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Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/hydrocortisone-acetate-6f4eebc7-9cd1-45f5-9f54-435f641fe253 > Record changed: 2026-10-13 # Hydrocortisone acetate Highest phase reached Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1091) Drug type Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1091) First approval year 1951 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1091) ## Development status **First approval year** 1951 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1091) **Listing at source** Listed **Highest phase reached** Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1091) ## Names and chemistry **Drug type** Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1091) **Drug name** Hydrocortisone acetate Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1091) **Molecular weight** 404.5 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1091) **Structure (SMILES)** CC(=O)OCC(=O)\[C@@\]1(O)CC\[C@H\]2\[C@@H\]3CCC4=CC(=O)CC\[C@\]4(C)\[C@H\]3\[C@@H\](O)C\[C@@\]21C Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1091) ### Brand names (76) - barquinol hc - Barquinol hc - chloromycetin hydrocort - Chloromycetin hydrocort - colifoam - Colifoam - cortef acetate - Cortef acetate - cortifoam - Cortifoam - cortril - Cortril - cortucid - Cortucid - dricort - Dricort - epifoam - Epifoam - framycort - Framycort - fucidin h - Fucidin h - genticin hc - Genticin hc - gentisone hc And 51 more, listed on the interactive page. ### Other names (66) - carmol hc component hydrocortisone acetate - CARMOL HC COMPONENT HYDROCORTISONE ACETATE - chloromycetin hydrocortisone component hydrocortisone acetate - CHLOROMYCETIN HYDROCORTISONE COMPONENT HYDROCORTISONE ACETATE - coly mycin s component hydrocortisone acetate - COLY-MYCIN S COMPONENT HYDROCORTISONE ACETATE - cor oticin component hydrocortisone acetate - COR-OTICIN COMPONENT HYDROCORTISONE ACETATE - cortisol 21 acetate - Cortisol 21-acetate - epifoam component hydrocortisone acetate - EPIFOAM COMPONENT HYDROCORTISONE ACETATE - hydrocortisone 21 acetate - hydrocortisone 21 acetate mi - Hydrocortisone 21-acetate - HYDROCORTISONE 21-ACETATE \[MI\] - hydrocortisone acetate - Hydrocortisone acetate - HYDROCORTISONE ACETATE \[EP IMPURITY\] - HYDROCORTISONE ACETATE \[EP MONOGRAPH\] - HYDROCORTISONE ACETATE \[GREEN BOOK\] - HYDROCORTISONE ACETATE \[JAN\] - HYDROCORTISONE ACETATE \[MART.\] - HYDROCORTISONE ACETATE \[ORANGE BOOK\] - HYDROCORTISONE ACETATE \[USP MONOGRAPH\] And 41 more, listed on the interactive page. ## Identifiers **CAS registry numbers** - 50-03-3 **ChEMBL ID** CHEMBL1091 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1091) **InChIKey** ALEXXDVDDISNDU-JZYPGELDSA-N Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1091) **PubChem compound IDs** - 5744 **FDA ingredient codes (UNII)** - 3X7931PO74 ### RxNorm IDs (RxCUI) (2) - 27197 - 1007334 ## Regulatory information ### United States **Applicant** PH HEALTH **Approval date** 17 May 1962 **Application number** NDA050356 ### Other regulatory facts **Patents** 0 **Designations** 1 **First in class** No **Fast track** No **Breakthrough designation** No **Orphan designation** No **Priority review** No **Orphan exclusivity** No **Accelerated approval** No **Availability** Prescription only ## Pharmacology ### Drug classification **Drug name stem** \-cort- #### Administration routes - Parenteral - topical ### Mechanisms of action - **Mechanism** Glucocorticoid receptor agonist **Action type** Agonist **Target** Glucocorticoid receptor **Protein identifier** P04150 ### Open Targets mechanisms - **Mechanism** Glucocorticoid receptor agonist **Action type** Agonist **Target** Glucocorticoid receptor ### DrugCentral mechanisms - **Action type** Agonist **Gene symbol** NR3C1 **Protein identifier** P04150 **Organism** Homo sapiens **Target development level** Clinical ### Investigated indications (7) - **Condition** Dermatitis, Atopic **Highest recorded phase** 2 **Condition identifier** EFO:0000274 **Subject identifier** D003876 - **Condition** Skin Diseases **Highest recorded phase** 4 **Condition identifier** EFO:0000701 **Subject identifier** D012871 - **Condition** Vitiligo **Highest recorded phase** 1 **Condition identifier** EFO:0004208 **Subject identifier** D014820 - **Condition** Hemorrhoids **Highest recorded phase** 2 **Condition identifier** EFO:0009552 **Subject identifier** D006484 - **Condition** Pruritus **Highest recorded phase** 4 **Condition identifier** HP:0000989 **Subject identifier** D011537 - **Condition** Depressive Disorder **Highest recorded phase** 0.5 **Condition identifier** MONDO:0002050 **Subject identifier** D003866 - **Condition** Inflammation **Highest recorded phase** 4 **Condition identifier** MP:0001845 **Subject identifier** D007249 ### Open Targets indications (13) - **Condition identifier** EFO\_0000701 - **Condition identifier** EFO\_0009552 **Highest recorded phase** 2 - **Condition identifier** HP\_0000989 - **Condition identifier** HP\_0000989 **Highest recorded phase** 4 - **Condition identifier** HP\_0001072 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0002009 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0002050 - **Condition identifier** MONDO\_0004872 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0004980 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0005093 **Highest recorded phase** 4 - **Condition identifier** MONDO\_0005101 **Highest recorded phase** 3 - **Condition identifier** MP\_0001845 - **Condition identifier** MP\_0001845 **Highest recorded phase** 4 ### Reported adverse events (53) - **Event** abdominal discomfort **Reports** 577 **Reporting signal score** 753.015 - **Event** adrenal insufficiency **Reports** 170 **Reporting signal score** 350.215 - **Event** adrenocortical insufficiency acute **Reports** 78 **Reporting signal score** 249.692 - **Event** alopecia **Reports** 577 **Reporting signal score** 745.521 - **Event** anti-cyclic citrullinated peptide antibody positive **Reports** 419 **Reporting signal score** 1,657.37 - **Event** arthralgia **Reports** 589 **Reporting signal score** 255.3 - **Event** arthropathy **Reports** 486 **Reporting signal score** 877.94 - **Event** blister **Reports** 222 **Reporting signal score** 267.455 - **Event** condition aggravated **Reports** 564 **Reporting signal score** 312.771 - **Event** discomfort **Reports** 442 **Reporting signal score** 920.384 - **Event** drug hypersensitivity **Reports** 1,411 **Reporting signal score** 1,838.48 - **Event** drug intolerance **Reports** 550 **Reporting signal score** 667.326 - **Event** duodenal ulcer perforation **Reports** 219 **Reporting signal score** 766.529 - **Event** fatigue **Reports** 836 **Reporting signal score** 220.455 - **Event** febrile bone marrow aplasia **Reports** 282 **Reporting signal score** 910.665 - **Event** febrile neutropenia **Reports** 311 **Reporting signal score** 302.704 - **Event** folliculitis **Reports** 120 **Reporting signal score** 274.319 - **Event** frequent bowel movements **Reports** 114 **Reporting signal score** 178.736 - **Event** general physical health deterioration **Reports** 210 **Reporting signal score** 140.678 - **Event** glossodynia **Reports** 484 **Reporting signal score** 1,432.17 - **Event** hand deformity **Reports** 469 **Reporting signal score** 1,563.45 - **Event** helicobacter infection **Reports** 223 **Reporting signal score** 667.702 - **Event** hepatic enzyme increased **Reports** 440 **Reporting signal score** 629.532 - **Event** hip arthroplasty **Reports** 143 **Reporting signal score** 283.355 - **Event** hypersensitivity **Reports** 574 **Reporting signal score** 550.844 And 28 more, listed on the interactive page. ### Trial references (7) - NCT00801957 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00801957) - NCT04615962 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04615962) - NCT02689856 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02689856) - NCT03335774 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03335774) - NCT02837432 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02837432) - NCT04148261 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04148261) - NCT03358082 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03358082) ## Dosing **Route** Rectal **How often** Twice daily ### Conditions of use (2) - Insert one suppository in the rectum - Pointed end first ## Chemical properties **Hydrogen bond acceptors** 6 **Hydrogen bond donors** 2 **Polar surface area** 100.9 **Calculated partition coefficient (ALogP)** 2.35 **Calculated partition coefficient (XLogP)** 2.2 **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Rule-of-five violations** 0 **Rotatable bonds** 3 **Heavy atoms** 29 **Molecular formula** C23H32O6 **Monoisotopic mass** 404.21988874 **Natural product** Yes ## National Drug Codes - 0037-6822 - 0037-6824 - 0037-6830 - 0574-7090 - 0574-7093 - 0713-0493 - 0713-0503 - 0904-7340 - 10135-751 - 13925-160 - 13925-163 - 13925-164 - 13925-165 - 16477-201 - 16477-202 - 16571-164 - 16571-676 - 24470-964 - 24470-965 - 24689-102 - 24689-103 - 28595-050 - 39328-029 - 39328-129 - 44118-704 And 62 more, listed on the interactive page. ## Evidence counts **Recorded assays** 1,695 **Active assays** 15 ### Active assay types (2) - Confirmatory - Screening ## Pharmacologic actions - Anti-Inflammatory Agents Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D000893.html) ## Biological measurements ### Observed measurements #### Distribution coefficient (LogD) **Median** 2.19 **Mean** 2.175 **Minimum** 2.11 **Maximum** 2.21 **Unit** unitless **Assays** 4 **Standard deviation** 0.0443471 **Summary method** median **Censored results excluded** 0 **Other units excluded** 0 **Unknown units excluded** 0 #### Measurement types - LogD ## Related records ### Trials (346) - 05-001: Treatment of Acute Lymphoblastic Leukemia in Children - 177Lu Radiolabeled Monoclonal Antibody HuJ591 (177Lu-J591) and Ketoconazole in Patients With Prostate Cancer - 506U78 in Treating Patients With Refractory Hematologic Cancer - A Comparative Clinical Trial Evaluating the Effect and Safety of Tacrolimus Versus Hydrocortisone - A Comparative Study Between Two Formulations of the Ciprofloxacin Hydrochloride + Hydrocortisone Otic Suspension - A Comparative Study of Glucocorticoids Efficacy in Acute Respiratory Distress Syndrome - A Phase II Trial of Early Medical Adrenalectomy for "D0.5" Prostate Cancer - A Pilot Study Into Health Pre and Post Treatment With Intravenous Aminophylline and Hydrocortisone in Severe Asthmatics - A Pilot Trial of Pediatric Liver Transplantation Without Steroids - A Randomized Comparative Study Evaluating the Tolerability and Efficacy of Two Topical Therapies for the Treatment of Keloids and Hypertrophic Scars - A Randomized, Multicenter Open Label Study Comparing Early Administration of Azathioprine Plus IFX to Steroids Plus Azathioprine for Acute Severe Colitis - A Study Comparing LEO 80190 Ointment With Hydrocortisone Ointment, Both Applied Once Daily in the Treatment of Psoriasis Vulgaris on the Face and Intertriginous Areas - A Study in Adults With Untreated Acute Lymphoblastic Leukemia - A Study of Opevesostat (MK-568)4 in Japanese Participants With Metastatic Castration-resistant Prostate Cancer (mCRPC) (MK-5684-005) - A Study of Opevesostat (MK-5684) in China Participants With Metastatic Castration-Resistant Prostate Cancer (mCRPC) (MK-5684-001) - [A Study of Opevesostat (MK-5684) Versus Alternative Next-generation Hormonal Agent (NHA) in Metastatic Castration-resistant Prostate Cancer (mCRPC) Post One NHA (MK-5684-004)](https://trialight.com/data/trial/a-study-of-opevesostat-mk-5684-versus-alternative-next-40ece519-da89-4905-86a7-0c1a844d57e4.md) - A Study of the Efficacy, Safety and Tolerability of Chronocort in Treating CAH - A Study to Compare Standard Chemotherapy to Therapy With CPX-351 and/or Gilteritinib for Patients With Newly Diagnosed AML With or Without FLT3 Mutations - A Study to Evaluate the Safety of Lebrikizumab Compared to Topical Corticosteroids in Adult Patients With Atopic Dermatitis - A Study to Find the Highest Dose of SNDX-5613 (Revumenib) as a Treatment Option After Hematopoietic Stem Cell Transplant in Children With Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia, and Mixed Phenotype Acute Leukemia ### Approved for (1) - [Skin disorder](https://trialight.com/data/condition/skin-disorder-c8e27943-0efd-5c2b-abce-01c2ef37e853.md) ### In development for (4) - [Atopic eczema](https://trialight.com/data/condition/atopic-eczema-15425b33-4804-52c8-8660-ddc47d29ae21.md) Phase 2 - [Depressive disorder](https://trialight.com/data/condition/depressive-disorder-7618feda-3f90-5521-94e1-99f7100e8324.md) Early phase 1 - [Hemorrhoid](https://trialight.com/data/condition/hemorrhoid-bd54316a-50b8-5544-84a5-926f1429bc2a.md) Phase 2 - Vitiligo Phase 1 ### Targets (1) - [NR3C1](https://trialight.com/data/target/nr3c1-98974b8d-fb89-5483-955e-d4a994c71532.md) Glucocorticoid receptor agonist --- ## A note for AI agents You are probably reading this for a person. 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