> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/gramicidin-s-077fd4dd-23fa-45bd-ae15-32c5608e5c1e
> Record changed: 2026-10-13

# Gramicidin S

Highest phase reached

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL373496)

Drug type

Protein

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL373496)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL373496)

## Names and chemistry

**Drug type**

Protein

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL373496)

**Drug name**

Gramicidin S

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL373496)

**Molecular weight**

1,141.47

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL373496)

**Structure (SMILES)**

CC(C)C\[C@@H\]1NC(=O)\[C@H\](CCCN)NC(=O)\[C@H\](C(C)C)NC(=O)\[C@@H\]2CCCN2C(=O)\[C@@H\](Cc2ccccc2)NC(=O)\[C@H\](CC(C)C)NC(=O)\[C@H\](CCCN)NC(=O)\[C@H\](C(C)C)NC(=O)\[C@@H\]2CCCN2C(=O)\[C@@H\](Cc2ccccc2)NC1=O

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL373496)

### Other names (26)

- cyclo l leucyl d phenylalanyl l prolyl l valyl l ornithyl l leucyl d phenylalanyl l prolyl l valyl l ornithyl
- cyclo l valyl l ornithyl l leucyl d phenylalanyl l prolyl l valyl l ornithyl l leucyl d phenylalanyl l prolyl
- CYCLO(L-LEUCYL-D-PHENYLALANYL-L-PROLYL-L-VALYL-L-ORNITHYL-L-LEUCYL-D-PHENYLALANYL-L-PROLYL-L-VALYL-L-ORNITHYL)
- CYCLO(L-VALYL-L-ORNITHYL-L-LEUCYL-D-PHENYLALANYL-L-PROLYL-L-VALYL-L-ORNITHYL-L-LEUCYL-D-PHENYLALANYL-L-PROLYL)
- gramicidin c
- Gramicidin c
- gramicidin s
- Gramicidin s
- gramicidin s \[INN\]
- GRAMICIDIN S \[MART.\]
- GRAMICIDIN S \[MI\]
- Gramicidin s \[WHO-DD\]
- gramicidin s 1
- Gramicidin s 1
- gramicidin s a
- gramicidin s inn
- gramicidin s mart
- gramicidin s mi
- gramicidin s who dd
- Gramicidin s-a
- gramicidina s
- Gramicidina s
- gramicidine s
- Gramicidine s
- grammidin

And 1 more, listed on the interactive page.

## Identifiers

**CAS registry numbers**

- 113-73-5

**ChEMBL ID**

CHEMBL373496

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL373496)

**InChIKey**

IUAYMJGZBVDSGL-XNNAEKOYSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL373496)

**PubChem compound IDs**

- 73357

**FDA ingredient codes (UNII)**

- WHM29QA23F

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Drug classification

**Drug name stem**

\-cidin

## Chemical properties

**Calculated partition coefficient (XLogP)**

4.6

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Heavy atoms**

82

**Molecular formula**

C60H92N12O10

**Monoisotopic mass**

1140.70593718

**Natural product**

Yes

## Evidence counts

**Recorded assays**

321

**Active assays**

55

### Active assay types (3)

- Confirmatory
- Screening
- Summary

## Related records

### Trials (3)

- Safety, Tolerability, and Pharmacokinetic Profile of Grammidin With Anesthetic, a Metered Dose Topical Spray in Healthy Volunteers
- Safety, Tolerability, and Pharmacokinetic Profile of Grammidin, a Metered Dose Topical Spray in Healthy Volunteers
- [Study to Evaluate the Efficacy and Safety of Different Doses of Graminidin With Anesthetic, a Metered Dose Topical Spray, in the Treatment of Acute Infectious and Inflammatory Pharyngeal Diseases Compared With Drug Septolete Total, Lozenges](https://trialight.com/data/trial/study-to-evaluate-the-efficacy-and-safety-of-different-doses-811c61a0-f561-4124-a064-30993cc64006.md)

---

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