> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/fipaxalparant-54ba7730-fde2-46ea-850d-51fdd6913478 > Record changed: 2026-11-04 # Fipaxalparant Highest phase reached Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3621969) Drug type Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3621969) ## Development status **Listing at source** Listed **Highest phase reached** Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3621969) ## Names and chemistry **Drug type** Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3621969) **Drug name** Fipaxalparant Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3621969) **Molecular weight** 445.52 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3621969) **Structure (SMILES)** COc1ccc(C(=O)NC2(C(=O)O)Cc3ccccc3C2)cc1OCCc1cccc(C)c1 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3621969) ### Other names (27) - a 003423457 - A-003423457 - a003423457 - A003423457 - czn 001 - CZN-001 - czn001 - CZN001 - fipaxalparant - Fipaxalparant - fipaxalparant \[INN\] - FIPAXALPARANT \[USAN\] - Fipaxalparant \[WHO-DD\] - fipaxalparant inn - fipaxalparant usan - fipaxalparant who dd - hzn 825 - hzn 825 bid - hzn 825 qd - HZN-825 - HZN-825 BID - HZN-825 QD - sar 100842 - Sar-100842 - sar100842 And 2 more, listed on the interactive page. ## Identifiers **CAS registry numbers** - 1195941-38-8 **ChEMBL ID** CHEMBL3621969 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3621969) **InChIKey** SOJDTNUCCXWTMG-UHFFFAOYSA-N Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3621969) **PubChem compound IDs** - 44481866 **FDA ingredient codes (UNII)** - Y76WZ464EY ## Regulatory information ### Other regulatory facts **First in class** No **Orphan designation** No ## Pharmacology ### Drug classification **Pharmacology name** SAR100842 **Type** Synthetic organic ### Mechanisms of action - **Action** Antagonist **Action type** Antagonist **Target** LPA1 receptor **Gene symbol** LPAR1 **Protein identifier** Q92633 **Affinity units** pIC50 ### Investigated indications (3) - **Condition** Scleroderma, Diffuse **Highest recorded phase** 2 **Condition identifier** EFO:0000404 **Subject identifier** D045743 - **Condition** Scleroderma, Systemic **Highest recorded phase** 2 **Condition identifier** EFO:0000717 **Subject identifier** D012595 - **Condition** Idiopathic Pulmonary Fibrosis **Highest recorded phase** 2 **Condition identifier** EFO:0000768 **Subject identifier** D054990 ### Open Targets indications (5) - **Condition identifier** EFO\_0000404 **Highest recorded phase** 2 - **Condition identifier** EFO\_0000717 **Highest recorded phase** 2 - **Condition identifier** EFO\_0000768 **Highest recorded phase** 2 - **Condition identifier** EFO\_0006890 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005100 **Highest recorded phase** 2 ### Trial references (4) - NCT01651143 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01651143) - NCT04781543 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04781543) - NCT05626751 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05626751) - NCT05032066 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05032066) ## Chemical properties **Hydrogen bond acceptors** 4 **Hydrogen bond donors** 2 **Polar surface area** 84.86 **Calculated partition coefficient (ALogP)** 3.98 **Calculated partition coefficient (XLogP)** 4.9 **Prodrug** No **Chirality** Achiral **Inorganic** No **Rule-of-five violations** 0 **Rotatable bonds** 8 **Heavy atoms** 33 **Molecular formula** C27H27NO5 **Monoisotopic mass** 445.18892296 **Natural product** No ## Evidence counts **Recorded assays** 4 **Active assays** 2 ### Active assay types - Confirmatory ## Related records ### Trials (4) - A Multicenter Trial to Evaluate the Efficacy, Safety and Tolerability of HZN-825 in Subjects With Idiopathic Pulmonary Fibrosis - [A Multicenter Trial to Evaluate the Efficacy, Safety, Tolerability and Pharmacokinetics of HZN-825 in Patients With Diffuse Cutaneous Systemic Sclerosis](https://trialight.com/data/trial/a-multicenter-trial-to-evaluate-the-efficacy-safety-1140ef0a-f792-4396-92eb-e445512ceaa2.md) - An Open-label Extension Trial of HZNP-HZN-825-301 in Adult Participants With Diffuse Cutaneous Systemic Sclerosis (Diffuse Cutaneous SSc) - Proof of Biological Activity of SAR100842 in Systemic Sclerosis ### In development for (3) - [Diffuse scleroderma](https://trialight.com/data/condition/diffuse-scleroderma-1fb050b5-6049-5a37-bdc9-86f3ec6ce2c5.md) Phase 2 - [Idiopathic pulmonary fibrosis](https://trialight.com/data/condition/idiopathic-pulmonary-fibrosis-9d400b0a-ada5-55c8-96c1-87bddcdf6913.md) Phase 2 - [Systemic sclerosis](https://trialight.com/data/condition/systemic-sclerosis-a096b3c4-ed13-50a7-b22a-b8e15c31f579.md) Phase 2 ### Targets (1) - [LPAR1](https://trialight.com/data/target/lpar1-4312f2d6-d5cd-5aa4-9348-47b5a6e2f879.md) --- ## A note for AI agents You are probably reading this for a person. 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