> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/fosgemcitabine-palabenamide-a9df1192-c4dc-4eb2-98eb-1b41a5c7f51c
> Record changed: 2026-11-04

# Fosgemcitabine palabenamide

Highest phase reached

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3126004)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3126004)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3126004)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3126004)

**Drug name**

Fosgemcitabine palabenamide

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3126004)

**Molecular weight**

580.48

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3126004)

**Structure (SMILES)**

C\[C@H\](NP(=O)(OC\[C@H\]1O\[C@@H\](n2ccc(N)nc2=O)C(F)(F)\[C@@H\]1O)Oc1ccccc1)C(=O)OCc1ccccc1

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3126004)

### Other names (24)

- acelarin
- Acelarin
- bio 1031
- BIO-1031
- cpf 31
- CPF-31
- cpf31
- CPF31
- fosgemcitabine palabenamide
- Fosgemcitabine palabenamide
- fosgemcitabine palabenamide p rs
- Fosgemcitabine palabenamide, p(rs)-
- gemictabine protide
- Gemictabine protide
- nuc 1031
- nuc 1031 500 mg
- nuc 1031 750mg
- nuc 1031 and carboplatin
- nuc 1031 s
- Nuc-1031
- NUC-1031
- NUC-1031 500 mg
- NUC-1031 750mg
- NUC-1031, (S)-

## Identifiers

**CAS registry numbers**

- 840506-29-8

**ChEMBL ID**

CHEMBL3126004

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3126004)

**InChIKey**

NHTKGYOMICWFQZ-KKQYNPQSSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3126004)

**PubChem compound IDs**

- 11169170

**FDA ingredient codes (UNII)**

- XCL1K2T28K

## Regulatory information

### Other regulatory facts

**Patents**

0

**Designations**

1

**First in class**

No

**Fast track**

No

**Breakthrough designation**

No

**Orphan designation**

No

**Priority review**

No

**Orphan exclusivity**

No

**Accelerated approval**

No

## Pharmacology

### Drug classification

**Drug name stem**

\-citabine; fos-

### Investigated indications (6)

- **Condition**  
Neoplasms

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000616

**Subject identifier**  
D009369
- **Condition**  
Pancreatic Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0002618

**Subject identifier**  
D010190
- **Condition**  
Biliary Tract Neoplasms

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0009534

**Subject identifier**  
D001661
- **Condition**  
Biliary Tract Neoplasms

**Highest recorded phase**  
3

**Condition identifier**  
MONDO:0003060

**Subject identifier**  
D001661
- **Condition**  
Neoplasms

**Highest recorded phase**  
1

**Condition identifier**  
MONDO:0004992

**Subject identifier**  
D009369
- **Condition**  
Ovarian Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0008170

**Subject identifier**  
D010051

### Open Targets indications (13)

- **Condition identifier**  
EFO\_0000616
- **Condition identifier**  
EFO\_0009534
- **Condition identifier**  
MONDO\_0003060

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0003210

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0004868
- **Condition identifier**  
MONDO\_0004975

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0004992

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005070
- **Condition identifier**  
MONDO\_0005192

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005411

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0008170

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0017590

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0019087

**Highest recorded phase**  
1

### Trial references (4)

- NCT01621854  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01621854)
- NCT03146663  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03146663)
- NCT03610100  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03610100)
- NCT04163900  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04163900)

## Chemical properties

**Hydrogen bond acceptors**

11

**Hydrogen bond donors**

3

**Polar surface area**

164.23

**Calculated partition coefficient (ALogP)**

2.64

**Calculated partition coefficient (XLogP)**

1.4

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Rule-of-five violations**

2

**Rotatable bonds**

11

**Heavy atoms**

40

**Molecular formula**

C25H27F2N4O8P

**Monoisotopic mass**

580.15345715

**Natural product**

No

## Evidence counts

**Recorded assays**

129

**Active assays**

37

### Active assay types

- Confirmatory

## Related records

### Trials (11)

- ABC-08: Phase Ib Trial of Acelarin in Combination With Cisplatin in Locally Advanced/ Metastatic Biliary Tract Cancers
- ABX Combined With Cisplatin Compared With Gemcitabine Combined With Cisplatin in NSCLC
- Acelarin First Line Randomised Pancreatic Study
- Comparing NUC-1031 Plus Cisplatin to Gemcitabine Plus Cisplatin in Patients With Advanced Biliary Tract Cancer
- Durvalumab With Chemotherapy as First Line Treatment in Patients With Advanced Biliary Tract Cancers (aBTCs)
- Neoadjuvant Treatment in Resectable Pancreatic Cancer
- NUC-1031 in Patients With Advanced Solid Tumours
- NUC-1031 in Patients With Platinum-Resistant Ovarian Cancer
- Phase 2 Trial of Gemcitabine vs S-1 vs Gemcitabine Plus Nab-paclitaxel as Adjuvant Chemotherapy of Post-operative Pancreatic Cancer Patients
- Safety and Efficacy Study of Nuc-1031 and Carboplatin Combination to Treat Recurrent Ovarian Cancer
- [Spevatamig (PT886) as Monotherapy or in Combination With Chemo and/or Targeted Therapy and/or ICI, for the Treatment of Patients With Advanced Gastrointestinal Cancers, Including Gastric, Gastroesophageal Junction, Pancreatic Ductal or Biliary Tract Carcinomas (the TWINPEAK Study)](https://trialight.com/data/trial/spevatamig-pt886-as-monotherapy-or-in-combination-with-chemo-abae84e5-79dd-40d9-9825-a26db6db581a.md)

### In development for (11)

- [Alzheimer disease](https://trialight.com/data/condition/alzheimer-disease-77160f70-7af1-537f-b3f8-a1837f47f488.md) Phase 1
- [Biliary tract cancer](https://trialight.com/data/condition/biliary-tract-cancer-6b9535c9-ccaa-5b47-8c46-0d05d39d7c62.md) Phase 3
- Biliary tract disorder Phase 3
- [Cancer](https://trialight.com/data/condition/cancer-703b1dfc-4812-50eb-83f4-d7a205d16bdb.md) Phase 1
- Carcinoma of the ampulla of vater Phase 3
- [Cholangiocarcinoma](https://trialight.com/data/condition/cholangiocarcinoma-3777afe4-5189-5eb1-82f8-0c3446cb902f.md) Phase 1
- Exocrine pancreatic carcinoma Phase 2
- Gallbladder cancer Phase 3
- Intrahepatic cholangiocarcinoma Phase 3
- [Neoplasm](https://trialight.com/data/condition/neoplasm-2a973797-359b-5982-907e-98f9b7c1a284.md) Phase 1
- [Ovarian cancer](https://trialight.com/data/condition/ovarian-cancer-f64f2018-55a5-553a-8960-76cb4906aa17.md) Phase 2

---

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