> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/furaprevir-5e28de6d-e0d7-4582-bf7b-0a49343633ea
> Record changed: 2026-10-13

# Furaprevir

Highest phase reached

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297647)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297647)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297647)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297647)

**Drug name**

Furaprevir

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297647)

**Molecular weight**

897.06

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297647)

**Structure (SMILES)**

CC(C)Oc1ccc(-c2nc(O\[C@@H\]3C\[C@H\]4C(=O)N\[C@\]5(C(=O)NS(=O)(=O)C6(C)CC6)C\[C@H\]5/C=C\\CCCCC\[C@H\](NC(=O)OC5CCCC5)C(=O)N4C3)c3oc4ccccc4c3n2)cc1

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297647)

### Other names (12)

- dag181 200 mg plus tg 2349 400 mg
- furaprevir
- Furaprevir
- furaprevir \[INN\]
- Furaprevir \[WHO-DD\]
- Furaprevir capsule (MAD)
- Furaprevir capsule (SAD)
- furaprevir inn
- furaprevir who dd
- tg 2349
- Tg-2349
- TG-2349

## Identifiers

**CAS registry numbers**

- 1435923-88-8

**ChEMBL ID**

CHEMBL4297647

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297647)

**InChIKey**

GZRNOYTVBWWFLJ-NTPALUMKSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297647)

**PubChem compound IDs**

- 51037069

**FDA ingredient codes (UNII)**

- 0UMM44REU9

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Drug classification

**Drug name stem**

\-vir

### Mechanisms of action (2)

- **Mechanism**  
Hepatitis C virus serine protease, NS3/NS4A inhibitor

**Action type**  
Inhibitor

**Target**  
Hepatitis C virus serine protease, NS3/NS4A

**Protein identifier**  
A3EZI9
- **Mechanism**  
Hepatitis C virus serine protease, NS3/NS4A inhibitor

**Action type**  
Inhibitor

**Target**  
Hepatitis C virus serine protease, NS3/NS4A

**Protein identifier**  
D2K2A8

### Open Targets mechanisms

- **Mechanism**  
Hepatitis C virus serine protease, NS3/NS4A inhibitor

**Action type**  
Inhibitor

**Target**  
Hepatitis C virus serine protease, NS3/NS4A

### Investigated indications (2)

- **Condition**  
Hepatitis C

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0003047

**Subject identifier**  
D006526
- **Condition**  
Hepatitis C, Chronic

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0004220

**Subject identifier**  
D019698

### Open Targets indications (4)

- **Condition identifier**  
EFO\_0003047

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0004220

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005231

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0005354

**Highest recorded phase**  
2

### Trial references (3)

- NCT01523990  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01523990)
- NCT02340962  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02340962)
- NCT04155515  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04155515)

## Chemical properties

**Hydrogen bond acceptors**

12

**Hydrogen bond donors**

3

**Polar surface area**

208.36

**Calculated partition coefficient (ALogP)**

6.61

**Calculated partition coefficient (XLogP)**

7.3

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Rule-of-five violations**

3

**Rotatable bonds**

10

**Heavy atoms**

64

**Molecular formula**

C47H56N6O10S

**Monoisotopic mass**

896.37786318

**Natural product**

Yes

## Evidence counts

**Recorded assays**

8

**Active assays**

8

### Active assay types

- Confirmatory

## Related records

### Trials (28)

- A Phase I Clinical Trial to Evaluate HECN30227 Injection in Healthy Subjects and Subjects With Chronic Hepatitis B
- A Phase I Study of DDN-A-0101 in Healthy Volunteers and Elder People
- A Phase I Study of RC1416 Injection
- A Phase III Study to Evaluate Efficacy and Safety of TG-2349 in Combination With DAG181 and RBV for HCV Type I Patients
- A Single- and Multiple-Ascending Dose Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of THDBH120 Injection in Healthy Subjects
- A Study Evaluating GS-9620 in Treatment Naive Subjects With Chronic Hepatitis B
- A Study Evaluating GS-9620 in Virologically Suppressed Subjects With Chronic Hepatitis B Virus Infection
- A Study to Evaluate the Safety of K-755 in Healthy Volunteers
- A Study to Evaluate the Safety, Tolerability, and PK in Healthy Volunteers and HCV Genotype 1 Infected Patients
- A Study to Examine the Safety, Tolerability, and Pharmacokinetics of Single- and Multiple-ascending Doses of ACT-1014-6470 in Healthy Subjects
- A Study to Examine the Safety, Tolerability, and Pharmacokinetics of Single- and Multiple-ascending Doses of ACT-777991 in Healthy Subjects
- A Study to Find a Suitable Dose of Exl-111 for Further Research
- A Study to Investigate the Safety, Tolerability and Pharmacokinetics of Inhaled CHF6001
- BnH-015B Clinical Trial in Moderate Alzheimer's Disease
- EAST-1 (ERAP-inhibition in Axial Spondyloarthritis Trial - 1)
- Evaluate the Efficacy and Safety of TG-2349 in Subjects With Hepatitis C Infection
- Evaluation of Safety and Pharmacokinetics of Oral Controlled-ileal-release Nicotinic Acid (CIR-NA) Compared to Immediate-release Nicotinic Acid and Placebo in Healthy Subjects and Subjects With Prediabetes
- Evaluation of Safety, Side Effects and How the Drug CHF6467 Administered Via Intranasal Route is Absorbed, Modified and Removed in Healthy Subjects
- Prevention of Seasonal Affective Disorder
- Safety and Pharmacokinetics of Oral Controlled-ileocolonic-release Nicotinamide (CICR-NAM)

### In development for (2)

- [Chronic hepatitis C virus infection](https://trialight.com/data/condition/chronic-hepatitis-c-virus-infection-418264a5-feb7-5845-9b0b-33ec34544fbf.md) Phase 2
- Hepatitis C virus infection Phase 3

---

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