> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/goserelin-68dc1cbd-3cb9-4d98-bc21-86d000fac02c
> Record changed: 2026-11-04

# Goserelin

Highest phase reached

Approved

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1201247)

Drug type

Protein

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1201247)

First approval year

1989

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1201247)

## Development status

**First approval year**

1989

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1201247)

**Listing at source**

Listed

**Highest phase reached**

Approved

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1201247)

## Names and chemistry

**Drug type**

Protein

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1201247)

**Drug name**

Goserelin

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1201247)

**Molecular weight**

1,269.43

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1201247)

**Structure (SMILES)**

CC(C)C\[C@H\](NC(=O)\[C@@H\](COC(C)(C)C)NC(=O)\[C@H\](Cc1ccc(O)cc1)NC(=O)\[C@H\](CO)NC(=O)\[C@H\](Cc1c\[nH\]c2ccccc12)NC(=O)\[C@H\](Cc1cnc\[nH\]1)NC(=O)\[C@@H\]1CCC(=O)N1)C(=O)N\[C@@H\](CCCNC(=N)N)C(=O)N1CCC\[C@H\]1C(=O)NNC(N)=O

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1201247)

### Other names (28)

- 1 5 oxo l prolyl l histidyl l tryptophyl l seryl l tyrosyl o tert butyl d seryl l leucyl l arginyl l prolyl semicarbazide
- 1-(5-OXO-L-PROLYL-L-HISTIDYL-L-TRYPTOPHYL-L-SERYL-L-TYROSYL-O-TERT-BUTYL-D-SERYL-L-LEUCYL-L-ARGINYL-L-PROLYL)SEMICARBAZIDE
- goserelin
- Goserelin
- GOSERELIN \[EP MONOGRAPH\]
- GOSERELIN \[HSDB\]
- goserelin \[INN\]
- GOSERELIN \[MART.\]
- GOSERELIN \[MI\]
- GOSERELIN \[USAN\]
- Goserelin \[WHO-DD\]
- goserelin ep monograph
- goserelin hsdb
- goserelin inn
- goserelin mart
- goserelin mi
- goserelin usan
- goserelin who dd
- goserelina
- Goserelina
- gosereline
- Gosereline
- ici 118 630
- ICI 118,630
- ici 118630

And 3 more, listed on the interactive page.

## Identifiers

**ATC classification codes**

- L02AE03

Sources for recorded values

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1201247)

**CAS registry numbers**

- 65807-02-5

**ChEMBL ID**

CHEMBL1201247

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1201247)

**InChIKey**

BLCLNMBMMGCOAS-URPVMXJPSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1201247)

**PubChem compound IDs**

- 5311128

**FDA ingredient codes (UNII)**

- 0F65R8P09N

### RxNorm IDs (RxCUI) (2)

- 50610
- 203146

## Regulatory information

### United States

**Applicant**

TERSERA

**Approval date**

29 Dec 1989

**Application number**

NDA019726

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

**Availability**

Prescription only

## Approval status

**United States (FDA)**

Approved

## Pharmacology

### Drug classification

**Pharmacology name**

goserelin

**Type**

Peptide

**Drug name stem**

\-relin

**Approval recorded by Guide to Pharmacology**

Yes

#### Administration routes

- Parenteral

### Mechanisms of action

- **Action**  
Full agonist

**Action type**  
FULL\_AGONIST

**Target**  
GnRH1 receptor

**Gene symbol**  
GNRHR

**Protein identifier**  
P30968

**Primary target**  
Yes

### Open Targets mechanisms

- **Mechanism**  
Gonadotropin-releasing hormone receptor agonist

**Action type**  
Agonist

**Target**  
Gonadotropin-releasing hormone receptor

### DrugCentral mechanisms

- **Action type**  
Agonist

**Gene symbol**  
GNRHR

**Protein identifier**  
P30968

**Organism**  
Homo sapiens

**Target development level**  
Clinical

### Investigated indications (16)

- **Condition**  
Hodgkin Disease

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000183

**Subject identifier**  
D006689
- **Condition**  
Metabolic Syndrome

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000195

**Subject identifier**  
D024821
- **Condition**  
Prostatic Neoplasms

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000196

**Subject identifier**  
D011471
- **Condition**  
Breast Neoplasms

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000305

**Subject identifier**  
D001943
- **Condition**  
Infertility

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000545

**Subject identifier**  
D007246
- **Condition**  
Carcinoma, Lobular

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000553

**Subject identifier**  
D018275
- **Condition**  
Neoplasms

**Highest recorded phase**  
4

**Condition identifier**  
EFO:0000616

**Subject identifier**  
D009369
- **Condition**  
Prostatic Neoplasms

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000673

**Subject identifier**  
D011471
- **Condition**  
Leiomyoma

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000731

**Subject identifier**  
D007889
- **Condition**  
Prostatic Neoplasms

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0001663

**Subject identifier**  
D011471
- **Condition**  
Breast Neoplasms

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0003869

**Subject identifier**  
D001943
- **Condition**  
Adenomyosis

**Highest recorded phase**  
2

**Condition identifier**  
EFO:1001757

**Subject identifier**  
D062788
- **Condition**  
Primary Ovarian Insufficiency

**Highest recorded phase**  
2

**Condition identifier**  
HP:0008209

**Subject identifier**  
D016649
- **Condition**  
Salivary Gland Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0004669

**Subject identifier**  
D012468
- **Condition**  
Breast Neoplasms

**Highest recorded phase**  
3

**Condition identifier**  
MONDO:0007254

**Subject identifier**  
D001943
- **Condition**  
Prostatic Neoplasms, Castration-Resistant

**Highest recorded phase**  
3

**Condition identifier**  
MONDO:0008315

**Subject identifier**  
D064129

### Open Targets indications (36)

- **Condition identifier**  
EFO\_0000183

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0000195

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0000305

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0000545

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000616
- **Condition identifier**  
EFO\_0000673
- **Condition identifier**  
EFO\_0000731

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0003869

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0008008

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0009003

**Highest recorded phase**  
2
- **Condition identifier**  
HP\_0000131

**Highest recorded phase**  
3
- **Condition identifier**  
HP\_0000855

**Highest recorded phase**  
2
- **Condition identifier**  
HP\_0008209

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0000521

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0002113

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0004669

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0004989

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0004992

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005051

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005070

**Highest recorded phase**  
4
- **Condition identifier**  
MONDO\_0005082

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0005133
- **Condition identifier**  
MONDO\_0005140

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005148

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005494

**Highest recorded phase**  
2

And 11 more, listed on the interactive page.

### Reported adverse events (41)

- **Event**  
abdominal lymphadenopathy

**Reports**  
26

**Reporting signal score**

107.418
- **Event**  
adnexa uteri mass

**Reports**  
10

**Reporting signal score**

42.0788
- **Event**  
arterial injury

**Reports**  
10

**Reporting signal score**

34.1699
- **Event**  
ascites

**Reports**  
36

**Reporting signal score**

40.1539
- **Event**  
blood testosterone increased

**Reports**  
12

**Reporting signal score**

34.2239
- **Event**  
bone lesion

**Reports**  
22

**Reporting signal score**

55.8547
- **Event**  
breast cancer

**Reports**  
93

**Reporting signal score**

171.084
- **Event**  
breast cancer metastatic

**Reports**  
75

**Reporting signal score**

245.713
- **Event**  
breast cancer recurrent

**Reports**  
16

**Reporting signal score**

39.4196
- **Event**  
carbohydrate antigen 15-3 increased

**Reports**  
10

**Reporting signal score**

35.2477
- **Event**  
carcinoid tumour pulmonary

**Reports**  
13

**Reporting signal score**

59.6145
- **Event**  
central nervous system lesion

**Reports**  
22

**Reporting signal score**

33.9997
- **Event**  
circumstance or information capable of leading to device use error

**Reports**  
14

**Reporting signal score**

59.6325
- **Event**  
cyp3a4 polymorphism

**Reports**  
8

**Reporting signal score**

52.7301
- **Event**  
device safety feature issue

**Reports**  
8

**Reporting signal score**

41.4062
- **Event**  
disease progression

**Reports**  
91

**Reporting signal score**

81.8334
- **Event**  
expulsion of medication

**Reports**  
24

**Reporting signal score**

129.699
- **Event**  
hot flush

**Reports**  
101

**Reporting signal score**

174.242
- **Event**  
interstitial lung disease

**Reports**  
67

**Reporting signal score**

74.9696
- **Event**  
jaundice

**Reports**  
37

**Reporting signal score**

35.2953
- **Event**  
lymphadenopathy

**Reports**  
37

**Reporting signal score**

36.685
- **Event**  
malignant neoplasm progression

**Reports**  
390

**Reporting signal score**  
1,031.87
- **Event**  
metastases to bone

**Reports**  
168

**Reporting signal score**

557.05
- **Event**  
metastases to central nervous system

**Reports**  
31

**Reporting signal score**

58.7844
- **Event**  
metastases to liver

**Reports**  
126

**Reporting signal score**

383.584

And 16 more, listed on the interactive page.

### Trial references (104)

- NCT00002633  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00002633)
- NCT00002889  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00002889)
- NCT00003653  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00003653)
- NCT00004124  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00004124)
- NCT00004635  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00004635)
- NCT00028769  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00028769)
- NCT00223171  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00223171)
- NCT00303784  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00303784)
- NCT00349557  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00349557)
- NCT00388804  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00388804)
- NCT00482807  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00482807)
- NCT00631527  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00631527)
- NCT00651326  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00651326)
- NCT00669162  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00669162)
- NCT00769795  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00769795)
- NCT00771017  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00771017)
- NCT00831233  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00831233)
- NCT00833248  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00833248)
- NCT00841113  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00841113)
- NCT00884273  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00884273)
- NCT00936390  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00936390)
- NCT01252693  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01252693)
- NCT01377389  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01377389)
- NCT01496131  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01496131)
- NCT01744366  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01744366)

And 79 more, listed on the interactive page.

## Dosing

**Dose**

3.6 mg

**Route**

Subcutaneous

**How often**

Every 28 days

## Chemical properties

**Calculated partition coefficient (XLogP)**

\-1.5

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Heavy atoms**

91

**Molecular formula**

C59H84N18O14

**Monoisotopic mass**

1268.64143943

**Natural product**

Yes

## Evidence counts

**Recorded assays**

117

**Active assays**

1

### Active assay types

- Other

## Pharmacologic actions

- Antineoplastic Agents, Hormonal  
Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D018931.html)

## Related records

### Trials (129)

- (Z)-Endoxifen for the Treatment of Premenopausal Women With ER+/HER2- Breast Cancer
- A Phase Ib Dose Escalation Study of the Combination of LEE011 With Letrozole and Dose Expansion of LEE011 With Hormonal Therapy for the Treatment of Pre-(With Goserelin) and Postmenopausal Women With Hormone Receptor Positive, HER2-negative, Advanced Breast Cancer
- [A Study of Imlunestrant (LY3484356) in Premenopausal Women With Estrogen Receptor-Positive (ER+) Human Epidermal Growth Factor Receptor 2 Negative (HER2-) Early Breast Cancer](https://trialight.com/data/trial/a-study-of-imlunestrant-ly3484356-in-premenopausal-women-b04685f6-ad54-43a6-9256-b71555ef4617.md)
- A Study to Compare the Effect of ASP3550 With Goserelin in Patients With Prostate Cancer
- Abarelix Versus Goserelin Plus Bicalutamide in Patients With Advanced or Metastatic Prostate Cancer
- Adaptions and Resiliency to Multi-Stressor OpeRations
- Adjuvant Ovarian Suppression Plus Aromatase Inhibitor or Tamoxifen in Young Women
- Adjuvant Toremifene With or Without Goserrelin in Premenopausal Women With Stage I-IIIA, Hormonal Receptor Positive Breast Cancer Accompanied With or Without Chemotherapy Induced Amenorrhoea
- Administration During Chemotherapy to Reduce Ovarian Failure Following Chemotherapy in Early Stage, Hormone-Receptor Negative Breast Cancer
- Alternative Dosing Schedule of Palbociclib in Metastatic Hormone Receptor Positive Breast Cancer
- Amcenestrant (SAR439859) Plus Palbociclib as First Line Therapy for Patients With ER (+) HER2(-) Advanced Breast Cancer
- Androgen Ablation Therapy With or Without Vaccine Therapy in Treating Patients With Prostate Cancer
- Androgen Deprivation Therapy on Bone Mineral Density Change in Prostate Cancer Patients
- Androgen Suppression and Radiation With/Out Docetaxel in High-Risk Localized Prostate Cancer
- Antiandrogen Therapy and Radiation Therapy With or Without Docetaxel in Treating Patients With Prostate Cancer That Has Been Removed by Surgery
- Aromatase Inhibitors or GnRH-a for Uterine Adenomyosis
- Assessing the Efficacy and Safety of Anti-HER2 Therapy in Nigerian Women With HER2+ Breast Cancer Before and After Surgery
- Bevacizumab Plus Paclitaxel Optimization Study With Interventional Aintenance Endocrine Therapy in Breast Cancer
- Bevacizumab With Hormonal and Radiotherapy for High-Risk Prostate Cancer
- Biological and Clinical Effects of Palbociclib With Ovarian Suppression and Letrozole in the Neoadjuvant Treatment of Breast Cancer

### Approved for (1)

- [Neoplasm](https://trialight.com/data/condition/neoplasm-2a973797-359b-5982-907e-98f9b7c1a284.md)

### In development for (28)

- Adenomyoma Phase 2
- Adenomyosis Phase 2
- [Breast cancer](https://trialight.com/data/condition/breast-cancer-8ac10da3-93bd-54c5-a93b-265bc6699689.md) Phase 3
- [Breast carcinoma](https://trialight.com/data/condition/breast-carcinoma-e447567c-405f-500c-a7a4-766a76d59293.md) Phase 3
- [Breast neoplasm](https://trialight.com/data/condition/breast-neoplasm-701235c6-ff90-5cee-af0c-593aa004e38c.md) Phase 3
- [Cancer](https://trialight.com/data/condition/cancer-703b1dfc-4812-50eb-83f4-d7a205d16bdb.md) Phase 2
- [Estrogen-receptor positive breast cancer](https://trialight.com/data/condition/estrogen-receptor-positive-breast-cancer-3bdba21b-1ba5-534a-9e7a-1d3f4d76885f.md) Phase 2
- Fallopian tube carcinoma Phase 2
- Hodgkins lymphoma Phase 2
- Infertility disorder Phase 3
- Invasive lobular breast carcinoma Phase 2
- Malignant epithelial tumor of ovary Phase 2
- Metabolic syndrome X Phase 2
- [Metastatic prostate carcinoma](https://trialight.com/data/condition/metastatic-prostate-carcinoma-d5fb1084-bad5-5db6-8240-897dc47ea451.md) Phase 3
- [Ovarian carcinoma](https://trialight.com/data/condition/ovarian-carcinoma-e5ec8fdc-01ec-5cd9-9507-107d23d3a30b.md) Phase 2
- Ovarian dysfunction Phase 2
- Peritoneal carcinoma Phase 2
- Premature ovarian failure 1 Phase 2
- Primary ovarian failure Phase 2
- Prostate adenocarcinoma Phase 3

### Other linked conditions (1)

- [Endometriosis](https://trialight.com/data/condition/endometriosis-3a5471b6-6d24-50b8-b1e6-8803dd78b0db.md)

### Targets (1)

- [GNRHR](https://trialight.com/data/target/gnrhr-ac2ad3c8-85c9-5310-a5fb-e2b215542909.md) Gonadotropin-releasing hormone receptor agonist

---

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