> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/ibrutinib-0b3ac4fd-6e98-4847-a711-2f599e8bb93d > Record changed: 2026-10-13 # Ibrutinib Highest phase reached Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1873475) Drug type Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1873475) First approval year 2013 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1873475) ## Development status **First approval year** 2013 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1873475) **Listing at source** Listed **Highest phase reached** Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1873475) ## Names and chemistry **Drug type** Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1873475) **Drug name** Ibrutinib Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1873475) **Molecular weight** 440.51 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1873475) **Structure (SMILES)** C=CC(=O)N1CCC\[C@@H\](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1873475) ### Brand names (2) - imbruvica - Imbruvica ### Other names (50) - carfilzomib ibrutinib - cra 032765 - CRA-032765 - ibrutinib - Ibrutinib - IBRUTINIB - Ibrutinib (Arm 4) - Ibrutinib (as Subsequent Therapy) - Ibrutinib (Induction) - Ibrutinib (Maintenance) - Ibrutinib (Treatment B) - Ibrutinib (Treatment C) - Ibrutinib (Treatment D) - Ibrutinib (Treatment E) - Ibrutinib (Treatment F) - ibrutinib \[INN\] - IBRUTINIB \[JAN\] - IBRUTINIB \[MI\] - IBRUTINIB \[ORANGE BOOK\] - IBRUTINIB \[USAN\] - IBRUTINIB \[VANDF\] - Ibrutinib \[WHO-DD\] - Ibrutinib 420 mg - Ibrutinib 560 mg - Ibrutinib 560mg PO daily (Imbruvica) And 25 more, listed on the interactive page. ## Identifiers **ATC classification codes** - L01EL01 Sources for recorded values Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1873475) **CAS registry numbers** - 936563-96-1 **ChEMBL ID** CHEMBL1873475 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1873475) **InChIKey** XYFPWWZEPKGCCK-GOSISDBHSA-N Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1873475) **PubChem compound IDs** - 24821094 **RxNorm IDs (RxCUI)** - 1442981 **FDA ingredient codes (UNII)** - 1X70OSD4VX ## Regulatory information ### United States **Applicant** PHARMACYCLICS LLC **Approval date** 13 Nov 2013 **Application number** NDA205552 ### European Union **Status** Authorised **Status date** 21 Oct 2014 **Authorisation date** 21 Oct 2014 **Approved indications** Imbruvica in combination with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone (IMBRUVICA + R-CHOP) alternating with R-DHAP (or R-DHAOx) without Imbruvica, followed by Imbruvica monotherapy, is indicated for the treatment of adult patients with previously untreated mantle cell lymphoma (MCL) who would be eligible for autologous stem cell transplantation (ASCT).Imbruvica as a single agent is indicated for the treatment of adult patients with relapsed or refractory MCL.Imbruvica as a single agent or in combination with rituximab or obinutuzumab or venetoclax is indicated for the treatment of adult patients with previously untreated chronic lymphocytic leukaemia (CLL) (see section 5.1).Imbruvica as a single agent or in combination with bendamustine and rituximab (BR) is indicated for the treatment of adult patients with CLL who have received at least one prior therapy.Imbruvica as a single agent is indicated for the treatment of adult patients with Waldenström’s macroglobulinaemia (WM) who have received at least one prior therapy, or in first line treatment for patients unsuitable for chemo immunotherapy. IMBRUVICA in combination with rituximab is indicated for the treatment of adult patients with WM. **Product number** EMEA/H/C/003791 **Authorisation holder** Janssen-Cilag International NV **Priority medicines scheme** No **Generic** No **Biosimilar** No **Generic medicines** 0 **Biosimilar medicines** 0 **Advanced therapy** No **Conditional approval** No **Additional monitoring** No **Accelerated assessment** No **Exceptional circumstances** No #### Therapeutic areas - Leukemia, Lymphocytic, Chronic, B-Cell - Lymphoma, Mantle-Cell European medicines record Source: [www.ema.europa.eu](https://www.ema.europa.eu/en/medicines/human/EPAR/imbruvica) ### Other regulatory facts **Patents** 187 **Designations** 7 **Earliest recorded loss of exclusivity** 14 Jun 2039 **First in class** Yes **Fast track** Yes **Breakthrough designation** Yes **Orphan designation** No **Priority review** Yes **Orphan exclusivity** No **Accelerated approval** Yes **Availability** Prescription only ## Pharmacology ### Drug classification **Pharmacology name** ibrutinib **Type** Synthetic organic **Drug name stem** \-tinib **Approval recorded by Guide to Pharmacology** Yes #### Administration routes - Oral ### Mechanisms of action (17) - **Action** Inhibition **Action type** Inhibitor **Target** epidermal growth factor receptor **Gene symbol** EGFR **Protein identifier** P00533 **Median affinity** 8.28 **Affinity units** pIC50 - **Action** Inhibition **Action type** Inhibitor **Target** erb-b2 receptor tyrosine kinase 2 **Gene symbol** ERBB2 **Protein identifier** P04626 **Median affinity** 8.19 **Affinity units** pIC50 - **Action** Inhibition **Action type** Inhibitor **Target** LCK proto-oncogene, Src family tyrosine kinase **Gene symbol** LCK **Protein identifier** P06239 **Median affinity** 8.2 **Affinity units** pIC50 - **Action** Inhibition **Action type** Inhibitor **Target** FYN proto-oncogene, Src family tyrosine kinase **Gene symbol** FYN **Protein identifier** P06241 **Median affinity** 7.54 **Affinity units** pIC50 - **Action** Inhibition **Action type** Inhibitor **Target** YES proto-oncogene 1, Src family tyrosine kinase **Gene symbol** YES1 **Protein identifier** P07947 **Median affinity** 8.39 **Affinity units** pIC50 - **Action** Inhibition **Action type** Inhibitor **Target** LYN proto-oncogene, Src family tyrosine kinase **Gene symbol** LYN **Protein identifier** P07948 **Median affinity** 7.7 **Affinity units** pIC50 - **Action** Inhibition **Action type** Inhibitor **Target** HCK proto-oncogene, Src family tyrosine kinase **Gene symbol** HCK **Protein identifier** P08631 **Median affinity** 7.54 **Affinity units** pIC50 - **Action** Inhibition **Action type** Inhibitor **Target** SRC proto-oncogene, non-receptor tyrosine kinase **Gene symbol** SRC **Protein identifier** P12931 **Median affinity** 7.72 **Affinity units** pIC50 - **Action** Inhibition **Action type** Inhibitor **Target** tec protein tyrosine kinase **Gene symbol** TEC **Protein identifier** P42680 **Median affinity** 8.15 **Affinity units** pIC50 - **Action** Inhibition **Action type** Inhibitor **Target** TXK tyrosine kinase **Gene symbol** TXK **Protein identifier** P42681 **Median affinity** 8.7 **Affinity units** pIC50 - **Action** Inhibition **Action type** Inhibitor **Target** BLK proto-oncogene, Src family tyrosine kinase **Gene symbol** BLK **Protein identifier** P51451 **Median affinity** 9.3 **Affinity units** pIC50 - **Action** Inhibition **Action type** Inhibitor **Target** BMX non-receptor tyrosine kinase **Gene symbol** BMX **Protein identifier** P51813 **Median affinity** 9.1 **Affinity units** pIC50 - **Action** Inhibition **Action type** Inhibitor **Target** Janus kinase 3 **Gene symbol** JAK3 **Protein identifier** P52333 **Median affinity** 7.49 **Affinity units** pIC50 - **Action** Inhibition **Action type** Inhibitor **Target** Bruton tyrosine kinase **Gene symbol** BTK **Protein identifier** Q06187 **Median affinity** 9.3 **Affinity units** pIC50 **Primary target** Yes - **Action** Inhibition **Action type** Inhibitor **Target** IL2 inducible T cell kinase **Gene symbol** ITK **Protein identifier** Q08881 **Median affinity** 8.31 **Affinity units** pIC50 - **Action** Inhibition **Action type** Inhibitor **Target** erb-b2 receptor tyrosine kinase 4 **Gene symbol** ERBB4 **Protein identifier** Q15303 **Median affinity** 8.47 **Affinity units** pIC50 - **Mechanism** Tyrosine-protein kinase BTK inhibitor **Action type** Inhibitor **Target** Tyrosine-protein kinase BTK **Protein identifier** Q06187 ### Open Targets mechanisms - **Mechanism** Tyrosine-protein kinase BTK inhibitor **Action type** Inhibitor **Target** Tyrosine-protein kinase BTK ### DrugCentral mechanisms (14) - **Action type** Inhibitor **Gene symbol** ERBB2 **Protein identifier** P04626 **Organism** Homo sapiens **Target development level** Clinical - **Action type** Inhibitor **Gene symbol** LCK **Protein identifier** P06239 **Organism** Homo sapiens **Target development level** Clinical - **Action type** Inhibitor **Gene symbol** FYN **Protein identifier** P06241 **Organism** Homo sapiens **Target development level** Clinical - **Action type** Inhibitor **Gene symbol** YES1 **Protein identifier** P07947 **Organism** Homo sapiens **Target development level** Clinical - **Action type** Inhibitor **Gene symbol** HCK **Protein identifier** P08631 **Organism** Homo sapiens **Target development level** Clinical - **Action type** Inhibitor **Gene symbol** FGR **Protein identifier** P09769 **Organism** Homo sapiens **Target development level** Chemical evidence - **Action type** Inhibitor **Gene symbol** SRC **Protein identifier** P12931 **Organism** Homo sapiens **Target development level** Clinical - **Action type** Inhibitor **Gene symbol** TEC **Protein identifier** P42680 **Organism** Homo sapiens **Target development level** Chemical evidence - **Action type** Inhibitor **Gene symbol** TXK **Protein identifier** P42681 **Organism** Homo sapiens **Target development level** Chemical evidence - **Action type** Inhibitor **Gene symbol** BLK **Protein identifier** P51451 **Organism** Homo sapiens **Target development level** Chemical evidence - **Action type** Inhibitor **Gene symbol** JAK3 **Protein identifier** P52333 **Organism** Homo sapiens **Target development level** Clinical - **Action type** Inhibitor **Gene symbol** BTK **Protein identifier** Q06187 **Organism** Homo sapiens **Target development level** Clinical - **Action type** Inhibitor **Gene symbol** ITK **Protein identifier** Q08881 **Organism** Homo sapiens **Target development level** Clinical - **Action type** Inhibitor **Gene symbol** ERBB4 **Protein identifier** Q15303 **Organism** Homo sapiens **Target development level** Clinical ### Investigated indications (49) - **Condition** Leukemia, Lymphocytic, Chronic, B-Cell **Highest recorded phase** 4 **Condition identifier** EFO:0000095 **Subject identifier** D015451 - **Condition** Lymphoma, Follicular **Highest recorded phase** 3 **Condition identifier** EFO:0000096 **Subject identifier** D008224 - **Condition** Carcinoma, Squamous Cell **Highest recorded phase** 2 **Condition identifier** EFO:0000181 **Subject identifier** D002294 - **Condition** Hodgkin Disease **Highest recorded phase** 2 **Condition identifier** EFO:0000183 **Subject identifier** D006689 - **Condition** Myelodysplastic Syndromes **Highest recorded phase** 1 **Condition identifier** EFO:0000198 **Subject identifier** D009190 - **Condition** Precursor Cell Lymphoblastic Leukemia-Lymphoma **Highest recorded phase** 1 **Condition identifier** EFO:0000220 **Subject identifier** D054198 - **Condition** Leukemia, Myeloid, Acute **Highest recorded phase** 2 **Condition identifier** EFO:0000222 **Subject identifier** D015470 - **Condition** Burkitt Lymphoma **Highest recorded phase** 2 **Condition identifier** EFO:0000309 **Subject identifier** D002051 - **Condition** Melanoma **Highest recorded phase** 2 **Condition identifier** EFO:0000389 **Subject identifier** D008545 - **Condition** Lymphoma, Large B-Cell, Diffuse **Highest recorded phase** 3 **Condition identifier** EFO:0000403 **Subject identifier** D016403 - **Condition** Glioblastoma **Highest recorded phase** 1 **Condition identifier** EFO:0000519 **Subject identifier** D005909 - **Condition** Leukemia **Highest recorded phase** 2 **Condition identifier** EFO:0000565 **Subject identifier** D007938 - **Condition** Lymphoma **Highest recorded phase** 3 **Condition identifier** EFO:0000574 **Subject identifier** D008223 - **Condition** Neoplasms **Highest recorded phase** 4 **Condition identifier** EFO:0000616 **Subject identifier** D009369 - **Condition** Carcinoma, Renal Cell **Highest recorded phase** 1 **Condition identifier** EFO:0000681 **Subject identifier** D002292 - **Condition** Multiple Myeloma **Highest recorded phase** 2 **Condition identifier** EFO:0001378 **Subject identifier** D009101 - **Condition** Liver Diseases **Highest recorded phase** 1 **Condition identifier** EFO:0001421 **Subject identifier** D008107 - **Condition** Hematologic Neoplasms **Highest recorded phase** 2 **Condition identifier** EFO:0001642 **Subject identifier** D019337 - **Condition** Waldenstrom Macroglobulinemia **Highest recorded phase** 4 **Condition identifier** EFO:0002616 **Subject identifier** D008258 - **Condition** Melanoma **Highest recorded phase** 2 **Condition identifier** EFO:0002617 **Subject identifier** D008545 - **Condition** Carcinoma, Non-Small-Cell Lung **Highest recorded phase** 2 **Condition identifier** EFO:0003060 **Subject identifier** D002289 - **Condition** Carcinoid Tumor **Highest recorded phase** 2 **Condition identifier** EFO:0004243 **Subject identifier** D002276 - **Condition** Leukemia, Lymphoid **Highest recorded phase** 2 **Condition identifier** EFO:0004289 **Subject identifier** D007945 - **Condition** Lymphoma, Non-Hodgkin **Highest recorded phase** 3 **Condition identifier** EFO:0005952 **Subject identifier** D008228 - **Condition** Head and Neck Neoplasms **Highest recorded phase** 2 **Condition identifier** EFO:0006859 **Subject identifier** D006258 And 24 more, listed on the interactive page. ### Open Targets indications (96) - **Condition identifier** EFO\_0000095 - **Condition identifier** EFO\_0000096 **Highest recorded phase** 2 - **Condition identifier** EFO\_0000183 **Highest recorded phase** 2 - **Condition identifier** EFO\_0000198 **Highest recorded phase** 1 - **Condition identifier** EFO\_0000222 - **Condition identifier** EFO\_0000389 **Highest recorded phase** 2 - **Condition identifier** EFO\_0000403 **Highest recorded phase** 3 - **Condition identifier** EFO\_0000519 **Highest recorded phase** 1 - **Condition identifier** EFO\_0000565 **Highest recorded phase** 2 - **Condition identifier** EFO\_0000574 **Highest recorded phase** 3 - **Condition identifier** EFO\_0000616 - **Condition identifier** EFO\_0000681 - **Condition identifier** EFO\_0001378 **Highest recorded phase** 2 - **Condition identifier** EFO\_0001421 **Highest recorded phase** 1 - **Condition identifier** EFO\_0002616 - **Condition identifier** EFO\_0002616 **Highest recorded phase** 4 - **Condition identifier** EFO\_0002617 **Highest recorded phase** 2 - **Condition identifier** EFO\_0003060 **Highest recorded phase** 2 - **Condition identifier** EFO\_0003860 **Highest recorded phase** 3 - **Condition identifier** EFO\_0004289 **Highest recorded phase** 2 - **Condition identifier** EFO\_0005952 **Highest recorded phase** 3 - **Condition identifier** EFO\_0007359 **Highest recorded phase** 2 - **Condition identifier** EFO\_0009441 **Highest recorded phase** 3 - **Condition identifier** EFO\_1000157 **Highest recorded phase** 2 - **Condition identifier** EFO\_1000359 **Highest recorded phase** 3 And 71 more, listed on the interactive page. ### Reported adverse events (21) - **Event** atrial fibrillation **Reports** 1,004 **Reporting signal score** 1,643.98 - **Event** cerebral aspergillosis **Reports** 47 **Reporting signal score** 173.645 - **Event** chronic lymphocytic leukaemia **Reports** 149 **Reporting signal score** 404.348 - **Event** contusion **Reports** 414 **Reporting signal score** 459.827 - **Event** drug hypersensitivity **Reports** 16 **Reporting signal score** 165.26 - **Event** epistaxis **Reports** 245 **Reporting signal score** 165.838 - **Event** haematoma **Reports** 195 **Reporting signal score** 215.502 - **Event** haemorrhage **Reports** 500 **Reporting signal score** 554.015 - **Event** injection site pain **Reports** 1 **Reporting signal score** 169.734 - **Event** lymphadenopathy **Reports** 222 **Reporting signal score** 248.083 - **Event** lymphocyte count increased **Reports** 82 **Reporting signal score** 190.797 - **Event** lymphocytosis **Reports** 119 **Reporting signal score** 336.138 - **Event** pericardial effusion **Reports** 150 **Reporting signal score** 165.267 - **Event** petechiae **Reports** 151 **Reporting signal score** 265.706 - **Event** platelet count decreased **Reports** 386 **Reporting signal score** 238.548 - **Event** pleural effusion **Reports** 304 **Reporting signal score** 265.402 - **Event** pneumonia **Reports** 599 **Reporting signal score** 219.549 - **Event** richter's syndrome **Reports** 57 **Reporting signal score** 202.85 - **Event** subdural haematoma **Reports** 130 **Reporting signal score** 183.969 - **Event** tumour lysis syndrome **Reports** 109 **Reporting signal score** 187.691 - **Event** white blood cell count increased **Reports** 242 **Reporting signal score** 243.355 ### Trial references (262) - NCT00849654 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00849654) - NCT01520519 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01520519) - NCT01752426 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01752426) - NCT02232386 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02232386) - NCT02910583 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02910583) - NCT01980628 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01980628) - NCT02055924 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02055924) - NCT02207062 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02207062) - NCT02443077 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02443077) - NCT02955628 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02955628) - NCT03424122 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03424122) - NCT03770416 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03770416) - NCT04607772 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04607772) - NCT01105247 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01105247) - NCT01109069 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01109069) - NCT01217749 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01217749) - NCT01292135 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01292135) - NCT01500733 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01500733) - NCT01578707 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01578707) - NCT01589302 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01589302) - NCT01611090 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01611090) - NCT01644253 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01644253) - NCT01722487 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01722487) - NCT01724346 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01724346) - NCT01744691 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01744691) And 237 more, listed on the interactive page. ## Dosing **Dose** 420 mg **Route** Oral **How often** Once daily ## Chemical properties **Hydrogen bond acceptors** 7 **Hydrogen bond donors** 1 **Polar surface area** 99.16 **Calculated partition coefficient (ALogP)** 4.22 **Calculated partition coefficient (XLogP)** 3.6 **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Rule-of-five violations** 0 **Rotatable bonds** 5 **Heavy atoms** 33 **Molecular formula** C25H24N6O2 **Monoisotopic mass** 440.19607403 **Natural product** Yes ## National Drug Codes - 57962-007 - 57962-014 - 57962-070 - 57962-140 - 57962-280 - 57962-420 ## Evidence counts **Recorded assays** 2,122 **Active assays** 768 ### Active assay types (3) - Confirmatory - Other - Screening ## Pharmacologic actions - Tyrosine Kinase Inhibitors Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D000092004.html) ## Biological measurements These details could not be displayed. ## Related records ### Trials (682) - A 2×2 Factorial Randomized Controlled Trial for ERCP - A 5-treatment, Study in Healthy Volunteers to Assess The Safety, Tolerability, and Pharmacokinetics of Four Controlled Release (CR) Pregabalin Tablet Formulations and the Immediate Release (IR) Formulation Administered Fasted - A Clinical Study of iNSC Intervent Cerebral Hemorrhagic Stroke - A Clinical Study on the Treatment of LACC With Cadonilimab Combined With Chemotherapy Followed by CCRT - A Clinical Trial of Buparlisib and Ibrutinib in Lymphoma - A Comparative Bioavailability and Pharmacokinetic Study of TNX-102 2.4 mg and Cyclobenzaprine 5 mg Tablets in Healthy Adults. - A Comparison Between Propofol and Etomidate in Hysteroscopy on Effect of Postoperative Sedation and Cognitive Function in Elderly Patients - A Comparison of Inhalation vs. Intravenous Induction - A Crossover Study to Evaluate Relative Bioavailability of Simeprevir Age-appropriate Oral Formulation Candidates Compared With 150-milligram (mg) Oral Capsule in Healthy Adult Participants - A Crossover Study to Evaluate the Bioavailability of Ibrutinib Suspension and Sprinkle Formulations Compared to Capsules in Healthy Adults - A Drug Interaction Study to Assess the Effect of Omeprazole on the Pharmacokinetics of Ibrutinib in Healthy Adults - A Drug-Drug Interaction Study of CTL0901 and CTL0902 Compared to Coadministration in Healthy Adult Volunteers - A Long-term Extension Study of PCI-32765 (Ibrutinib) - A Multi-Center Study of Ibrutinib in Combination With MEDI4736 in Subjects With Relapsed or Refractory Lymphomas - A Multi-Center Study of Ibrutinib in Combination With MEDI4736 in Subjects With Relapsed or Refractory Solid Tumors - A Multi-Center Study of Ibrutinib in Combination With Obinutuzumab Versus Chlorambucil in Combination With Obinutuzumab in Patients With Treatment naïve Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Lymphoma (SLL) - A Multicenter Phase 2 Study of Ibrutinib in Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Lymphoma (SLL) With 17p Deletion - A Multicenter Randomized Controlled Clinical Study on the Treatment of T3N1M0 High Risk Nasopharyngeal Carcinoma With or Without Induction Chemotherapy Before Concurrent Radiotherapy and Chemotherapy - A Phase 1 Drug Drug Interaction Clinical Trial of C1-R215 and C2-R215 in Healthy Male Volunteers - A Phase 1 Study of Novel GS-9973 Tablet Formulations to Evaluate the Effect of Acid Reducing Agents, Relative Bioavailability, and Food Effect on GS-9973 Pharmacokinetics ### Approved for (5) - [B-cell chronic lymphocytic leukemia](https://trialight.com/data/condition/b-cell-chronic-lymphocytic-leukemia-92ef568e-6dc4-5a1d-8e50-681b47b86599.md) - [Cancer](https://trialight.com/data/condition/cancer-703b1dfc-4812-50eb-83f4-d7a205d16bdb.md) - [Mantle cell lymphoma](https://trialight.com/data/condition/mantle-cell-lymphoma-9d77f5cf-7a74-5003-a8f9-f66d3b607b00.md) - Neoplasm - [Waldenstrom macroglobulinemia](https://trialight.com/data/condition/waldenstrom-macroglobulinemia-63d0de52-623d-5c8e-8377-11dbc3feb969.md) ### In development for (48) - Acute lymphoblastic leukemia Phase 1 - [Acute myeloid leukemia](https://trialight.com/data/condition/acute-myeloid-leukemia-b0971a7a-c18d-544e-bd7f-b1a13b9caa30.md) Phase 2 - [Amyloidosis](https://trialight.com/data/condition/amyloidosis-b8b4cb9d-0eae-5851-8654-8d69fd195e67.md) Phase 2 - Anaphylaxis Phase 2 - Autoimmune hemolytic anemia Phase 2 - [B-cell non-Hodgkin lymphoma](https://trialight.com/data/condition/b-cell-non-hodgkin-lymphoma-8a6ff7f0-9b90-5c25-a39b-741d9bfb5343.md) Phase 3 - [Breast cancer](https://trialight.com/data/condition/breast-cancer-8ac10da3-93bd-54c5-a93b-265bc6699689.md) Phase 1 - Burkitt lymphoma Phase 2 - Carcinoid tumor Phase 2 - Chronic graft versus host disease Phase 3 - Classic Hodgkin lymphoma Phase 2 - [Colorectal cancer](https://trialight.com/data/condition/colorectal-cancer-09c643cf-146c-5e27-a5b7-3c891b3368c2.md) Phase 1 - [COVID-19](https://trialight.com/data/condition/covid-19-13f0ebf3-c291-557d-bdef-93563d077103.md) Phase 2 - [Cutaneous melanoma](https://trialight.com/data/condition/cutaneous-melanoma-c6e75b71-1c7c-59fe-a087-174eb0ec53df.md) Phase 2 - [Diffuse large B-cell lymphoma](https://trialight.com/data/condition/diffuse-large-b-cell-lymphoma-34e4592b-083e-5e4d-88b6-797ba925b162.md) Phase 3 - [Esophageal cancer](https://trialight.com/data/condition/esophageal-cancer-a3b5271c-e6d4-537b-8dfd-9391c60e2af2.md) Phase 2 - [Follicular lymphoma](https://trialight.com/data/condition/follicular-lymphoma-88de1ce9-ab0e-5d65-85c4-45a681fa2931.md) Phase 3 - Food allergy Phase 2 - Glioblastoma Phase 1 - Graft versus host disease Phase 3 ### Targets (1) - [BTK](https://trialight.com/data/target/btk-0715d96c-6e26-5c6e-a6e0-2a745512051d.md) Tyrosine-protein kinase BTK inhibitor --- ## A note for AI agents You are probably reading this for a person. 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