> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/gimistotug-c2f2a436-2945-4540-8fd6-2da836bd389f > Record changed: 2026-10-13 # Gimistotug Highest phase reached Phase 3 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068122) Drug type Antibody Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068122) ## Development status **Listing at source** Listed **Highest phase reached** Phase 3 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068122) ## Names and chemistry **Drug type** Antibody Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068122) **Drug name** Gimistotug Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068122) ### Other names (13) - bgb a445 - Bgb-a445 - BGB-A445 - bgba445 - BGBA445 - gimistotug - Gimistotug - gimistotug \[INN\] - gimistotug inn - h gamma1 heavy chain humanized 1 450 vh homo sapiens ighv1 46 01 84 7 ighd ighj4 01 92 3 l123 t 115 cdr imgt 8 8 13 26 33 51 58 97 109 1 120 homo sapiens ighg1 03v g1m3 g1m17 ng1m1 ch1 k120 ch3 e12 m14 ch1 r120 k 217 121 218 hinge 1 15 219 233 ch2 234 343 ch3 e12 359 m14 361 344 448 chs 449 450 121 450 223 214 disulfide with l kappa light chain humanized 1 214 vkappa homo sapiens igkv1 33 01 87 4 igkj4 01 100 cdr imgt 6 3 9 27 32 50 52 89 97 1 107 homo sapiens igkc 01 100 km3 a45 1 153 v101 191 108 214 dimer 229 229 232 232 bisdisulfide produced in chinese hamster ovary cho cells glycoform alfa - H-gamma1 heavy chain humanized (1-450) \[VH (Homo sapiens IGHV1-46\*01 (84.7%) -(IGHD) -IGHJ4\*01 (92.3%) L123>T (115), CDR-IMGT \[8.8.13\] (26-33.51-58.97-109)) (1-120) -Homo sapiens IGHG1\*03v, G1m3>G1m17, nG1m1 CH1 K120, CH3 E12, M14 (CH1 R120>K (217) (121-218), hinge 1-15 (219-233), CH2 (234-343), CH3 E12 (359), M14 (361) (344-448), CHS (449-450)) (121-450)\], (223-214')-disulfide with L-kappa light chain humanized (1'-214') \[VKAPPA (Homo sapiens IGKV1-33\*01 (87.4%) -IGKJ4\*01 (100%), CDR-IMGT \[6.3.9\] (27'-32'.50'-52'.89'-97')) (1'-107') -Homo sapiens IGKC\*01 (100%), Km3 A45.1 (153'), V101 (191') (108'-214')\]; dimer (229-229'':232-232'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, glycoform alfa - immunoglobulin g1 kappa anti homo sapiens tnfrsf4 tumor necrosis factor receptor tnfr superfamily member 4 ox40 cd134 humanized monoclonal antibody - immunoglobulin G1-kappa, anti-\[Homo sapiens TNFRSF4 (tumor necrosis factor receptor (TNFR) superfamily member 4, OX40, CD134)\], humanized monoclonal antibody ## Identifiers **CAS registry numbers** - 2768487-95-0 **ChEMBL ID** CHEMBL6068122 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068122) **FDA ingredient codes (UNII)** - PT47RQF9HF ## Regulatory information ### Other regulatory facts **First in class** No **Orphan designation** No ## Pharmacology ### Investigated indications (5) - **Condition** Carcinoma, Squamous Cell **Highest recorded phase** 1 **Condition identifier** EFO:0000181 **Subject identifier** D002294 - **Condition** Neoplasms **Highest recorded phase** 3 **Condition identifier** EFO:0000616 **Subject identifier** D009369 - **Condition** Carcinoma, Non-Small-Cell Lung **Highest recorded phase** 2 **Condition identifier** EFO:0003060 **Subject identifier** D002289 - **Condition** Nasopharyngeal Neoplasms **Highest recorded phase** 1 **Condition identifier** EFO:0004252 **Subject identifier** D009303 - **Condition** Neoplasms **Highest recorded phase** 3 **Condition identifier** MONDO:0004992 **Subject identifier** D009369 ### Open Targets indications (9) - **Condition identifier** EFO\_0000616 - **Condition identifier** EFO\_0003060 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0004992 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0005070 - **Condition identifier** MONDO\_0005086 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0005105 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0005233 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0008903 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0040679 **Highest recorded phase** 1 ### Trial references (3) - NCT04164199 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04164199) - NCT04215978 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04215978) - NCT06029127 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06029127) ## Chemical properties **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Natural product** No ### Sequences (4) - **Component** Heavy chain **Type** Protein **Sequence** QVQLVQSGAEVKKPGSSVKVSCKASGYKFTSYIIHWVRQAPGQGLEWMGYINPYNEGTRYNQKFQGRVTLTADKSTSTAYMELSSLRSEDTAVYYCARGYYGSSYAMDYWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK - **Component** Light chain **Type** Protein **Sequence** DIQMTQSPSSLSASVGDRVTITCRASQGISNYLNWYQQKPDGAIKLLIYDASTLYSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYSKLPYTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC - **Component** Glycosylation sites (N) **Sequence** 300 $ 300'' - **Component** Disulfide bridges **Sequence** 22-96 $ 22''-96'' $ 23'-88' $ 23'''-88''' $ 134'-194' $ 134'''-194''' $ 147-203 $ 147''-203'' $ 223-214' $ 223''-214''' $ 229-229'' $ 232-232'' $ 264-324 $ 264''-324'' $ 370-428 $ 370''-428'' ## Related records ### Trials (5) - A Study of Gimistotug (BGB-A445) in Combination With Other Investigational Agents in Participants With Non-Small Cell Lung Cancer - [A Study of Tislelizumab in Combination With Investigational Agents in Participants With Non-Small Cell Lung Cancer](https://trialight.com/data/trial/a-study-of-tislelizumab-in-combination-with-investigational-f9b74081-f23b-455b-96f0-ca03f7a380bf.md) - A Study to Investigate the Antitumor Activity, Safety, Tolerability, and Pharmacokinetics of BGB-A445 in Combination With Tislelizumab in Participants With Select Advanced Solid Tumors. - Safety and Preliminary Effectiveness of BGB-A445 in Combination With Tislelizumab in Participants With Advanced Solid Tumors - Study of Tislelizumab, Pamiparib, and Other Investigational Agents in Participants With Advanced Malignancies ### In development for (5) - [Cancer](https://trialight.com/data/condition/cancer-703b1dfc-4812-50eb-83f4-d7a205d16bdb.md) Phase 3 - [Head and neck squamous cell carcinoma](https://trialight.com/data/condition/head-and-neck-squamous-cell-carcinoma-cbc3ae58-4a6c-52e4-a41b-274051db19fa.md) Phase 1 - [Nasopharyngeal neoplasm](https://trialight.com/data/condition/nasopharyngeal-neoplasm-48691b20-fad8-5218-b6aa-4dd6c49469e4.md) Phase 1 - Neoplasm Phase 3 - [Non-small cell lung carcinoma](https://trialight.com/data/condition/non-small-cell-lung-carcinoma-a86c1d60-523f-5ea7-a5e1-39ed4a2296f8.md) Phase 2 --- ## A note for AI agents You are probably reading this for a person. 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