> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/golcadomide-8667ef1b-1e52-4cc0-a88a-bd3392173874
> Record changed: 2026-10-13

# Golcadomide

Highest phase reached

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095226)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095226)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095226)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095226)

**Drug name**

Golcadomide

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095226)

**Molecular weight**

535.58

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095226)

**Structure (SMILES)**

O=C1CC\[C@H\](N2C(=O)c3cccc(NCc4ccc(CN5CC(N6CCOCC6)C5)cc4F)c3C2=O)C(=O)N1

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095226)

### Other names (17)

- cc 99282
- Cc 99282
- CC-99282
- cc1007548
- CC1007548
- cc99282
- CC99282
- golcadomida
- Golcadomida
- golcadomide
- Golcadomide
- golcadomide \[INN\]
- GOLCADOMIDE \[USAN\]
- Golcadomide \[WHO-DD\]
- golcadomide inn
- golcadomide usan
- golcadomide who dd

## Identifiers

**CAS registry numbers**

- 2379572-34-4

**ChEMBL ID**

CHEMBL5095226

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095226)

**InChIKey**

NZYDBVQXOGPDDU-QHCPKHFHSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095226)

**PubChem compound IDs**

- 146195299

**FDA ingredient codes (UNII)**

- 29HLR8Z5BR

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Drug classification

**Pharmacology name**

golcadomide

**Type**

Synthetic organic

**Drug name stem**

\-domide

### Mechanisms of action

- **Action**  
Binding

**Action type**  
Binding

**Target**  
cereblon

**Gene symbol**  
CRBN

**Protein identifier**  
Q96SW2

### Investigated indications (5)

- **Condition**  
Lymphoma, Large B-Cell, Diffuse

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000403

**Subject identifier**  
D016403
- **Condition**  
Lymphoma

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000574

**Subject identifier**  
D008223
- **Condition**  
Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000616

**Subject identifier**  
D009369
- **Condition**  
Lymphoma, Non-Hodgkin

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0005952

**Subject identifier**  
D008228
- **Condition**  
Lymphoma, Follicular

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0018906

**Subject identifier**  
D008224

### Open Targets indications (12)

- **Condition identifier**  
EFO\_0000616

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0005952

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0000430

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0004948

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005070
- **Condition identifier**  
MONDO\_0015760

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0017604

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0018876

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0018905

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0018906

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0018908

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0044889

**Highest recorded phase**  
2

### Trial references (10)

- NCT03310619  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03310619)
- NCT05788081  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05788081)
- NCT06108232  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06108232)
- NCT06425302  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06425302)
- NCT06356129  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06356129)
- NCT03930953  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03930953)
- NCT04434196  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04434196)
- NCT05169515  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05169515)
- NCT05283720  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05283720)
- NCT04884035  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04884035)

## Chemical properties

**Hydrogen bond acceptors**

8

**Hydrogen bond donors**

2

**Polar surface area**

111.29

**Calculated partition coefficient (ALogP)**

1.36

**Calculated partition coefficient (XLogP)**

1.6

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Rule-of-five violations**

1

**Rotatable bonds**

7

**Heavy atoms**

39

**Molecular formula**

C28H30FN5O5

**Monoisotopic mass**

535.22309724

**Natural product**

No

## Related records

### Trials (23)

- A Combination of Rituximab and CC-99282 as Front-line Therapy for Older Frail Patients With Diffuse Large B-cells Non-Hodgkin Lymphoma Evaluated With a Simplified Geriatric Assessment (sGA): a Phase II Study of the Fondazione Italiana Linfomi (FIL)
- A Platform Trial Evaluating New Drugs or Combination in R/R Peripheral T-cell Lymphomas
- A Safety and Efficacy Trial of JCAR017 Combinations in Subjects With Relapsed/Refractory B-cell Malignancies
- A Safety and Preliminary Efficacy Study of CC-99282 in Combination With Obinutuzumab in Subjects With Relapsed or Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
- A Safety and Preliminary Efficacy Study of CC-99282, Alone and in Combination With Anti-lymphoma Agents in Participants With Relapsed or Refractory Non-Hodgkin Lymphomas (R/R NHL)
- A Study Evaluating the Safety, Pharmacokinetics, and Efficacy of Mosunetuzumab or Glofitamab in Combination With CC-220 and/or CC-99282 in Participants With B-Cell Non-Hodgkin Lymphoma
- [A Study to Assess BMS-986458 Alone and in Combination With Anti-lymphoma Agents in Relapsed/Refractory Non-Hodgkin Lymphomas](https://trialight.com/data/trial/a-study-to-assess-bms-986458-alone-and-in-combination-with-823872d4-8715-481a-ab2a-e4108a436484.md)
- A Study to Compare the Efficacy and Safety of Golcadomide in Combination With Rituximab (Golca + R) vs Investigator's Choice in Participants With Relapsed/Refractory Follicular Lymphoma Who Have Received at Least 1 Prior Line of Systemic Therapy (GOLSEEK-4)
- A Study to Evaluate Adverse Events and Change in Disease Activity of Subcutaneous (SC) Epcoritamab in Combination With Oral and Intravenous Anti-Neoplastic Agents in Adult Participants With Non-Hodgkin Lymphoma
- A Study to Evaluate the Effect of Cytochrome P450 (CYP) 3A Inhibitor (Itraconazole) and Inducer (Rifampin) on the Drug Levels of Golcadomide (BMS-986369) in Healthy Participants
- A Study to Evaluate the Efficacy and Safety of Golcadomide in Combination With Rituximab in Participants With Newly Diagnosed Advanced Stage Follicular Lymphoma
- A Study to Evaluate the Pharmacokinetics and Safety of Golcadomide in Participants With Severe Renal Impairment and End-Stage Renal Disease Compared With Participants With Normal Renal Function
- CC-99282 + Rituximab Early Post CART for Non-Hodgkin's Lymphoma
- Golcadomide and Nivolumab in Patients With Non-Hodgkin Lymphoma With Refractory Disease After Chimeric Antigen T-cell Therapy
- Golcadomide and Rituximab as Bridging Therapy for Relapsed or Refractory Aggressive B-cell Non-Hodgkin Lymphoma Before CAR T-cell Therapy
- Golcadomide in Combination With Rituximab for the Treatment of Patients With Relapsed or Refractory Mantle Cell Lymphoma
- Golcadomide Post-CAR T-cell in R/R Aggressive Large B-cell Lymphoma Patients With High Risk of Relapse
- Golcadomide With Pemetrexed, Rituximab, and Dexamethasone for Relapsed and Refractory CNS Lymphomas
- Golcadomide, Poseltinib, and Rituximab for Relapsed/Refractory Diffuse Large B-cell Lymphoma
- Phase 2 Trial of Obinutuzumab and CC-99282 for Patients With Previously Untreated High Tumor Burden Follicular Lymphoma

### In development for (5)

- [Diffuse large B-cell lymphoma](https://trialight.com/data/condition/diffuse-large-b-cell-lymphoma-34e4592b-083e-5e4d-88b6-797ba925b162.md) Phase 3
- [Follicular lymphoma](https://trialight.com/data/condition/follicular-lymphoma-88de1ce9-ab0e-5d65-85c4-45a681fa2931.md) Phase 2
- [Lymphoma](https://trialight.com/data/condition/lymphoma-de4db685-7419-5e0e-b958-4591ffd69d43.md) Phase 1
- Neoplasm Phase 2
- [Non-Hodgkin lymphoma](https://trialight.com/data/condition/non-hodgkin-lymphoma-9fc07e31-fd30-5055-991f-04d10cc1f646.md) Phase 2

---

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