> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/iberdomide-c87e8a0b-9d3e-422e-9876-8c8310fab473
> Record changed: 2026-11-04

# Iberdomide

Highest phase reached

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3989927)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3989927)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3989927)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3989927)

**Drug name**

Iberdomide

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3989927)

**Molecular weight**

449.51

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3989927)

**Structure (SMILES)**

O=C1CC\[C@H\](N2Cc3c(OCc4ccc(CN5CCOCC5)cc4)cccc3C2=O)C(=O)N1

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3989927)

### Other names (16)

- cc 220
- CC-220
- iberdomida
- Iberdomida
- IBERDOMIDA
- iberdomide
- Iberdomide
- IBERDOMIDE
- IBERDOMIDE (CC220)
- iberdomide \[INN\]
- IBERDOMIDE \[USAN\]
- Iberdomide \[WHO-DD\]
- iberdomide cc220
- iberdomide inn
- iberdomide usan
- iberdomide who dd

## Identifiers

**CAS registry numbers**

- 1323403-33-3

**ChEMBL ID**

CHEMBL3989927

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3989927)

**InChIKey**

IXZOHGPZAQLIBH-NRFANRHFSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3989927)

**PubChem compound IDs**

- 67335295

**RxNorm IDs (RxCUI)**

- 2749731

**FDA ingredient codes (UNII)**

- 8V66F27X44

## Regulatory information

### Other regulatory facts

**Patents**

0

**Designations**

1

**First in class**

No

**Fast track**

No

**Breakthrough designation**

No

**Orphan designation**

No

**Priority review**

No

**Orphan exclusivity**

No

**Accelerated approval**

No

## Pharmacology

### Drug classification

**Pharmacology name**

iberdomide

**Type**

Synthetic organic

**Drug name stem**

\-domide

**Approval recorded by Guide to Pharmacology**

Yes

### Mechanisms of action (5)

- **Action**  
Binding

**Action type**  
Binding

**Target**  
cereblon

**Gene symbol**  
CRBN

**Protein identifier**  
Q96SW2

**Median affinity**

7.22

**Affinity units**  
pIC50
- **Mechanism**  
CRL4(CRBN) E3 ubiquitin ligase modulator

**Action type**  
MODULATOR

**Target**  
CRL4(CRBN) E3 ubiquitin ligase

**Protein identifier**  
P62877
- **Mechanism**  
CRL4(CRBN) E3 ubiquitin ligase modulator

**Action type**  
MODULATOR

**Target**  
CRL4(CRBN) E3 ubiquitin ligase

**Protein identifier**  
Q13619
- **Mechanism**  
CRL4(CRBN) E3 ubiquitin ligase modulator

**Action type**  
MODULATOR

**Target**  
CRL4(CRBN) E3 ubiquitin ligase

**Protein identifier**  
Q16531
- **Mechanism**  
CRL4(CRBN) E3 ubiquitin ligase modulator

**Action type**  
MODULATOR

**Target**  
CRL4(CRBN) E3 ubiquitin ligase

**Protein identifier**  
Q96SW2

### Open Targets mechanisms

- **Mechanism**  
CRL4(CRBN) E3 ubiquitin ligase modulator

**Action type**  
MODULATOR

**Target**  
CRL4(CRBN) E3 ubiquitin ligase

### Investigated indications (2)

- **Condition**  
Multiple Myeloma

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0001378

**Subject identifier**  
D009101
- **Condition**  
Renal Insufficiency

**Highest recorded phase**  
1

**Condition identifier**  
HP:0000083

**Subject identifier**  
D051437

### Open Targets indications (9)

- **Condition identifier**  
EFO\_0001378

**Highest recorded phase**  
3
- **Condition identifier**  
HP\_0000083

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005072

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005235

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0006611

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0007915

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0009693

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0018908

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0019338

**Highest recorded phase**  
2

### Trial references (26)

- NCT04392037  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04392037)
- NCT04564703  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04564703)
- NCT04975997  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04975997)
- NCT04998786  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04998786)
- NCT05177536  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05177536)
- NCT05199311  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05199311)
- NCT05272826  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05272826)
- NCT05289492  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05289492)
- NCT05354557  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05354557)
- NCT05392946  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05392946)
- NCT05434689  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05434689)
- NCT05527340  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05527340)
- NCT05558319  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05558319)
- NCT05560399  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05560399)
- NCT05583617  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05583617)
- NCT05827016  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05827016)
- NCT05896228  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05896228)
- NCT06107738  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06107738)
- NCT06121843  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06121843)
- NCT06179888  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06179888)
- NCT06215118  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06215118)
- NCT06216158  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06216158)
- NCT06232044  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06232044)
- NCT06348108  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06348108)
- NCT06465316  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06465316)

And 1 more, listed on the interactive page.

## Chemical properties

**Hydrogen bond acceptors**

6

**Hydrogen bond donors**

1

**Polar surface area**

88.18

**Calculated partition coefficient (ALogP)**

1.86

**Calculated partition coefficient (XLogP)**

1.1

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Rule-of-five violations**

0

**Rotatable bonds**

6

**Heavy atoms**

33

**Molecular formula**

C25H27N3O5

**Monoisotopic mass**

449.19507097

**Natural product**

Yes

## Evidence counts

**Recorded assays**

235

**Active assays**

31

### Active assay types

- Confirmatory

## Biological measurements

These details could not be displayed.

## Related records

### Trials (53)

- 2-part Study to Assess Safety, Pharmacokinetics & Pharmacodynamics of CC-220 & Effect of Food on CC-220 in Healthy Subjects
- 3-part Study to Evaluate Safety, Tolerability, Pharmacokinetics & Pharmacodynamics of Multiple Doses of CC-220 and Relative Bioavailability of a Formulated CC-220 Capsule
- A Dose Finding and Safety Study of CC-220, Alone and in Combination With an Anti-CD20 Monoclonal Antibody (mAb) in Subjects With Relapsed or Refractory Lymphomas
- A Multi-center Open-label Phase 2 Study of Ixazomib, Iberdomide and Dexamethasone in Elderly Patients With Multiple Myeloma at First Relapse."
- A Phase 2 Study With CC-220 in Skin Sarcoidosis
- A Pilot Study of CC-220 to Treat Systemic Lupus Erythematosus.
- A Safety and Efficacy Trial of JCAR017 Combinations in Subjects With Relapsed/Refractory B-cell Malignancies
- A Study Evaluating the Safety and Efficacy of Multiple Treatments in Participants With Multiple Myeloma
- [A Study Evaluating the Safety, Pharmacokinetics, and Efficacy of Mosunetuzumab or Glofitamab in Combination With CC-220 and/or CC-99282 in Participants With B-Cell Non-Hodgkin Lymphoma](https://trialight.com/data/trial/a-study-evaluating-the-safety-pharmacokinetics-and-efficacy-24d3dd74-b0b1-4441-b334-5514bb423656.md)
- A Study of Iberdomide (CC-220) in Combination With Elotuzumab and Dexamethasone for Relapsed/Refractory Multiple Myeloma
- [A Study to Assess Change in Disease Activity and Adverse Events (AE)s in Adult Participants With Multiple Myeloma Receiving T Cell Engaging Bi/Tri-specific Antibodies Intravenously (IV)/Subcutaneously (SC) Alone or in Combinations](https://trialight.com/data/trial/a-study-to-assess-change-in-disease-activity-and-adverse-0c89a22e-9bd3-4d81-adc9-ea130724e718.md)
- A Study to Assess the Relative Bioavailability of a New CC-220 Capsule Formulation, Compared to a Reference CC-220 Capsule Formulation, in Healthy Adult Subjects
- [A Study to Compare Iberdomide Maintenance Versus Lenalidomide Maintenance Therapy Following Autologous Stem Cell Transplant in Participants With Newly Diagnosed Multiple Myeloma](https://trialight.com/data/trial/a-study-to-compare-iberdomide-maintenance-versus-26209b4b-47ae-4ef8-b9c2-453f80751c1f.md)
- A Study to Compare the Relative Bioavailability of Two Iberdomide (CC-220) Formulations and to Assess The Effect Of Food on the Drug Levels of Iberdomide in Healthy Adult Participants
- A Study to Determine Dose, Safety, Tolerability and Efficacy of CC-220 Monotherapy, and in Combination With Other Treatments in Subjects With Multiple Myeloma
- A Study to Evaluate the Efficacy and Safety of CC-220 in Subjects With Active Systemic Lupus Erythematosus
- [A Study to Evaluate the Safety, Effectiveness and Tolerable Dose of Arlocabtagene Autoleucel (BMS-986393) in Novel Combinations in Participants With Relapsed and/or Refractory Multiple Myeloma](https://trialight.com/data/trial/a-study-to-evaluate-the-safety-effectiveness-and-tolerable-bf2618cc-f052-43c0-a005-bd672213d933.md)
- A Study to Learn About the Effects of the Combination of Elranatamab (PF-06863135) and Iberdomide in Patients With Relapsed or Refractory Multiple Myeloma (MagnetisMM-30)
- Carfilzomib, Iberdomide (CC-220) and Dexamethasone (KID) in Transplant Eligible Multiple Myeloma
- COMbination Regimens in MM Post AHCT to elimiNate MRD Utilizing IbERdomide

### In development for (8)

- Kidney failure Phase 1
- Neuroblastoma Phase 1
- [Non-Hodgkin lymphoma](https://trialight.com/data/condition/non-hodgkin-lymphoma-9fc07e31-fd30-5055-991f-04d10cc1f646.md) Phase 1
- [Plasma cell myeloma](https://trialight.com/data/condition/plasma-cell-myeloma-37186689-2591-5775-9042-2f2bf046a2b5.md) Phase 3
- [Sarcoidosis](https://trialight.com/data/condition/sarcoidosis-cdc064df-8a7a-53b8-b711-ec1830da35dd.md) Phase 2
- Skin sarcoidosis Phase 2
- [Smoldering plasma cell myeloma](https://trialight.com/data/condition/smoldering-plasma-cell-myeloma-2df90d99-88b3-53ff-adb8-a9c88ee1b83e.md) Phase 2
- [Systemic lupus erythematosus](https://trialight.com/data/condition/systemic-lupus-erythematosus-6c9d074f-cc5f-588b-bf0c-6338d30c6eac.md) Phase 2

### Targets (4)

- [CRBN](https://trialight.com/data/target/crbn-169cf6df-ae17-5b19-8d78-a31c5759df96.md) CRL4(CRBN) E3 ubiquitin ligase modulator
- [CUL4A](https://trialight.com/data/target/cul4a-e258e883-4774-5319-a48e-25d3215b89ac.md) CRL4(CRBN) E3 ubiquitin ligase modulator
- [DDB1](https://trialight.com/data/target/ddb1-48083fd0-0468-51ed-be9d-dedeac3d554b.md) CRL4(CRBN) E3 ubiquitin ligase modulator
- [RBX1](https://trialight.com/data/target/rbx1-84bf5aec-13d0-56fa-b3c2-574a7e5dee8e.md) CRL4(CRBN) E3 ubiquitin ligase modulator

---

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