> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/iclepertin-4c0281d8-fbd3-472f-97e8-f7007cb50348
> Record changed: 2026-10-13

# Iclepertin

Highest phase reached

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314576)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314576)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314576)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314576)

**Drug name**

Iclepertin

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314576)

**Molecular weight**

512.43

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314576)

**Structure (SMILES)**

C\[C@@H\](Oc1ccc(S(C)(=O)=O)cc1C(=O)N1C\[C@@H\]2C\[C@\]2(c2cc(C(F)(F)F)on2)C1)C(F)(F)F

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314576)

### Other names (12)

- bi 425809
- BI 425809
- BI 425809 tablet
- iclepertin
- Iclepertin
- iclepertin (BI 425809)
- iclepertin \[INN\]
- ICLEPERTIN \[USAN\]
- Iclepertin \[WHO-DD\]
- iclepertin inn
- iclepertin usan
- iclepertin who dd

## Identifiers

**CAS registry numbers**

- 1421936-85-7

**ChEMBL ID**

CHEMBL5314576

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314576)

**InChIKey**

MYHDQTVHHMSLEF-DDBGAENHSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314576)

**PubChem compound IDs**

- 155259577

**FDA ingredient codes (UNII)**

- M43ZDU10DD

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Drug classification

**Pharmacology name**

iclepertin

**Type**

Synthetic organic

**Drug name stem**

\-pertin

### Mechanisms of action

- **Action**  
Inhibition

**Action type**  
Inhibitor

**Target**  
GlyT1

**Gene symbol**  
SLC6A9

**Protein identifier**  
P48067

**Median affinity**

8.3

**Affinity units**  
pIC50

### Investigated indications (4)

- **Condition**  
Renal Insufficiency

**Highest recorded phase**  
1

**Condition identifier**  
HP:0000083

**Subject identifier**  
D051437
- **Condition**  
Cognitive Dysfunction

**Highest recorded phase**  
1

**Condition identifier**  
HP:0001268

**Subject identifier**  
D060825
- **Condition**  
Alzheimer Disease

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0004975

**Subject identifier**  
D000544
- **Condition**  
Schizophrenia

**Highest recorded phase**  
3

**Condition identifier**  
MONDO:0005090

**Subject identifier**  
D012559

### Open Targets indications (7)

- **Condition identifier**  
HP\_0000083

**Highest recorded phase**  
1
- **Condition identifier**  
HP\_0001268
- **Condition identifier**  
HP\_0001399

**Highest recorded phase**  
1
- **Condition identifier**  
HP\_0100543

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0004975
- **Condition identifier**  
MONDO\_0004975

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005090

**Highest recorded phase**  
3

### Trial references (8)

- NCT02788513  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02788513)
- NCT02832037  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02832037)
- NCT03859973  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03859973)
- NCT04846868  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04846868)
- NCT04846881  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04846881)
- NCT04860830  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04860830)
- NCT05211947  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05211947)
- NCT05718843  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05718843)

## Chemical properties

**Hydrogen bond acceptors**

6

**Hydrogen bond donors**

0

**Polar surface area**

89.71

**Calculated partition coefficient (ALogP)**

3.84

**Calculated partition coefficient (XLogP)**

3.5

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Rule-of-five violations**

1

**Rotatable bonds**

5

**Heavy atoms**

34

**Molecular formula**

C20H18F6N2O5S

**Monoisotopic mass**

512.08406182

**Natural product**

No

## Evidence counts

**Recorded assays**

11

**Active assays**

1

### Active assay types

- Confirmatory

## Related records

### Trials (27)

- A Study in Healthy Men and Women to Test Which Effects Donepezil and BI 425809 Have on Each Other
- A Study in Healthy Men and Women to Test Which Effects Memantine and BI 425809 Have on Each Other
- A Study in Healthy Men to Find Out How BI 425809 is Taken up and Handled by the Body
- A Study in Healthy Men to Measure the Amount of BI 425809 in the Blood When Taken as a Tablet
- A Study in Healthy Men to Test How Fluconazole Influences the Amount of BI 425809 in the Blood
- A Study in Healthy Men to Test Whether BI 409306, BI 425809 or Lamotrigine Can Reverse the Memory Problems Caused by Ketamine
- A Study in Healthy Men to Test Whether BI 425809 Influences the Amount of Midazolam in the Blood
- A Study in Healthy Men to Test Whether Bosentan Influences the Amount of BI 425809 in the Blood
- A Study in Healthy Men to Test Whether Rifampicin Influences the Amount of BI 425809 in the Blood
- A Study in Healthy People to Test How BI 425809 is Taken up in the Body When Taken With or Without Food
- A Study in Healthy People to Test Whether Iclepertin Has an Effect on Cardiac Safety
- A Study in Healthy Women to Test Whether BI 425809 Influences the Amount of a Contraceptive in the Blood
- A Study to Test How Iclepertin is Taken up in the Blood of People With and Without Kidney Problems
- A Study to Test How Iclepertin is Taken up in the Blood of People With and Without Liver Problems
- [A Study to Test Long-term Safety of Iclepertin in People With Schizophrenia Who Took Part in a Previous CONNEX Study](https://trialight.com/data/trial/a-study-to-test-long-term-safety-of-iclepertin-in-people-bc5ded37-c415-4bd8-8a20-c951b1c3df0d.md)
- BI 425809 in Patients With Cognitive Impairment Due to Alzheimer's Disease.
- Clinical Trial of BI 425809 Effect on Cognition and Functional Capacity in Schizophrenia
- Clinical Trial of Iclepertin Effect on Cognition and Functional Capacity in Schizophrenia (CONNEX-1)
- Clinical Trial of Iclepertin Effect on Cognition and Functional Capacity in Schizophrenia (CONNEX-2)
- CONNEX-3: A Study to Test Whether Iclepertin Improves Learning and Memory in People With Schizophrenia

### In development for (3)

- [Alzheimer disease](https://trialight.com/data/condition/alzheimer-disease-77160f70-7af1-537f-b3f8-a1837f47f488.md) Phase 2
- [Kidney failure](https://trialight.com/data/condition/kidney-failure-f26737b4-3a55-50be-b6c3-b76514cb5067.md) Phase 1
- [Schizophrenia](https://trialight.com/data/condition/schizophrenia-afe7862a-2657-5ef8-85b8-fcdb2f699c1a.md) Phase 3

---

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