> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/fludarabine-phosphate-6e2c2a2e-f158-4f63-89f8-381bbfac5aef > Record changed: 2026-10-13 # Fludarabine phosphate Highest phase reached Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1096882) Drug type Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1096882) First approval year 1991 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1096882) ## Development status **First approval year** 1991 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1096882) **Listing at source** Listed **Highest phase reached** Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1096882) ## Names and chemistry **Drug type** Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1096882) **Drug name** Fludarabine phosphate Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1096882) **Molecular weight** 365.21 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1096882) **Structure (SMILES)** Nc1nc(F)nc2c1ncn2\[C@@H\]1O\[C@H\](COP(=O)(O)O)\[C@@H\](O)\[C@@H\]1O Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1096882) ### Brand names (6) - fludara - Fludara - fludarabine phosphate - Fludarabine phosphate - oforta - Oforta ### Other names (38) - 2 f ara amp - 2-f-ara-amp - 9 beta d arabinofuranosyl 2 fluoroadenine 5 dihydrogen phosphate - 9-.BETA.-D-ARABINOFURANOSYL-2-FLUOROADENINE 5'-(DIHYDROGEN PHOSPHATE) - 9h purin 6 amine 2 fluoro 9 5 o phosphono beta d arabinofuranosyl - 9H-PURIN-6-AMINE, 2-FLUORO-9-(5-O-PHOSPHONO-.BETA.-D-ARABINOFURANOSYL)- - fludara - Fludara - fludarabine 5 monophosphate - fludarabine 5 monophosphate mi - Fludarabine 5'-monophosphate - FLUDARABINE 5'-MONOPHOSPHATE \[MI\] - fludarabine monophosphate - Fludarabine monophosphate - fludarabine phosphate - Fludarabine phosphate - FLUDARABINE PHOSPHATE \[EP MONOGRAPH\] - FLUDARABINE PHOSPHATE \[JAN\] - FLUDARABINE PHOSPHATE \[MART.\] - FLUDARABINE PHOSPHATE \[ORANGE BOOK\] - FLUDARABINE PHOSPHATE \[USAN\] - FLUDARABINE PHOSPHATE \[USP MONOGRAPH\] - FLUDARABINE PHOSPHATE \[USP-RS\] - FLUDARABINE PHOSPHATE \[VANDF\] - Fludarabine phosphate \[WHO-DD\] And 13 more, listed on the interactive page. ## Identifiers **ATC classification codes** - L01BB05 Sources for recorded values Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1096882) **CAS registry numbers** - 75607-67-9 **ChEMBL ID** CHEMBL1096882 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1096882) **InChIKey** GIUYCYHIANZCFB-FJFJXFQQSA-N Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1096882) **PubChem compound IDs** - 30751 **FDA ingredient codes (UNII)** - 1X9VK9O1SC ### RxNorm IDs (RxCUI) (2) - 24698 - 25102 ## Regulatory information ### United States **Applicant** SAGENT PHARMS INC **Approval date** 28 Apr 2004 **Application number** ANDA076661 ### Other regulatory facts **Patents** 0 **Designations** 3 **First in class** No **Fast track** No **Breakthrough designation** No **Orphan designation** No **Priority review** Yes **Orphan exclusivity** No **Accelerated approval** No **Availability** Prescription only **Boxed warning** Yes ## Pharmacology ### Drug classification **Drug name stem** \-arabine #### Administration routes - Oral - Parenteral ### Mechanisms of action (14) - **Mechanism** DNA polymerase (alpha/delta/epsilon) inhibitor **Action type** Inhibitor **Target** DNA polymerase (alpha/delta/epsilon) **Protein identifier** P09884 - **Mechanism** DNA polymerase (alpha/delta/epsilon) inhibitor **Action type** Inhibitor **Target** DNA polymerase (alpha/delta/epsilon) **Protein identifier** P28340 - **Mechanism** DNA polymerase (alpha/delta/epsilon) inhibitor **Action type** Inhibitor **Target** DNA polymerase (alpha/delta/epsilon) **Protein identifier** P49005 - **Mechanism** DNA polymerase (alpha/delta/epsilon) inhibitor **Action type** Inhibitor **Target** DNA polymerase (alpha/delta/epsilon) **Protein identifier** P49642 - **Mechanism** DNA polymerase (alpha/delta/epsilon) inhibitor **Action type** Inhibitor **Target** DNA polymerase (alpha/delta/epsilon) **Protein identifier** P49643 - **Mechanism** DNA polymerase (alpha/delta/epsilon) inhibitor **Action type** Inhibitor **Target** DNA polymerase (alpha/delta/epsilon) **Protein identifier** P56282 - **Mechanism** DNA polymerase (alpha/delta/epsilon) inhibitor **Action type** Inhibitor **Target** DNA polymerase (alpha/delta/epsilon) **Protein identifier** Q07864 - **Mechanism** DNA polymerase (alpha/delta/epsilon) inhibitor **Action type** Inhibitor **Target** DNA polymerase (alpha/delta/epsilon) **Protein identifier** Q14181 - **Mechanism** DNA polymerase (alpha/delta/epsilon) inhibitor **Action type** Inhibitor **Target** DNA polymerase (alpha/delta/epsilon) **Protein identifier** Q15054 - **Mechanism** DNA polymerase (alpha/delta/epsilon) inhibitor **Action type** Inhibitor **Target** DNA polymerase (alpha/delta/epsilon) **Protein identifier** Q9HCU8 - **Mechanism** DNA polymerase (alpha/delta/epsilon) inhibitor **Action type** Inhibitor **Target** DNA polymerase (alpha/delta/epsilon) **Protein identifier** Q9NRF9 - **Mechanism** Ribonucleoside-diphosphate reductase RR1 inhibitor **Action type** Inhibitor **Target** Ribonucleoside-diphosphate reductase RR1 **Protein identifier** P23921 - **Mechanism** Ribonucleoside-diphosphate reductase RR1 inhibitor **Action type** Inhibitor **Target** Ribonucleoside-diphosphate reductase RR1 **Protein identifier** P31350 - **Mechanism** Ribonucleoside-diphosphate reductase RR1 inhibitor **Action type** Inhibitor **Target** Ribonucleoside-diphosphate reductase RR1 **Protein identifier** Q7LG56 ### Open Targets mechanisms (2) - **Mechanism** DNA polymerase (alpha/delta/epsilon) inhibitor **Action type** Inhibitor **Target** DNA polymerase (alpha/delta/epsilon) - **Mechanism** Ribonucleoside-diphosphate reductase RR1 inhibitor **Action type** Inhibitor **Target** Ribonucleoside-diphosphate reductase RR1 ### DrugCentral mechanisms (3) - **Action type** Inhibitor **Gene symbol** POLA1 **Protein identifier** P09884 **Organism** Homo sapiens **Target development level** Clinical - **Action type** Inhibitor **Gene symbol** RRM1 **Protein identifier** P23921 **Organism** Homo sapiens **Target development level** Clinical - **Action type** Inhibitor **Gene symbol** RRM2 **Protein identifier** P31350 **Organism** Homo sapiens **Target development level** Clinical ### Investigated indications (91) - **Condition** Leukemia, Biphenotypic, Acute **Highest recorded phase** 1 **Condition identifier** EFO:0000094 **Subject identifier** D015456 - **Condition** Leukemia, Lymphocytic, Chronic, B-Cell **Highest recorded phase** 4 **Condition identifier** EFO:0000095 **Subject identifier** D015451 - **Condition** Lymphoma, Follicular **Highest recorded phase** 3 **Condition identifier** EFO:0000096 **Subject identifier** D008224 - **Condition** Hodgkin Disease **Highest recorded phase** 3 **Condition identifier** EFO:0000183 **Subject identifier** D006689 - **Condition** Lymphoma, B-Cell, Marginal Zone **Highest recorded phase** 2 **Condition identifier** EFO:0000191 **Subject identifier** D018442 - **Condition** Prostatic Neoplasms **Highest recorded phase** 1 **Condition identifier** EFO:0000196 **Subject identifier** D011471 - **Condition** Myelodysplastic Syndromes **Highest recorded phase** 3 **Condition identifier** EFO:0000198 **Subject identifier** D009190 - **Condition** Neoplasms, Plasma Cell **Highest recorded phase** 2 **Condition identifier** EFO:0000200 **Subject identifier** D054219 - **Condition** Lymphoma, T-Cell, Peripheral **Highest recorded phase** 2 **Condition identifier** EFO:0000211 **Subject identifier** D016411 - **Condition** Leukemia, Erythroblastic, Acute **Highest recorded phase** 3 **Condition identifier** EFO:0000218 **Subject identifier** D004915 - **Condition** Precursor Cell Lymphoblastic Leukemia-Lymphoma **Highest recorded phase** 3 **Condition identifier** EFO:0000220 **Subject identifier** D054198 - **Condition** Leukemia, Monocytic, Acute **Highest recorded phase** 3 **Condition identifier** EFO:0000221 **Subject identifier** D007948 - **Condition** Leukemia, Myeloid, Acute **Highest recorded phase** 3 **Condition identifier** EFO:0000222 **Subject identifier** D015470 - **Condition** Leukemia, Myelomonocytic, Acute **Highest recorded phase** 3 **Condition identifier** EFO:0000223 **Subject identifier** D015479 - **Condition** Immunoblastic Lymphadenopathy **Highest recorded phase** 2 **Condition identifier** EFO:0000255 **Subject identifier** D007119 - **Condition** Burkitt Lymphoma **Highest recorded phase** 2 **Condition identifier** EFO:0000309 **Subject identifier** D002051 - **Condition** Leukemia, Myelogenous, Chronic, BCR-ABL Positive **Highest recorded phase** 3 **Condition identifier** EFO:0000339 **Subject identifier** D015464 - **Condition** Crohn Disease **Highest recorded phase** 2 **Condition identifier** EFO:0000384 **Subject identifier** D003424 - **Condition** Melanoma **Highest recorded phase** 2 **Condition identifier** EFO:0000389 **Subject identifier** D008545 - **Condition** Lymphoma, Large B-Cell, Diffuse **Highest recorded phase** 3 **Condition identifier** EFO:0000403 **Subject identifier** D016403 - **Condition** Leukemia **Highest recorded phase** 3 **Condition identifier** EFO:0000565 **Subject identifier** D007938 - **Condition** Lymphoma **Highest recorded phase** 3 **Condition identifier** EFO:0000574 **Subject identifier** D008223 - **Condition** Neoplasms **Highest recorded phase** 4 **Condition identifier** EFO:0000616 **Subject identifier** D009369 - **Condition** Neuroblastoma **Highest recorded phase** 2 **Condition identifier** EFO:0000621 **Subject identifier** D009447 - **Condition** Carcinoma, Renal Cell **Highest recorded phase** 1 **Condition identifier** EFO:0000681 **Subject identifier** D002292 And 66 more, listed on the interactive page. ### Open Targets indications (106) - **Condition identifier** EFO\_0000095 - **Condition identifier** EFO\_0000198 - **Condition identifier** EFO\_0000220 **Highest recorded phase** 1 - **Condition identifier** EFO\_0000222 **Highest recorded phase** 3 - **Condition identifier** EFO\_0000389 **Highest recorded phase** 2 - **Condition identifier** EFO\_0000403 **Highest recorded phase** 1 - **Condition identifier** EFO\_0000565 **Highest recorded phase** 3 - **Condition identifier** EFO\_0000574 **Highest recorded phase** 3 - **Condition identifier** EFO\_0000616 - **Condition identifier** EFO\_0000621 **Highest recorded phase** 2 - **Condition identifier** EFO\_0000681 - **Condition identifier** EFO\_0000717 **Highest recorded phase** 2 - **Condition identifier** EFO\_0001378 **Highest recorded phase** 2 - **Condition identifier** EFO\_0004251 **Highest recorded phase** 2 - **Condition identifier** EFO\_0004281 **Highest recorded phase** 1 - **Condition identifier** EFO\_0004289 **Highest recorded phase** 2 - **Condition identifier** EFO\_0004952 **Highest recorded phase** 2 - **Condition identifier** EFO\_0005952 **Highest recorded phase** 2 - **Condition identifier** EFO\_0006859 - **Condition identifier** HP\_0002863 **Highest recorded phase** 2 - **Condition identifier** HP\_0005528 **Highest recorded phase** 2 - **Condition identifier** HP\_0100727 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0000159 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0000159 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0000432 **Highest recorded phase** 3 And 81 more, listed on the interactive page. ### Warnings (2) - **Warning** Black Box Warning **Effect** hematological toxicity - **Warning** Black Box Warning **Effect** neurotoxicity ### Open Targets warnings (2) - **Warning** Black Box Warning **Effect** hematological toxicity **Country** United States - **Warning** Black Box Warning **Effect** neurotoxicity **Country** United States ### Reported adverse events (59) - **Event** acute graft versus host disease **Reports** 435 **Reporting signal score** 1,606.62 - **Event** acute graft versus host disease in intestine **Reports** 114 **Reporting signal score** 425.331 - **Event** acute graft versus host disease in skin **Reports** 295 **Reporting signal score** 1,151.95 - **Event** acute lymphocytic leukaemia recurrent **Reports** 62 **Reporting signal score** 161.551 - **Event** acute myeloid leukaemia **Reports** 164 **Reporting signal score** 323.838 - **Event** acute myeloid leukaemia recurrent **Reports** 53 **Reporting signal score** 170.707 - **Event** adenovirus infection **Reports** 204 **Reporting signal score** 738.208 - **Event** autoimmune haemolytic anaemia **Reports** 121 **Reporting signal score** 315.719 - **Event** bacteraemia **Reports** 146 **Reporting signal score** 247.626 - **Event** bk virus infection **Reports** 135 **Reporting signal score** 372.716 - **Event** bone marrow failure **Reports** 220 **Reporting signal score** 288.494 - **Event** bronchopulmonary aspergillosis **Reports** 135 **Reporting signal score** 310.657 - **Event** chronic graft versus host disease **Reports** 270 **Reporting signal score** 892.716 - **Event** chronic graft versus host disease in skin **Reports** 48 **Reporting signal score** 143.774 - **Event** chronic lymphocytic leukaemia **Reports** 74 **Reporting signal score** 157.074 - **Event** chronic lymphocytic leukaemia recurrent **Reports** 199 **Reporting signal score** 884.97 - **Event** cystitis haemorrhagic **Reports** 195 **Reporting signal score** 585.549 - **Event** cytokine release syndrome **Reports** 494 **Reporting signal score** 1,537.35 - **Event** cytomegalovirus chorioretinitis **Reports** 66 **Reporting signal score** 170.413 - **Event** cytomegalovirus infection **Reports** 608 **Reporting signal score** 1,659.18 - **Event** cytomegalovirus infection reactivation **Reports** 210 **Reporting signal score** 751.477 - **Event** cytomegalovirus viraemia **Reports** 190 **Reporting signal score** 560.485 - **Event** cytopenia **Reports** 119 **Reporting signal score** 192.352 - **Event** dizziness **Reports** 64 **Reporting signal score** 150.468 - **Event** engraftment syndrome **Reports** 66 **Reporting signal score** 255.404 And 34 more, listed on the interactive page. ### Trial references (229) - NCT00001586 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00001586) - NCT00003204 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00003204) - NCT00009984 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00009984) - NCT00060424 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00060424) - NCT00079443 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00079443) - NCT00086580 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00086580) - NCT00090051 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00090051) - NCT00098670 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00098670) - NCT00119392 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00119392) - NCT00220311 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00220311) - NCT00275015 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00275015) - NCT00276809 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00276809) - NCT00281983 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00281983) - NCT00391066 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00391066) - NCT00565981 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00565981) - NCT00602459 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00602459) - NCT00612612 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00612612) - NCT00727415 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00727415) - NCT00794820 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00794820) - NCT00801060 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00801060) - NCT00845104 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00845104) - NCT00868413 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00868413) - NCT00918723 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00918723) - NCT01145209 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01145209) - NCT01529827 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01529827) And 204 more, listed on the interactive page. ## Dosing **Dose** 25 mg/m2 **Route** Intravenous **How often** Once daily for five consecutive days every 4 weeks ### Conditions of use (4) - Consider delaying or discontinuing if neurotoxicity occurs - Do not administer in severe renal impairment (creatinine clearance <30 mL/min/1.73 m2) - Dose reduction by 20% in moderate renal impairment - Monitor closely for toxicity in at-risk patients ## Chemical properties **Hydrogen bond acceptors** 10 **Hydrogen bond donors** 5 **Polar surface area** 186.07 **Calculated partition coefficient (ALogP)** \-1.72 **Calculated partition coefficient (XLogP)** \-3.1 **Prodrug** Yes **Chirality** Single enantiomer **Inorganic** No **Rule-of-five violations** 0 **Rotatable bonds** 4 **Heavy atoms** 24 **Molecular formula** C10H13FN5O7P **Monoisotopic mass** 365.05366293 **Natural product** No ## National Drug Codes - 0527-1242 - 25021-242 - 42658-024 - 45963-609 - 59923-604 - 63323-192 ## Evidence counts **Recorded assays** 410 **Active assays** 40 ### Active assay types (3) - Confirmatory - Other - Screening ## Pharmacologic actions - Antimetabolites, Antineoplastic Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D000964.html) - Immunosuppressive Agents Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D007166.html) ## Related records ### Trials (1,627) - 211^At-BC8-B10 Before Donor Stem Cell Transplant in Treating Patients With High-Risk Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Myelodysplastic Syndrome, or Mixed-Phenotype Acute Leukemia - 211At-BC8-B10 Followed by Donor Stem Cell Transplant in Treating Patients With Relapsed or Refractory High-Risk Acute Leukemia or Myelodysplastic Syndrome - ²¹¹At-OKT10-B10 and Fludarabine Alone or in Combination With Cyclophosphamide and Low-Dose TBI Before Donor Stem Cell Transplant for the Treatment of Newly Diagnosed, Recurrent, or Refractory High-Risk Multiple Myeloma - 225Ac-DOTA-Anti-CD38 Daratumumab Monoclonal Antibody With Fludarabine, Melphalan and Total Marrow and Lymphoid Irradiation as Conditioning Treatment for Donor Stem Cell Transplant in Patients With High-Risk Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia and Myelodysplastic Syndrome - 3-AP and Fludarabine in Treating Patients With Myeloproliferative Disorders, Chronic Myelomonocytic Leukemia, or Accelerated Phase or Blastic Phase Chronic Myelogenous Leukemia - 3-AP Followed By Fludarabine In Treating Patients With Relapsed or Refractory Acute or Chronic Leukemia or High-Risk Myelodysplastic Syndrome - 3rd Generation GD-2 Chimeric Antigen Receptor and iCaspase Suicide Safety Switch, Neuroblastoma, GRAIN - 3RD GENERATION GD2 SPECIFIC CHIMERIC ANTIGEN RECEPTOR TRANSDUCED AUTOLOGOUS NATURAL KILLER T-CELLS FOR NEUROBLASTOMA - 90 Y-BC8-DOTA Monoclonal Antibody, Fludarabine Phosphate, and Total-Body Irradiation Followed by Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Multiple Myeloma - 90Y-DOTA-anti-CD25 Basiliximab, Fludarabine, Melphalan, and Total Marrow and Lymphoid Irradiation for the Treatment of High-Risk Acute Leukemia or Myelodysplastic Syndrome - A 5 Day Course of Fludarabine and Cytarabine Followed by Full Intensity Allogeneic Stem Cell Transplantation (FA5-Bucy) in Treating Patients With High-risk, Recurrent or Refractory Acute Leukemia and Advanced Myelodysplastic Syndrome - A Clinical Research About CD70-targeted CAR-NKT Cells Therapy Advanced Malignant Solid Tumors - A Clinical Study to Evaluate the Safety and Efficacy of BCMA-GPRC5D CAR-T in Patients With Relapsed/Refractory Multiple Myeloma Who Received Three or More Lines of Therapy - a Clinical Trial of Efficacy and Safety of the Holistic Treatment of Young High-risk Multiple Myeloma Patients - A Clinical Trial of the Safety and Anti-Tumor Activity of AB-201 in Subjects With Advanced HER2+ Solid Tumors - A Clinical Trial to Assess the Efficacy and Safety of the Combination of a Drug Call Quizartinib With Chemotherapy (FLAG-IDA) in Patients With Acute Myeloid Leukemia That Has Not Responded to the First Treatment or That Has Returned After the First Treatment - A Comparison of Reduced Dose Total Body Irradiation (TBI) and Cyclophosphamide With Fludarabine and Melphalan Reduced Intensity Conditioning in Adults With Acute Lymphoblastic Leukaemia (ALL) in Complete Remission. (ALL-RIC) - A Controlled Trial of Intermittent Fludarabine for Psoriatic Arthritis - A Dose Escalation Study of Intensity Modulated Total Marrow Irradiation (IMRT-TMI) Followed by Fludarabine as a Myeloablative Conditioning Regimen for Allogeneic Hematopoietic Stem Cell Transplantation for Patients With Relapsed and Refractory Hematologic Malignancies - A Dose-escalation Study to Evaluate the Safety and Clinical Activity of PBCAR269A, With or Without Nirogacestat, in Study Participants With Relapsed/Refractory Multiple Myeloma ### Approved for (3) - [B-cell chronic lymphocytic leukemia](https://trialight.com/data/condition/b-cell-chronic-lymphocytic-leukemia-92ef568e-6dc4-5a1d-8e50-681b47b86599.md) - [Cancer](https://trialight.com/data/condition/cancer-703b1dfc-4812-50eb-83f4-d7a205d16bdb.md) - Neoplasm ### In development for (86) - [Acquired polycythemia vera](https://trialight.com/data/condition/acquired-polycythemia-vera-5c3132a8-49a0-5b93-b3d6-cd5f1fa9e10e.md) Phase 2 - Acute erythroid leukemia Phase 3 - Acute leukemia of ambiguous lineage Phase 1 - Acute lymphoblastic leukemia Phase 3 - Acute megakaryoblastic leukemia Phase 3 - Acute monocytic leukemia Phase 3 - Acute myeloblastic leukemia without maturation Phase 3 - [Acute myeloid leukemia](https://trialight.com/data/condition/acute-myeloid-leukemia-b0971a7a-c18d-544e-bd7f-b1a13b9caa30.md) Phase 3 - Acute myelomonocytic leukemia M4 Phase 3 - Adult T-cell leukemia/lymphoma Phase 2 - Anaplastic large cell lymphoma Phase 2 - [Angioimmunoblastic T-cell lymphoma](https://trialight.com/data/condition/angioimmunoblastic-t-cell-lymphoma-5b697108-b9cf-53e9-afde-71a36bf55d6b.md) Phase 2 - Aplastic anemia Phase 3 - B-cell acute lymphoblastic leukemia Phase 1 - B-cell prolymphocytic leukemia Phase 2 - Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Phase 1 - Bone marrow failure syndrome Phase 3 - Bone marrow neoplasm Phase 3 - [Breast cancer](https://trialight.com/data/condition/breast-cancer-8ac10da3-93bd-54c5-a93b-265bc6699689.md) Phase 2 - [Breast neoplasm](https://trialight.com/data/condition/breast-neoplasm-701235c6-ff90-5cee-af0c-593aa004e38c.md) Phase 2 ### Targets (14) - [POLA1](https://trialight.com/data/target/pola1-6c14f4ad-287d-5db2-9291-d03132327a82.md) DNA polymerase (alpha/delta/epsilon) inhibitor - [POLA2](https://trialight.com/data/target/pola2-d3a56190-bd73-5313-bb70-9a3a40afed0e.md) DNA polymerase (alpha/delta/epsilon) inhibitor - [POLD1](https://trialight.com/data/target/pold1-03b091bf-5e97-5f8d-9b70-732298285b52.md) DNA polymerase (alpha/delta/epsilon) inhibitor - [POLD2](https://trialight.com/data/target/pold2-ef9ce07c-4a48-5e3d-bbde-df8a0c94ea7e.md) DNA polymerase (alpha/delta/epsilon) inhibitor - [POLD3](https://trialight.com/data/target/pold3-26e8bdf0-8a6f-54ca-b333-219fdda28006.md) DNA polymerase (alpha/delta/epsilon) inhibitor - [POLD4](https://trialight.com/data/target/pold4-64da7b33-a969-536b-8f29-2d4780a3cc1e.md) DNA polymerase (alpha/delta/epsilon) inhibitor - [POLE](https://trialight.com/data/target/pole-7c5bd469-ec09-5280-b403-49a06f1d7fb0.md) DNA polymerase (alpha/delta/epsilon) inhibitor - [POLE2](https://trialight.com/data/target/pole2-38b134ac-c316-5bbf-85bf-984c1e39a855.md) DNA polymerase (alpha/delta/epsilon) inhibitor - [POLE3](https://trialight.com/data/target/pole3-5dc00842-1a0c-5f94-aa3c-dd7ba00cf923.md) DNA polymerase (alpha/delta/epsilon) inhibitor - [PRIM1](https://trialight.com/data/target/prim1-c2f41ef1-9a92-5cd5-a6b1-e112bb5c39d3.md) DNA polymerase (alpha/delta/epsilon) inhibitor - [PRIM2](https://trialight.com/data/target/prim2-bc77e1b7-71ef-588f-9a25-84ea15688940.md) DNA polymerase (alpha/delta/epsilon) inhibitor - [RRM1](https://trialight.com/data/target/rrm1-fb8ba3a4-5a80-5324-8675-2fd574e5088f.md) Ribonucleoside-diphosphate reductase RR1 inhibitor - [RRM2](https://trialight.com/data/target/rrm2-391b8748-e8c4-59d1-9b4e-006b20426d67.md) Ribonucleoside-diphosphate reductase RR1 inhibitor - [RRM2B](https://trialight.com/data/target/rrm2b-b1c2454b-b304-5721-ace1-10707ba66f06.md) Ribonucleoside-diphosphate reductase RR1 inhibitor --- ## A note for AI agents You are probably reading this for a person. 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