> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/icotrokinra-f675941c-89be-40ab-ac5f-61dd8f1f9e24 > Record changed: 2026-10-13 # Icotrokinra Highest phase reached Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068124) Drug type Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068124) ## Development status **Listing at source** Listed **Highest phase reached** Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068124) ## Names and chemistry **Drug type** Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068124) **Drug name** Icotrokinra Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068124) **Structure (SMILES)** c1c2ccccc2ccc1C\[C@H\](NC(=O)\[C@@H\](NC(=O)\[C@H\]3NC(\[C@H\](CCCCNC(=O)C)NC(=O)\[C@H\](Cc4c5c(c(ccc5)C)\[nH\]c4)NC(\[C@@\](NC(=O)\[C@@H\](NC(=O)\[C@H\](C(C)(SSC3(C)C)C)NC(=O)C)CC(=O)N)(\[C@@H\](C)O)\[H\])=O)=O)Cc6ccc(OCCN)cc6)C(=O)NC7(C(=O)N\[C@H\](C(N\[C@@H\](CC(=O)N)C(=O)N\[C@@H\](Cc8cnccc8)C(N(CC(=O)N)C)=O)=O)CCC(O)=O)CCOCC7 Source: [gsrs.ncats.nih.gov](https://gsrs.ncats.nih.gov/ginas/app/beta/substances/MUW8FP7HNZ) ### Other names (12) - icotrokinra - Icotrokinra - icotrokinra \[INN\] - ICOTROKINRA \[USAN\] - Icotrokinra \[WHO-DD\] - icotrokinra inn - icotrokinra usan - icotrokinra who dd - jnj 77242113 - jnj 77242113 aac free base - JNJ-77242113 - JNJ-77242113-AAC FREE BASE ## Identifiers **CAS registry numbers** - 2763602-16-8 **ChEMBL ID** CHEMBL6068124 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068124) **InChIKey** IVFNYXYPMJQSGF-QMRCQSNESA-N Source: [gsrs.ncats.nih.gov](https://gsrs.ncats.nih.gov/ginas/app/beta/substances/MUW8FP7HNZ) **PubChem compound IDs** - 162462321 **RxNorm IDs (RxCUI)** - 2739030 **FDA ingredient codes (UNII)** - MUW8FP7HNZ ## Regulatory information ### Other regulatory facts **Patents** 3 **Designations** 0 **Earliest recorded loss of exclusivity** 19 Nov 2041 **First in class** No **Fast track** No **Breakthrough designation** No **Orphan designation** No **Priority review** No **Orphan exclusivity** No **Accelerated approval** No ## Pharmacology ### Drug classification **Pharmacology name** icotrokinra **Type** Peptide **Drug name stem** \-kinra **Approval recorded by Guide to Pharmacology** Yes ### Mechanisms of action (4) - **Action** Inhibition **Action type** Inhibitor **Target** Interleukin-23 receptor **Gene symbol** IL12RB1 **Protein identifier** P42701 **Median affinity** 11.33 **Affinity units** pIC50 **Primary target** Yes - **Action** Inhibition **Action type** Inhibitor **Target** Interleukin-23 receptor **Gene symbol** IL12RB1 **Protein identifier** P42701 **Median affinity** 11.7 **Affinity units** pKd **Primary target** Yes - **Action** Inhibition **Action type** Inhibitor **Target** Interleukin-23 receptor **Gene symbol** IL23R **Protein identifier** Q5VWK5 **Median affinity** 11.33 **Affinity units** pIC50 **Primary target** Yes - **Action** Inhibition **Action type** Inhibitor **Target** Interleukin-23 receptor **Gene symbol** IL23R **Protein identifier** Q5VWK5 **Median affinity** 11.7 **Affinity units** pKd **Primary target** Yes ### Open Targets indications (9) - **Condition identifier** EFO\_0000384 - **Condition identifier** EFO\_0000729 **Highest recorded phase** 3 - **Condition identifier** EFO\_0003778 **Highest recorded phase** 3 - **Condition identifier** EFO\_1001494 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0005011 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005083 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005101 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0011849 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0100491 **Highest recorded phase** 3 ## Chemical properties **Calculated partition coefficient (XLogP)** \-3.4 **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Heavy atoms** 134 **Monoisotopic mass** 1896.83274788 **Natural product** No ## National Drug Codes - 57894-201 ## Related records ### Trials (16) - A Long-term Extension Study of JNJ-77242113 in Participants With Moderate-to-Severe Plaque Psoriasis - A Protocol of Icotrokinra Therapy in Adult and Adolescent Participants With Moderately to Severely Active Ulcerative Colitis - [A Study of Icotrokinra in Participants With Moderately to Severely Active Crohn's Disease](https://trialight.com/data/trial/a-study-of-icotrokinra-in-participants-with-moderately-to-cef224ab-36cb-4db6-8fb4-e5d9ed2b9bb6.md) - A Study of JNJ-77242113 Following Oral Administration in Healthy Chinese Adult Participants - A Study of JNJ-77242113 for the Treatment of Moderate-to-Severe Plaque Psoriasis - A Study of JNJ-77242113 for the Treatment of Participants With Generalized Pustular Psoriasis or Erythrodermic Psoriasis - A Study of JNJ-77242113 for the Treatment of Participants With Moderate to Severe Plaque Psoriasis - A Study of JNJ-77242113 for the Treatment of Participants With Moderate to Severe Plaque Psoriasis (ICONIC-ADVANCE 2) - A Study of JNJ-77242113 for the Treatment of Participants With Plaque Psoriasis Involving Special Areas (Scalp, Genital, and/or Palms of the Hands and the Soles of the Feet) - A Study of JNJ-77242113 in Adolescent and Adult Participants With Moderate to Severe Plaque Psoriasis - A Study of JNJ-77242113 in Healthy Japanese and Chinese Participants - A Study of JNJ-77242113 in Participants With Moderate-to-severe Plaque Psoriasis - A Study of JNJ-77242113 in Participants With Moderately to Severely Active Ulcerative Colitis - A Study to Assess Efficacy and Safety of JNJ-77242113 Compared to Placebo and Ustekinumab in Participants With Moderate to Severe Plaque Psoriasis - A Study to Evaluate the Efficacy and Safety of Icotrokinra (JNJ-77242113) in Biologic-experienced and Biologic-naive Participants With Active Psoriatic Arthritis - A Study to Evaluate the Efficacy and Safety of JNJ-77242113 (Icotrokinra) in Biologic-naïve Participants With Active Psoriatic Arthritis ### In development for (2) - [Psoriatic arthritis](https://trialight.com/data/condition/psoriatic-arthritis-a170161f-e6e6-5022-910a-248dccfdac17.md) Phase 3 - [Ulcerative colitis](https://trialight.com/data/condition/ulcerative-colitis-afbc4579-f001-5a8a-b904-28f09f344ab5.md) Phase 3 ### Other linked conditions (1) - [Crohn disease](https://trialight.com/data/condition/crohn-disease-f7aa2cd8-9680-56b5-858c-2b75f88fb0d0.md) --- ## A note for AI agents You are probably reading this for a person. 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