> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/fluticasone-07b854dc-6b49-4d3b-8c5a-54e2b7a89943
> Record changed: 2026-10-13

# Fluticasone

Highest phase reached

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1201396)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1201396)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1201396)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1201396)

**Drug name**

Fluticasone

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1201396)

**Molecular weight**

444.52

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1201396)

**Structure (SMILES)**

C\[C@@H\]1C\[C@H\]2\[C@@H\]3C\[C@H\](F)C4=CC(=O)C=C\[C@\]4(C)\[C@@\]3(F)\[C@@H\](O)C\[C@\]2(C)\[C@@\]1(O)C(=O)SCF

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1201396)

### Other names (29)

- azithromycin and fluticasone
- fluticaps
- FLUTICAPS
- fluticasone
- Fluticasone
- FLUTICASONE \[HSDB\]
- fluticasone \[INN\]
- FLUTICASONE \[MART.\]
- FLUTICASONE \[VANDF\]
- Fluticasone \[WHO-DD\]
- Fluticasone 100 mcg
- Fluticasone 220 mcg
- Fluticasone 250 mcg
- Fluticasone 44 mcg
- fluticasone 500 mcg
- fluticasone hsdb
- fluticasone inn
- fluticasone mart
- fluticasone vandf
- fluticasone who dd
- Inhaled corticosteroid (fluticasone)
- opn 375
- OPN-375
- optinose
- OPTINOSE

And 4 more, listed on the interactive page.

## Identifiers

**CAS registry numbers**

- 90566-53-3

**ChEMBL ID**

CHEMBL1201396

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1201396)

**InChIKey**

MGNNYOODZCAHBA-GQKYHHCASA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1201396)

**PubChem compound IDs**

- 5311101

**RxNorm IDs (RxCUI)**

- 41126

**FDA ingredient codes (UNII)**

- CUT2W21N7U

### ATC classification codes (3)

- D07AC17
- R01AD08
- R03BA05

Sources for recorded values

Source: [mor.nlm.nih.gov](https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=41126)

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Drug classification

**Pharmacology name**

fluticasone

**Type**

Synthetic organic

**Approval recorded by Guide to Pharmacology**

Yes

### Mechanisms of action

- **Action**  
Agonist

**Action type**  
Agonist

**Target**  
Glucocorticoid receptor

**Gene symbol**  
NR3C1

**Protein identifier**  
P04150

**Primary target**  
Yes

### Investigated indications (5)

- **Condition**  
Pulmonary Disease, Chronic Obstructive

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000341

**Subject identifier**  
D029424
- **Condition**  
Diabetes Mellitus

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000400

**Subject identifier**  
D003920
- **Condition**  
Eosinophilic Esophagitis

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0004232

**Subject identifier**  
D057765
- **Condition**  
Croup

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0007227

**Subject identifier**  
D003440
- **Condition**  
Asthma

**Highest recorded phase**  
3

**Condition identifier**  
MONDO:0004979

**Subject identifier**  
D001249

### Open Targets indications (24)

- **Condition identifier**  
EFO\_0000274

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000341

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000400

**Highest recorded phase**  
1
- **Condition identifier**  
EFO\_0000684
- **Condition identifier**  
EFO\_0004232

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0005854
- **Condition identifier**  
EFO\_0007227

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0008521
- **Condition identifier**  
EFO\_1001461
- **Condition identifier**  
HP\_0002094

**Highest recorded phase**  
1
- **Condition identifier**  
HP\_0006536
- **Condition identifier**  
HP\_0100582
- **Condition identifier**  
MONDO\_0004784
- **Condition identifier**  
MONDO\_0004822

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0004979

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0005002

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0005324
- **Condition identifier**  
MONDO\_0005361

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0006031
- **Condition identifier**  
MONDO\_0006314
- **Condition identifier**  
MONDO\_0007147

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0009061
- **Condition identifier**  
MONDO\_0011786

**Highest recorded phase**  
4
- **Condition identifier**  
MONDO\_0015265

### Reported adverse events (90)

- **Event**  
adrenal insufficiency

**Reports**  
139

**Reporting signal score**

320.02
- **Event**  
adrenal suppression

**Reports**  
82

**Reporting signal score**

337.896
- **Event**  
anosmia

**Reports**  
67

**Reporting signal score**

154.939
- **Event**  
asthma

**Reports**  
1,646

**Reporting signal score**  
5,224.28
- **Event**  
asthma-chronic obstructive pulmonary disease overlap syndrome

**Reports**  
49

**Reporting signal score**

240.48
- **Event**  
asthmatic crisis

**Reports**  
46

**Reporting signal score**

142.391
- **Event**  
blood cortisol decreased

**Reports**  
46

**Reporting signal score**

169.933
- **Event**  
blood count abnormal

**Reports**  
324

**Reporting signal score**

918.159
- **Event**  
blood immunoglobulin e increased

**Reports**  
36

**Reporting signal score**

92.1508
- **Event**  
blood test abnormal

**Reports**  
58

**Reporting signal score**

97.2065
- **Event**  
breath sounds abnormal

**Reports**  
85

**Reporting signal score**

244.373
- **Event**  
bronchial obstruction

**Reports**  
38

**Reporting signal score**

116.845
- **Event**  
bronchial wall thickening

**Reports**  
27

**Reporting signal score**

96.9819
- **Event**  
bronchiectasis

**Reports**  
135

**Reporting signal score**

396.747
- **Event**  
bronchitis

**Reports**  
158

**Reporting signal score**

148.129
- **Event**  
bursitis

**Reports**  
113

**Reporting signal score**

274.076
- **Event**  
candida infection

**Reports**  
60

**Reporting signal score**

91.9006
- **Event**  
central obesity

**Reports**  
27

**Reporting signal score**

91.6916
- **Event**  
chest discomfort

**Reports**  
300

**Reporting signal score**

375.114
- **Event**  
chronic obstructive pulmonary disease

**Reports**  
328

**Reporting signal score**

699.115
- **Event**  
chronic sinusitis

**Reports**  
39

**Reporting signal score**

95.1247
- **Event**  
coeliac disease

**Reports**  
115

**Reporting signal score**

340.147
- **Event**  
condition aggravated

**Reports**  
260

**Reporting signal score**

86.7498
- **Event**  
cough

**Reports**  
718

**Reporting signal score**

907.064
- **Event**  
cushing's syndrome

**Reports**  
186

**Reporting signal score**

625.47

And 65 more, listed on the interactive page.

### Trial references (17)

- NCT00079937  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00079937)
- NCT00504062  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00504062)
- NCT00543686  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00543686)
- NCT00646009  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00646009)
- NCT00695604  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00695604)
- NCT01202084  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01202084)
- NCT03238482  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03238482)
- NCT04265105  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04265105)
- NCT00535366  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00535366)
- NCT00908362  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00908362)
- NCT01315249  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01315249)
- NCT01709903  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01709903)
- NCT01834885  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01834885)
- NCT01860066  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01860066)
- NCT00674050  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00674050)
- NCT01702701  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01702701)
- NCT01748162  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01748162)

## Chemical properties

**Hydrogen bond acceptors**

5

**Hydrogen bond donors**

2

**Polar surface area**

74.6

**Calculated partition coefficient (ALogP)**

3.47

**Calculated partition coefficient (XLogP)**

3.2

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Rule-of-five violations**

0

**Rotatable bonds**

2

**Heavy atoms**

30

**Molecular formula**

C22H27F3O4S

**Monoisotopic mass**

444.15821500

**Natural product**

No

## Evidence counts

**Recorded assays**

40

**Active assays**

2

### Active assay types (2)

- Confirmatory
- Other

## Pharmacologic actions

- Anti-Inflammatory Agents  
Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D000893.html)
- Bronchodilator Agents  
Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D001993.html)
- Dermatologic Agents  
Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D003879.html)
- Anti-Allergic Agents  
Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D018926.html)

## Biological measurements

### Observed measurements

#### Solubility

**Median**

0.5

**Mean**

0.5

**Minimum**

0.5

**Maximum**

0.5

**Unit**

ug/mL

**Assays**

1

**Standard deviation**

0

**Summary method**

median

**Censored results excluded**

0

**Other units excluded**

0

**Unknown units excluded**

0

#### Measurement types

- Solubility

#### Oral bioavailability

**Median**

1

**Mean**

1

**Minimum**

1

**Maximum**

1

**Unit**

%

**Assays**

1

**Standard deviation**

0

**Summary method**

median

**Censored results excluded**

0

**Other units excluded**

0

**Unknown units excluded**

0

#### Measurement types

- F

## Related records

### Trials (737)

- 2nd-line Treatment of Metastatic Colorectal Cancer
- 3D Evaluation of Postoperative Edema After Third Molar Surgery
- 4SC-202 in Combination With Pembrolizumab in Patients Primary Refractory/Non-responding to Prior Anti-PD-1 Therapy
- 5-Azacytidine and/or Nivolumab in Resectable HPV-Associated HNSCC
- 5-Fluorouracil and Calcipotriene for Treatment of Low Grade Skin Cancer
- A 1-year Multi-center, Prospective, Cohort Study in Patients With Chronic Obstructive Pulmonary Disease Treated With Long-acting Bronchodilator
- A 12 Week Study of QVA149 Compared to Fluticasone/Salmeterol (Advair) for Treatment of COPD
- A 12 Week Study of QVA149 Compared to Fluticasone/Salmeterol (Advair) for Treatment of COPD
- A 12-week Study to Compare the Efficacy and Safety of Fixed Combinations of Fenofibrate/Simvastatin 145/20mg and Fenofibrate/Simvastatin 145/40mg Tablets Versus Fenofibrate or Simvastatin Monotherapies in Subjects With Abnormal Blood Levels of Fats (Lipids) and at High Risk of Cardiovascular Disease
- A 26-week Treatment Randomized, Double-blind, Double Dummy Study to Assess the Efficacy and Safety of QVA149
- A 6-week Safety & Efficacy Study of Combination Intraocular Pressure-lowering Therapy in Patients With Open-angle Glaucoma or Ocular Hypertension
- A Clinical Study on Evaluating Intravenous Administration of IDOV-SAFE
- A Clinical Study to Evaluate Efficacy and Safety of Fimasartan/Hydrochlorothiazide Combination-therapy
- A Clinical Study to Evaluate GK01 Cell Injection in Combination With PD-1 Monoclonal Antibody for Advanced Solid Tumors
- A Clinical Study to Evaluate the Safety and Tolerability of JS107 in Advanced Pancreatic Cancer
- A Clinical Trial Evaluating Efficacy and Safety of MC2-01 Cream
- A Clinical Trial to Compare Lasotronix Alone or in Combination With CPP-ACP to Treat DH
- A Combination Drug Including Fimasartan and Statins in Patients With Hypertension and Dyslipidemia
- A Combination of Antibiotics to Decrease Neonatal Morbidity and Mortality for Previable Threatened Labor
- A Comparative Effectiveness RCT of Optimized Cessation Treatments

### In development for (6)

- [Asthma](https://trialight.com/data/condition/asthma-247437fb-0e60-5885-8a3a-ce40099cea88.md) Phase 3
- [Atopic eczema](https://trialight.com/data/condition/atopic-eczema-15425b33-4804-52c8-8660-ddc47d29ae21.md) Phase 3
- [Chronic obstructive pulmonary disease](https://trialight.com/data/condition/chronic-obstructive-pulmonary-disease-8e23f74b-95b9-5920-a241-c0278555234f.md) Phase 3
- Croup Phase 3
- [Diabetes mellitus](https://trialight.com/data/condition/diabetes-mellitus-1a0391a8-9f84-5600-a2bf-ec97c2229de4.md) Phase 1
- Eosinophilic esophagitis Phase 3

### Other linked conditions (5)

- [Allergic asthma](https://trialight.com/data/condition/allergic-asthma-09fdf0b0-d623-5f2a-9bed-3f05a0ce487a.md)
- [Allergic rhinitis](https://trialight.com/data/condition/allergic-rhinitis-5900f04b-c465-5b16-bbb0-e03e4c2cbdfc.md)
- [Cystic fibrosis](https://trialight.com/data/condition/cystic-fibrosis-6f9870eb-6ebc-5bec-a50b-34b0b323a7c3.md)
- Respiratory system disorder
- [Rhinitis](https://trialight.com/data/condition/rhinitis-0b0ed4e7-156d-5522-93d0-5e6462deb160.md)

---

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