Galvokimig
Highest phase reached
Phase 2
Drug type
Antibody
- Listing at source
- Listed
- Highest phase reached
- Phase 2
- Drug type
- Antibody
- Drug name
- Galvokimig
- fused g1 vh ch1 h scfv heavy kappa heavy chain humanized 1 492 vh ighg1 ch1 h anti il 17a f humanized 1 228 vh homo sapiens ighv3 7 01 88 7 ighd ighj6 01 90 9 t123 l 120 cdr imgt 8 8 18 26 33 51 58 97 114 1 125 homo sapiens ighg1 01 g1m17 ch1 k120 ch1 k120 222 126 223 hinge 1 5 224 228 126 228 11 mer seryl tetraglycyl threonyl tetraglycyl seryl linker 229 239 scfv heavy kappa anti alb humanized scfv v1 c49 vh c120 vl 240 492 vh homo sapiens ighv3 23 01 78 6 ighd ighj2 01 93 3 c49 283 cdr imgt 8 7 15 265 272 290 296 335 349 240 360 20 mer tetrakis tetraglycyl seryl linker 361 380 v kappa homo sapiens igkv1 12 01 86 5 ighd igkj1 01 90 9 c120 483 cdr imgt 7 3 11 407 413 431 433 470 480 381 492 228 214 disulfide with the fused l kappa scfv heavy kappa light chain humanized 1 469 l kappa anti il 17a f humanized 1 215 v kappa homo sapiens igkv1 13 02 80 0 igkj1 01 100 cdr imgt 6 3 9 27 32 50 52 89 97 1 107 homo sapiens igkc 01 100 km3 a45 1 153 v101 191 108 214 11 mer seryl bis tetraglycyl seryl linker 215 225 scfv heavy kappa anti il13 humanized scfv v1 c49 vh c120 vl 226 469 vh homo sapiens ighv1 69 08 81 6 ighd ighj1 01 100 c49 269 cdr imgt 8 8 9 251 258 276 283 322 330 226 341 20 mer tetrakis tetraglycyl seryl linker 342 361 v kappa homo sapiens igkv1 nl1 01 83 9 ighd igkj2 01 91 7 c120 460 cdr imgt 6 3 8 388 393 411 413 450 457 362 469 produced in chinese hamster ovary cho cells cell line cho dg44 non glycosylated
- Fused G1(VH-CH1-h)-scFv heavy-kappa heavy chain humanized (1-492) [VH-IGHG1 CH1-h anti-IL-17A/F humanized (1-228) [VH (Homo sapiens IGHV3-7*01 (88.7%) -(IGHD) -IGHJ6*01 (90.9%) T123>L (120), CDR-IMGT [8.8.18] (26-33.51-58.97-114)) (1-125)-Homo sapiens IGHG1*01, G1m17 CH1 K120 (CH1 K120 (222) (126-223), hinge 1-5 (224-228)(126-228))] -11-mer (seryl-tetraglycyl-threonyl-tetraglycyl-seryl) linker (229-239) -scFv heavy-kappa anti-ALB humanized, scFv-v1 C49 (VH)-C120 (VL) (240-492) [VH (Homo sapiens IGHV3-23*01 (78.6%) -(IGHD) -IGHJ2*01 (93.3%), C49 (283), CDR-IMGT [8.7.15] (265-272.290-296.335-349)) (240-360) -20-mer tetrakis(tetraglycyl-seryl) linker (361-380) -V-KAPPA (Homo sapiens IGKV1-12*01 (86.5%) -(IGHD) -IGKJ1*01 (90.9%) C120 (483), CDR-IMGT [7.3.11] (407-413.431-433.470-480))(381-492)]], (228-214')-disulfide with the fused L-kappa-scFv heavy-kappa light chain humanized (1'-469') [L-kappa anti-IL-17A/F humanized (1'-215') [V-KAPPA (Homo sapiens IGKV1-13*02 (80.0%) -IGKJ1*01 (100%), CDR-IMGT [6.3.9] (27'-32'.50'-52'.89'-97')) (1'-107') -Homo sapiens IGKC*01 (100%),Km3, A45.1 (153), V101 (191) (108'-214')] -11-mer seryl-bis(tetraglycyl-seryl) linker (215'-225') -scFv heavy-kappa anti-IL13 humanized, scFv-v1 C49 (VH)-C120 (VL) (226'-469') [VH(Homo sapiens IGHV1-69*08 (81.6%) -(IGHD) -IGHJ1*01 (100%), C49 (269'), CDR-IMGT [8.8.9] (251'-258'.276'-283'.322'-330')) (226'-341') -20-mer tetrakis(tetraglycyl-seryl) linker (342'-361') -V-KAPPA (Homo sapiens IGKV1-NL1*01(83.9%) -(IGHD) -IGKJ2*01 (91.7%), C120 (460'), CDR-IMGT [6.3.8] (388'-393'.411'-413'.450'-457')) (362'-469')]], produced in Chinese hamster ovary (CHO) cells, cell line CHO-DG44, non-glycosylated
- galvokimig
- Galvokimig
- galvokimig [INN]
- GALVOKIMIG [USAN]
- galvokimig inn
- galvokimig usan
- immunoglobulin g1 anti human interleukin 17a interleukin 17f human rattus norvegicus γ1 chain c terminal fragment fusion protein with peptide linker sggggtggggs fusion protein with immunoglobulin 283 cysteine 483 cysteine anti human serum al
- immunoglobulin g1 vh ch1 h scfv l kappa scfv anti homo sapiens il17a interleukin 17a il 17a and il17f interleukin 17f il 17f anti homo sapiens il13 interleukin 13 il 13 anti homo sapiens alb albumin human serum albumin hsa humanized monoclonal antibody trispecific trivalent
- Immunoglobulin G1, anti-(human interleukin 17A/interleukin 17F) (human-Rattus norvegicus γ1-chain C-terminal fragment) fusion protein with peptide linker (SGGGGTGGGGS) fusion protein with immunoglobulin [283-cysteine,483-cysteine] anti-(human serum al...
- Immunoglobulin G1(VH-CH1-h)-scFv_L-kappa-scFv, anti-[Homo sapiens IL17A (interleukin 17A, IL-17A) and IL17F (interleukin 17F, IL-17F)], anti-[Homo sapiens IL13 (interleukin 13, IL-13)], anti-[Homo sapiens ALB (albumin, human serum albumin, HSA], humanized monoclonal antibody, trispecific, trivalent
- ucb 9741
- UCB-9741
- ucb9741
- UCB9741
- CAS registry numbers
- 2648456-30-6
- ChEMBL ID
- CHEMBL5314834
- FDA ingredient codes (UNII)
- 85A4592PC8
- First in class
- No
- Orphan designation
- No
- Drug name stem
- -mig
Investigated indications
- Condition
- Inflammation
- Highest recorded phase
- 2
- Condition identifier
- MP:0001845
- Subject identifier
- D007249
- Condition identifier
- EFO_0000274
- Highest recorded phase
- 2
- Condition identifier
- MONDO_0004980
- Highest recorded phase
- 2
- Condition identifier
- MP_0001845
- Prodrug
- No
- Chirality
- Single enantiomer
- Inorganic
- No
- Natural product
- No
- Component
- Heavy chain
- Type
- Protein
- Sequence
- EVQLVESGGGLVQPGGSLRLSCAASGFTFSDYNMAWVRQAPGKGLEWVATITYEGRNTYYRDSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCASPPQYYEGSIYRLWFAHWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCSGGGGTGGGGSEVQLLESGGGLVQPGGSLRLSCAVSGIDLSNYAINWVRQAPGKCLEWIGIIWASGTTFYATWAKGRFTISRDNSKNTVYLQMNSLRAEDTAVYYCARTVPGYSTAPYFDLWGQGTLVTVSSGGGGSGGGGSGGGGSGGGGSDIQMTQSPSSVSASVGDRVTITCQSSPSVWSNFLSWYQQKPGKAPKLLIYEASKLTSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCGGGYSSISDTTFGCGTKVEIKRT
- Component
- Disulfide bridges
- Sequence
- 22-96 $ 23'-88' $ 134'-194' $ 152-208 $ 228-214' $ 247'-321' $ 261-334 $ 269'-460' $ 283-483 $ 384'-449' $ 403-469
- Component
- Light chain
- Type
- Protein
- Sequence
- AIQLTQSPSSLSASVGDRVTITCRADESVRTLMHWYQQKPGKAPKLLIYLVSNSEIGVPDRFSGSGSGTDFRLTISSLQPEDFATYYCQQTWSDPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECSGGGGSGGGGSEVQLVQSGAEVKKPGSSVKVSCKASGYSFTSYYIHWVRQAPGQCLEWMGRIGPGSGDINYNEKFKGRATFTVDKSTSTAYMELSSLRSEDTAVYYCARFHYDGADWGQGTLVTVSSGGGGSGGGGSGGGGSGGGGSDIQMTQSPSSLSASVGDRVTITCKASQNINENLDWYQQKPGKAPKLLIYYTDILQTGIPSRFSGSGSGTDYTLTISSLQPEDFATYYCYQYYSGYTFGCGTKLEIKRT
Related records
Trials (5)
- A Dose-ranging Study to Evaluate the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of Galvokimig in Adult Study Participants With Atopic Dermatitis
- A Study of 24 to 52 Weeks Treatment to Evaluate The Efficacy And Safety of Galvokimig in Adult Study Participants With Non-Cystic Fibrosis Bronchiectasis
- A Study of 24 to 52 Weeks Treatment to Evaluate The Efficacy And Safety of Galvokimig in Study Participants With Moderate-to-Severe Chronic Obstructive Pulmonary Disease (COPD) With Chronic Bronchitis
- A Study to Assess the Safety and Pharmacokinetics of a Single Dose of UCB9741 in Healthy Caucasian and Japanese Participants
- A Study to Test the Safety, Pharmacokinetics, and Efficacy of UCB9741 in Healthy Study Participants and in Study Participants With Atopic Dermatitis
In development for (1)
- Atopic eczema Phase 2