> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/fr-135313-2a9802a3-be7a-441c-967f-ad95755103fe > Record changed: 2026-10-13 # FR-135313 Drug type Protein Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL146250) ## Development status **Listing at source** Listed ## Names and chemistry **Drug type** Protein Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL146250) **Drug name** FR-135313 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL146250) **Molecular weight** 542.72 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL146250) **Structure (SMILES)** C/C=C1\\NC(=O)\[C@@H\](CS)NC(=O)\[C@@H\](C(C)C)NC(=O)C\[C@@H\](/C=C/CCS)OC(=O)\[C@H\](C(C)C)NC1=O Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL146250) ### Other names (11) - fk 228 reduced - FK-228 (REDUCED) - fr 135313 - Fr-135313 - Insuline glargine U100 (reduced) - insuline glargine u100 reduced - Reduced-Dose Daily Buserelin - Reduced-dose HHT - reduced-dose PTCy - romidepsin reduced - ROMIDEPSIN REDUCED ## Identifiers **CAS registry numbers** - 390745-19-4 **ChEMBL ID** CHEMBL146250 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL146250) **InChIKey** MEJLVLMAJJRLCR-GCCNXGTGSA-N Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL146250) **PubChem compound IDs** - 9828788 **FDA ingredient codes (UNII)** - 4MQ5UQAIB8 ## Regulatory information ### Other regulatory facts **First in class** No **Orphan designation** No ## Chemical properties **Hydrogen bond acceptors** 8 **Hydrogen bond donors** 6 **Polar surface area** 142.7 **Calculated partition coefficient (ALogP)** 0.89 **Calculated partition coefficient (XLogP)** 2.2 **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Rule-of-five violations** 2 **Rotatable bonds** 6 **Heavy atoms** 36 **Molecular formula** C24H38N4O6S2 **Monoisotopic mass** 542.22327729 **Natural product** No ## Evidence counts **Recorded assays** 44 **Active assays** 29 ### Active assay types - Confirmatory ## Related records ### Trials (102) - [A Clinical Trial of Adsorbed Cell-free DPT Vaccine (5-component) (for People Aged 6 Years and Above)](https://trialight.com/data/trial/a-clinical-trial-of-adsorbed-cell-free-dpt-vaccine-5-0ae3b104-374b-4a86-a746-841bf44fdded.md) - [A Clinical Trials of Adsorbed Cell-free DPT Vaccine (Five-component)](https://trialight.com/data/trial/a-clinical-trials-of-adsorbed-cell-free-dpt-vaccine-five-dca16796-773d-4e86-acf1-c706700c4704.md) - A Phase 4, Placebo-Controlled, Randomized Study to Evaluate the Immunogenicity and Safety of HPV and Tdap When Administered With MenACWY in Adolescents - A Research Study to Look Into How Semaglutide, Together With a Lower Dose of Insulin Glargine, Compares to a Higher Dose of Insulin Glargine Alone in People With Type 2 Diabetes (SUSTAIN OPTIMIZE) - A Study Comparing Non Myeloablative (Flu-TBI) and Reduced Intensity (FLU-BU-ATG) Conditioning in Allogenic Transplantation - A Study to Assess the Safety of Adacel® Vaccine - A Study to Compare Three Different Formulations of Tenofovir 1% Gel When Administered Rectally - A Study to Evaluate Safety, Reactogenicity, and Immune Response of GVGH iNTS-TCV Vaccine Against Invasive Nontyphoidal Salmonella and Typhoid Fever - A Test of Short and Long Term Naturalistic Outcomes of Smokers Who Sample Smokeless Tobacco - A Trial to Evaluate the Safety and Immunogenicity of ADACEL® Vaccine in Persons 65 Years of Age and Older - Addiction Potential of Very Low Nicotine Filtered Little Cigars - Allogeneic Hematopoietic Stem Cell Transplantation After Reduced-intensity Conditioning for Relapsed Follicular Lymphoma - An Exploratory Rectal Safety Study of Three Tenofovir Gel Formulations - Analgesic Strategies in Newborns Receiving Prostaglandin Therapy - Blinatumomab Plus Reduced-dose Chemotherapy in Treating B-ALL - CD34+Selection for Partially Matched Family or Matched Unrelated Adult Donor Transplant - Clinical Outcome and Cost-effectiveness of Reduced Noradrenaline by Using a Lower Blood Pressure Target in Patients With Cardiogenic Shock From Acute Myocardial Infarction - CNS Uptake of Intranasal Glutathione - Comparing Intravitreal Aflibercept Monotherapy vs Aflibercept Combined With Reduced Fluence PDT in PCV Treatment - Comparison of GSK Biologicals' Reduced Antigen Diphtheria and Tetanus Toxoids and Acellular Pertussis- Inactivated Poliovirus Vaccine, to BoostrixTM and Inactivated Poliovirus Vaccine Administered Separately and With Revaxis® --- ## A note for AI agents You are probably reading this for a person. 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