Glofitamab
Highest phase reached
Approved
Drug type
Antibody
First approval year
2023
- First approval year
- 2023
- Listing at source
- Listed
- Highest phase reached
- Approved
- Drug type
- Antibody
- Drug name
- Glofitamab
- columvi
- Columvi
- anti cd20 cd3 bispecific monoclonal antibody ro7082859
- ANTI-CD20/CD3 BISPECIFIC MONOCLONAL ANTIBODY RO7082859
- columvi
- Columvi
- columvi 10 mg concentrate for solution for infusion
- glofitamab
- Glofitamab
- glofitamab [INN]
- Glofitamab [MI]
- GLOFITAMAB [USAN]
- Glofitamab [WHO-DD]
- glofitamab gxbm
- Glofitamab gxbm [WHO-DD]
- glofitamab gxbm who dd
- glofitamab inn
- glofitamab mi
- glofitamab usan
- glofitamab who dd
- Glofitamab-gxbm
- IMMUNOGLOBULIN G1 (149-GLUTAMIC ACID,215-GLUTAMIC ACID,461-ALANINE,462-ALANINE,556-GLYCINE,581-CYSTEINE,593-TRYPTOPHAN), ANTI-(HUMAN CD20 ANTIGEN) (HUMAN-MUS MUSCULUS MONOCLONAL RG6026 VH-CH1 FRAGMENT) FUSION PROTEIN WITH PEPTIDE (SYNTHETIC 10-AMINO ACID LINKER) FUSION PROTEIN WITH IMMUNOGLOBULIN ANTI-(HUMAN CD3 ANTIGEN .EPSILON.-CHAIN) (HUMAN-MUS MUSCULUS MONOCLONAL RG6026 HEAVY CHAIN VL(.LAMBDA.)-CH1-CH2-CH3), (222->219''')-DISULFIDE WITH IMMUNOGLOBULIN ANTI-(HUMAN CD20 ANTIGEN) (HUMAN-MUS MUSCULUS MONOCLONAL RG6026 .KAPPA.-CHAIN (128-ARGININE,129-LYSINE)) AND (447->232'')-DISULFIDE WITH IMMUNOGLOBULIN ANTI-(HUMAN CD3 ANTIGEN .EPSILON.-CHAIN) (HUMAN-MUS MUSCULUS MONOCLONAL RG6026 LIGHT CHAIN VH-CL(.KAPPA.)), (453->228'), (456->231'), (581->351')-TRIS(DISULFIDE) WITH IMMUNOGLOBULIN G1 (149-GLUTAMIC ACID,215-GLUTAMIC ACID,236-ALANINE,237-ALANINE,331-GLYCINE,351-CYSTEINE,368-SERINE,370-ALANINE,409-VALINE) ANTI-(HUMAN CD20 ANTIGEN) (HUMAN-MUS MUSCULUS MONOCLONAL RG6026 .GAMMA.1-CHAIN) DISULFIDE WITH HUMAN-MUS MUSCULUS MONOCLONAL RG6026 .KAPPA.-CHAIN (128-ARGININE,129-LYSINE)
- immunoglobulin g1 149 glutamic acid 215 glutamic acid 461 alanine 462 alanine 556 glycine 581 cysteine 593 tryptophan anti human cd20 antigen human mus musculus monoclonal rg6026 vh ch1 fragment fusion protein with peptide synthetic 10 amino acid linker fusion protein with immunoglobulin anti human cd3 antigen epsilon chain human mus musculus monoclonal rg6026 heavy chain vl lambda ch1 ch2 ch3 222 219 disulfide with immunoglobulin anti human cd20 antigen human mus musculus monoclonal rg6026 kappa chain 128 arginine 129 lysine and 447 232 disulfide with immunoglobulin anti human cd3 antigen epsilon chain human mus musculus monoclonal rg6026 light chain vh cl kappa 453 228 456 231 581 351 tris disulfide with immunoglobulin g1 149 glutamic acid 215 glutamic acid 236 alanine 237 alanine 331 glycine 351 cysteine 368 serine 370 alanine 409 valine anti human cd20 antigen human mus musculus monoclonal rg6026 gamma 1 chain disulfide with human mus musculus monoclonal rg6026 kappa chain 128 arginine 129 lysine
- immunoglobulin g1 lambda kappa with domain cross over anti homo sapiens ms4a1 membrane spanning 4 domains subfamily a member 1 cd20 and anti homo sapiens cd3e cd3 epsilon leu 4 monoclonal antibody bispecific trivalentgamma lambda heavy chain anti ms4a1 and anti cd3e vh ch1 v lambda ch1 ch2 ch3 1 674 humanized vh anti ms4a1 homo sapiens ighv1 69 02 84 7 ighd ighj4 01 100 8 8 12 1 119 homo sapiens ighg1 01 g1m17 ch1 k26 e 149 k119 e 215 k120 216 120 217 hinge 1 6 218 223 120 223 10 mer bis tetraglycyl seryl linker 224 233 v lamdda anti cd3e mus musculus iglv1 01 81 2 iglj1 01 100 homo sapiens iglv7 46 01 80 0 iglj3 01 100 9 3 9 234 342 2 mer biseryl linker 343 344 homo sapiens ighg1 01 g1m17 g1m1 ch1 k120 441 345 442 hinge 1 15 443 457 ch2 l1 3 a 461 l1 2 a 462 p114 g 556 458 567 ch3 s10 c 581 d12 583 l14 585 t22 w 593 568 672 chs 673 674 345 674 222 219 disulfide with kappa light chain humanized anti ms4a1 1 219 humanized v kappa homo sapiens igkv2 28 01 87 0 igkj4 01 100 11 3 9 1 112 homo sapiens igkc 01 98 1 e12 r 128 q13 k 129 km3 a45 1 158 v101 196 113 219 447 232 disulfide with vh c kappa light chain humanized anti cd3e 1 232 humanized vh homo sapiens ighv3 23 03 87 0 igkj6 01 90 9 8 10 16 1 125 homo sapiens igkc 01 99 1 t1 3 s 127 km3 a45 1 171 v101 209 126 232 gamma1 heavy chain humanized anti ms4a1 1 449 humanized vh homo sapiens ighv1 69 02 84 7 ighd ighj4 01 100 8 8 12 1 119 homo sapiens ighg1 01 g1m17 1 ch1 k26 e 149 k119 e 215 k120 216 120 217 hinge 1 15 218 232 ch2 l1 3 a 236 l1 2 a 237 p114 g 331 233 342 ch3 y5 c 351 d12 358 l14 360 t22 s 368 l24 a 370 y86 v 409 343 447 chs 448 449 120 449 222 219 disulfide with kappa light chain humanized anti ms4a1 1 219 humanized v kappa homo sapiens igkv2 28 01 87 0 igkj4 01 100 11 3 9 1 112 homo sapiens igkc 01 98 1 e12 r 128 q13 k 129 km3 a45 1 158 v101 196 113 219 dimer 453 228 456 231 581 351 trisdisulfide
- IMMUNOGLOBULIN G1-LAMBDA/KAPPA WITH DOMAIN CROSS-OVER, ANTI-(HOMO SAPIENS MS4A1 (MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MEMBER 1, CD20)) AND ANTI-(HOMO SAPIENS CD3E (CD3 EPSILON, LEU-4)) MONOCLONAL ANTIBODY, BISPECIFIC, TRIVALENTGAMMA-LAMBDA HEAVY CHAIN ANTI-MS4A1 AND ANTI-CD3E (VH-CH1-V-LAMBDA-CH1-CH2-CH3) (1-674) (HUMANIZED VH ANTI-MS4A1 (HOMO SAPIENS IGHV1-69*02 (84.7%)-(IGHD)-IGHJ4*01 (100%)) (8.8.12) (1-119)-HOMO SAPIENS IGHG1*01, G1M17 (CH1 K26>E (149), K119>E (215), K120 (216) (120-217), HINGE 1-6 (218-223)) (120-223)-10-MER BIS(TETRAGLYCYL-SERYL) LINKER (224-233)-V-LAMDDA ANTI-CD3E (MUS MUSCULUS IGLV1*01 (81.2%)-IGLJ1*01 (100%)/HOMO SAPIENS IGLV7-46*01 (80.0%)-IGLJ3*01 (100%)) (9.3.9) (234-342)-2-MER BISERYL LINKER (343-344)-HOMO SAPIENS IGHG1*01, G1M17, G1M1 (CH1 K120 (441) (345-442), HINGE 1-15 (443-457), CH2 L1.3>A (461), L1.2>A (462), P114>G (556) (458-567), CH3 S10>C (581), D12 (583), L14 (585), T22>W (593) (568-672), CHS (673-674)) (345-674)), (222-219')-DISULFIDE WITH KAPPA LIGHT CHAIN HUMANIZED ANTI-MS4A1 (1'-219') (HUMANIZED V-KAPPA (HOMO SAPIENS IGKV2-28*01 (87.0%)-IGKJ4*01 (100%)) (11.3.9) (1'-112')-HOMO SAPIENS IGKC*01 (98.1%), E12>R (128), Q13>K (129), KM3 A45.1 (158), V101 (196) (113'-219'))(447-232''')-DISULFIDE WITH VH-C-KAPPA LIGHT CHAIN HUMANIZED ANTI-CD3E (1'''-232''') (HUMANIZED VH (HOMO SAPIENS IGHV3-23*03 (87.0%)-IGKJ6*01 (90.9%)) (8.10.16) (1'''-125''')-HOMO SAPIENS IGKC*01 (99.1%), T1.3>S (127), KM3 A45.1 (171), V101 (209) (126'''-232''')), GAMMA1 HEAVY CHAIN HUMANIZED ANTI-MS4A1 (1''-449'') (HUMANIZED VH (HOMO SAPIENS IGHV1-69*02 (84.7%)-(IGHD)-IGHJ4*01 (100%)) (8.8.12) (1''-119'')-HOMO SAPIENS IGHG1*01, G1M17,1 (CH1 K26>E (149), K119>E (215), K120 (216) (120''-217''), HINGE 1-15 (218''-232''), CH2 L1.3>A (236), L1.2>A (237), P114>G (331) (233''-342''), CH3 Y5>C (351), D12 (358), L14 (360), T22>S (368), L24>A (370), Y86>V (409) (343''-447''), CHS (448''-449'')) (120''-449'')), (222''-219'''')-DISULFIDE WITH KAPPA LIGHT CHAIN HUMANIZED ANTI-MS4A1 (1''''-219'''') (HUMANIZED V-KAPPA (HOMO SAPIENS IGKV2-28*01 (87.0%)-IGKJ4*01 (100%)) (11.3.9) (1''''-112'''')-HOMO SAPIENS IGKC*01 (98.1%), E12>R (128), Q13>K (129), KM3 A45.1 (158), V101 (196) (113''''-219''''))DIMER (453-228'':456-231'':581-351'')-TRISDISULFIDE
- IV Glofitamab
- rg 6026
And 8 more, listed on the interactive page.
- ATC classification codes
- L01FX28
Sources for recorded values
- CAS registry numbers
- 2229047-91-8
- ChEMBL ID
- CHEMBL4298092
- FDA ingredient codes (UNII)
- 06P3KLK2J8
- 2639781
- 2639782
- Applicant
- GENENTECH INC
- Approval date
- 15 Jun 2023
- Application number
- BLA761309
- Status
- Authorised
- Status date
- 7 Jul 2023
- Authorisation date
- 7 Jul 2023
- Approved indications
- Columvi in combination with gemcitabine and oxaliplatin is indicated for the treatment of adult patients with relapsed or refractory diffuse large B-cell lymphoma not otherwise specified (DLBCL NOS) who are ineligible for autologous stem cell transplant (ASCT).Columvi as monotherapy is indicated for the treatment of adult patients with relapsed or refractory diffuse large B cell lymphoma (DLBCL), after two or more lines of systemic therapy.
- Product number
- EMEA/H/C/005751
- Authorisation holder
- Roche Registration GmbH
- Priority medicines scheme
- No
- Generic
- No
- Biosimilar
- No
- Generic medicines
- 0
- Biosimilar medicines
- 0
- Advanced therapy
- No
- Conditional approval
- No
- Additional monitoring
- Yes
- Accelerated assessment
- No
- Exceptional circumstances
- No
Therapeutic areas
- Lymphoma, Large B-Cell, Diffuse
European medicines record
- Patents
- 0
- Designations
- 4
- First in class
- No
- Fast track
- Yes
- Breakthrough designation
- No
- Orphan designation
- No
- Priority review
- Yes
- Orphan exclusivity
- No
- Accelerated approval
- Yes
- Availability
- Prescription only
- Boxed warning
- Yes
- Pharmacology name
- glofitamab
- Type
- Antibody
- Drug name stem
- -mab
- Approval recorded by Guide to Pharmacology
- Yes
Administration routes
- Parenteral
- Mechanism
- B-lymphocyte antigen CD20 binding agent
- Action type
- BINDING_AGENT
- Target
- B-lymphocyte antigen CD20
- Protein identifier
- P11836
- Mechanism
- T cell surface glycoprotein CD3 binding agent
- Action type
- BINDING_AGENT
- Target
- T cell surface glycoprotein CD3
- Protein identifier
- P04234
- Mechanism
- T cell surface glycoprotein CD3 binding agent
- Action type
- BINDING_AGENT
- Target
- T cell surface glycoprotein CD3
- Protein identifier
- P07766
- Mechanism
- T cell surface glycoprotein CD3 binding agent
- Action type
- BINDING_AGENT
- Target
- T cell surface glycoprotein CD3
- Protein identifier
- P09693
- Action
- Binding
- Action type
- Binding
- Target
- CD20 (membrane-spanning 4-domains, subfamily A, member 1)
- Gene symbol
- MS4A1
- Protein identifier
- P11836
- Median affinity
- 8.32
- Affinity units
- pEC50
- Mechanism
- B-lymphocyte antigen CD20 binding agent
- Action type
- BINDING AGENT
- Target
- B-lymphocyte antigen CD20
- Mechanism
- T cell surface glycoprotein CD3 binding agent
- Action type
- BINDING AGENT
- Target
- T cell surface glycoprotein CD3
- Condition
- Lymphoma, Follicular
- Highest recorded phase
- 1
- Condition identifier
- EFO:0000096
- Subject identifier
- D008224
- Condition
- Lymphoma, Large B-Cell, Diffuse
- Highest recorded phase
- 4
- Condition identifier
- EFO:0000403
- Subject identifier
- D016403
- Condition
- Lymphoma
- Highest recorded phase
- 3
- Condition identifier
- EFO:0000574
- Subject identifier
- D008223
- Condition
- Neoplasms
- Highest recorded phase
- 4
- Condition identifier
- EFO:0000616
- Subject identifier
- D009369
- Condition
- Lymphoma, Non-Hodgkin
- Highest recorded phase
- 1
- Condition identifier
- EFO:0005952
- Subject identifier
- D008228
- Condition
- Lymphoma, Mantle-Cell
- Highest recorded phase
- 2
- Condition identifier
- EFO:1001469
- Subject identifier
- D020522
- Condition identifier
- EFO_0000403
- Condition identifier
- EFO_0000574
- Highest recorded phase
- 2
- Condition identifier
- EFO_0000616
- Condition identifier
- EFO_0005952
- Condition identifier
- EFO_1001469
- Highest recorded phase
- 2
- Condition identifier
- EFO_1001938
- Highest recorded phase
- 2
- Condition identifier
- MONDO_0002083
- Highest recorded phase
- 2
- Condition identifier
- MONDO_0002571
- Highest recorded phase
- 1
- Condition identifier
- MONDO_0004948
- Highest recorded phase
- 2
- Condition identifier
- MONDO_0005070
- Highest recorded phase
- 4
- Condition identifier
- MONDO_0007243
- Highest recorded phase
- 1
- Condition identifier
- MONDO_0015759
- Highest recorded phase
- 2
- Condition identifier
- MONDO_0017604
- Highest recorded phase
- 2
- Condition identifier
- MONDO_0018876
- Highest recorded phase
- 3
- Condition identifier
- MONDO_0018905
- Highest recorded phase
- 4
- Condition identifier
- MONDO_0018906
- Highest recorded phase
- 1
- Condition identifier
- MONDO_0018906
- Highest recorded phase
- 2
- Condition identifier
- MONDO_0018908
- Highest recorded phase
- 2
- Condition identifier
- MONDO_0044889
- Highest recorded phase
- 2
Warnings
- Warning
- Black Box Warning
- Effect
- immune system toxicity
Open Targets warnings
- Warning
- Black Box Warning
- Effect
- immune system toxicity
- Country
- United States
- Event
- alanine aminotransferase increased
- Reports
- 16
- Reporting signal score
- 23.6396
- Event
- anaemia
- Reports
- 19
- Reporting signal score
- 15.5759
- Event
- aspartate aminotransferase increased
- Reports
- 14
- Reporting signal score
- 20.4399
- Event
- bacterial infection
- Reports
- 12
- Reporting signal score
- 35.7362
- Event
- blood type incompatibility
- Reports
- 1
- Reporting signal score
- 8.17944
- Event
- covid-19
- Reports
- 17
- Reporting signal score
- 35.3799
- Event
- cytokine release syndrome
- Reports
- 89
- Reporting signal score
- 479.77
- Event
- cytomegalovirus infection reactivation
- Reports
- 4
- Reporting signal score
- 13.8118
- Event
- diaphragm neoplasm
- Reports
- 1
- Reporting signal score
- 6.79345
- Event
- diffuse large b-cell lymphoma
- Reports
- 4
- Reporting signal score
- 10.5312
- Event
- diffuse large b-cell lymphoma recurrent
- Reports
- 9
- Reporting signal score
- 40.8162
- Event
- disease progression
- Reports
- 48
- Reporting signal score
- 118.681
- Event
- disseminated tuberculosis
- Reports
- 3
- Reporting signal score
- 8.93193
- Event
- febrile neutropenia
- Reports
- 10
- Reporting signal score
- 11.5787
- Event
- hepatic cytolysis
- Reports
- 3
- Reporting signal score
- 8.10299
- Event
- hyperpyrexia
- Reports
- 7
- Reporting signal score
- 24.1642
- Event
- hypogammaglobulinaemia
- Reports
- 3
- Reporting signal score
- 6.94462
- Event
- immune effector cell-associated hlh-like syndrome
- Reports
- 1
- Reporting signal score
- 8.87253
- Event
- immune effector cell-associated neurotoxicity syndrome
- Reports
- 19
- Reporting signal score
- 106.14
- Event
- infection
- Reports
- 9
- Reporting signal score
- 6.6718
- Event
- mantle cell lymphoma
- Reports
- 6
- Reporting signal score
- 29.3017
- Event
- neutropenia
- Reports
- 24
- Reporting signal score
- 30.5136
- Event
- parainfluenzae virus infection
- Reports
- 2
- Reporting signal score
- 6.63898
- Event
- parvovirus infection
- Reports
- 2
- Reporting signal score
- 8.83738
- Event
- platelet count decreased
- Reports
- 9
- Reporting signal score
- 6.72604
And 3 more, listed on the interactive page.
- NCT03075696
- NCT03467373
- NCT03533283
- NCT04077723
- NCT05169515
- NCT05219513
- NCT04313608
- NCT04970901
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- NCT04161248
- NCT04657302
- NCT04980222
- NCT06084936
- NCT06213311
- NCT04408638
- NCT04703686
- NCT04889716
- NCT05335018
- NCT05364424
- NCT05798156
- NCT05896163
- NCT06047080
- NCT06050694
- NCT06071871
- NCT05833763
And 5 more, listed on the interactive page.
- Dose
- 1,000 mg
- Route
- Intravenous
- How often
- Every 21 days
- Administer as an intravenous infusion
- Administer in a healthcare setting with immediate access to medical support
- Prodrug
- No
- Chirality
- Single enantiomer
- Inorganic
- No
- Natural product
- No
- Component
- Heavy chain 1-674 anti-MS4A1, anti-CD3
- Type
- Protein
- Sequence
- QVQLVQSGAEVKKPGSSVKVSCKASGYAFSYSWINWVRQAPGQGLEWMGRIFPGDGDTDYNGKFKGRVTITADKSTSTAYMELSSLRSEDTAVYYCARNVFDGYWLVYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVEDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDEKVEPKSCDGGGGSGGGGSQAVVTQEPSLTVSPGGTVTLTCGSSTGAVTTSNYANWVQEKPGQAFRGLIGGTNKRAPGTPARFSGSLLGGKAALTLSGAQPEDEAEYYCALWYSNLWVFGGGTKLTVLSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALGAPIEKTISKAKGQPREPQVYTLPPCRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
- Component
- Heavy chain 1''-449'' anti-MS4A1
- Type
- Protein
- Sequence
- QVQLVQSGAEVKKPGSSVKVSCKASGYAFSYSWINWVRQAPGQGLEWMGRIFPGDGDTDYNGKFKGRVTITADKSTSTAYMELSSLRSEDTAVYYCARNVFDGYWLVYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVEDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDEKVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALGAPIEKTISKAKGQPREPQVCTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
- Component
- Glycosylation sites (N)
- Sequence
- 524 $ 299''''
- Component
- Glycosylation sites (N)
- Sequence
- 524 $ 299''
- Component
- Disulfide bridges
- Sequence
- 22-96 $ 22''-96'' $ 22'''-98''' $ 23'-93' $ 23''''-93'''' $ 139'-199' $ 139''''-199'''' $ 146-202 $ 146''-202'' $ 152'''-212''' $ 222-219' $ 222''-219'''' $ 263''-323'' $ 369''-427'' $ 371-427 $ 447-232'''' $ 453-228'' $ 456-231'' $ 488-548 $ 581-351'' $ 594-652
- Component
- Light chain: 1'''-232''' anti-CD3E
- Type
- Protein
- Sequence
- EVQLLESGGGLVQPGGSLRLSCAASGFTFSTYAMNWVRQAPGKGLEWVSRIRSKYNNYATYYADSVKGRFTISRDDSKNTLYLQMNSLRAEDTAVYYCVRHGNFGNSYVSWFAYWGQGTLVTVSSASVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
- Component
- Light chain: 1'-219' plus 1''''-219'''' anti-MS4A1
- Type
- Protein
- Sequence
- DIVMTQTPLSLPVTPGEPASISCRSSKSLLHSNGITYLYWYLQKPGQSPQLLIYQMSNLVSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCAQNLELPYTFGGGTKVEIKRTVAAPSVFIFPPSDRKLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
- 50242-125
- 50242-127
Related records
Trials (91)
- A Dose Escalation Study of Glofitamab (RO7082859) as a Single Agent and in Combination With Obinutuzumab, Administered After a Fixed, Single Pre-treatment Dose of Obinutuzumab in Participants With Relapsed/Refractory B-cell Non-hodgkin's Lymphoma
- A Multicentre, Parallel Arm, Open-label Trial of Frontline R-CHOP/Pola-RCHP and Glofitamab in Younger, Higher Risk Patients With Diffuse Large B Cell Lymphoma (DLBCL)
- A Phase 2 Trial of GlOfitamab anD pIrtobrutinib in Mantle Cell Lymphoma Patients With Prior BTK Inhibitor Exposure.
- A Phase 2 Trial of Glofitamab for Minimal Residual Disease in Patients With Large B-cell Lymphoma
- A Phase II Study of Glofitamab Plus Polatuzumab-R-CHP for Patients With High-risk Diffuse Large B-cell Lymphoma
- A Phase III Study Evaluating Glofitamab in Combination With Gemcitabine + Oxaliplatin vs Rituximab in Combination With Gemcitabine + Oxaliplatin in Participants With Relapsed/Refractory Diffuse Large B-Cell Lymphoma
- A Prospective, Single-Center Study Evaluating the Efficacy and Safety of Glofitamab Combined With Orelabrutinib and Bortezomib in Patients With High-Risk Mantle Cell Lymphoma
- A Study Evaluating the Efficacy, Safety, and Pharmacokinetics of Glofitamab in Combination With Rituximab Plus Ifosfamide, Carboplatin Etoposide Phosphate in Participants With Relapsed/Refractory Transplant or CAR-T Therapy Eligible Diffuse B-Cell Lymphoma
- A Study Evaluating the Safety and Efficacy of Glofitamab + Gemcitabine + Oxaliplatin in U.S. Patients With Relapsed or Refractory Diffuse Large B-Cell Lymphoma
- A Study Evaluating the Safety and Efficacy of Glofitamab or Mosunetuzumab in Combination With Gemcitabine Plus Oxaliplatin in Participants With Relapsed or Refractory Diffuse Large B-Cell Lymphoma and High-Grade Large B-Cell Lymphoma
- A Study Evaluating the Safety, Pharmacokinetics, and Efficacy of Mosunetuzumab or Glofitamab in Combination With CC-220 and/or CC-99282 in Participants With B-Cell Non-Hodgkin Lymphoma
- A Study of ARV-393 in Relapsed/Refractory Non-Hodgkin Lymphoma.
- A Study of Axicabtagene Ciloleucel and Glofitamab as Second-Line Therapy for Relapsed or Refractory Patients With Large B Cell Lymphoma
- A Study of Efficacy and Safety of Glofitamab in Combination With Salvage Therapy in a Real-world Setting in Chinese Adult Patients With Relapsed or Refractory B-cell Non-Hodgkin Lymphoma.
- A Study of Glofitamab and Lenalidomide in People With Mantle Cell Lymphoma
- A Study of Glofitamab in Combination With Rituximab or Obinutuzumab Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (CHOP), or Polatuzumab Vedotin Plus Rituximab, Cyclophosphamide, Doxorubicin, and Prednisone (CHP) in Participants With Non-Hodgkin Lymphomas or With DLBCL
- A Study of Glofitamab Plus GemOx Compared With Standard of Care in Patients With Relapsed/Refractory Diffuse Large B-Cell Lymphoma
- A Study of Glofitamab-based Treatment in People With Diffuse Large B-cell Lymphoma
- A Study of Polatuzumab Vedotin and Glofitamab in Patients With Relapsed or Refractory Diffuse Large B-Cell Lymphoma Within 12 Months After R-CHOP
- A Study to Assess BMS-986458 Alone and in Combination With Anti-lymphoma Agents in Relapsed/Refractory Non-Hodgkin Lymphomas
Approved for (2)
- Diffuse large B-cell lymphoma
- Neoplasm
In development for (7)
- B-cell non-Hodgkin lymphoma Phase 2
- Follicular lymphoma Phase 1
- Lymphoma Phase 3
- Mantle cell lymphoma Phase 2
- Neoplasm of mature B-cells Phase 1
- Non-Hodgkin lymphoma Phase 1
- Richter transformation Phase 2