> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/fluzoparib-601a6702-a689-4bd0-921a-398feba5d180
> Record changed: 2026-11-04

# Fluzoparib

Highest phase reached

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3930624)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3930624)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3930624)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3930624)

**Drug name**

Fluzoparib

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3930624)

**Molecular weight**

472.4

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3930624)

**Structure (SMILES)**

O=C(c1cc(Cc2n\[nH\]c(=O)c3ccccc23)ccc1F)N1CCn2nc(C(F)(F)F)nc2C1

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3930624)

### Other names (37)

- adebrelimab paclitaxel carboplatin bevacizumab fluzoparib
- adebrelimab plus fluzoparib
- arsenic trioxide tablet fuzuloparib capsules
- camrelizumab fluzoparib
- fluzoparib
- Fluzoparib
- fluzoparib and camrelizumab
- fluzoparib bevacizumab
- fluzoparib camrelizumab
- fluzoparib capsule
- Fluzoparib Capsule
- fluzoparib capsules
- Fluzoparib capsules
- Fluzoparib Capsules
- fluzoparib chidamide
- fluzoparib dalpiciclib
- fluzoparib paclitaxel
- fluzoparib with temozolomide
- fuzuloparib
- Fuzuloparib
- fuzuloparib \[INN\]
- Fuzuloparib \[WHO-DD\]
- fuzuloparib inn
- fuzuloparib who dd
- fuzuopali

And 12 more, listed on the interactive page.

## Identifiers

**CAS registry numbers**

- 1358715-18-0

**ChEMBL ID**

CHEMBL3930624

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3930624)

**InChIKey**

XJGXCBHXFWBOTN-UHFFFAOYSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3930624)

**PubChem compound IDs**

- 56649297

**FDA ingredient codes (UNII)**

- TWF0ML1CK8

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Drug classification

**Pharmacology name**

fluzoparib

**Type**

Synthetic organic

**Drug name stem**

\-parib

**Approval recorded by Guide to Pharmacology**

Yes

### Mechanisms of action

- **Action**  
Inhibition

**Action type**  
Inhibitor

**Target**  
poly(ADP-ribose) polymerase 1

**Gene symbol**  
PARP1

**Protein identifier**  
P09874

**Median affinity**

8.05

**Affinity units**  
pIC50

### Investigated indications (21)

- **Condition**  
Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000616

**Subject identifier**  
D009369
- **Condition**  
Carcinoma, Renal Cell

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000681

**Subject identifier**  
D002292
- **Condition**  
Sarcoma

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000691

**Subject identifier**  
D012509
- **Condition**  
Small Cell Lung Carcinoma

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000702

**Subject identifier**  
D055752
- **Condition**  
Melanoma

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000756

**Subject identifier**  
D008545
- **Condition**  
Liver Diseases

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0001421

**Subject identifier**  
D008107
- **Condition**  
Pancreatic Neoplasms

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0002618

**Subject identifier**  
D010190
- **Condition**  
Carcinoma, Non-Small-Cell Lung

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0003060

**Subject identifier**  
D002289
- **Condition**  
Kidney Diseases

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0003086

**Subject identifier**  
D007674
- **Condition**  
Ovarian Neoplasms

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0003893

**Subject identifier**  
D010051
- **Condition**  
Triple Negative Breast Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0005537

**Subject identifier**  
D064726
- **Condition**  
Esophageal Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0005922

**Subject identifier**  
D004938
- **Condition**  
Pancreatic Neoplasms

**Highest recorded phase**  
3

**Condition identifier**  
EFO:1000359

**Subject identifier**  
D010190
- **Condition**  
Endometrial Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
EFO:1001512

**Subject identifier**  
D016889
- **Condition**  
Sarcoma

**Highest recorded phase**  
2

**Condition identifier**  
EFO:1001968

**Subject identifier**  
D012509
- **Condition**  
Stomach Neoplasms

**Highest recorded phase**  
1

**Condition identifier**  
MONDO:0001056

**Subject identifier**  
D013274
- **Condition**  
Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0004992

**Subject identifier**  
D009369
- **Condition**  
Breast Neoplasms

**Highest recorded phase**  
3

**Condition identifier**  
MONDO:0007254

**Subject identifier**  
D001943
- **Condition**  
Ovarian Neoplasms

**Highest recorded phase**  
3

**Condition identifier**  
MONDO:0008170

**Subject identifier**  
D010051
- **Condition**  
Prostatic Neoplasms, Castration-Resistant

**Highest recorded phase**  
3

**Condition identifier**  
MONDO:0008315

**Subject identifier**  
D064129
- **Condition**  
Nasopharyngeal Carcinoma

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0015459

**Subject identifier**  
D000077274

### Open Targets indications (40)

- **Condition identifier**  
EFO\_0000174

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0000616

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0000681

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0000691

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0000756
- **Condition identifier**  
EFO\_0001421

**Highest recorded phase**  
1
- **Condition identifier**  
EFO\_0002618

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0003060

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0003086

**Highest recorded phase**  
1
- **Condition identifier**  
EFO\_0005922

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_1000359
- **Condition identifier**  
EFO\_1001968

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0001056

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0002158

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0002974

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0004992

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005070

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005097

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005105

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005140

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0005192

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005233

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005494

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0005575

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0006047

**Highest recorded phase**  
1

And 15 more, listed on the interactive page.

### Trial references (56)

- NCT02575651  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02575651)
- NCT03645200  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03645200)
- NCT04193319  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04193319)
- NCT02747342  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02747342)
- NCT04102124  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04102124)
- NCT04108247  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04108247)
- NCT04691804  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04691804)
- NCT04869488  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04869488)
- NCT05223582  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05223582)
- NCT02759666  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02759666)
- NCT03062982  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03062982)
- NCT03182673  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03182673)
- NCT04013048  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04013048)
- NCT04108676  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04108676)
- NCT05349409  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05349409)
- NCT05440006  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05440006)
- NCT06208410  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06208410)
- NCT03026881  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03026881)
- NCT03509636  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03509636)
- NCT03863860  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03863860)
- NCT04517357  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04517357)
- NCT04718740  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04718740)
- NCT05170594  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05170594)
- NCT05479487  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05479487)
- NCT05585281  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05585281)

And 31 more, listed on the interactive page.

## Chemical properties

**Hydrogen bond acceptors**

6

**Hydrogen bond donors**

1

**Polar surface area**

96.77

**Calculated partition coefficient (ALogP)**

2.92

**Calculated partition coefficient (XLogP)**

2.4

**Prodrug**

No

**Chirality**

Achiral

**Inorganic**

No

**Rule-of-five violations**

0

**Rotatable bonds**

3

**Heavy atoms**

34

**Molecular formula**

C22H16F4N6O2

**Monoisotopic mass**

472.12708642

**Natural product**

No

## Evidence counts

**Recorded assays**

19

**Active assays**

8

### Active assay types

- Confirmatory

## Pharmacologic actions

- Poly(ADP-ribose) Polymerase Inhibitors  
Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D000067856.html)

## Biological measurements

### Observed measurements

#### Oral bioavailability

**Median**

35.8

**Mean**

35.8

**Minimum**

35.8

**Maximum**

35.8

**Unit**

%

**Assays**

1

**Standard deviation**

0

**Summary method**

median

**Censored results excluded**

0

**Other units excluded**

0

**Unknown units excluded**

0

#### Measurement types

- F

## Related records

### Trials (96)

- A Clinical Study of Chemoradiotherapy Sequential Fluzoparib in Pan-solid Tumors
- [A Clinical Study of JS105 in Combination With Other Anti-tumor Therapies in Patients With Solid Tumors](https://trialight.com/data/trial/a-clinical-study-of-js105-in-combination-with-other-anti-a416fdf1-1a18-433c-aa31-f3b60bad7915.md)
- A Drug-drug Interaction Study Of Fluzoparib (SHR3162) on Patients With Recurrent Ovarian Cancer
- A Drug-drug Interaction Trial of Rifampicin Pharmacokinetics Effect on Fluzoparib
- A Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase III Study of Fuzuloparib Combined With Abiraterone Acetate and Prednisone (AA-P) Versus Placebo Combined With AA-P as First-Line Treatment in Patients With Metastatic Castration-Resistant Prostate Cancer
- A Non-interventional Registry Study of Fluzoparib in the Treatment of Ovarian Cancer
- A Phase 1 Trial of SHR3680 With or Without SHR3162 in Prostate Cancer
- A Phase 2 Trial of Fluzoparib Combined With Apatinib Versus Fluzoparib Monotherapy in Treatment With Relapsed Ovarian Cancer Patients
- A Phase I Study of Fluzoparib in Patient With Advanced Solid Malignancies
- A Phase I Trial of SHR3162 in Subjects With Advanced Solid Tumors
- A Phase II Clinical Study to Evaluate the Efficacy and Safety of Flazoparib Combined With Temozolomide After the Completion of Standard Concurrent Chemoradiotherapy (CCRT) in Newly Diagnosed Glioblastoma
- A Randomized, Open-label, Double-cohort Study of Fluzoparib Combined With Famitinib Malate or SHR-1701 for Neoadjuvant Therapy in Patients With Advanced Ovarian Cancer
- A Single-Arm Phase Ⅱ Study of Fluzoparib Maintenance in Platinum-sensitive Advanced Triple-Negative Breast Cance
- A Study of Abiraterone in Combination With SHR3162 in the Treatment of mCRPC
- A Study of Bevacizumab Combined With Fluzoparib/Chemotherapy or Fluzoparib in the Treatment of Ovarian Cancer
- A Study of Fluzoparib (SHR-3162) and Temozolomide With or Without SHR-1316 in Treating Patients With Replapsed Small Cell Lung Cancer
- A Study of Fluzoparib Combined With Apatinib as Second-Line Treatment of Patients With Extensive Stage Small Cell Lung Cancer（FA-ES-SCLC）
- A Study of Fluzoparib Combined With QL1101 Maintenance Treatment in Patients With Advanced Ovarian Cancer Following Response on Front-Line Platinum-Based Chemotherapy
- A Study of Fluzoparib Given in Combination With Apatinib and Paclitaxel in Gastric Cancer Patients
- A Study of Fluzoparib Given in Combination With Apatinib in Ovarian or Breast Cancer Patients

### In development for (35)

- Bone sarcoma Phase 2
- [Breast cancer](https://trialight.com/data/condition/breast-cancer-8ac10da3-93bd-54c5-a93b-265bc6699689.md) Phase 3
- [Cancer](https://trialight.com/data/condition/cancer-703b1dfc-4812-50eb-83f4-d7a205d16bdb.md) Phase 2
- [Cervical cancer](https://trialight.com/data/condition/cervical-cancer-10fb8f6c-5aac-5281-8f06-7238adeec443.md) Phase 2
- [Colorectal cancer](https://trialight.com/data/condition/colorectal-cancer-09c643cf-146c-5e27-a5b7-3c891b3368c2.md) Phase 2
- [Endometrial cancer](https://trialight.com/data/condition/endometrial-cancer-4da2a0bc-7943-502b-a698-cc2beccbed8c.md) Phase 2
- [Endometrial carcinoma](https://trialight.com/data/condition/endometrial-carcinoma-d0794a04-ff16-5af6-8fb7-7b3d6bd6c537.md) Phase 2
- [Esophageal squamous cell carcinoma](https://trialight.com/data/condition/esophageal-squamous-cell-carcinoma-c10bd9c9-02f9-5805-8008-b021f4604e7a.md) Phase 2
- Ewing sarcoma Phase 2
- Exocrine pancreatic carcinoma Phase 3
- [Fallopian tube cancer](https://trialight.com/data/condition/fallopian-tube-cancer-b95d05ee-41d5-565a-87e1-041170b88760.md) Phase 3
- [Gastric cancer](https://trialight.com/data/condition/gastric-cancer-3c1e2785-2672-5b3e-afce-9335f684c159.md) Phase 1
- Glioblastoma Phase 2
- [Kidney disorder](https://trialight.com/data/condition/kidney-disorder-e50371fe-f1a7-53fe-9cfb-9d6da9130e3c.md) Phase 1
- [Liver disorder](https://trialight.com/data/condition/liver-disorder-8388d30a-2581-5015-9ddf-adc5f6a331d7.md) Phase 1
- Malignant epithelial tumor of ovary Phase 2
- [Malignant pancreatic neoplasm](https://trialight.com/data/condition/malignant-pancreatic-neoplasm-5dd0b53e-5962-50ea-a2e5-cf2444bd0485.md) Phase 3
- [Melanoma](https://trialight.com/data/condition/melanoma-457e9de6-dcd9-56fb-be48-0290fb4386ef.md) Phase 1
- [Nasopharyngeal carcinoma](https://trialight.com/data/condition/nasopharyngeal-carcinoma-9ead4a97-f794-5dda-b62e-20f8ca202f89.md) Phase 2
- [Neoplasm](https://trialight.com/data/condition/neoplasm-2a973797-359b-5982-907e-98f9b7c1a284.md) Phase 2

### Targets (1)

- [PARP1](https://trialight.com/data/target/parp1-78c558f2-1477-56b9-9f9f-c1e925a07421.md)

---

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