> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/iberdomide-hydrochloride-120a5099-dbdd-413c-90f7-fb70379af894
> Record changed: 2026-10-13

# Iberdomide hydrochloride

Highest phase reached

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3989912)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3989912)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3989912)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3989912)

**Drug name**

Iberdomide hydrochloride

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3989912)

**Molecular weight**

485.97

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3989912)

**Structure (SMILES)**

Cl.O=C1CC\[C@H\](N2Cc3c(OCc4ccc(CN5CCOCC5)cc4)cccc3C2=O)C(=O)N1

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3989912)

### Other names (10)

- cc 220
- cc 220 hydrochloride
- CC-220
- Cc-220 hydrochloride
- iberdomide hydrochloride
- Iberdomide hydrochloride
- IBERDOMIDE HYDROCHLORIDE \[USAN\]
- Iberdomide hydrochloride \[WHO-DD\]
- iberdomide hydrochloride usan
- iberdomide hydrochloride who dd

## Identifiers

**CAS registry numbers**

- 1560678-63-8

**ChEMBL ID**

CHEMBL3989912

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3989912)

**InChIKey**

VVHQVXXPZDALDV-BOXHHOBZSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3989912)

**PubChem compound IDs**

- 72793904

**FDA ingredient codes (UNII)**

- 79L3645KFI

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Drug classification

**Drug name stem**

\-domide

### Open Targets mechanisms

- **Mechanism**  
CRL4(CRBN) E3 ubiquitin ligase modulator

**Action type**  
MODULATOR

**Target**  
CRL4(CRBN) E3 ubiquitin ligase

### Investigated indications (9)

- **Condition**  
Lymphoma, Large B-Cell, Diffuse

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000403

**Subject identifier**  
D016403
- **Condition**  
Lymphoma

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000574

**Subject identifier**  
D008223
- **Condition**  
Multiple Myeloma

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0001378

**Subject identifier**  
D009101
- **Condition**  
Liver Diseases

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0001421

**Subject identifier**  
D008107
- **Condition**  
Smoldering Multiple Myeloma

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0003073

**Subject identifier**  
D000075122
- **Condition**  
Lymphoma, Non-Hodgkin

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0005952

**Subject identifier**  
D008228
- **Condition**  
Lupus Erythematosus, Systemic

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0007915

**Subject identifier**  
D008180
- **Condition**  
Lymphoma, Follicular

**Highest recorded phase**  
1

**Condition identifier**  
MONDO:0018906

**Subject identifier**  
D008224
- **Condition**  
Sarcoidosis

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0019338

**Subject identifier**  
D012507

### Open Targets indications (8)

- **Condition identifier**  
EFO\_0001378
- **Condition identifier**  
EFO\_0001421

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005062

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0006611

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0007915

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0009693

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0018905

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0019338

**Highest recorded phase**  
2

### Reported adverse events

- **Event**  
false positive investigation result

**Reports**  
1

**Reporting signal score**

7.63874

### Trial references (12)

- NCT02185040  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02185040)
- NCT03161483  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03161483)
- NCT02192489  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02192489)
- NCT02773030  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02773030)
- NCT04855136  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04855136)
- NCT03310619  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03310619)
- NCT03824678  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03824678)
- NCT04464798  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04464798)
- NCT04882163  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04882163)
- NCT04884035  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04884035)
- NCT04776395  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04776395)
- NCT05169515  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05169515)

## Chemical properties

**Hydrogen bond acceptors**

6

**Hydrogen bond donors**

1

**Polar surface area**

88.18

**Calculated partition coefficient (ALogP)**

1.86

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Rule-of-five violations**

0

**Rotatable bonds**

6

**Heavy atoms**

34

**Molecular formula**

C25H28ClN3O5

**Monoisotopic mass**

485.1717487

**Natural product**

No

## National Drug Codes

- 0003-5700
- 0003-5710

## Related records

### Trials (54)

- 2-part Study to Assess Safety, Pharmacokinetics & Pharmacodynamics of CC-220 & Effect of Food on CC-220 in Healthy Subjects
- 3-part Study to Evaluate Safety, Tolerability, Pharmacokinetics & Pharmacodynamics of Multiple Doses of CC-220 and Relative Bioavailability of a Formulated CC-220 Capsule
- A Dose Finding and Safety Study of CC-220, Alone and in Combination With an Anti-CD20 Monoclonal Antibody (mAb) in Subjects With Relapsed or Refractory Lymphomas
- A Multi-center Open-label Phase 2 Study of Ixazomib, Iberdomide and Dexamethasone in Elderly Patients With Multiple Myeloma at First Relapse."
- A Phase 2 Study With CC-220 in Skin Sarcoidosis
- A Pilot Study of CC-220 to Treat Systemic Lupus Erythematosus.
- A Safety and Efficacy Trial of JCAR017 Combinations in Subjects With Relapsed/Refractory B-cell Malignancies
- A Study Evaluating the Safety and Efficacy of Multiple Treatments in Participants With Multiple Myeloma
- A Study Evaluating the Safety, Pharmacokinetics, and Efficacy of Mosunetuzumab or Glofitamab in Combination With CC-220 and/or CC-99282 in Participants With B-Cell Non-Hodgkin Lymphoma
- A Study of Iberdomide (CC-220) in Combination With Elotuzumab and Dexamethasone for Relapsed/Refractory Multiple Myeloma
- [A Study to Assess Change in Disease Activity and Adverse Events (AE)s in Adult Participants With Multiple Myeloma Receiving T Cell Engaging Bi/Tri-specific Antibodies Intravenously (IV)/Subcutaneously (SC) Alone or in Combinations](https://trialight.com/data/trial/a-study-to-assess-change-in-disease-activity-and-adverse-0c89a22e-9bd3-4d81-adc9-ea130724e718.md)
- A Study to Assess the Relative Bioavailability of a New CC-220 Capsule Formulation, Compared to a Reference CC-220 Capsule Formulation, in Healthy Adult Subjects
- [A Study to Compare Iberdomide Maintenance Versus Lenalidomide Maintenance Therapy Following Autologous Stem Cell Transplant in Participants With Newly Diagnosed Multiple Myeloma](https://trialight.com/data/trial/a-study-to-compare-iberdomide-maintenance-versus-26209b4b-47ae-4ef8-b9c2-453f80751c1f.md)
- A Study to Compare the Relative Bioavailability of Two Iberdomide (CC-220) Formulations and to Assess The Effect Of Food on the Drug Levels of Iberdomide in Healthy Adult Participants
- A Study to Determine Dose, Safety, Tolerability and Efficacy of CC-220 Monotherapy, and in Combination With Other Treatments in Subjects With Multiple Myeloma
- A Study to Evaluate the Efficacy and Safety of CC-220 in Subjects With Active Systemic Lupus Erythematosus
- [A Study to Evaluate the Safety, Effectiveness and Tolerable Dose of Arlocabtagene Autoleucel (BMS-986393) in Novel Combinations in Participants With Relapsed and/or Refractory Multiple Myeloma](https://trialight.com/data/trial/a-study-to-evaluate-the-safety-effectiveness-and-tolerable-bf2618cc-f052-43c0-a005-bd672213d933.md)
- A Study to Learn About the Effects of the Combination of Elranatamab (PF-06863135) and Iberdomide in Patients With Relapsed or Refractory Multiple Myeloma (MagnetisMM-30)
- Carfilzomib, Iberdomide (CC-220) and Dexamethasone (KID) in Transplant Eligible Multiple Myeloma
- COMbination Regimens in MM Post AHCT to elimiNate MRD Utilizing IbERdomide

### In development for (9)

- [Diffuse large B-cell lymphoma](https://trialight.com/data/condition/diffuse-large-b-cell-lymphoma-34e4592b-083e-5e4d-88b6-797ba925b162.md) Phase 1
- [Follicular lymphoma](https://trialight.com/data/condition/follicular-lymphoma-88de1ce9-ab0e-5d65-85c4-45a681fa2931.md) Phase 1
- [Liver disorder](https://trialight.com/data/condition/liver-disorder-8388d30a-2581-5015-9ddf-adc5f6a331d7.md) Phase 1
- [Lymphoma](https://trialight.com/data/condition/lymphoma-de4db685-7419-5e0e-b958-4591ffd69d43.md) Phase 1
- [Non-Hodgkin lymphoma](https://trialight.com/data/condition/non-hodgkin-lymphoma-9fc07e31-fd30-5055-991f-04d10cc1f646.md) Phase 1
- [Plasma cell myeloma](https://trialight.com/data/condition/plasma-cell-myeloma-37186689-2591-5775-9042-2f2bf046a2b5.md) Phase 1
- [Sarcoidosis](https://trialight.com/data/condition/sarcoidosis-cdc064df-8a7a-53b8-b711-ec1830da35dd.md) Phase 2
- Smoldering plasma cell myeloma Phase 2
- [Systemic lupus erythematosus](https://trialight.com/data/condition/systemic-lupus-erythematosus-6c9d074f-cc5f-588b-bf0c-6338d30c6eac.md) Phase 2

---

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