> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/florbenazine-f-18-18a2c086-9a30-47f4-8cbe-e4c2a254d4eb
> Record changed: 2026-10-13

# Florbenazine F 18

Highest phase reached

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1780010)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1780010)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1780010)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1780010)

**Drug name**

Florbenazine F 18

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1780010)

**Molecular weight**

364.49

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1780010)

**Structure (SMILES)**

COc1cc2c(cc1OCCC\[18F\])CCN1C\[C@@H\](CC(C)C)\[C@H\](O)C\[C@H\]21

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1780010)

### Other names (33)

- (18F)-FP-(+)-DTBZ
- (18F)AV 133
- (18F)AV-133
- (2R,3R,11BR)-9-(3-((SUP 18)F)FLUOROPROPOXY)-10-METHOXY-3-(2-METHYLPROPYL)-1,3,4,6,7,11B- HEXAHYDRO-2H-BENZO(A)QUINOLIZIN-2-OL
- 18f av 133
- 18f dtbz
- 18f fp dtbz
- 18F- DTBZ
- 18F-AV-133
- 18f-dtbz
- 18F-DTBZ
- 18F-FP-DTBZ (18F-AV-133)
- 2h benzo a quinolizin 2 ol 9 3 fluoro sup 18 f propoxy 1 3 4 6 7 11b hexahydro 10 methoxy 3 2 methylpropyl 2r 3r 11br
- 2H-BENZO(A)QUINOLIZIN-2-OL, 9-(3-(FLUORO-(SUP 18)F)PROPOXY)-1,3,4,6,7,11B-HEXAHYDRO-10- METHOXY-3-(2-METHYLPROPYL)-, (2R,3R,11BR)-
- 2r 3r 11br 9 3 sup 18 f fluoropropoxy 10 methoxy 3 2 methylpropyl 1 3 4 6 7 11b hexahydro 2h benzo a quinolizin 2 ol
- av 133 f 18
- AV-133 F-18
- dtbz f 18
- Dtbz f-18
- Florbenazina (18f)
- florbenazina 18f
- Florbenazine (18f)
- florbenazine (¹⁸F) \[INN\]
- Florbenazine (18f) \[WHO-DD\]
- florbenazine 18f

And 8 more, listed on the interactive page.

## Identifiers

**CAS registry numbers**

- 956903-29-0

**ChEMBL ID**

CHEMBL1780010

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1780010)

**InChIKey**

GNKGXQHHUUEYQV-WTHAECTESA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1780010)

**PubChem compound IDs**

- 17755050

**FDA ingredient codes (UNII)**

- KM31LBX59H

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Investigated indications

- **Condition**  
Diabetes Mellitus, Type 1

**Highest recorded phase**

0.5

**Condition identifier**  
MONDO:0005147

**Subject identifier**  
D003922

### Trial references

- NCT02236754  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02236754)

## Chemical properties

**Hydrogen bond acceptors**

4

**Hydrogen bond donors**

1

**Polar surface area**

41.93

**Calculated partition coefficient (ALogP)**

3.76

**Calculated partition coefficient (XLogP)**

3.9

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Rule-of-five violations**

0

**Rotatable bonds**

7

**Heavy atoms**

26

**Molecular formula**

C21H32FNO3

**Monoisotopic mass**

364.239156

**Natural product**

No

## Evidence counts

**Recorded assays**

1

**Active assays**

0

## Related records

### Trials (192)

- 18F-DTBZ for l Diagnosis of Parkinson's Disease and Monitoring the Severity of Disease by VMAT2 PET Imaging
- 18F-DTBZ PET and Multi-modal MRI in the Patients With Vascular Parkinsonism
- 2013/2017 H7N9 Prime-Boost Interval
- 2017 A/H7N9 IIV Revaccination
- A Clinical Trial of Breast Cancer Neo-adjuvant Therapy Based on Molecular Pathway in FUSCC
- A Clinical Trial to Evaluate Pharmacokinetics of Daewon DW-ES(A) 625mg/5ml, Daewon DW-ES(B) 625mg/5ml and Megace 800mg/20ml in Healthy Male Volunteers Under Fed Condition
- A First Time in Human Study of SNP318 as a Treatment for Neurodegenerative Diseases Including Alzheimer's Disease
- A Patient Handling Study of Mometasone Furoate/Formortoral Fumarate (MF/F) Metered Dose Inhaler (MDI) With an Integrated Dose Counter in Adolescent and Adult Subjects With Asthma or Chronic Obstructive Pulmonary Disease (Study P04703AM1)
- A Phase 1 Study of XH-S003 in Healthy Volunteers
- A Phase 1 Study to Evaluate the Safety and Effects of a Single Dose of HCXT-2001 Tablets and HCXT-2001 Tablets(A) in Healthy Adults.
- A Phase I Study to Assess the Pharmacokinetics of GSK2798745 Tablets
- A Study in Healthy Men to Test if Taking Different Formulations of BI 1358894 With or Without Food Influences the Amount of BI 1358894 in the Blood
- A Study of Darunavir/Cobicistat/Emtricitabine/Tenofovir Alafenamide (D/C/F/TAF) Evaluated as a Fixed Dose Combination Regimen in Participants Switching From an Integrase Inhibitor Who Have Experienced Rapid Weight Gain
- A Study of GS-3242 in Combination With Lenacapavir Versus Biktarvy in Virologically Suppressed People With HIV-1
- [A Study of INI-822 in Healthy Volunteers and Participants With Metabolic Dysfunction-Associated Steatohepatitis (MASH) or Presumed MASH](https://trialight.com/data/trial/a-study-of-ini-822-in-healthy-volunteers-and-participants-20c3b890-c377-4536-9208-f2b5d2c9af89.md)
- A Study to Evaluate Efficacy and Safety of Darunavir/Cobicistat/Emtricitabine/Tenofovir Alafenamide (D/C/F/TAF) Fixed Dose Combination (FDC) Versus a Regimen Consisting of Darunavir/Cobicistat FDC With Emtricitabine/Tenofovir Disoproxil Fumarate FDC in Treatment-naive HIV Type 1 Infected Subjects
- A Study to Evaluate Safety and Efficacy Following Dosing of Oxycodone/Naltrexone for Treatment of Adults With Pain Following Bunionectomy Surgery
- A Study to Evaluate the Pharmacokinetics and Absolute Bioavailability of GSK962040 Given as an Oral Dose Simultaneously With an Intravenous Microtracer Dose of \[14C\]-GSK962040 in Healthy Volunteers
- A Study to Evaluate the Safety and Reactogenicity of DPX-RSV(A), a Respiratory Syncytial Virus Vaccine
- A Study to Investigate the Bioequivalence Test of DA-1229\_01(A) at Fasting State

### In development for (1)

- Type 1 diabetes mellitus Early phase 1

---

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