> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/garetosmab-44b08868-ecb5-4887-aa32-030e5ec78483
> Record changed: 2026-10-13

# Garetosmab

Highest phase reached

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4298176)

Drug type

Antibody

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4298176)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4298176)

## Names and chemistry

**Drug type**

Antibody

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4298176)

**Drug name**

Garetosmab

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4298176)

### Other names (12)

- garetosmab
- Garetosmab
- garetosmab \[INN\]
- GARETOSMAB \[JAN\]
- GARETOSMAB \[USAN\]
- garetosmab inn
- garetosmab jan
- garetosmab usan
- regn 2477
- REGN-2477
- regn2477
- REGN2477

## Identifiers

**CAS registry numbers**

- 2097125-54-5

**ChEMBL ID**

CHEMBL4298176

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4298176)

**FDA ingredient codes (UNII)**

- KR9ZSKO5QE

## Regulatory information

### Other regulatory facts

**Patents**

0

**Designations**

1

**First in class**

No

**Fast track**

No

**Breakthrough designation**

No

**Orphan designation**

No

**Priority review**

No

**Orphan exclusivity**

No

**Accelerated approval**

No

## Pharmacology

### Drug classification

**Drug name stem**

\-mab

### Mechanisms of action

- **Mechanism**  
Inhibin beta A chain inhibitor

**Action type**  
Inhibitor

**Target**  
Inhibin beta A chain

**Protein identifier**  
P08476

### Open Targets mechanisms

- **Mechanism**  
Inhibin beta A chain inhibitor

**Action type**  
Inhibitor

**Target**  
Inhibin beta A chain

### Investigated indications (2)

- **Condition**  
Myositis, Inclusion Body

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0007323

**Subject identifier**  
D018979
- **Condition**  
Myositis Ossificans

**Highest recorded phase**  
3

**Condition identifier**  
MONDO:0007606

**Subject identifier**  
D009221

### Open Targets indications (6)

- **Condition identifier**  
EFO\_0007323

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0009851

**Highest recorded phase**  
1
- **Condition identifier**  
HP\_0001513

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0007606

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0007827

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0011122

**Highest recorded phase**  
2

### Trial references (3)

- NCT03188666  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03188666)
- NCT05394116  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05394116)
- NCT03710941  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03710941)

## Chemical properties

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Natural product**

No

### Sequences (5)

- **Component**  
Heavy chain

**Type**  
Protein

**Sequence**  
QVQLQESGPGLVKPSETLSLTCTVSGGSFSSHFWSWIRQPPGKGLEWIGYILYTGGTSFNPSLKSRVSMSVGTSKNQFSLKLSSVTAADTAVYYCARARSGITFTGIIVPGSFDIWGQGTMVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK
- **Component**  
Glycosylation sites (N)

**Sequence**  
Asn-303 $ Asn-303''''
- **Component**  
Disulfide bridges

**Sequence**  
22-95 $ 22''-95'' $ 23'-89' $ 23'''-89''' $ 135'-195' $ 135'''-195''' $ 140-215' $ 140''-215''' $ 153-209 $ 153''-209'' $ 232-232'' $ 235-235'' $ 267-327 $ 267''-327'' $ 373-431 $ 373''-431''
- **Component**  
Glycosylation sites (N)

**Sequence**  
Asn-303 $ Asn-303''
- **Component**  
Light chain: X', X'''

**Type**  
Protein

**Sequence**  
EIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC

## National Drug Codes

- 61755-012

## Related records

### Trials (10)

- A Study to Assess Safety, Tolerability and Efficacy of Garetosmab Versus Placebo Administered Intravenously (IV) in Adult Participants With Fibrodysplasia Ossificans Progressiva (FOP)
- A Study to Examine the Safety and Tolerability of Single Ascending Doses of REGN2477
- A Study to Examine the Safety, Tolerability and Effects on Abnormal Bone Formation of REGN2477 in Patients With Fibrodysplasia Ossificans Progressiva
- A Study to Investigate the Safety, Pharmacokinetics (PK), and Efficacy of Garetosmab in Children and Adolescents With Fibrodysplasia Ossificans Progressiva (FOP)
- [A Study to Test if Trevogrumab or Trevogrumab With Garetosmab When Taken With Semaglutide is Safe and How Well They Work in Adult Patients With Obesity for Weight Loss, Fat Loss, and Lean Mass Preservation](https://trialight.com/data/trial/a-study-to-test-if-trevogrumab-or-trevogrumab-with-27a2d2f7-21b9-477c-8ef5-a7612093efc8.md)
- An Expanded Access Program of Garetosmab in Adult Patients With Fibrodysplasia Ossificans Progressiva (FOP)
- Safety and Efficacy of REGN2477+REGN1033 in Patients With Sporadic Inclusion Body Myositis
- Study of Safety and Effects of Garetosmab in Healthy Obese Men and Post-Menopausal Women
- Study of Safety, Tolerability, and Pharmacokinetics of REGN2477 Alone and in Combination With REGN1033 in Healthy Postmenopausal Women and Healthy Adult Men
- Study to Assess the Efficacy and Safety of Garetosmab in Japanese Adult Patients With Fibrodysplasia Ossificans Progressiva (FOP)

### In development for (2)

- Fibrodysplasia ossificans progressiva Phase 3
- Inclusion body myositis Phase 2

### Targets (1)

- [INHBA](https://trialight.com/data/target/inhba-1f763b06-8782-5c80-88da-569a281eb471.md) Inhibin beta A chain inhibitor

---

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