> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/gumarontinib-54f5d71c-06e7-48e2-b5e1-49eb7ab0db7c
> Record changed: 2026-10-13

# Gumarontinib

Highest phase reached

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4594400)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4594400)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4594400)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4594400)

**Drug name**

Gumarontinib

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4594400)

**Molecular weight**

459.5

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4594400)

**Structure (SMILES)**

Cn1cc(-c2cnc3cnn(S(=O)(=O)c4cnc5ccc(-c6cnn(C)c6)cn45)c3c2)cn1

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4594400)

### Other names (17)

- glumetinib
- Glumetinib
- Glumetinib \[WHO-DD\]
- Glumetinib tablets
- Glumetinib Tablets
- glumetinib who dd
- gumarontinib
- Gumarontinib
- gumarontinib \[INN\]
- Gumarontinib \[MI\]
- gumarontinib inn
- gumarontinib mi
- Gumarontinib Tablets
- sc c244
- Sc-c244
- scc244
- Scc244

## Identifiers

**CAS registry numbers**

- 1642581-63-2

**ChEMBL ID**

CHEMBL4594400

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4594400)

**InChIKey**

RYBLECYFLJXEJX-UHFFFAOYSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4594400)

**PubChem compound IDs**

- 117797905

**FDA ingredient codes (UNII)**

- 7JTT036WGX

## Regulatory information

### Other regulatory facts

**Patents**

0

**Designations**

1

**First in class**

No

**Fast track**

No

**Breakthrough designation**

No

**Orphan designation**

No

**Priority review**

No

**Orphan exclusivity**

No

**Accelerated approval**

No

## Pharmacology

### Drug classification

**Pharmacology name**

gumarontinib

**Type**

Synthetic organic

**Drug name stem**

\-tinib

### Mechanisms of action

- **Action**  
Inhibition

**Action type**  
Inhibitor

**Target**  
MET proto-oncogene, receptor tyrosine kinase

**Gene symbol**  
MET

**Protein identifier**  
P08581

**Median affinity**

9.38

**Affinity units**  
pIC50

### Investigated indications (2)

- **Condition**  
Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000616

**Subject identifier**  
D009369
- **Condition**  
Carcinoma, Non-Small-Cell Lung

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0003060

**Subject identifier**  
D002289

### Open Targets indications (8)

- **Condition identifier**  
EFO\_0000616

**Highest recorded phase**  
1
- **Condition identifier**  
EFO\_0003060
- **Condition identifier**  
EFO\_1001480
- **Condition identifier**  
MONDO\_0001056

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0003219

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005070
- **Condition identifier**  
MONDO\_0005233

**Highest recorded phase**  
4
- **Condition identifier**  
MONDO\_0005575

**Highest recorded phase**  
1

### Trial references (3)

- NCT03457532  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03457532)
- NCT03466268  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03466268)
- NCT06452433  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06452433)

## Chemical properties

**Hydrogen bond acceptors**

11

**Hydrogen bond donors**

0

**Polar surface area**

117.79

**Calculated partition coefficient (ALogP)**

2.12

**Calculated partition coefficient (XLogP)**

1.9

**Prodrug**

No

**Chirality**

Achiral

**Inorganic**

No

**Rule-of-five violations**

1

**Rotatable bonds**

4

**Heavy atoms**

33

**Molecular formula**

C21H17N9O2S

**Monoisotopic mass**

459.12259199

**Natural product**

No

## Evidence counts

**Recorded assays**

2

**Active assays**

2

### Active assay types

- Confirmatory

## Related records

### Trials (12)

- A Phase I Study of SCC244 in Patients with Advanced MET Alterations Solid Tumors
- A Study to Evaluate the Efficacy and Safety of Glumetinib Combined With Osimertinib Mesylate Versus Platinum-based Doublet Chemotherapy in Non-Small Cell Lung Cancer Patients After Resistance to EGFR-TKIs
- A Study to Evaluate the Efficacy and Safety of the Combination of Glumetinib and Docetaxel（Albumin Bound）Verse Docetaxel for the Treatment of MET-overexpressed Non-small Cell Lung Cancer
- Assessment of Anti-tumor and Safety in Glumetinib in Patients With c-MET-positive Non-Small Cell Lung Cancer
- Glumetinib Combined With Fruquintinib in the Treatment of MET Amplification or Protein Overexpression in Third-Line Unresectable Metastatic Colorectal Cancer
- Glumetinib Combined With Osimertinib in the Treatment of Relapsed and Metastatic Non-small Cell Lung Cancer Patients Who Failed to Receive EGFR Inhibitors
- Glumetinib Combined With Osimertinib Treatment for Non-Small Cell Lung Cancer Patients
- Glumetinib Combined With Toripalimab in the Treatment of Relapsed or Metastatic Non-small Cell Lung Cancer.
- Gumarontinib Combined With 3rd EGFR-TKI in Patients With Non-small Cell Lung Cancer.
- [Safety and Efficacy of Glumetinib Combined With Docetaxel for Injection (Albumin-bound) in Patients With Advanced Gastric Cancer/Gastroesophageal Junction Adenocarcinoma and Other Solid Tumors](https://trialight.com/data/trial/safety-and-efficacy-of-glumetinib-combined-with-docetaxel-b1610249-4d6f-484e-9d59-a7933a59a867.md)
- Single Dose Glumetinib in Healthy Chinese Male Subjects
- Study to Evaluate the Safety and Anti-tumor Activity of SCC244

### In development for (2)

- Neoplasm Phase 2
- [Non-small cell lung carcinoma](https://trialight.com/data/condition/non-small-cell-lung-carcinoma-a86c1d60-523f-5ea7-a5e1-39ed4a2296f8.md) Phase 2

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