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Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/gumokimab-77d20696-f65c-4018-957e-b5a57e8772a8 > Record changed: 2026-10-13 # Gumokimab Highest phase reached Phase 3 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095302) Drug type Antibody Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095302) ## Development status **Listing at source** Listed **Highest phase reached** Phase 3 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095302) ## Names and chemistry **Drug type** Antibody Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095302) **Drug name** Gumokimab Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095302) ### Other names (12) - ak 111 - AK-111 - ak111 - AK111 - gumokimab - Gumokimab - gumokimab \[INN\] - Gumokimab \[WHO-DD\] - gumokimab inn - gumokimab who dd - immunoglobulin g1 anti human interleukin 17a human mus musculus monoclonal ak111 gamma 1 chain disulfide with human mus musculus monoclonal ak111 kappa chain dimer - IMMUNOGLOBULIN G1, ANTI-(HUMAN INTERLEUKIN 17A) (HUMAN-MUS MUSCULUS MONOCLONAL AK111 .GAMMA.1-CHAIN), DISULFIDE WITH HUMAN-MUS MUSCULUS MONOCLONAL AK111 .KAPPA.-CHAIN, DIMER ## Identifiers **CAS registry numbers** - 2428381-52-4 **ChEMBL ID** CHEMBL5095302 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095302) **FDA ingredient codes (UNII)** - 6YS6C7XEC8 ## Regulatory information ### Other regulatory facts **First in class** No **Orphan designation** No ## Pharmacology ### Drug classification **Pharmacology name** gumokimab **Type** Antibody **Drug name stem** \-mab ### Mechanisms of action - **Action** Binding **Action type** Binding **Target** IL-17A **Gene symbol** IL-17A **Median affinity** 9.29 **Affinity units** pKd ### Investigated indications (2) - **Condition** Psoriasis **Highest recorded phase** 3 **Condition identifier** EFO:0000676 **Subject identifier** D011565 - **Condition** Spondylitis, Ankylosing **Highest recorded phase** 3 **Condition identifier** EFO:0003898 **Subject identifier** D013167 ### Open Targets indications (4) - **Condition identifier** EFO\_0000676 **Highest recorded phase** 2 - **Condition identifier** EFO\_0003898 **Highest recorded phase** 3 - **Condition identifier** EFO\_1001494 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0005306 **Highest recorded phase** 3 ### Trial references (7) - NCT03622021 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03622021) - NCT05096364 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05096364) - NCT05504317 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05504317) - NCT06061471 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06061471) - NCT06066125 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06066125) - NCT05467995 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05467995) - NCT06378697 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06378697) ## Chemical properties **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Natural product** No ## Related records ### Trials (7) - A Clinical Study of AK139 in Healthy Subjects - A Phase 2 Study of Efficacy and Safety of AK111 in Subjects With Moderate-to-Severe Psoriasis - A Phase III Study to Evaluate the Efficacy and Safety of AK111 in Subjects With Active Ankylosing Spondylitis - A Study of AK111 in Subjects With Moderate-to-severe Plaque Psoriasis - A Study to Evaluate the Efficacy and Safety of AK111 in Subjects With Active Ankylosing Spondylitis - A Study to Evaluate the Efficacy and Safety of AK111 in Subjects With Moderate to Severe Plaque Psoriasis - [To Evaluate the Efficacy and Safety of AK111 Injection in the Treatment of Moderate to Severe Plaque Psoriasis](https://trialight.com/data/trial/to-evaluate-the-efficacy-and-safety-of-ak111-injection-in-82843ecc-fd56-4dd9-8699-51e6937006f2.md) ### In development for (2) - [Ankylosing spondylitis](https://trialight.com/data/condition/ankylosing-spondylitis-9b1fe73f-f462-5baf-85b0-5cbf33725458.md) Phase 3 - [Psoriasis](https://trialight.com/data/condition/psoriasis-4340caf0-883c-54c7-886d-31e59b80dead.md) Phase 3 --- ## A note for AI agents You are probably reading this for a person. 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