> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/icovamenib-e775ec52-9b3d-4f8d-a0f2-7c632a43d1ef
> Record changed: 2026-10-13

# Icovamenib

Highest phase reached

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068392)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068392)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068392)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068392)

**Drug name**

Icovamenib

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068392)

**Molecular weight**

566.67

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068392)

**Structure (SMILES)**

C=CC(=O)N\[C@@H\]1CCCN(Cc2ccnc(C(=O)Nc3ccc(-c4cc5c(N6CCOCC6)ncnc5\[nH\]4)cc3)c2)C1

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068392)

### Other names (13)

- bmf 219
- BMF 219 \[WHO-DD\]
- bmf 219 who dd
- Bmf-219
- BMF-219
- icovamenib
- Icovamenib
- icovamenib \[INN\]
- ICOVAMENIB \[USAN\]
- icovamenib 100 mg
- icovamenib 100mg
- icovamenib inn
- icovamenib usan

## Identifiers

**CAS registry numbers**

- 2448172-22-1

**ChEMBL ID**

CHEMBL6068392

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068392)

**InChIKey**

CPRLHPSXWZTPMC-XMMPIXPASA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068392)

**PubChem compound IDs**

- 154988914

**FDA ingredient codes (UNII)**

- 2Z737MY35A

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Drug classification

**Pharmacology name**

icovamenib

**Type**

Synthetic organic

**Drug name stem**

\-menib

### Investigated indications (9)

- **Condition**  
Leukemia, Myeloid, Acute

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000222

**Subject identifier**  
D015470
- **Condition**  
Colorectal Neoplasms

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000365

**Subject identifier**  
D015179
- **Condition**  
Diabetes Mellitus

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000400

**Subject identifier**  
D003920
- **Condition**  
Neoplasms

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000616

**Subject identifier**  
D009369
- **Condition**  
Carcinoma, Non-Small-Cell Lung

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0003060

**Subject identifier**  
D002289
- **Condition**  
Diabetes Mellitus, Type 1

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0005147

**Subject identifier**  
D003922
- **Condition**  
Diabetes Mellitus, Type 2

**Highest recorded phase**  
1

**Condition identifier**  
MONDO:0005148

**Subject identifier**  
D003924
- **Condition**  
Carcinoma, Pancreatic Ductal

**Highest recorded phase**  
1

**Condition identifier**  
MONDO:0005184

**Subject identifier**  
D021441
- **Condition**  
Colorectal Neoplasms

**Highest recorded phase**  
1

**Condition identifier**  
MONDO:0005575

**Subject identifier**  
D015179

### Open Targets indications (16)

- **Condition identifier**  
EFO\_0000222
- **Condition identifier**  
EFO\_0000400
- **Condition identifier**  
EFO\_0000616
- **Condition identifier**  
MONDO\_0004948

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0004967

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005015
- **Condition identifier**  
MONDO\_0005070
- **Condition identifier**  
MONDO\_0005147

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005148
- **Condition identifier**  
MONDO\_0005148

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005233

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005575

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0009693

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0009831

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0018874

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0018905

**Highest recorded phase**  
1

### Trial references (3)

- NCT05631574  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05631574)
- NCT05731544  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05731544)
- NCT06152042  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06152042)

## Chemical properties

**Hydrogen bond acceptors**

8

**Hydrogen bond donors**

3

**Polar surface area**

128.37

**Calculated partition coefficient (ALogP)**

3.38

**Calculated partition coefficient (XLogP)**

2.8

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Rule-of-five violations**

1

**Rotatable bonds**

8

**Heavy atoms**

42

**Molecular formula**

C31H34N8O3

**Monoisotopic mass**

566.27538698

**Natural product**

No

## Related records

### Trials (7)

- Food Effect Study in Healthy Volunteers
- Phase 2 Trial of BMF-219 in Participants With Type 1 Diabetes Mellitus
- Phase 2 Trial of Icovamenib in Participants With Type 2 Diabetes Mellitus Who Are Not Achieving Glycemic Targets While Using GLP-1-Based Therapy
- Phase 2 Trial of Icovamenib in Participants With Type 2 Diabetes Who Are Not Achieving Glycemic Targets
- [Study of BMF-219 in Healthy Adult Subjects and in Adult Subjects With Type 2 Diabetes Mellitus (T2D)](https://trialight.com/data/trial/study-of-bmf-219-in-healthy-adult-subjects-and-in-adult-49a7005b-488c-471a-be4a-271d899a4d13.md)
- Study of BMF-219, a Covalent Menin Inhibitor, in Adult Patients With AML, ALL (With KMT2A/ MLL1r, NPM1 Mutations), DLBCL, MM, and CLL/SLL
- Study of Covalent Menin Inhibitor BMF-219 in Adult Patients With KRAS Driven Non-Small Cell Lung Cancer, Pancreatic Cancer, and Colorectal Cancer

### In development for (9)

- [Acute myeloid leukemia](https://trialight.com/data/condition/acute-myeloid-leukemia-b0971a7a-c18d-544e-bd7f-b1a13b9caa30.md) Phase 1
- [Colorectal adenocarcinoma](https://trialight.com/data/condition/colorectal-adenocarcinoma-49107d5a-ece1-5f2b-8783-f2077e298ffa.md) Phase 1
- [Colorectal cancer](https://trialight.com/data/condition/colorectal-cancer-09c643cf-146c-5e27-a5b7-3c891b3368c2.md) Phase 1
- [Diabetes mellitus](https://trialight.com/data/condition/diabetes-mellitus-1a0391a8-9f84-5600-a2bf-ec97c2229de4.md) Phase 1
- Neoplasm Phase 1
- [Non-small cell lung carcinoma](https://trialight.com/data/condition/non-small-cell-lung-carcinoma-a86c1d60-523f-5ea7-a5e1-39ed4a2296f8.md) Phase 1
- [Pancreatic ductal adenocarcinoma](https://trialight.com/data/condition/pancreatic-ductal-adenocarcinoma-77c1c5a8-638b-51d0-b18e-2c881b8902e5.md) Phase 1
- Type 1 diabetes mellitus Phase 2
- [Type 2 diabetes mellitus](https://trialight.com/data/condition/type-2-diabetes-mellitus-98e14a90-bb06-5174-90c7-901a0a259fb9.md) Phase 1

---

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