> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/hydronidone-28528eb3-b95a-4220-b549-b5f5935263bd > Record changed: 2026-10-13 # Hydronidone Highest phase reached Phase 3 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297288) Drug type Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297288) ## Development status **Listing at source** Listed **Highest phase reached** Phase 3 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297288) ## Names and chemistry **Drug type** Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297288) **Drug name** Hydronidone Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297288) **Molecular weight** 201.22 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297288) **Structure (SMILES)** Cc1ccc(=O)n(-c2ccc(O)cc2)c1 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297288) ### Other names (8) - f 351 - F 351 - F-351 - hydronidone - Hydronidone - Hydronidone (270mg) - Hydronidone capsules - Hydronidone Capsules ## Identifiers **CAS registry numbers** - 851518-71-3 **ChEMBL ID** CHEMBL4297288 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297288) **InChIKey** NETTXQJYJRFTFS-UHFFFAOYSA-N Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297288) **PubChem compound IDs** - 11217901 **FDA ingredient codes (UNII)** - RXQ128313W ## Regulatory information ### Other regulatory facts **First in class** No **Orphan designation** No ## Pharmacology ### Investigated indications (3) - **Condition** Liver Cirrhosis **Highest recorded phase** 3 **Condition identifier** EFO:0001422 **Subject identifier** D008103 - **Condition** Hepatitis B, Chronic **Highest recorded phase** 2 **Condition identifier** EFO:0004239 **Subject identifier** D019694 - **Condition** Liver Diseases **Highest recorded phase** 1 **Condition identifier** HP:0001410 **Subject identifier** D008107 ### Open Targets indications (10) - **Condition identifier** EFO\_0001421 **Highest recorded phase** 2 - **Condition identifier** EFO\_0001422 **Highest recorded phase** 3 - **Condition identifier** EFO\_0003884 **Highest recorded phase** 1 - **Condition identifier** EFO\_0004239 **Highest recorded phase** 2 - **Condition identifier** HP\_0001395 **Highest recorded phase** 1 - **Condition identifier** HP\_0001395 **Highest recorded phase** 3 - **Condition identifier** HP\_0001410 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0005154 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005155 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0005366 **Highest recorded phase** 3 ### Trial references (4) - NCT02499562 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02499562) - NCT04123769 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04123769) - NCT05115942 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05115942) - NCT05905172 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05905172) ## Chemical properties **Hydrogen bond acceptors** 3 **Hydrogen bond donors** 1 **Polar surface area** 42.23 **Calculated partition coefficient (ALogP)** 1.85 **Calculated partition coefficient (XLogP)** 1.5 **Prodrug** No **Chirality** Achiral **Inorganic** No **Rule-of-five violations** 0 **Rotatable bonds** 1 **Heavy atoms** 15 **Molecular formula** C12H11NO2 **Monoisotopic mass** 201.078978594 **Natural product** No ## Evidence counts **Recorded assays** 6 **Active assays** 0 ## Related records ### Trials (16) - \[¹⁴C\] Hydronidone Mass Balance Study - A Clinical Trial Evaluating the Safety of Hydronidone Capsules in Patients With Hepatic Fibrosis and Liver Cirrhosis - A Phase II Clinical Trial of Hydronidone Capsules(F351) in Patients With Liver Fibrosis Induced by HBV Chronic Hepatitis - [A Phase IIIc Clinical Study to Evaluate the Long-term Treatment of Hydronidone Capsules for Liver Fibrosis in Patients With Chronic Hepatitis B.](https://trialight.com/data/trial/a-phase-iiic-clinical-study-to-evaluate-the-long-term-188beaf5-157a-47da-a164-1270b53b2858.md) - A Study of Hydronidone Capsules in Patients With Chronic Hepatitis B Virus-Related Liver Fibrosis - [A Study to Evaluate the Safety of Hydronidone Capsules in Patients With Liver Fibrosis](https://trialight.com/data/trial/a-study-to-evaluate-the-safety-of-hydronidone-capsules-in-f181dbff-b2c6-448e-896e-0881619723a0.md) - A Trial of Hydroxynidone Capsules in Single-dose Administration for Patients With Renal Insufficiency - Hydronidone Capsules in Long-term Treatment in Patients With Chronic Viral Hepatitis B Liver Fibrosis - Hydronidone for the Treatment of Liver Fibrosis Associated with Chronic Viral Hepatitis B Phase 3 Trial. - Pharmacokinetic Interactions Between Hydronidone and Entecavir Capsules in Healthy Chinese Subjects - QTc Assessment in a Single-Dose Study of Hydronidone Capsules - Study of Hydroxynidone Capsules in Patients With Hepatic Impairment and Matched Healthy Controls - Study on Hydronidone Capsule BE - Study on Pharmacokinetics of Hydronidone - Study on PK of Hydronidone in Patients and Special Population - The Phase Ⅰd Clinical Trial of Hydronidone Capsules ### In development for (4) - [Chronic hepatitis B virus infection](https://trialight.com/data/condition/chronic-hepatitis-b-virus-infection-f0c75c88-745f-5098-8240-0ee9c839439b.md) Phase 2 - [Chronic kidney disease](https://trialight.com/data/condition/chronic-kidney-disease-dc1fecbb-338b-5bbc-8d68-08e49db49918.md) Phase 1 - [Cirrhosis of liver](https://trialight.com/data/condition/cirrhosis-of-liver-d90e4a84-9e82-54fc-a553-1e42086e8382.md) Phase 3 - [Liver disorder](https://trialight.com/data/condition/liver-disorder-8388d30a-2581-5015-9ddf-adc5f6a331d7.md) Phase 1 --- ## A note for AI agents You are probably reading this for a person. 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