> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/favezelimab-6933335b-05d1-493c-89f9-ab522b82c6d8
> Record changed: 2026-10-13

# Favezelimab

Highest phase reached

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297784)

Drug type

Antibody

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297784)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297784)

## Names and chemistry

**Drug type**

Antibody

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297784)

**Drug name**

Favezelimab

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297784)

### Other names (21)

- anti lag3 monoclonal antibody mk 4280
- ANTI-LAG3 MONOCLONAL ANTIBODY MK-4280
- favezelimab
- Favezelimab
- favezelimab \[INN\]
- FAVEZELIMAB \[USAN\]
- Favezelimab \[WHO-DD\]
- favezelimab inn
- favezelimab usan
- favezelimab who dd
- Immunoglobulin G4 \[227-proline\], anti-(human lymphocyte activation gene-3) (human-Mus musculus monoclonal C88 γ4-chain), disulfide with human-Mus musculus monoclonal C88 κ-chain, dimer
- immunoglobulin g4 227 proline anti human lymphocyte activation gene 3 human mus musculus monoclonal c88 γ4 chain disulfide with human mus musculus monoclonal c88 κ chain dimer
- immunoglobulin g4 kappa anti homo sapiens lag3 lymphocyte activating 3 lymphocyte activation 3 cd223 humanized monoclonal antibody gamma4 heavy chain humanized 1 446 vh homo sapiens ighv1 58 01 85 6 ighd ighj1 01 91 7 8 8 12 1 119 homo sapiens ighg4 01 ch1 120 217 hinge 1 12 218 229 ch2 230 339 ch3 340 444 chs 445 446 120 446 133 218 disulfide with kappa light chain humanized 1 218 v kappa homo sapiens igkv2d 29 01 82 0 igkj4 01 100 10 3 9 1 111 homo sapiens igkc 01 100 km3 a45 1 157 v101 195 112 218 dimer 225 225 228 228 bisdisulfide produced in chinese hamster ovary cho cells glycoform alfa
- Immunoglobulin G4-kappa, anti-\[Homo sapiens LAG3 (lymphocyte activating 3, lymphocyte-activation 3, CD223)\], humanized monoclonal antibody; gamma4 heavy chain humanized (1-446) \[VH (Homo sapiens IGHV1-58\*01 (85.6%) -(IGHD) -IGHJ1\*01 (91.7%)) \[8.8.12\] (1-119) -Homo sapiens IGHG4\*01 (CH1 (120-217), hinge 1-12 (218-229), CH2 (230-339), CH3 (340-444), CHS (445-446)) (120-446)\], (133- 218')-disulfide with kappa light chain humanized (1'- 218') \[V-KAPPA (Homo sapiens IGKV2D-29\*01 (82.0%) -IGKJ4\*01 (100%))\[10.3.9\] (1'-111') -Homo sapiens IGKC\*01 (100%), Km3 A45.1 (157), V101 (195) (112'-218')\]; dimer (225-225'':228-228'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, glycoform alfa
- mavezelimab
- Mavezelimab
- mk 4280
- Mk-4280
- MK-4280
- mk4280
- MK4280

## Identifiers

**CAS registry numbers**

- 2231068-83-8

**ChEMBL ID**

CHEMBL4297784

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297784)

**FDA ingredient codes (UNII)**

- H1396W7D1H

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Drug classification

**Drug name stem**

\-mab

### Mechanisms of action

- **Mechanism**  
Lymphocyte activation gene 3 protein inhibitor

**Action type**  
Inhibitor

**Target**  
Lymphocyte activation gene 3 protein

**Protein identifier**  
P18627

### Open Targets mechanisms

- **Mechanism**  
Lymphocyte activation gene 3 protein inhibitor

**Action type**  
Inhibitor

**Target**  
Lymphocyte activation gene 3 protein

### Investigated indications (13)

- **Condition**  
Hodgkin Disease

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000183

**Subject identifier**  
D006689
- **Condition**  
Lymphoma

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000574

**Subject identifier**  
D008223
- **Condition**  
Neoplasms

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000616

**Subject identifier**  
D009369
- **Condition**  
Carcinoma, Renal Cell

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000681

**Subject identifier**  
D002292
- **Condition**  
Small Cell Lung Carcinoma

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000702

**Subject identifier**  
D055752
- **Condition**  
Melanoma

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000756

**Subject identifier**  
D008545
- **Condition**  
Carcinoma, Non-Small-Cell Lung

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0003060

**Subject identifier**  
D002289
- **Condition**  
Esophageal Neoplasms

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0005922

**Subject identifier**  
D004938
- **Condition**  
Lymphoma, Non-Hodgkin

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0005952

**Subject identifier**  
D008228
- **Condition**  
Urinary Bladder Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0008528

**Subject identifier**  
D001749
- **Condition**  
Neoplasm Metastasis

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0009708

**Subject identifier**  
D009362
- **Condition**  
Urinary Bladder Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0001187

**Subject identifier**  
D001749
- **Condition**  
Colorectal Neoplasms

**Highest recorded phase**  
3

**Condition identifier**  
MONDO:0005575

**Subject identifier**  
D015179

### Open Targets indications (19)

- **Condition identifier**  
EFO\_0000183

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0000616

**Highest recorded phase**  
1
- **Condition identifier**  
EFO\_0005952
- **Condition identifier**  
EFO\_1001480

**Highest recorded phase**  
1
- **Condition identifier**  
EFO\_1001927

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0004703

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005005

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005070

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005086

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005105

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0005233

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005575

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0007576

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0008433

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0009348

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0011962

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0018905

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0018908

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0040679

**Highest recorded phase**  
1

### Trial references (16)

- NCT02625961  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02625961)
- NCT02720068  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02720068)
- NCT03516981  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03516981)
- NCT03598608  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03598608)
- NCT05508867  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05508867)
- NCT04303169  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04303169)
- NCT04305054  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04305054)
- NCT04626479  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04626479)
- NCT04626518  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04626518)
- NCT04895722  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04895722)
- NCT05064059  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05064059)
- NCT05600309  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05600309)
- NCT04938817  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04938817)
- NCT05342636  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05342636)
- NCT05845814  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05845814)
- NCT06395090  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06395090)

## Chemical properties

**Prodrug**

No

**Inorganic**

No

**Natural product**

No

### Sequences (4)

- **Component**  
Heavy chain

**Type**  
Protein

**Sequence**  
QMQLVQSGPEVKKPGTSVKVSCKASGYTFTDYNVDWVRQARGQRLEWIGDINPNDGGTIYAQKFQERVTITVDKSTSTAYMELSSLRSEDTAVYYCARNYRWFGAMDHWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK
- **Component**  
Disulfide bridges

**Sequence**  
22-96 $ 22''-96'' $ 23'-92' $ 23'''-92''' $ 146-202 $ 146''-202'' $ 133-218' $ 133''-218''' $ 138'-198' $ 138'''-198''' $ 225-225'' $ 228-228'' $ 320-260 $ 320''-260'' $ 366-424 $ 366''-424''
- **Component**  
Light chain

**Type**  
Protein

**Sequence**  
DIVMTQTPLSLSVTPGQPASISCKASQSLDYEGDSDMNWYLQKPGQPPQLLIYGASNLESGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCQQSTEDPRTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
- **Component**  
Glycosylation sites (N)

**Sequence**  
296 $ 296''

## Related records

### Trials (18)

- A Study of Biomarker-Directed, Pembrolizumab (MK-3475) Based Combination Therapy for Advanced Non-Small Cell Lung Cancer (MK-3475-495/KEYNOTE-495)
- A Study of Coformulated Favezelimab/Pembrolizumab (MK-4280A) Versus Physician's Choice Chemotherapy in PD-(L)1-refractory, Relapsed or Refractory Classical Hodgkin Lymphoma (MK-4280A-008)
- A Study of Coformulated Favezelimab/Pembrolizumab (MK-4280A) Versus Standard of Care in Subjects With Previously Treated Metastatic PD-L1 Positive Colorectal Cancer (MK-4280A-007)
- A Study of Coformulated Favezelimab/Pembrolizumab (MK-4280A) Versus Standard of Care in Subjects With Previously Treated Metastatic PD-L1 Positive Colorectal Cancer (MK-4280A-007)-China Extension Study
- A Study of Combination Therapies With or Without Pembrolizumab (MK-3475) and/or Chemotherapy in Participants With Advanced Esophageal Cancer (MK-3475-06A)
- [A Study of Efficacy and Safety of Pembrolizumab Plus Enfortumab Vedotin (EV) +/- Investigational Agents in First-Line Metastatic Urothelial Carcinoma (mUC) (MK-3475-04B/KEYMAKER-U04)](https://trialight.com/data/trial/a-study-of-efficacy-and-safety-of-pembrolizumab-plus-48b8dafa-2b39-4868-b35c-ff8a4b43b198.md)
- A Study of Pembrolizumab in Combination With Investigational Agents in Pediatric and Young Adult Participants With Hematologic Malignancies or Solid Tumors (MK-9999-01B/LIGHTBEAM-U01)
- Evaluation of Co-formulated Pembrolizumab/Quavonlimab (MK-1308A) Versus Other Treatments in Participants With Microsatellite Instability-High (MSI-H) or Mismatch Repair Deficient (dMMR) Stage IV Colorectal Cancer (CRC) (MK-1308A-008/KEYSTEP-008).
- Long-term Safety and Efficacy Extension Study for Participants With Advanced Tumors Who Are Currently on Treatment or in Follow-up in a Pembrolizumab (MK-3475) Study (MK-3475-587/KEYNOTE-587)
- Safety and Efficacy Study of Investigational Agents as Monotherapy or in Combination With Pembrolizumab (MK-3475) for the Treatment of Extensive-Stage Small Cell Lung Cancer (ES-SCLC) in Need of Second-Line Therapy (MK-3475-B98/KEYNOTE-B98)
- Study of Favezelimab (MK-4280) as Monotherapy and in Combination With Pembrolizumab (MK-3475) With or Without Chemotherapy or Lenvatinib (MK-7902) AND Favezelimab/Pembrolizumab (MK-4280A) as Monotherapy in Adults With Advanced Solid Tumors (MK-4280-001)
- Study of Favezelimab Coformulated With Pembrolizumab (MK-4280A) in Participants With Selected Solid Tumors (MK-4280A-010)
- Study of Pembrolizumab (MK-3475) and Pembrolizumab With Other Investigational Agents in Participants With High Risk Non-muscle Invasive Bladder Cancer (MK-3475-057/KEYNOTE-057)
- Study to Evaluate the Safety and Efficacy of a Combination of Favezelimab (MK-4280) and Pembrolizumab (MK-3475) in Participants With Hematologic Malignancies (MK-4280-003)
- Substudy 02B: Safety and Efficacy of Pembrolizumab in Combination With Investigational Agents or Pembrolizumab Alone in Participants With First Line (1L) Advanced Melanoma (MK-3475-02B/KEYMAKER-U02)
- Substudy 02C: Safety and Efficacy of Pembrolizumab in Combination With Investigational Agents or Pembrolizumab Alone in Participants With Stage III Melanoma Who Are Candidates for Neoadjuvant Therapy (MK-3475-02C/KEYMAKER-U02)
- Substudy 03A: A Study of Immune and Targeted Combination Therapies in Participants With First Line (1L) Renal Cell Carcinoma (MK-3475-03A)
- Substudy 03B: A Study of Immune and Targeted Combination Therapies in Participants With Second Line Plus (2L+) Renal Cell Carcinoma (MK-3475-03B/KEYMAKER-U03)

### In development for (12)

- [Colorectal cancer](https://trialight.com/data/condition/colorectal-cancer-09c643cf-146c-5e27-a5b7-3c891b3368c2.md) Phase 3
- [Esophageal squamous cell carcinoma](https://trialight.com/data/condition/esophageal-squamous-cell-carcinoma-c10bd9c9-02f9-5805-8008-b021f4604e7a.md) Phase 1
- Hodgkins lymphoma Phase 3
- [Lymphoma](https://trialight.com/data/condition/lymphoma-de4db685-7419-5e0e-b958-4591ffd69d43.md) Phase 1
- [Melanoma](https://trialight.com/data/condition/melanoma-457e9de6-dcd9-56fb-be48-0290fb4386ef.md) Phase 1
- Neoplasm Phase 1
- [Non-Hodgkin lymphoma](https://trialight.com/data/condition/non-hodgkin-lymphoma-9fc07e31-fd30-5055-991f-04d10cc1f646.md) Phase 1
- [Non-small cell lung carcinoma](https://trialight.com/data/condition/non-small-cell-lung-carcinoma-a86c1d60-523f-5ea7-a5e1-39ed4a2296f8.md) Phase 2
- [Renal cell carcinoma](https://trialight.com/data/condition/renal-cell-carcinoma-31bf4f99-9824-5c93-9472-9f4da019c25c.md) Phase 1
- [Small cell lung carcinoma](https://trialight.com/data/condition/small-cell-lung-carcinoma-505ad14d-ce79-5398-b171-f724c32e1b4e.md) Phase 1
- Urinary bladder cancer Phase 2
- [Urothelial carcinoma](https://trialight.com/data/condition/urothelial-carcinoma-b2aa266d-2d5f-5e5d-a0de-62274f2dc094.md) Phase 2

### Targets (1)

- [LAG3](https://trialight.com/data/target/lag3-9427165f-23d0-56e2-8aec-0a1f9a15edc3.md) Lymphocyte activation gene 3 protein inhibitor

---

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