> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/gilvetmab-4079fd36-a0c4-44f0-96bd-7888b5841291
> Record changed: 2026-10-13

# Gilvetmab

Highest phase reached

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3990007)

Drug type

Antibody

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3990007)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3990007)

## Names and chemistry

**Drug type**

Antibody

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3990007)

**Drug name**

Gilvetmab

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3990007)

### Other names (18)

- endostar pd 1 inhibitor
- gilvetmab
- Gilvetmab
- gilvetmab \[INN\]
- GILVETMAB \[USAN\]
- gilvetmab inn
- gilvetmab usan
- immunoglobulin gb anti canis familiaris programmed cell death protein 1 canis familiaris mus musculus monoclonal heavy chain disulfide with canis familiaris mus musculus light chain dimer
- IMMUNOGLOBULIN GB, ANTI-(CANIS FAMILIARIS PROGRAMMED CELL DEATH PROTEIN 1) (CANIS FAMILIARIS-MUS MUSCULUS MONOCLONAL HEAVY CHAIN), DISULFIDE WITH CANIS FAMILIARIS-MUS MUSCULUS LIGHT CHAIN, DIMER
- pd 1 gilvetmab
- pd 1 inhibitor gilvetmab
- Pd-1 (gilvetmab)
- PD-1 inhibitor
- PD-1 Inhibitor
- Pd-1 inhibitor (gilvetmab)
- PD-1inhibitor
- pd1
- PD1

## Identifiers

**CAS registry numbers**

- 1808081-43-7

**ChEMBL ID**

CHEMBL3990007

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3990007)

**FDA ingredient codes (UNII)**

- 949NG8376D

## Regulatory information

### Other regulatory facts

**Patents**

0

**Designations**

1

**First in class**

No

**Fast track**

No

**Breakthrough designation**

No

**Orphan designation**

No

**Priority review**

No

**Orphan exclusivity**

No

**Accelerated approval**

No

## Pharmacology

### Drug classification

**Drug name stem**

\-mab

### Open Targets indications (12)

- **Condition identifier**  
EFO\_0000181

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0005537
- **Condition identifier**  
MONDO\_0001056

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0002691

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0003060

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0004952

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005105

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005575

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0007256

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0009831

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0010150

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0040679

**Highest recorded phase**  
2

### Reported adverse events (70)

- **Event**  
abdominal infection

**Reports**  
3

**Reporting signal score**

13.1537
- **Event**  
abdominal pain

**Reports**  
15

**Reporting signal score**

21.1216
- **Event**  
adrenal insufficiency

**Reports**  
4

**Reporting signal score**

11.2464
- **Event**  
alanine aminotransferase increased

**Reports**  
20

**Reporting signal score**

51.4244
- **Event**  
amylase increased

**Reports**  
2

**Reporting signal score**

6.17235
- **Event**  
anaemia

**Reports**  
32

**Reporting signal score**

69.7599
- **Event**  
ascites

**Reports**  
5

**Reporting signal score**

11.0281
- **Event**  
aspartate aminotransferase increased

**Reports**  
20

**Reporting signal score**

53.7244
- **Event**  
blood bilirubin increased

**Reports**  
8

**Reporting signal score**

20.2336
- **Event**  
blood creatinine increased

**Reports**  
5

**Reporting signal score**

6.80073
- **Event**  
cardiotoxicity

**Reports**  
3

**Reporting signal score**

8.31973
- **Event**  
cerebral radiation injury

**Reports**  
1

**Reporting signal score**

8.35679
- **Event**  
constipation

**Reports**  
11

**Reporting signal score**

15.3768
- **Event**  
cortisol abnormal

**Reports**  
1

**Reporting signal score**

6.37632
- **Event**  
decreased appetite

**Reports**  
25

**Reporting signal score**

56.394
- **Event**  
dermatitis

**Reports**  
5

**Reporting signal score**

14.1823
- **Event**  
diarrhoea

**Reports**  
35

**Reporting signal score**

51.3806
- **Event**  
endocrine toxicity

**Reports**  
1

**Reporting signal score**

6.97075
- **Event**  
fatigue

**Reports**  
29

**Reporting signal score**

35.0731
- **Event**  
gastrointestinal disorder

**Reports**  
6

**Reporting signal score**

10.5574
- **Event**  
gastrointestinal haemorrhage

**Reports**  
8

**Reporting signal score**

13.0745
- **Event**  
gastrointestinal toxicity

**Reports**  
3

**Reporting signal score**

10.0581
- **Event**  
gingival bleeding

**Reports**  
3

**Reporting signal score**

7.58019
- **Event**  
haematotoxicity

**Reports**  
5

**Reporting signal score**

15.5255
- **Event**  
hepatic function abnormal

**Reports**  
14

**Reporting signal score**

40.3843

And 45 more, listed on the interactive page.

## Chemical properties

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Natural product**

No

### Sequences (3)

- **Component**  
Heavy chain

**Type**  
Protein

**Sequence**  
EVQLVQSGGDLVKPGGSVRLSCVASGFNIKNTYMHWVRQAPGKGLQWIGRIAPANVDTKYAPKFQGKATISADTAKNTAYMQLNSLRAEDTAVYYCVLIYYDYDGDIDVWGQGTLVTVSSASTTAPSVFPLAPSCGSTSGSTVALACLVSGYFPEPVTVSWNSGSLTSGVHTFPSVLQSSGLYSLSSMVTVPSSRWPSETFTCNVAHPASKTKVDKPVPKRENGRVPRPPDCPKCPAPEMLGGPSVFIFPPKPKDTLLIARTPEVTCVVVALDPEDPEVQISWFVDGKQMQTAKTQPREEQFAGTYRVVSVLPIGHQDWLKGKQFTCKVNNKALPSPIERTISKARGQAHQPSVYVLPPSREELSKNTVSLTCLIKDFFPPDIDVEWQSNGQQEPESKYRTTPPQLDEDGSYFLYSKLSVDKSRWQRGDTFICAVMHEALHNHYTQESLSHSPGK
- **Component**  
Disulfide bridges location

**Sequence**  
22-96$22''-96$23'-88'$23'''-88'''$134'-194'$134'''-194'''$135-214'$135''-214'''$147-203$147''-203''$232-232''$235-235''$267-327$267''-327''$373-433$373''-433''
- **Component**  
Light chain

**Type**  
Protein

**Sequence**  
DIVMTQTPLSLSVSLGEPASISCHASQNINVWLSWYRQKPGQIPQLLIYKASHLHTGVPDRFSGSGSGTDFTLRISRVEADDAGVYYCQQGQSWPLTFGQGTKVEIKRNDAQPAVYLFQPSPDQLHTGSASVVCLLNSFYPKDINVKWKVDGVIQDTGIQESVTEQDSKDSTYSLSSTLTMSSTEYLSHELYSCEITHKSLPSTLIKSFQRSECQRVD

## Related records

### Trials (266)

- A Clinical Study Evaluating the Efficacy and Safety of Disitamab Vedotin Combined With PD-1 Inhibitor and Radiotherapy as Bladder-preserving Therapy in Patients With Localized HER2-high Expressing Muscle-invasive Bladder Urothelial Carcinoma Following Maximal Transurethral Resection
- A Clinical Study of Recombinant Human Vascular Endothelial Inhibitor in Combination With PRaG for Advanced Refractory Non-small Cell Lung Cancer
- A Combination Study of CAR-T Therapy in r/r B-NHL
- A Phase 1 Study of ADA-011 for Subjects With Advanced Solid Tumors
- A Phase Ib/II Study of BM230 in Combination With PD-1 Inhibitor for HER2-related Advanced Solid Tumors
- A Phase II Study of PD-1/IL-2α-bias Bispecific Antibody Fusion Protein Monotherapy in Advanced Esophageal Squamous Cell Carcinoma After Failure of Prior ICI Plus Platinum-Based Chemotherapy
- A Phase II Study of SSGJ-706 Monotherapy and Combination Therapy in Advanced Non-Small Cell Lung Cancer（NSCLC） Patients
- A Phase II Study of SSGJ-707 Combination Therapy in Advanced NSCLC Patients
- A Phase II Trial Comparing Immunotherapy Versus Capecitabine Maintenance After Chemo-chemoradiotherapy for High-risk Nasopharyngeal Carcinoma
- A Phase II Trial of LM103 for Adjuvant Treatment in Patients With Non-small Cell Lung Cancer
- A Phase III Trial of Neoadjuvant Sintilimab and Chemotherapy for NSCLC Harboring No Driver Mutations
- A Prospective Study of PD-1 Inhibitor Combined With ICE in the Treatment of Relapsed/Refractory Gray Area Lymphoma
- A Prospective, Multicenter, Observational Cohort Study Assessing the Efficacy and Safety of Radiotherapy-sensitized Immunotherapy in Advanced Breast Cancer
- A Real-world Study of Chidamide in Combination with PD-1/PD-L1 Antibodies and Anti-angiogenic Agents in Advanced MSS Colorectal Cancer
- A Single Center Study of Donafenib Combined With PD-1 + TACE in the First-line Treatment of aHCC
- A Study Comparing BL-B01D1 in Combination With PD-1/VEGF Bispecific Antibody Versus Chemotherapy in Combination With PD-1/VEGF Bispecific Antibody in First-line Patients With Locally Advanced or Metastatic Squamous Non-small Cell Lung Cancer(PANKU-Lung05)
- A Study Evaluating BL-B01D1 in Combination With a PD-1/VEGF Bispecific Antibody Versus Tislelizumab Plus Platinum-doublet Chemotherapy as First-line Treatment for Locally Advanced or Metastatic Non-squamous Non-small Cell Lung Cancer(PANKU-Lung06)
- A Study Investigating AGEN1777 in Participants With Advanced Solid Tumors
- A Study of Anlotinib Combined With or Without PD-1 Antibody on Unresectable High-grade Chondrosarcoma
- A Study of BL-B01D1 + PD-1 in Patients With Locally Advanced or Metastatic Urothelial Carcinoma

### In development for (1)

- [Head and neck squamous cell carcinoma](https://trialight.com/data/condition/head-and-neck-squamous-cell-carcinoma-cbc3ae58-4a6c-52e4-a41b-274051db19fa.md) Phase 2

### Other linked conditions (1)

- [Triple-negative breast carcinoma](https://trialight.com/data/condition/triple-negative-breast-carcinoma-059174a2-9b5f-5234-90b9-4a4fee6eb9bb.md)

---

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