> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/gonadorelin-8424d688-4462-4eb8-8a4b-86a101540a4a
> Record changed: 2026-10-13

# Gonadorelin

Highest phase reached

Approved

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1007)

Drug type

Protein

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1007)

First approval year

1982

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1007)

## Development status

**First approval year**

1982

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1007)

**Listing at source**

Listed

**Highest phase reached**

Approved

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1007)

## Names and chemistry

**Drug type**

Protein

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1007)

**Drug name**

Gonadorelin

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1007)

**Molecular weight**

1,182.31

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1007)

**Structure (SMILES)**

CC(C)C\[C@H\](NC(=O)CNC(=O)\[C@H\](Cc1ccc(O)cc1)NC(=O)\[C@H\](CO)NC(=O)\[C@H\](Cc1c\[nH\]c2ccccc12)NC(=O)\[C@H\](Cc1cnc\[nH\]1)NC(=O)\[C@@H\]1CCC(=O)N1)C(=O)N\[C@@H\](CCCNC(=N)N)C(=O)N1CCC\[C@H\]1C(=O)NCC(N)=O

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1007)

### Brand names (4)

- fertiral lh rh
- Fertiral lh-rh
- relefact lh rh
- Relefact lh-rh

### Other names (50)

- 5 oxopro his trp ser tyr gly leu arg pro gly nh2
- 5-OXOPRO-HIS-TRP-SER-TYR-GLY-LEU-ARG-PRO-GLY-NH2
- Auxiliary Medicinal Product - Luteinizing hormone-releasing hormone (LHRH) analogues
- auxiliary medicinal product luteinizing hormone releasing hormone lhrh analogues
- gnrh
- GNRH
- gonadorelin
- Gonadorelin
- GONADORELIN (GONADORELIN DECAPEPTIDE (GNRH))
- gonadorelin \[INN\]
- GONADORELIN \[JAN\]
- GONADORELIN \[MART.\]
- GONADORELIN \[MI\]
- GONADORELIN \[VANDF\]
- Gonadorelin \[WHO-DD\]
- gonadorelin decapeptide
- Gonadorelin decapeptide
- gonadorelin gonadorelin decapeptide gnrh
- gonadorelin inn
- gonadorelin jan
- gonadorelin mart
- gonadorelin mi
- gonadorelin vandf
- gonadorelin who dd
- gonadorelina

And 25 more, listed on the interactive page.

## Identifiers

**CAS registry numbers**

- 33515-09-2

**ChEMBL ID**

CHEMBL1007

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1007)

**InChIKey**

XLXSAKCOAKORKW-AQJXLSMYSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1007)

**PubChem compound IDs**

- 638793

**FDA ingredient codes (UNII)**

- 9O7312W37G

### ATC classification codes (2)

- H01CA01
- V04CM01

Sources for recorded values

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1007)

### RxNorm IDs (RxCUI) (2)

- 6384
- 204193

## Regulatory information

### United States

**Applicant**

HIKMA

**Approval date**

30 Sept 1982

**Application number**

NDA018123

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

**Availability**

discontinued

## Pharmacology

### Drug classification

**Pharmacology name**

\[125I\]GnRH I (human, mouse, rat)

**Type**

Peptide

**Drug name stem**

\-relin

#### Administration routes

- Parenteral

### Mechanisms of action

- **Action**  
Full agonist

**Action type**  
FULL\_AGONIST

**Target**  
GnRH1 receptor

**Gene symbol**  
GNRHR

**Protein identifier**  
P30968

### Open Targets mechanisms

- **Mechanism**  
Gonadotropin-releasing hormone receptor agonist

**Action type**  
Agonist

**Target**  
Gonadotropin-releasing hormone receptor

### DrugCentral mechanisms

- **Action type**  
Agonist

**Gene symbol**  
GNRHR

**Protein identifier**  
P30968

**Organism**  
Homo sapiens

**Target development level**  
Clinical

### Investigated indications (4)

- **Condition**  
Cocaine-Related Disorders

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0002610

**Subject identifier**  
D019970
- **Condition**  
Osteoporosis

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0003882

**Subject identifier**  
D010024
- **Condition**  
Breast Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0007254

**Subject identifier**  
D001943
- **Condition**  
Prostatic Neoplasms, Castration-Resistant

**Highest recorded phase**  
3

**Condition identifier**  
MONDO:0008315

**Subject identifier**  
D064129

### Open Targets indications (42)

- **Condition identifier**  
EFO\_0000195
- **Condition identifier**  
EFO\_0000544

**Highest recorded phase**  
1
- **Condition identifier**  
EFO\_0000545

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0002950

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0008008
- **Condition identifier**  
EFO\_1000653
- **Condition identifier**  
GO\_0042697

**Highest recorded phase**  
2
- **Condition identifier**  
HP\_0000131
- **Condition identifier**  
HP\_0000786

**Highest recorded phase**  
2
- **Condition identifier**  
HP\_0000789

**Highest recorded phase**  
3
- **Condition identifier**  
HP\_0000822

**Highest recorded phase**  
1
- **Condition identifier**  
HP\_0000823

**Highest recorded phase**  
1
- **Condition identifier**  
HP\_0001513
- **Condition identifier**  
HP\_0001518
- **Condition identifier**  
HP\_0008209

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0000521

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0000596
- **Condition identifier**  
MONDO\_0001119

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0001572

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0002146
- **Condition identifier**  
MONDO\_0002447

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0004975
- **Condition identifier**  
MONDO\_0004995
- **Condition identifier**  
MONDO\_0005044

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005047

**Highest recorded phase**  
3

And 17 more, listed on the interactive page.

### Reported adverse events (15)

- **Event**  
activated pi3 kinase delta syndrome

**Reports**  
1

**Reporting signal score**

9.01185
- **Event**  
breast cancer

**Reports**  
7

**Reporting signal score**

25.5881
- **Event**  
carcinoembryonic antigen increased

**Reports**  
3

**Reporting signal score**

16.9686
- **Event**  
central nervous system lesion

**Reports**  
5

**Reporting signal score**

22.0346
- **Event**  
malignant neoplasm progression

**Reports**  
6

**Reporting signal score**

17.0197
- **Event**  
meningeal disorder

**Reports**  
4

**Reporting signal score**

28.8867
- **Event**  
metastases to bone

**Reports**  
6

**Reporting signal score**

26.3439
- **Event**  
neutropenia

**Reports**  
6

**Reporting signal score**

11.6784
- **Event**  
ovarian disorder

**Reports**  
2

**Reporting signal score**

12.0723
- **Event**  
ovarian hyperstimulation syndrome

**Reports**  
4

**Reporting signal score**

20.8793
- **Event**  
pigmentary glaucoma

**Reports**  
1

**Reporting signal score**

8.65519
- **Event**  
reproductive tract hypoplasia, male

**Reports**  
1

**Reporting signal score**

8.47288
- **Event**  
uterine disorder

**Reports**  
2

**Reporting signal score**

10.0115
- **Event**  
uterine enlargement

**Reports**  
2

**Reporting signal score**

12.8088
- **Event**  
visual impairment

**Reports**  
4

**Reporting signal score**

9.67962

### Trial references (6)

- NCT00000325  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00000325)
- NCT00175383  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00175383)
- NCT00329797  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00329797)
- NCT01603420  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01603420)
- NCT03009981  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03009981)
- NCT04293393  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04293393)

## Dosing

**Dose**

100 mcg

**Route**

Intramuscular

**How often**

As specified in program steps

## Chemical properties

**Calculated partition coefficient (XLogP)**

\-2.4

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Heavy atoms**

85

**Molecular formula**

C55H75N17O13

**Monoisotopic mass**

1181.57302551

**Natural product**

Yes

### Sequences

- **Component**  
Sequence

**Type**  
Protein

**Sequence**  
QHWSYGLRPG

## Evidence counts

**Recorded assays**

34

**Active assays**

6

### Active assay types (2)

- Confirmatory
- Other

## Biological measurements

These details could not be displayed.

## Related records

### Trials (285)

- 12-week Open-label Evaluation of Efficacy and Safety of Indacaterol
- 90% Effective Dose of Norepinephrine Infusions Under Intensive and Standard Treatment
- 90% Effective Dose of Norepinephrine Infusions Under Intensive and Standard Treatment in Preeclamptic Patients
- 90% Effective Dose of Phenylephrine Infusions Under Intensive and Standard Treatment
- 90% Effective Dose of Phenylephrine Infusions Under Intensive and Standard Treatment in Preeclamptic Patients
- A Clinical Study of SHR-1314 Injection in the Treatment of Moderate to Severe Plaque Psoriasis in Adults
- A Comparative Study of AZD9833 Plus Palbociclib Versus Anastrozole Plus Palbociclib in Patients With ER-Positive HER2 Negative Breast Cancer Who Have Not Received Any Systemic Treatment for Advanced Disease
- A Comparison of Symbicort® Single Inhaler Therapy and Conventional Best Practice for the Treatment of Persistent Asthma
- A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Assess the Efficacy and Safety of Three Dosage Strengths of Pulsatile GnRH
- A Novel Drug for Borderline Personality Disorder
- A Novel Stimulation Protocol and the Conventional Low Dose Step-up and Step Down Regimens
- [A Phase 1, First-in-human Study of OKN4395 and Pembrolizumab in Patients With Solid Tumors](https://trialight.com/data/trial/a-phase-1-first-in-human-study-of-okn4395-and-pembrolizumab-d5f0ed43-9c3d-4e12-976c-c1165c2cdf30.md)
- A Phase I Dose-Escalation Study of BMS-641988 in Patients With Castration-Resistant Prostate Cancer
- A Safety Study of Xolair (Omalizumab) in Patients With Chronic Idiopathic Urticaria (CIU) Who Remain Symptomatic Despite Treatment With H1 Antihistamines, H2 Blockers, and/or Leukotriene Receptor Antagonists
- A Study Evaluating the Efficacy and Safety of Adjuvant Giredestrant Compared With Physician's Choice of Adjuvant Endocrine Monotherapy in Participants With Estrogen Receptor-Positive, HER2-Negative Early Breast Cancer (lidERA Breast Cancer)
- A Study Evaluating the Efficacy and Safety of Biomarker-Driven Therapies in Patients With Persistent or Recurrent Rare Epithelial Ovarian Tumors
- A Study Evaluating the Efficacy and Safety of Giredestrant Combined With Palbociclib Compared With Letrozole Combined With Palbociclib in Participants With Estrogen Receptor-Positive, HER2-Negative Locally Advanced or Metastatic Breast Cancer (persevERA Breast Cancer)
- A Study Evaluating the Efficacy and Safety of Giredestrant Compared With Physician's Choice of Endocrine Monotherapy in Participants With Previously Treated Estrogen Receptor-Positive, HER2-Negative Locally Advanced or Metastatic Breast Cancer (acelERA Breast Cancer)
- A Study Evaluating the Efficacy and Safety of Giredestrant Plus Everolimus Compared With the Physician's Choice of Endocrine Therapy Plus Everolimus in Participants With Estrogen Receptor-Positive, HER2-Negative, Locally Advanced or Metastatic Breast Cancer (evERA Breast Cancer)
- A Study of A4I Antagonist in Patients With Relapsing Multiple Sclerosis.

### In development for (5)

- [Breast cancer](https://trialight.com/data/condition/breast-cancer-8ac10da3-93bd-54c5-a93b-265bc6699689.md) Phase 2
- Cocaine dependence Phase 1
- Infertility disorder Phase 3
- Osteoporosis Phase 3
- [Prostate cancer](https://trialight.com/data/condition/prostate-cancer-3659fc70-617b-5868-a093-ae819ffc6755.md) Phase 3

### Other linked conditions (1)

- Hypogonadotropic hypogonadism

### Targets (1)

- [GNRHR](https://trialight.com/data/target/gnrhr-ac2ad3c8-85c9-5310-a5fb-e2b215542909.md) Gonadotropin-releasing hormone receptor agonist

---

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