> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/huperzine-a-4f6060e7-e789-4faf-98cb-0e5290fda10b
> Record changed: 2026-11-04

# Huperzine A

Highest phase reached

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL395280)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL395280)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL395280)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL395280)

**Drug name**

Huperzine A

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL395280)

**Molecular weight**

242.32

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL395280)

**Structure (SMILES)**

C/C=C1\\\[C@H\]2C=C(C)C\[C@\]1(N)c1ccc(=O)\[nH\]c1C2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL395280)

### Other names (29)

- (-)-huperzine a
- (-)-selagine
- (5R,9R,11E)-5-AMINO-11-ETHYLIDENE-5,6,9,10-TETRAHYDRO-7-METHYL-5,9-METHANOCYCLOOCTA(B)PYRIDIN-2(1H)-ONE
- 5r 9r 11e 5 amino 11 ethylidene 5 6 9 10 tetrahydro 7 methyl 5 9 methanocycloocta b pyridin 2 1h one
- huperzine a
- huperzine A
- Huperzine a
- Huperzine A
- HUPERZINE A \[MI\]
- HUPERZINE A \[VANDF\]
- Huperzine a \[WHO-DD\]
- huperzine a 0 4 mg
- huperzine a 0 8 mg
- Huperzine A 0.4 mg
- Huperzine A 0.8 mg
- huperzine a for injection
- Huperzine A for Injection
- huperzine a injection
- Huperzine A injection
- Huperzine A Injection
- huperzine a mi
- huperzine a oral solution
- Huperzine A Oral Solution
- huperzine a vandf
- huperzine a who dd

And 4 more, listed on the interactive page.

## Identifiers

**CAS registry numbers**

- 102518-79-6

**ChEMBL ID**

CHEMBL395280

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL395280)

**InChIKey**

ZRJBHWIHUMBLCN-YQEJDHNASA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL395280)

**PubChem compound IDs**

- 854026

**RxNorm IDs (RxCUI)**

- 2267703

**FDA ingredient codes (UNII)**

- 0111871I23

## Regulatory information

### Other regulatory facts

**Patents**

0

**Designations**

3

**First in class**

No

**Fast track**

No

**Breakthrough designation**

No

**Orphan designation**

No

**Priority review**

No

**Orphan exclusivity**

No

**Accelerated approval**

No

## Pharmacology

### Drug classification

**Pharmacology name**

huperzine A

**Type**

Synthetic organic

**Approval recorded by Guide to Pharmacology**

Yes

### Mechanisms of action (2)

- **Action**  
Inhibition

**Action type**  
Inhibitor

**Target**  
acetylcholinesterase (Yt blood group)

**Gene symbol**  
ACHE

**Protein identifier**  
P22303

**Median affinity**

7.77

**Affinity units**  
pKd
- **Mechanism**  
Acetylcholinesterase inhibitor

**Action type**  
Inhibitor

**Target**  
Acetylcholinesterase

**Protein identifier**  
P22303

### Open Targets mechanisms

- **Mechanism**  
Acetylcholinesterase inhibitor

**Action type**  
Inhibitor

**Target**  
Acetylcholinesterase

### Investigated indications (4)

- **Condition**  
Substance-Related Disorders

**Highest recorded phase**  
1

**Condition identifier**  
MONDO:0002491

**Subject identifier**  
D019966
- **Condition**  
Cocaine-Related Disorders

**Highest recorded phase**  
1

**Condition identifier**  
MONDO:0004456

**Subject identifier**  
D019970
- **Condition**  
Alzheimer Disease

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0004975

**Subject identifier**  
D000544
- **Condition**  
Brain Injuries

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0043510

**Subject identifier**  
D001930

### Open Targets indications (4)

- **Condition identifier**  
HP\_0100543
- **Condition identifier**  
MONDO\_0004456

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0004975
- **Condition identifier**  
MONDO\_0004975

**Highest recorded phase**  
4

### Trial references (4)

- NCT00083590  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00083590)
- NCT01282619  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01282619)
- NCT01030692  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01030692)
- NCT01676311  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01676311)

## Chemical properties

**Hydrogen bond acceptors**

2

**Hydrogen bond donors**

2

**Polar surface area**

58.88

**Calculated partition coefficient (ALogP)**

2

**Calculated partition coefficient (XLogP)**

0

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Rule-of-five violations**

0

**Rotatable bonds**

0

**Heavy atoms**

18

**Molecular formula**

C15H18N2O

**Monoisotopic mass**

242.141913202

**Natural product**

Yes

## Evidence counts

**Recorded assays**

1,156

**Active assays**

72

### Active assay types (2)

- Confirmatory
- Other

## Pharmacologic actions

- Cholinesterase Inhibitors  
Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D002800.html)
- Neuroprotective Agents  
Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D018696.html)

## Related records

### Trials (13)

- A Study of Huperzine A Injection in Reducing Postoperative Delirium in Elderly Patients Undergoing Non-cardiac Surgery
- Clinical Study of Huperzine A in the Treatment of Patients With Hypertensive Cerebral Hemorrhage
- [Clinical Study to Evaluate the Efficacy and Safety of Huperzine A Controlled-Release Tablets in Patients With Mild-to-Moderate Dementia of the Alzheimer's Type](https://trialight.com/data/trial/clinical-study-to-evaluate-the-efficacy-and-safety-of-08e2b285-e211-4a33-a0fe-857ca814b7ac.md)
- Comparative Bioavailability Study of an Immediate Release and Controlled Release Oral Formulations of Huperzine A
- Early Diagnosis and Early Treatment of Alzheimer's Disease Based on Senile Plaque Imaging
- Effects of Huperzine A in Treatment of Moderate to Severe TBI
- Evaluation of Three Potential Central Nervous System (CNS) Pretreatments for Soman Exposure on Human Performance
- Huperzine A in Alzheimer's Disease
- Huperzine-A to Help With Mental Problems and the Inability to Care for Onself in Patients With Schizophrenia
- Pharmacokinetics of Huperzine A Oral Solution in Healthy Participants
- Study of Huperzine A Sustained-Release Tablets in Patients With Alzheimer's Disease
- The Study of Ginkgo Leaf Dropping Pills and Huperzine A Injection Combined With Median Nerve Electrical Stimulation in the Treatment of Cognitive Impairment After Brain Injury
- The Study of Pharmacokinetics and Pharmacodynamics of Huperzine A Injection in Healthy Chinese Subjects

### In development for (4)

- [Alzheimer disease](https://trialight.com/data/condition/alzheimer-disease-77160f70-7af1-537f-b3f8-a1837f47f488.md) Phase 2
- Brain injury Phase 2
- Cocaine abuse Phase 1
- Substance abuse Phase 1

### Targets (1)

- [ACHE](https://trialight.com/data/target/ache-d2ea998f-6390-5915-be6d-023f0963eeba.md) Acetylcholinesterase inhibitor

---

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