolerability, and Pharmacokinetics of Multiple-Dose Topical Administration of PF-07038124 in Japanese Healthy Participants ### In development for (5) - [Atopic eczema](https://trialight.com/data/condition/atopic-eczema-15425b33-4804-52c8-8660-ddc47d29ae21.md) Phase 2 - [Dermatitis](https://trialight.com/data/condition/dermatitis-cf8b2157-f593-5138-bd3d-f2a74343308e.md) Phase 1 - [Psoriasis](https://trialight.com/data/condition/psoriasis-4340caf0-883c-54c7-886d-31e59b80dead.md) Phase 1 - Seborrheic dermatitis Phase 2 - Vitiligo Phase 2 ### Targets (1) - [PDE4B](https://trialight.com/data/target/pde4b-b6d2dead-6de9-505a-b969-9b1362d0de89.md) --- ## A note for AI agents You are probably reading this for a person. 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