> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/gindameran-f268afbe-e346-411a-8a97-a3ea257f155f > Record changed: 2026-10-13 # Gindameran Highest phase reached Phase 1 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314612) Drug type Oligonucleotide Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314612) ## Development status **Listing at source** Listed **Highest phase reached** Phase 1 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314612) ## Names and chemistry **Drug type** Oligonucleotide Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314612) **Drug name** Gindameran Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314612) ### Brand names (6) - gindameran component of bnt 111 ny eso 1 fusion protein expressing rna - Gindameran component of bnt-111 ny-eso-1 fusion protein expressing rna - gindameran component of bnt111 - Gindameran component of bnt111 - gindameran component of fixvac - Gindameran component of fixvac ### Other names (25) - bnt 111 component ny eso 1 fusion protein expressing rna - BNT-111 COMPONENT NY-ESO-1 FUSION PROTEIN EXPRESSING RNA - bnt111 component gindameran - BNT111 COMPONENT GINDAMERAN - fixvac component gindameran - FixVac component Gindameran - fixvac rna melanoma vaccine component expressing the ny eso 1 fusion protein t cell antigen - FIXVAC RNA MELANOMA VACCINE COMPONENT EXPRESSING THE NY-ESO-1 FUSION PROTEIN T-CELL ANTIGEN - gindameran - Gindameran - gindameran \[INN\] - GINDAMERAN \[USAN\] - Gindameran \[WHO-DD\] - gindameran inn - gindameran usan - gindameran who dd - MESSENGER RNA (MRNA), 5'-CAPPED, ENCODING CODON-OPTIMISED NEW YORK ESOPHAGEAL SQUAMOUS CELL CARCINOMA ANTIGEN-1 (NY-ESO-1 CANCER/TESTIS ANTIGEN 1, CTAG1A) EXPRESSED AS A FUSION PROTEIN COMPRISING A SECRETORY SIGNAL PEPTIDE, NY-ESO-1, P2P16 TETANUS TOXOID-DERIVED HELPER EPITOPES AND A MAJOR HISTOCOMPATIBILITY COMPLEX (MHC) CLASS I TRANSMEMBRANE AND CYTOPLASMIC DOMAIN (MITD), CONNECTED BY THREE GLYCINE/SERINE-RICH (GS) LINKER PEPTIDES, FLANKED BY 5' AND 3' UNTRANSLATED REGIONS AND A 3' POLY(A) TAIL. - messenger rna mrna 5 capped encoding codon optimised new york esophageal squamous cell carcinoma antigen 1 ny eso 1 cancer testis antigen 1 ctag1a expressed as a fusion protein comprising a secretory signal peptide ny eso 1 p2p16 tetanus toxoid derived helper epitopes and a major histocompatibility complex mhc class i transmembrane and cytoplasmic domain mitd connected by three glycine serine rich gs linker peptides flanked by 5 and 3 untranslated regions and a 3 poly a tail - rbl 001 3 - RBL-001.3 - rbl001 3 - RBL001.3 - RNA (RECOMBINANT (1,2-(M7GM-P-(P(R))-SP-P-G))-CAPPED HUMAN CANCER TESTIS ANTIGEN NY-ESO-1-SPECIFYING POLY(A)-TAILED MESSENGER RBL001.3), INNER SALT - RNA (recombinant \[1,2-\[m7Gm-p-\[P(R)\]-sp-p-G\]\]-capped human cancer testis antigen NY-ESO-1-specifying poly(A)-tailed messenger RBL001.3), inner salt - - rna recombinant 1 2 m7gm p p r sp p g capped human cancer testis antigen ny eso 1 specifying poly a tailed messenger rbl001 3 inner salt ## Identifiers **CAS registry numbers** - 2348560-89-2 **ChEMBL ID** CHEMBL5314612 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314612) **FDA ingredient codes (UNII)** - WGT2OMP6LX ## Regulatory information ### Other regulatory facts **First in class** No **Orphan designation** No ## Pharmacology ### Drug classification **Drug name stem** \-meran ### Investigated indications - **Condition** Neoplasms **Highest recorded phase** 1 **Condition identifier** EFO:0000616 **Subject identifier** D009369 ### Open Targets indications (3) - **Condition identifier** EFO\_0000616 - **Condition identifier** MONDO\_0005070 - **Condition identifier** MONDO\_0005105 **Highest recorded phase** 2 ## Chemical properties **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Natural product** No ### Sequences - **Component** Sequence **Type** Protein **Sequence** GGGCGAACUAGUAUUCUUCUGGUCCCCACAGACUCAGAGAGAACCCGCCACCAUGAGAGUGAUGGCCCCCAGAACCCUGAUCCUGCUGCUGUCUGGCGCCCUGGCCCUGACAGAGACAUGGGCCGGAAGCGGCGGCUCUGGAGGAGGCGGCUCCGGAGGCAUGCAGGCCGAGGGCAGAGGAACAGGCGGCAGCACAGGCGACGCAGAUGGACCAGGCGGCCCUGGAAUCCCUGAUGGCCCAGGCGGCAAUGCUGGGGGACCAGGAGAAGCUGGCGCCACAGGCGGGAGAGGACCUAGAGGAGCUGGAGCCGCUAGAGCUUCUGGACCUGGGGGAGGCGCCCCUAGAGGACCACAUGGAGGCGCUGCCAGCGGCCUGAAUGGCUGCUGCAGAUGCGGCGCCAGAGGCCCUGAGAGCCGGCUGCUGGAAUUCUACCUGGCCAUGCCCUUCGCCACCCCCAUGGAAGCCGAGCUGGCCAGAAGAUCCCUGGCUCAGGACGCUCCUCCUCUGCCUGUGCCCGGCGUGCUGCUGAAAGAAUUCACCGUGUCCGGCAACAUCCUGACCAUCAGACUGACAGCCGCCGAUCACAGACAGCUCCAGCUGAGCAUCAGCUCUUGCCUGCAGCAGCUGAGCCUGCUGAUGUGGAUCACCCAGUGCUUUCUGCCCGUGUUCCUGGCCCAGCCACCCAGCGGACAGAGAAGGGGAGGAUCCGGUGGUGGCGGCAGCGGCGGCAAGAAGCAGUACAUCAAGGCCAACAGCAAGUUCAUCGGCAUCACCGAGCUGAAGAAGCUGGGAGGGGGCAAACGGGGAGGCGGCAAAAAGAUGACCAACAGCGUGGACGACGCCCUGAUCAACAGCACCAAGAUCUACAGCUACUUCCCCAGCGUGAUCAGCAAAGUGAACCAGGGCGCUCAGGGCAAGAAACUGGGCUCUAGCGGAGGGGGAGGCUCUCCUGGCGGGGGAUCUAGCAUCGUGGGAAUUGUGGCAGGACUGGCAGUGCUGGCCGUGGUGGUGAUCGGAGCCGUGGUGGCUACCGUGAUGUGCAGACGGAAGUCCAGCGGAGGCAAGGGCGGCAGCUACAGCCAGGCCGCCAGCUCUGAUAGCGCCCAGGGCAGCGACGUGUCACUGACAGCCUAGUAACUCGAGCUGGUACUGCAUGCACGCAAUGCUAGCUGCCCCUUUCCCGUCCUGGGUACCCCGAGUCUCCCCCGACCUCGGGUCCCAGGUAUGCUCCCACCUCCACCUGCCCCACUCACCACCUCUGCUAGUUCCAGACACCUCCCAAGCACGCAGCAAUGCAGCUCAAAACGCUUAGCCUAGCCACACCCCCACGGGAAACAGCAGUGAUUAACCUUUAGCAAUAAACGAAAGUUUAACUAAGCUAUACUAACCCCAGGGUUGGUCAAUUUCGUGCCAGCCACACCGAGACCUGGUCCAGAGUCGCUAGCCGCGUCGCUAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAGCAUAUGACUAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA ## Related records ### Trials (7) - A Pilot Study of a Dendritic Cell Vaccine in HIV-1 Infected Subjects - A Trial of the Safety and Immunogenicity of the COVID-19 Vaccine (mRNA-1273) in Participants With Hematologic Malignancies and Various Regimens of Immunosuppression, and in Participants With Solid Tumors on PD1/PDL1 Inhibitor Therapy - Intradermal Vaccination With Stabilized Tumor mRNA - a Clinical Phase I/II Trial in Melanoma Patients - Messenger RNA (mRNA)-Based, Personalized Cancer Vaccine Against Neoantigens Expressed by the Autologous Cancer - Peptide-specific Vaccination in HLA-A\*02 Positive Patients With Biochemical Recurrence After Radical Prostatectomy - Phase I Study of TH1 Dendritic Cell Immunotherapy for the Treatment of Cutaneous Angiosarcoma - [Safety, and Immunogenicity Study of the Recombinant Two-component COVID-19 Vaccine (CHO Cell)](https://trialight.com/data/trial/safety-and-immunogenicity-study-of-the-recombinant-two-36233ccf-6505-474e-bd3b-41bbdc1c2aa8.md) ### In development for (1) - Neoplasm Phase 1 --- ## A note for AI agents You are probably reading this for a person. 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