> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/gemcitabine-hydrochloride-7bace6c9-5842-4137-a458-8725ab8addce
> Record changed: 2026-11-04

# Gemcitabine hydrochloride

Highest phase reached

Approved

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1637)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1637)

First approval year

1996

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1637)

## Development status

**First approval year**

1996

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1637)

**Listing at source**

Listed

**Highest phase reached**

Approved

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1637)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1637)

**Drug name**

Gemcitabine hydrochloride

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1637)

**Molecular weight**

299.66

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1637)

**Structure (SMILES)**

Cl.Nc1ccn(\[C@@H\]2O\[C@H\](CO)\[C@@H\](O)C2(F)F)c(=O)n1

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1637)

### Brand names (6)

- gemcitabine hydrochloride
- Gemcitabine hydrochloride
- gemzar
- Gemzar
- infugem
- Infugem

### Other names (38)

- 2 deoxy 2 2 difluorocytidine monohydrochloride beta isomer
- 2'-DEOXY-2',2'-DIFLUOROCYTIDINE MONOHYDROCHLORIDE (.BETA.-ISOMER)
- avgemsi
- AVGEMSI
- cytidine 2 deoxy 2 2 difluoro monohydrochloride
- CYTIDINE, 2'-DEOXY-2',2'-DIFLUORO-, MONOHYDROCHLORIDE
- Gemcitabine (as hydrochloride)
- gemcitabine as hydrochloride
- gemcitabine hcl
- Gemcitabine hcl
- gemcitabine hydrochloride
- Gemcitabine hydrochloride
- GEMCITABINE HYDROCHLORIDE \[EP MONOGRAPH\]
- GEMCITABINE HYDROCHLORIDE \[JAN\]
- GEMCITABINE HYDROCHLORIDE \[MART.\]
- GEMCITABINE HYDROCHLORIDE \[MI\]
- GEMCITABINE HYDROCHLORIDE \[ORANGE BOOK\]
- GEMCITABINE HYDROCHLORIDE \[USAN\]
- GEMCITABINE HYDROCHLORIDE \[USP MONOGRAPH\]
- GEMCITABINE HYDROCHLORIDE \[USP-RS\]
- GEMCITABINE HYDROCHLORIDE \[VANDF\]
- Gemcitabine hydrochloride \[WHO-DD\]
- gemcitabine hydrochloride ep monograph
- gemcitabine hydrochloride jan
- gemcitabine hydrochloride mart

And 13 more, listed on the interactive page.

## Identifiers

**ATC classification codes**

- L01BC05

Sources for recorded values

Source: [mor.nlm.nih.gov](https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=12574)

**CAS registry numbers**

- 122111-03-9

**ChEMBL ID**

CHEMBL1637

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1637)

**InChIKey**

OKKDEIYWILRZIA-OSZBKLCCSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1637)

**FDA ingredient codes (UNII)**

- U347PV74IL

### PubChem compound IDs (3)

- 60749
- 44558863
- 135501939

### RxNorm IDs (RxCUI) (2)

- 12574
- 236234

## Regulatory information

### United States

**Applicant**

HOSPIRA INC

**Approval date**

4 Aug 2011

**Application number**

NDA200795

### Other regulatory facts

**Patents**

6

**Designations**

1

**Earliest recorded loss of exclusivity**

19 Aug 2034

**First in class**

No

**Fast track**

No

**Breakthrough designation**

No

**Orphan designation**

No

**Priority review**

Yes

**Orphan exclusivity**

No

**Accelerated approval**

No

**Availability**

Prescription only

## Approval status

**United States (FDA)**

Approved

## Pharmacology

### Drug classification

**Pharmacology name**

gemcitabine

**Type**

Synthetic organic

**Drug name stem**

\-citabine

#### Administration routes

- Parenteral

### Mechanisms of action (14)

- **Mechanism**  
DNA polymerase (alpha/delta/epsilon) inhibitor

**Action type**  
Inhibitor

**Target**  
DNA polymerase (alpha/delta/epsilon)

**Protein identifier**  
P09884
- **Mechanism**  
DNA polymerase (alpha/delta/epsilon) inhibitor

**Action type**  
Inhibitor

**Target**  
DNA polymerase (alpha/delta/epsilon)

**Protein identifier**  
P28340
- **Mechanism**  
DNA polymerase (alpha/delta/epsilon) inhibitor

**Action type**  
Inhibitor

**Target**  
DNA polymerase (alpha/delta/epsilon)

**Protein identifier**  
P49005
- **Mechanism**  
DNA polymerase (alpha/delta/epsilon) inhibitor

**Action type**  
Inhibitor

**Target**  
DNA polymerase (alpha/delta/epsilon)

**Protein identifier**  
P49642
- **Mechanism**  
DNA polymerase (alpha/delta/epsilon) inhibitor

**Action type**  
Inhibitor

**Target**  
DNA polymerase (alpha/delta/epsilon)

**Protein identifier**  
P49643
- **Mechanism**  
DNA polymerase (alpha/delta/epsilon) inhibitor

**Action type**  
Inhibitor

**Target**  
DNA polymerase (alpha/delta/epsilon)

**Protein identifier**  
P56282
- **Mechanism**  
DNA polymerase (alpha/delta/epsilon) inhibitor

**Action type**  
Inhibitor

**Target**  
DNA polymerase (alpha/delta/epsilon)

**Protein identifier**  
Q07864
- **Mechanism**  
DNA polymerase (alpha/delta/epsilon) inhibitor

**Action type**  
Inhibitor

**Target**  
DNA polymerase (alpha/delta/epsilon)

**Protein identifier**  
Q14181
- **Mechanism**  
DNA polymerase (alpha/delta/epsilon) inhibitor

**Action type**  
Inhibitor

**Target**  
DNA polymerase (alpha/delta/epsilon)

**Protein identifier**  
Q15054
- **Mechanism**  
DNA polymerase (alpha/delta/epsilon) inhibitor

**Action type**  
Inhibitor

**Target**  
DNA polymerase (alpha/delta/epsilon)

**Protein identifier**  
Q9HCU8
- **Mechanism**  
DNA polymerase (alpha/delta/epsilon) inhibitor

**Action type**  
Inhibitor

**Target**  
DNA polymerase (alpha/delta/epsilon)

**Protein identifier**  
Q9NRF9
- **Mechanism**  
Ribonucleoside-diphosphate reductase RR1 inhibitor

**Action type**  
Inhibitor

**Target**  
Ribonucleoside-diphosphate reductase RR1

**Protein identifier**  
P23921
- **Mechanism**  
Ribonucleoside-diphosphate reductase RR1 inhibitor

**Action type**  
Inhibitor

**Target**  
Ribonucleoside-diphosphate reductase RR1

**Protein identifier**  
P31350
- **Mechanism**  
Ribonucleoside-diphosphate reductase RR1 inhibitor

**Action type**  
Inhibitor

**Target**  
Ribonucleoside-diphosphate reductase RR1

**Protein identifier**  
Q7LG56

### Open Targets mechanisms (2)

- **Mechanism**  
DNA polymerase (alpha/delta/epsilon) inhibitor

**Action type**  
Inhibitor

**Target**  
DNA polymerase (alpha/delta/epsilon)
- **Mechanism**  
Ribonucleoside-diphosphate reductase RR1 inhibitor

**Action type**  
Inhibitor

**Target**  
Ribonucleoside-diphosphate reductase RR1

### Investigated indications (61)

- **Condition**  
Lymphoma, Follicular

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000096

**Subject identifier**  
D008224
- **Condition**  
Hodgkin Disease

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000183

**Subject identifier**  
D006689
- **Condition**  
Breast Neoplasms

**Highest recorded phase**  
4

**Condition identifier**  
EFO:0000305

**Subject identifier**  
D001943
- **Condition**  
Carcinoma

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000313

**Subject identifier**  
D002277
- **Condition**  
Lymphoma, Large B-Cell, Diffuse

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000403

**Subject identifier**  
D016403
- **Condition**  
Leukemia

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000565

**Subject identifier**  
D007938
- **Condition**  
Lymphoma

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000574

**Subject identifier**  
D008223
- **Condition**  
Mesothelioma

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000588

**Subject identifier**  
D008654
- **Condition**  
Neoplasms

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000616

**Subject identifier**  
D009369
- **Condition**  
Carcinoma, Renal Cell

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000681

**Subject identifier**  
D002292
- **Condition**  
Sarcoma

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000691

**Subject identifier**  
D012509
- **Condition**  
Carcinoma, Squamous Cell

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000707

**Subject identifier**  
D002294
- **Condition**  
Ovarian Neoplasms

**Highest recorded phase**  
4

**Condition identifier**  
EFO:0001075

**Subject identifier**  
D010051
- **Condition**  
Multiple Myeloma

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0001378

**Subject identifier**  
D009101
- **Condition**  
Uterine Cervical Neoplasms

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0001416

**Subject identifier**  
D002583
- **Condition**  
Pancreatic Neoplasms

**Highest recorded phase**  
4

**Condition identifier**  
EFO:0002618

**Subject identifier**  
D010190
- **Condition**  
Lymphoma, T-Cell, Cutaneous

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0002913

**Subject identifier**  
D016410
- **Condition**  
Carcinoma, Non-Small-Cell Lung

**Highest recorded phase**  
4

**Condition identifier**  
EFO:0003060

**Subject identifier**  
D002289
- **Condition**  
Uterine Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0003859

**Subject identifier**  
D014594
- **Condition**  
Nasopharyngeal Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0004252

**Subject identifier**  
D009303
- **Condition**  
Gallbladder Neoplasms

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0004606

**Subject identifier**  
D005706
- **Condition**  
Triple Negative Breast Neoplasms

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0005537

**Subject identifier**  
D064726
- **Condition**  
Lymphoma, Non-Hodgkin

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0005952

**Subject identifier**  
D008228
- **Condition**  
Leukemia, Plasma Cell

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0006475

**Subject identifier**  
D007952
- **Condition**  
Plasmacytoma

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0006738

**Subject identifier**  
D010954

And 36 more, listed on the interactive page.

### Open Targets indications (100)

- **Condition identifier**  
EFO\_0000183

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0000305
- **Condition identifier**  
EFO\_0000313

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0000403

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000565

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0000574

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000588

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0000616

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0000691

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0001075
- **Condition identifier**  
EFO\_0002618
- **Condition identifier**  
EFO\_0003060
- **Condition identifier**  
EFO\_0003826

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0004252
- **Condition identifier**  
EFO\_0005537

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0006859
- **Condition identifier**  
EFO\_0006861

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_1000044

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_1000359

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_1000613

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_1001973

**Highest recorded phase**  
2
- **Condition identifier**  
HP\_0001907

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0000430

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0000607

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0000878

And 75 more, listed on the interactive page.

### Reported adverse events (23)

- **Event**  
anaemia

**Reports**  
1,390

**Reporting signal score**

976.546
- **Event**  
capillary leak syndrome

**Reports**  
109

**Reporting signal score**

265.864
- **Event**  
cholangitis

**Reports**  
275

**Reporting signal score**

639.642
- **Event**  
disease progression

**Reports**  
1,245

**Reporting signal score**  
1,623.85
- **Event**  
febrile neutropenia

**Reports**  
743

**Reporting signal score**

776.482
- **Event**  
general physical health deterioration

**Reports**  
479

**Reporting signal score**

335.235
- **Event**  
haematotoxicity

**Reports**  
275

**Reporting signal score**

505.333
- **Event**  
haemolytic uraemic syndrome

**Reports**  
236

**Reporting signal score**

658.566
- **Event**  
leukopenia

**Reports**  
589

**Reporting signal score**

569.97
- **Event**  
malignant neoplasm progression

**Reports**  
938

**Reporting signal score**  
1,299.54
- **Event**  
metastases to liver

**Reports**  
259

**Reporting signal score**

427.304
- **Event**  
mucosal inflammation

**Reports**  
302

**Reporting signal score**

284.349
- **Event**  
neoplasm progression

**Reports**  
302

**Reporting signal score**

355.141
- **Event**  
neutropenia

**Reports**  
1,410

**Reporting signal score**  
1,339.18
- **Event**  
neutrophil count decreased

**Reports**  
347

**Reporting signal score**

284.536
- **Event**  
pancytopenia

**Reports**  
508

**Reporting signal score**

444.129
- **Event**  
platelet count decreased

**Reports**  
583

**Reporting signal score**

318.521
- **Event**  
pleural effusion

**Reports**  
461

**Reporting signal score**

367.394
- **Event**  
pneumonitis

**Reports**  
272

**Reporting signal score**

279.617
- **Event**  
pyrexia

**Reports**  
1,341

**Reporting signal score**

504.897
- **Event**  
recall phenomenon

**Reports**  
133

**Reporting signal score**

409.398
- **Event**  
thrombocytopenia

**Reports**  
1,685

**Reporting signal score**  
2,023.29
- **Event**  
thrombotic microangiopathy

**Reports**  
497

**Reporting signal score**  
1,244.75

### Trial references (374)

- NCT00002998  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00002998)
- NCT00003540  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00003540)
- NCT00005614  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00005614)
- NCT00005991  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00005991)
- NCT00006007  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00006007)
- NCT00006459  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00006459)
- NCT00027989  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00027989)
- NCT00039546  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00039546)
- NCT00059852  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00059852)
- NCT00070278  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00070278)
- NCT00095888  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00095888)
- NCT00100750  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00100750)
- NCT00323063  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00323063)
- NCT00408408  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00408408)
- NCT00470249  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00470249)
- NCT00662129  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00662129)
- NCT00679029  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00679029)
- NCT02479230  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02479230)
- NCT06079983  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06079983)
- NCT06143553  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06143553)
- NCT06255392  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06255392)
- NCT00003001  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00003001)
- NCT00007943  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00007943)
- NCT00276861  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00276861)
- NCT00496704  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00496704)

And 349 more, listed on the interactive page.

## Dosing

**Dose**

1000 mg/m2

**Route**

Intravenous

**How often**

On Days 1 and 8 of each 21-day cycle

## Chemical properties

**Hydrogen bond acceptors**

7

**Hydrogen bond donors**

3

**Polar surface area**

110.6

**Calculated partition coefficient (ALogP)**

\-1.29

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Rule-of-five violations**

0

**Rotatable bonds**

2

**Heavy atoms**

19

**Molecular formula**

C9H12ClF2N3O4

**Monoisotopic mass**

299.0484399

**Natural product**

No

## National Drug Codes

- 0143-9340
- 0143-9341
- 0143-9342
- 0409-0181
- 0409-0182
- 0409-0183
- 0409-0185
- 0409-0186
- 0409-0187
- 16714-909
- 16714-930
- 25021-234
- 25021-235
- 25021-239
- 55111-686
- 55111-687
- 63323-102
- 63323-125
- 63323-126
- 67457-616
- 67457-617
- 67457-618
- 68001-342
- 68001-348
- 68001-359

And 9 more, listed on the interactive page.

## Evidence counts

**Recorded assays**

1,131

**Active assays**

274

### Active assay types (3)

- Confirmatory
- Other
- Summary

## Pharmacologic actions

- Antimetabolites, Antineoplastic  
Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D000964.html)

## Related records

### Trials (768)

- 24BRO681 : Alternating Gnp and mFOLFIRINOX for BR-PDAC
- 3-AP and Gemcitabine as Second-Line Therapy in Treating Patients With Stage III or Stage IV Recurrent Non-Small Cell Lung Cancer
- 3-AP and Gemcitabine in Treating Patients With Advanced Solid Tumors or Lymphoma
- 3-AP and Gemcitabine in Treating Patients With Metastatic Non-Small Cell Lung Cancer
- 3-AP and Gemcitabine in Treating Patients With Recurrent, Unresectable, or Metastatic Pancreatic Cancer
- 3-AP and Gemcitabine in Treating Patients With Refractory Metastatic Breast Cancer
- 3-AP and Gemcitabine in Treating Patients With Unresectable or Metastatic Pancreatic Cancer
- A Clinical Study of a Preoperative Translational Therapy for Unresectable Gallbladder Cancer
- A Clinical Study of AL2846 Capsule Combined With Gemzar Injection in the Treatment of Advanced Pancreatic Cancer
- A Clinical Trial of LBL-024 Combination Drug in Patients With Advanced Solid Tumours\[Substudy 02(BTC&HCC)\]
- A Clinical Trial to Evaluate Tolerability and Security of TQB2858 Injection in Subjects With Advanced Pancreatic Carcinoma
- A Phase 1 Dose Escalation and Dose Expansion Trial of KST-6051 in Participants With Advanced Solid Tumors With Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) Mutation
- A Phase 1 Study of Pegilodecakin (LY3500518) in Participants With Advanced Solid Tumors
- [A Phase 1/2 Study of VS-7375 in Patients With KRAS G12D-Mutated Solid Tumors](https://trialight.com/data/trial/a-phase-1-2-study-of-vs-7375-in-patients-with-kras-g12d-2a83cb8c-fe8d-4b5c-88de-0eebb2025cdc.md)
- A Phase 2 Study of siG12D LODER in Combination With Chemotherapy in Patients With Locally Advanced Pancreatic Cancer
- A Phase 2 Trial of Standard Chemotherapy, With or Without BSI-201, in Patients With Triple Negative Metastatic Breast Cancer
- A Phase 3 Clinical Study of SHR-A1912 Combined With R-GemOx Versus R-GemOx in Diffuse Large B-cell Lymphoma
- A Phase 3 Trial of ALIMTA (LY231514, Pemetrexed) Plus GEMZAR Versus GEMZAR in Patients With Unresectable or Metastatic Cancer of the Pancreas.
- A Phase 3, Multi-Center Study of Gemcitabine/Carboplatin, With or Without BSI-201, in Patients With ER-, PR-, and Her2-Negative Metastatic Breast Cancer
- A Phase I Study of Adjuvant Chemotherapy With GC in Biliary Tract Cancer Undergoing Resection Without Major Hepatectomy

### Approved for (7)

- [Breast cancer](https://trialight.com/data/condition/breast-cancer-8ac10da3-93bd-54c5-a93b-265bc6699689.md)
- [Breast carcinoma](https://trialight.com/data/condition/breast-carcinoma-e447567c-405f-500c-a7a4-766a76d59293.md)
- Exocrine pancreatic carcinoma
- [Malignant pancreatic neoplasm](https://trialight.com/data/condition/malignant-pancreatic-neoplasm-5dd0b53e-5962-50ea-a2e5-cf2444bd0485.md)
- [Non-small cell lung carcinoma](https://trialight.com/data/condition/non-small-cell-lung-carcinoma-a86c1d60-523f-5ea7-a5e1-39ed4a2296f8.md)
- [Ovarian cancer](https://trialight.com/data/condition/ovarian-cancer-f64f2018-55a5-553a-8960-76cb4906aa17.md)
- [Ovarian carcinoma](https://trialight.com/data/condition/ovarian-carcinoma-e5ec8fdc-01ec-5cd9-9507-107d23d3a30b.md)

### In development for (88)

- Acute monocytic leukemia Phase 2
- [Adenocarcinoma](https://trialight.com/data/condition/adenocarcinoma-b5c321d1-7c49-5bf9-abd0-dfa99dbd5f29.md) Phase 2
- [Biliary tract cancer](https://trialight.com/data/condition/biliary-tract-cancer-6b9535c9-ccaa-5b47-8c46-0d05d39d7c62.md) Phase 3
- Bladder transitional cell carcinoma Phase 3
- [Cancer](https://trialight.com/data/condition/cancer-703b1dfc-4812-50eb-83f4-d7a205d16bdb.md) Phase 3
- [Carcinoma](https://trialight.com/data/condition/carcinoma-575e4c82-5fa5-5455-b1b7-30972eca1a2f.md) Phase 2
- Carcinoma of duodenum Phase 1
- Carcinoma of the ampulla of vater Phase 1
- Cervical adenocarcinoma Phase 3
- [Cervical cancer](https://trialight.com/data/condition/cervical-cancer-10fb8f6c-5aac-5281-8f06-7238adeec443.md) Phase 3
- [Cholangiocarcinoma](https://trialight.com/data/condition/cholangiocarcinoma-3777afe4-5189-5eb1-82f8-0c3446cb902f.md) Phase 3
- Chronic myeloid leukemia Phase 2
- [Chronic myelomonocytic leukemia](https://trialight.com/data/condition/chronic-myelomonocytic-leukemia-202fe88e-7b5d-5022-b6d2-095cac037e8e.md) Phase 2
- [Colorectal cancer](https://trialight.com/data/condition/colorectal-cancer-09c643cf-146c-5e27-a5b7-3c891b3368c2.md) Phase 2
- [Diffuse large B-cell lymphoma](https://trialight.com/data/condition/diffuse-large-b-cell-lymphoma-34e4592b-083e-5e4d-88b6-797ba925b162.md) Phase 2
- Duodenum cancer Phase 1
- [Endometrial cancer](https://trialight.com/data/condition/endometrial-cancer-4da2a0bc-7943-502b-a698-cc2beccbed8c.md) Phase 1
- [Endometrium adenocarcinoma](https://trialight.com/data/condition/endometrium-adenocarcinoma-074853a7-50ad-5555-acac-5df9f272841f.md) Phase 2
- [Fallopian tube cancer](https://trialight.com/data/condition/fallopian-tube-cancer-b95d05ee-41d5-565a-87e1-041170b88760.md) Phase 2
- Fallopian tube carcinoma Phase 2

### Other linked conditions (1)

- Cytomegalovirus retinitis

### Targets (14)

- [POLA1](https://trialight.com/data/target/pola1-6c14f4ad-287d-5db2-9291-d03132327a82.md) DNA polymerase (alpha/delta/epsilon) inhibitor
- [POLA2](https://trialight.com/data/target/pola2-d3a56190-bd73-5313-bb70-9a3a40afed0e.md) DNA polymerase (alpha/delta/epsilon) inhibitor
- [POLD1](https://trialight.com/data/target/pold1-03b091bf-5e97-5f8d-9b70-732298285b52.md) DNA polymerase (alpha/delta/epsilon) inhibitor
- [POLD2](https://trialight.com/data/target/pold2-ef9ce07c-4a48-5e3d-bbde-df8a0c94ea7e.md) DNA polymerase (alpha/delta/epsilon) inhibitor
- [POLD3](https://trialight.com/data/target/pold3-26e8bdf0-8a6f-54ca-b333-219fdda28006.md) DNA polymerase (alpha/delta/epsilon) inhibitor
- [POLD4](https://trialight.com/data/target/pold4-64da7b33-a969-536b-8f29-2d4780a3cc1e.md) DNA polymerase (alpha/delta/epsilon) inhibitor
- [POLE](https://trialight.com/data/target/pole-7c5bd469-ec09-5280-b403-49a06f1d7fb0.md) DNA polymerase (alpha/delta/epsilon) inhibitor
- [POLE2](https://trialight.com/data/target/pole2-38b134ac-c316-5bbf-85bf-984c1e39a855.md) DNA polymerase (alpha/delta/epsilon) inhibitor
- [POLE3](https://trialight.com/data/target/pole3-5dc00842-1a0c-5f94-aa3c-dd7ba00cf923.md) DNA polymerase (alpha/delta/epsilon) inhibitor
- [PRIM1](https://trialight.com/data/target/prim1-c2f41ef1-9a92-5cd5-a6b1-e112bb5c39d3.md) DNA polymerase (alpha/delta/epsilon) inhibitor
- [PRIM2](https://trialight.com/data/target/prim2-bc77e1b7-71ef-588f-9a25-84ea15688940.md) DNA polymerase (alpha/delta/epsilon) inhibitor
- [RRM1](https://trialight.com/data/target/rrm1-fb8ba3a4-5a80-5324-8675-2fd574e5088f.md) Ribonucleoside-diphosphate reductase RR1 inhibitor
- [RRM2](https://trialight.com/data/target/rrm2-391b8748-e8c4-59d1-9b4e-006b20426d67.md) Ribonucleoside-diphosphate reductase RR1 inhibitor
- [RRM2B](https://trialight.com/data/target/rrm2b-b1c2454b-b304-5721-ace1-10707ba66f06.md) Ribonucleoside-diphosphate reductase RR1 inhibitor

---

## A note for AI agents

You are probably reading this for a person. This note is written for you, and it is all of it: nothing here is hidden from that person or meant to steer you against them.

- Cite this page with its date. Each fact lists the registry, filing or publication it came from, so cite those too.
- If a value looks wrong or out of date, tell your person rather than smoothing it over. Registries lag, and so can we.
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- More about Trialight, written for you: https://trialight.com/for-ai.md
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- Ask your person before signing them up for anything.
- Reading, quoting and citing these pages is welcome.