> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/flezurafenib-8afe7fa3-9474-4d70-b8a4-bbbfb72d7fbb
> Record changed: 2026-10-13

# Flezurafenib

Highest phase reached

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068010)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068010)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068010)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068010)

**Drug name**

Flezurafenib

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068010)

**Molecular weight**

456.48

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068010)

**Structure (SMILES)**

O=C1CCc2c(Oc3ccc4c(c3)C\[C@@H\](c3ncc(-c5ccc(F)cc5)\[nH\]3)CO4)ccnc2N1

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068010)

### Other names (10)

- flezurafenib
- Flezurafenib
- flezurafenib \[INN\]
- FLEZURAFENIB \[USAN\]
- flezurafenib inn
- flezurafenib usan
- jzp 815
- JZP-815
- jzp815
- JZP815

## Identifiers

**CAS registry numbers**

- 2760321-00-2

**ChEMBL ID**

CHEMBL6068010

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068010)

**InChIKey**

TWJSMWXWCWQPRO-QGZVFWFLSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068010)

**PubChem compound IDs**

- 162772363

**FDA ingredient codes (UNII)**

- P26TTM6U27

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Drug classification

**Pharmacology name**

flezurafenib

**Type**

Synthetic organic

**Drug name stem**

\-rafenib

### Investigated indications

- **Condition**  
Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000616

**Subject identifier**  
D009369

### Open Targets indications (2)

- **Condition identifier**  
EFO\_0000616
- **Condition identifier**  
MONDO\_0005070

## Chemical properties

**Hydrogen bond acceptors**

5

**Hydrogen bond donors**

2

**Polar surface area**

89.13

**Calculated partition coefficient (ALogP)**

5.01

**Calculated partition coefficient (XLogP)**

3.6

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Rule-of-five violations**

1

**Rotatable bonds**

4

**Heavy atoms**

34

**Molecular formula**

C26H21FN4O3

**Monoisotopic mass**

456.15976871

**Natural product**

No

## Related records

### Trials (1)

- [A Study of JZP815 Oral Capsules in Adult Participants With Advanced or Metastatic Solid Tumors Harboring Mitogen Activated Protein Kinase (MAPK) Pathway Alterations to Investigate the Safety, Dosing, and Antitumor Activity of JZP815](https://trialight.com/data/trial/a-study-of-jzp815-oral-capsules-in-adult-participants-with-6b0bc9ff-d3ef-4bc2-a4ed-c63947532baa.md)

### In development for (1)

- Neoplasm Phase 2

---

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