> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/ibuzatrelvir-0389fb99-e32d-4460-a13b-9d1558ca6e29
> Record changed: 2026-10-13

# Ibuzatrelvir

Highest phase reached

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5591580)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5591580)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5591580)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5591580)

**Drug name**

Ibuzatrelvir

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5591580)

**Molecular weight**

489.5

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5591580)

**Structure (SMILES)**

COC(=O)N\[C@H\](C(=O)N1C\[C@H\](C(F)(F)F)C\[C@H\]1C(=O)N\[C@H\](C#N)C\[C@@H\]1CCNC1=O)C(C)(C)C

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5591580)

### Other names (13)

- drug pf 07817883
- Drug: PF-07817883
- ibuzatrelvir
- Ibuzatrelvir
- ibuzatrelvir \[INN\]
- IBUZATRELVIR \[USAN\]
- Ibuzatrelvir \[WHO-DD\]
- ibuzatrelvir inn
- ibuzatrelvir usan
- ibuzatrelvir who dd
- pf 07817883
- Pf-07817883
- PF-07817883

## Identifiers

**CAS registry numbers**

- 2755812-39-4

**ChEMBL ID**

CHEMBL5591580

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5591580)

**InChIKey**

WGNWEPPRWQKSKI-AIEDFZFUSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5591580)

**PubChem compound IDs**

- 163362000

**FDA ingredient codes (UNII)**

- KZ2X7QH2VT

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Drug classification

**Pharmacology name**

ibuzatrelvir

**Type**

Synthetic organic

**Drug name stem**

\-vir

### Investigated indications (2)

- **Condition**  
COVID-19

**Highest recorded phase**  
1

**Condition identifier**  
MONDO:0100096

**Subject identifier**  
D000086382
- **Condition**  
Severe Acute Respiratory Syndrome

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0100096

**Subject identifier**  
D045169

### Open Targets indications (2)

- **Condition identifier**  
MONDO\_0100096

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0100096

**Highest recorded phase**  
3

### Trial references (2)

- NCT05799495  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05799495)
- NCT05884554  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05884554)

## Chemical properties

**Hydrogen bond acceptors**

6

**Hydrogen bond donors**

3

**Polar surface area**

140.63

**Calculated partition coefficient (ALogP)**

1.07

**Calculated partition coefficient (XLogP)**

1.7

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Rule-of-five violations**

0

**Rotatable bonds**

6

**Heavy atoms**

34

**Molecular formula**

C21H30F3N5O5

**Monoisotopic mass**

489.21990356

**Natural product**

No

## Evidence counts

**Recorded assays**

114

**Active assays**

22

### Active assay types

- Confirmatory

## Biological measurements

### Observed measurements

#### Distribution coefficient (LogD)

**Median**

0.9

**Mean**

0.9

**Minimum**

0.9

**Maximum**

0.9

**Unit**

unitless

**Assays**

1

**Standard deviation**

0

**Summary method**

median

**Censored results excluded**

0

**Other units excluded**

0

**Unknown units excluded**

0

#### Measurement types

- LogD

#### Oral bioavailability

**Median**

25.55

**Mean**

25.55

**Minimum**

21.9

**Maximum**

29.2

**Unit**

%

**Assays**

2

**Standard deviation**

5.16188

**Summary method**

median

**Censored results excluded**

0

**Other units excluded**

0

**Unknown units excluded**

0

#### Measurement types

- F

#### Plasma protein binding

**Median**

0.423

**Mean**

0.467

**Minimum**

0.121

**Maximum**

0.857

**Unit**

fraction unbound

**Assays**

3

**Standard deviation**

0.369968

**Summary method**

median

**Censored results excluded**

0

**Other units excluded**

0

**Unknown units excluded**

0

#### Measurement types

- Fu

## Related records

### Trials (11)

- A Study of How Ibuzatrelvir is Taken up Into the Blood of Healthy Adults After Taking Different Tablets of Ibuzatrelvir
- [A Study to Learn About a Study Medicine Called Ibuzatrelvir in Adult and Adolescent Patients With COVID-19 Who Are Not Hospitalized But Are at Risk For Severe Disease](https://trialight.com/data/trial/a-study-to-learn-about-a-study-medicine-called-ibuzatrelvir-1cad908c-0586-44f9-bb4b-6102e4e212a2.md)
- A Study to Learn About How Itraconazole Affects the Blood Level of Study Medicine (PF-07817883) in Healthy Adults.
- A Study to Learn About How Loss of Liver Function Affects the Blood Levels of the Study Medicine Called PF-07817883.
- A Study to Learn About the Study Medicine Ibuzatrelvir in Adults With COVID-19 Who Are Severely Immunocompromised
- A Study to Learn How Renal Impairment Affects the Pharmacokinetics of PF-07817883.
- A Study to Learn How the Study Medicine Called Ibuzatrelvir is Taken up Into the Blood in Healthy Chinese Adults
- A Study to Learn If the Study Medicine Called Carbamazepine Changes How the Body Processes the Other Study Medicine Ibuzatrelvir in Healthy Adults
- A Study to Learn PF-07817883 Blood Levels After Administration of Tablets of Study Drug to Healthy Adult Volunteers
- A Study to Learn Safety and Blood Levels of PF-07817883 in Healthy People
- A Study to Understand the Effect and Safety of the Study Medicine PF-07817883 in Adults Who Have Symptoms of COVID-19 But Are Not Hospitalized

### In development for (1)

- [COVID-19](https://trialight.com/data/condition/covid-19-13f0ebf3-c291-557d-bdef-93563d077103.md) Phase 2

---

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