> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/formoterol-1c4f9fc6-da8f-4ea7-b9d7-7327267ca099
> Record changed: 2026-10-13

# Formoterol

Highest phase reached

Approved

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1256786)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1256786)

First approval year

2001

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1256786)

## Development status

**First approval year**

2001

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1256786)

**Listing at source**

Listed

**Highest phase reached**

Approved

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1256786)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1256786)

**Drug name**

Formoterol

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1256786)

**Molecular weight**

344.41

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1256786)

**Structure (SMILES)**

COc1ccc(CC(C)NCC(O)c2ccc(O)c(NC=O)c2)cc1

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1256786)

### Brand names (2)

- oxis
- Oxis

### Other names (16)

- eformoterol
- EFORMOTEROL
- formoterol
- Formoterol
- FORMOTEROL \[HSDB\]
- formoterol \[INN\]
- FORMOTEROL \[MI\]
- FORMOTEROL \[VANDF\]
- Formoterol \[WHO-DD\]
- formoterol hsdb
- formoterol inn
- formoterol mi
- formoterol vandf
- formoterol who dd
- oxis
- Oxis

## Identifiers

**CAS registry numbers**

- 73573-87-2

**ChEMBL ID**

CHEMBL1256786

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1256786)

**InChIKey**

BPZSYCZIITTYBL-UHFFFAOYSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1256786)

**PubChem compound IDs**

- 3410

**RxNorm IDs (RxCUI)**

- 25255

**FDA ingredient codes (UNII)**

- 5ZZ84GCW8B

### ATC classification codes (2)

- R03AC13
- R03CC15

Sources for recorded values

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1256786)

## Regulatory information

### United States

**Applicant**

ASTRAZENECA AB

**Approval date**

23 Jul 2020

**Application number**

NDA212122

### Other regulatory facts

**Patents**

9

**Designations**

0

**Earliest recorded loss of exclusivity**

5 Oct 2038

**First in class**

No

**Fast track**

No

**Breakthrough designation**

No

**Orphan designation**

No

**Priority review**

No

**Orphan exclusivity**

No

**Accelerated approval**

No

**Availability**

Prescription only

## Pharmacology

### Drug classification

**Pharmacology name**

formoterol

**Type**

Synthetic organic

**Drug name stem**

\-terol

**Approval recorded by Guide to Pharmacology**

Yes

#### Administration routes

- topical

### Mechanisms of action (3)

- **Action**  
Agonist

**Action type**  
Agonist

**Target**  
β2-adrenoceptor

**Gene symbol**  
ADRB2

**Protein identifier**  
P07550

**Affinity units**  
pEC50

**Primary target**  
Yes
- **Action**  
Agonist

**Action type**  
Agonist

**Target**  
β1-adrenoceptor

**Gene symbol**  
ADRB1

**Protein identifier**  
P08588

**Median affinity**

8.3

**Affinity units**  
pEC50
- **Action**  
Agonist

**Action type**  
Agonist

**Target**  
β1-adrenoceptor

**Gene symbol**  
ADRB1

**Protein identifier**  
P08588

**Affinity units**  
pKi

### Open Targets mechanisms

- **Mechanism**  
Beta-2 adrenergic receptor agonist

**Action type**  
Agonist

**Target**  
Beta-2 adrenergic receptor

### DrugCentral mechanisms

- **Action type**  
Agonist

**Gene symbol**  
ADRB2

**Protein identifier**  
P07550

**Organism**  
Homo sapiens

**Target development level**  
Clinical

### Investigated indications (11)

- **Condition**  
Pulmonary Disease, Chronic Obstructive

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000341

**Subject identifier**  
D029424
- **Condition**  
Emphysema

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000464

**Subject identifier**  
D004646
- **Condition**  
Bronchiolitis Obliterans

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0007183

**Subject identifier**  
D001989
- **Condition**  
Bronchitis

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0009661

**Subject identifier**  
D001991
- **Condition**  
Respiratory Distress Syndrome

**Highest recorded phase**  
2

**Condition identifier**  
EFO:1000637

**Subject identifier**  
D012128
- **Condition**  
Bronchiectasis

**Highest recorded phase**  
3

**Condition identifier**  
HP:0002110

**Subject identifier**  
D001987
- **Condition**  
Lung Diseases, Obstructive

**Highest recorded phase**  
4

**Condition identifier**  
HP:0006536

**Subject identifier**  
D008173
- **Condition**  
Alzheimer Disease

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0004975

**Subject identifier**  
D000544
- **Condition**  
Asthma

**Highest recorded phase**  
3

**Condition identifier**  
MONDO:0004979

**Subject identifier**  
D001249
- **Condition**  
Hypersensitivity

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0005271

**Subject identifier**  
D006967
- **Condition**  
Severe Acute Respiratory Syndrome

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0100096

**Subject identifier**  
D045169

### Open Targets indications (25)

- **Condition identifier**  
EFO\_0000319
- **Condition identifier**  
EFO\_0000341
- **Condition identifier**  
EFO\_0000464

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0007183

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0009837
- **Condition identifier**  
EFO\_0022917
- **Condition identifier**  
EFO\_1000637

**Highest recorded phase**  
2
- **Condition identifier**  
HP\_0001943
- **Condition identifier**  
HP\_0006536
- **Condition identifier**  
HP\_0006536

**Highest recorded phase**  
4
- **Condition identifier**  
HP\_0012735
- **Condition identifier**  
MONDO\_0004822

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0004849

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0004975

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0004979
- **Condition identifier**  
MONDO\_0004979

**Highest recorded phase**  
4
- **Condition identifier**  
MONDO\_0005002

**Highest recorded phase**  
4
- **Condition identifier**  
MONDO\_0005147
- **Condition identifier**  
MONDO\_0005271
- **Condition identifier**  
MONDO\_0008903

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0013730

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0015265

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0100096
- **Condition identifier**  
MONDO\_0100096

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0100233

### Reported adverse events (105)

- **Event**  
adrenal cortex necrosis

**Reports**  
5

**Reporting signal score**

34.4
- **Event**  
adrenal insufficiency

**Reports**  
8

**Reporting signal score**

14.1815
- **Event**  
adrenal mass

**Reports**  
3

**Reporting signal score**

10.693
- **Event**  
anosmia

**Reports**  
6

**Reporting signal score**

13.2301
- **Event**  
asthma

**Reports**  
168

**Reporting signal score**

536.925
- **Event**  
asthma-chronic obstructive pulmonary disease overlap syndrome

**Reports**  
7

**Reporting signal score**

36.8492
- **Event**  
atrial enlargement

**Reports**  
9

**Reporting signal score**

50.8256
- **Event**  
blood count abnormal

**Reports**  
17

**Reporting signal score**

37.3328
- **Event**  
breath sounds abnormal

**Reports**  
11

**Reporting signal score**

34.4173
- **Event**  
bronchial hyperreactivity

**Reports**  
8

**Reporting signal score**

31.9318
- **Event**  
bronchial obstruction

**Reports**  
9

**Reporting signal score**

35.3706
- **Event**  
bronchiectasis

**Reports**  
10

**Reporting signal score**

26.4195
- **Event**  
bronchopulmonary aspergillosis allergic

**Reports**  
3

**Reporting signal score**

11.1969
- **Event**  
bronchospasm

**Reports**  
8

**Reporting signal score**

11.0515
- **Event**  
candida infection

**Reports**  
8

**Reporting signal score**

14.385
- **Event**  
cardiac failure chronic

**Reports**  
9

**Reporting signal score**

28.163
- **Event**  
cardiac murmur

**Reports**  
6

**Reporting signal score**

10.5572
- **Event**  
chest discomfort

**Reports**  
26

**Reporting signal score**

29.1667
- **Event**  
chronic obstructive pulmonary disease

**Reports**  
53

**Reporting signal score**

138.267
- **Event**  
chronic sinusitis

**Reports**  
9

**Reporting signal score**

29.3346
- **Event**  
cockroach allergy

**Reports**  
4

**Reporting signal score**

28.6672
- **Event**  
congenital pneumonia

**Reports**  
3

**Reporting signal score**

15.2657
- **Event**  
coronary artery stenosis

**Reports**  
11

**Reporting signal score**

28.797
- **Event**  
cough

**Reports**  
62

**Reporting signal score**

69.8708
- **Event**  
craniosynostosis

**Reports**  
3

**Reporting signal score**

10.1131

And 80 more, listed on the interactive page.

### Trial references (134)

- NCT00130351  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00130351)
- NCT00235911  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00235911)
- NCT00238784  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00238784)
- NCT00242775  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00242775)
- NCT00244608  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00244608)
- NCT00252785  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00252785)
- NCT00252824  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00252824)
- NCT00255255  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00255255)
- NCT00259766  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00259766)
- NCT00259792  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00259792)
- NCT00288379  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00288379)
- NCT00290264  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00290264)
- NCT00314509  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00314509)
- NCT00319306  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00319306)
- NCT00326053  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00326053)
- NCT00381485  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00381485)
- NCT00385593  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00385593)
- NCT00413387  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00413387)
- NCT00419757  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00419757)
- NCT00419952  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00419952)
- NCT00424008  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00424008)
- NCT00443482  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00443482)
- NCT00449501  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00449501)
- NCT00449527  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00449527)
- NCT00497237  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00497237)

And 109 more, listed on the interactive page.

## Dosing

**Dose**

20mcg

**Route**

Inhalation

**How often**

Twice daily

### Conditions of use

- Use with a standard jet nebulizer connected to an air compressor

## Chemical properties

**Hydrogen bond acceptors**

5

**Hydrogen bond donors**

4

**Polar surface area**

90.82

**Calculated partition coefficient (ALogP)**

2.22

**Calculated partition coefficient (XLogP)**

1.8

**Prodrug**

No

**Chirality**

Racemic

**Inorganic**

No

**Rule-of-five violations**

0

**Rotatable bonds**

9

**Heavy atoms**

25

**Molecular formula**

C19H24N2O4

**Monoisotopic mass**

344.17360725

**Natural product**

Yes

## National Drug Codes

- 0310-4616
- 0310-6616

## Evidence counts

**Recorded assays**

249

**Active assays**

47

### Active assay types (2)

- Confirmatory
- Other

## Pharmacologic actions

- Bronchodilator Agents  
Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D001993.html)
- Adrenergic beta-2 Receptor Agonists  
Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D058666.html)

## Biological measurements

These details could not be displayed.

## Related records

### Trials (244)

- 26 Week Efficacy, Safety and Tolerability Study of Indacaterol in Patients With Chronic Obstructive Pulmonary Disease (COPD)
- A 1-year Multi-center, Prospective, Cohort Study in Patients With Chronic Obstructive Pulmonary Disease Treated With Long-acting Bronchodilator
- A 42-day Parallel Group Safety Study of Revefenacin and Formoterol, Administered in Sequence and as a Combination, in Participants With COPD
- A Bioequivalence Pivotal Study of SYN010 HFA Inhaler and Symbicort® 160/4.5 in Healthy Volunteers With Charcoal Block
- A Bioequivalence Pivotal Study of SYN010 HFA Inhaler and Symbicort® 160/4.5 in Healthy Volunteers Without Charcoal Block
- A Clinical Study to Evaluate Symbicort Turbuhaler Used 'as Needed' in Adults and Adolescents With Asthma
- A Clinical Study to Evaluate Symbicort Turbuhaler Used 'as Needed' in Adults and Adolescents With Asthma.
- A Clinical Trial Comparing TQC3927 Inhaled Powder With Glycopyrronium Bromide and Formoterol Inhaled Aerosol (Biovoping® Lingchang®) for the Treatment of Chronic Obstructive Pulmonary Disease
- A Comparative Study Between Foraseq and Formoterol/Budesonide Inhalation Capsules in Patients with Asthma
- A Comparison of Symbicort® pMDI 2 x 160/4.5 μg Bid and 2 x 80/4.5 μg Bid With Formoterol Turbuhaler® 2 x 4.5 μg Bid and Placebo in Patients With COPD
- A Comparison of Symbicort® pMDI 2 x 160/4.5 μg Bid and Symbicort® pMDI 2 x 80/4.5 μg Bid With Formoterol Turbuhaler®, Budesonide pMDI, the Combination of Formoterol Turbuhaler® and Budesonide pMDI, and Placebo in COPD Patients
- A Comparison of SYMBICORT® pMDI With Formoterol Turbuhaler® in Subjects With COPD
- A Comparison of the Control of Asthma Provided by Symbicort® Turbuhaler® Versus Symbicort® Turbuhaler® Plus Pulmicort® Turbuhaler® Plus Terbutaline Turbuhaler®
- A Comparison Study Between the Fixed Dose Triple Combination of Fluticasone Furoate/ Umeclidinium/ Vilanterol Trifenatate (FF/UMEC/VI) With Budesonide/Formoterol in Subjects With Chronic Obstructive Pulmonary Disease (COPD)
- A Crossover Study in the Treatment of Patients With COPD
- A Dose Ranging Study With CHF 1531 in Subjects With Asthma (FLASH)
- A Dose Ranging Trial of 4 Doses of Indacaterol Delivered Via the TWISTHALER® Device in Patients With Chronic Obstructive Pulmonary Disease (COPD)
- A Dose Ranging Trial of 4 Doses of Indacaterol Delivered Via TWISTHALER® Device in Adult and Adolescent Patients With Persistent Asthma
- A Drug Utilisation Post-authorisation Study of New Users of Aclidinium Bromide (Monotherapy or in Combination)
- A Guideline Approach to Therapy Step-down Utilising Flutiform Change and Step-down

### Approved for (1)

- Obstructive lung disease

### In development for (10)

- [Acute respiratory distress syndrome](https://trialight.com/data/condition/acute-respiratory-distress-syndrome-8dc4b74c-8356-5dfd-bfa3-258d9d1e44ab.md) Phase 2
- Allergic disease Phase 2
- [Alzheimer disease](https://trialight.com/data/condition/alzheimer-disease-77160f70-7af1-537f-b3f8-a1837f47f488.md) Phase 2
- [Asthma](https://trialight.com/data/condition/asthma-247437fb-0e60-5885-8a3a-ce40099cea88.md) Phase 3
- [Bronchiectasis](https://trialight.com/data/condition/bronchiectasis-8d498aad-545e-518d-b298-07bc2c8370b0.md) Phase 3
- Bronchiolitis obliterans syndrome Phase 2
- [Bronchitis](https://trialight.com/data/condition/bronchitis-521c8a00-6a48-5246-b908-ec54f125daf0.md) Phase 3
- [Chronic obstructive pulmonary disease](https://trialight.com/data/condition/chronic-obstructive-pulmonary-disease-8e23f74b-95b9-5920-a241-c0278555234f.md) Phase 3
- [COVID-19](https://trialight.com/data/condition/covid-19-13f0ebf3-c291-557d-bdef-93563d077103.md) Phase 2
- [Pulmonary emphysema](https://trialight.com/data/condition/pulmonary-emphysema-7c09e667-0ffb-5ac1-bbd4-bd87b4f05fc6.md) Phase 3

### Other linked conditions (2)

- [Cardiovascular disorder](https://trialight.com/data/condition/cardiovascular-disorder-362e433e-88a4-575f-90af-50fe7239dec0.md)
- Type 1 diabetes mellitus

### Targets (1)

- [ADRB2](https://trialight.com/data/target/adrb2-dd50b672-19f0-5015-be62-c6f5861dc510.md) Beta-2 adrenergic receptor agonist

---

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