> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/faricimab-499c6bdf-255b-4e85-beb1-4b97ebbeaf6f
> Record changed: 2026-10-13

# Faricimab

Highest phase reached

Approved

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297750)

Drug type

Antibody

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297750)

First approval year

2022

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297750)

## Development status

**First approval year**

2022

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297750)

**Listing at source**

Listed

**Highest phase reached**

Approved

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297750)

## Names and chemistry

**Drug type**

Antibody

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297750)

**Drug name**

Faricimab

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297750)

### Brand names (2)

- vabysmo
- Vabysmo

### Other names (35)

- faricimab
- Faricimab
- faricimab \[INN\]
- FARICIMAB \[JAN\]
- Faricimab \[MI\]
- FARICIMAB \[USAN\]
- Faricimab \[WHO-DD\]
- Faricimab Injection
- faricimab inn
- faricimab jan
- faricimab mi
- faricimab svoa
- Faricimab svoa
- Faricimab svoa \[WHO-DD\]
- faricimab svoa who dd
- faricimab usan
- faricimab who dd
- Faricimab-svoa
- rg 7716
- rg 7716 antivascular endothelial growth factor anti angiopoietin 2 bispecific antibody
- Rg-7716
- RG-7716 (ANTIVASCULAR ENDOTHELIAL GROWTH FACTOR/ANTI-ANGIOPOIETIN 2 BISPECIFIC ANTIBODY)
- rg7716
- RG7716
- rg77161

And 10 more, listed on the interactive page.

## Identifiers

**CAS registry numbers**

- 1607793-29-2

**ChEMBL ID**

CHEMBL4297750

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297750)

**FDA ingredient codes (UNII)**

- QC4F7FKK7I

### ATC classification codes (2)

- S01L
- S01LA09

Sources for recorded values

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297750)

### RxNorm IDs (RxCUI) (2)

- 2591519
- 2591584

## Regulatory information

### United States

**Applicant**

GENENTECH INC

**Approval date**

28 Jan 2022

**Application number**

BLA761235

### European Union

**Status**

Authorised

**Status date**

15 Sept 2022

**Authorisation date**

15 Sept 2022

**Approved indications**

Vabysmo is indicated for the treatment of adult patients with: neovascular (wet) age-related macular degeneration (nAMD), visual impairment due to diabetic macular oedema (DME), visual impairment due to macular oedema secondary to retinal vein occlusion (branch RVO or central RVO).

**Product number**

EMEA/H/C/005642

**Authorisation holder**

Roche Registration GmbH

**Priority medicines scheme**

No

**Generic**

No

**Biosimilar**

No

**Generic medicines**

0

**Biosimilar medicines**

0

**Advanced therapy**

No

**Conditional approval**

No

**Additional monitoring**

Yes

**Accelerated assessment**

No

**Exceptional circumstances**

No

#### Therapeutic areas

- Diabetes Complications
- Macular Edema
- Wet Macular Degeneration

European medicines record

Source: [www.ema.europa.eu](https://www.ema.europa.eu/en/medicines/human/EPAR/vabysmo)

### Other regulatory facts

**Patents**

0

**Designations**

1

**First in class**

No

**Fast track**

No

**Breakthrough designation**

No

**Orphan designation**

No

**Priority review**

No

**Orphan exclusivity**

No

**Accelerated approval**

No

**Availability**

Prescription only

## Pharmacology

### Drug classification

**Pharmacology name**

faricimab

**Type**

Antibody

**Drug name stem**

\-mab

**Approval recorded by Guide to Pharmacology**

Yes

#### Administration routes

- Parenteral

### Mechanisms of action (4)

- **Action**  
Binding

**Action type**  
Binding

**Target**  
angiopoietin-2

**Gene symbol**  
angiopoietin-2

**Median affinity**

7.66

**Affinity units**  
pKd

**Primary target**  
Yes
- **Action**  
Binding

**Action type**  
Binding

**Target**  
VEGFA

**Gene symbol**  
VEGFA

**Median affinity**

8.52

**Affinity units**  
pKd

**Primary target**  
Yes
- **Mechanism**  
Angiopoietin-2 inhibitor

**Action type**  
Inhibitor

**Target**  
Angiopoietin-2

**Protein identifier**  
O15123
- **Mechanism**  
Vascular endothelial growth factor A inhibitor

**Action type**  
Inhibitor

**Target**  
Vascular endothelial growth factor A, long form

**Protein identifier**  
P15692

### Open Targets mechanisms (2)

- **Mechanism**  
Angiopoietin-2 inhibitor

**Action type**  
Inhibitor

**Target**  
Angiopoietin-2
- **Mechanism**  
Vascular endothelial growth factor A inhibitor

**Action type**  
Inhibitor

**Target**  
Vascular endothelial growth factor A, long form

### Investigated indications (9)

- **Condition**  
Macular Degeneration

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0001365

**Subject identifier**  
D008268
- **Condition**  
Wet Macular Degeneration

**Highest recorded phase**  
4

**Condition identifier**  
EFO:0004683

**Subject identifier**  
D057135
- **Condition**  
Retinal Neovascularization

**Highest recorded phase**  
4

**Condition identifier**  
EFO:0005753

**Subject identifier**  
D015861
- **Condition**  
Macular Degeneration

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0009606

**Subject identifier**  
D008268
- **Condition**  
Diabetes Complications

**Highest recorded phase**  
4

**Condition identifier**  
EFO:0010977

**Subject identifier**  
D048909
- **Condition**  
Eye Diseases

**Highest recorded phase**  
1

**Condition identifier**  
HP:0000478

**Subject identifier**  
D005128
- **Condition**  
Macular Edema

**Highest recorded phase**  
4

**Condition identifier**  
MONDO:0003005

**Subject identifier**  
D008269
- **Condition**  
Macular Edema

**Highest recorded phase**  
4

**Condition identifier**  
MONDO:0007935

**Subject identifier**  
D008269
- **Condition**  
Choroidal Neovascularization

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0810000

**Subject identifier**  
D020256

### Open Targets indications (21)

- **Condition identifier**  
EFO\_0001365

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0004683
- **Condition identifier**  
EFO\_0005753
- **Condition identifier**  
EFO\_0009321
- **Condition identifier**  
EFO\_0009606

**Highest recorded phase**  
1
- **Condition identifier**  
EFO\_0009760

**Highest recorded phase**  
2
- **Condition identifier**  
HP\_0000478
- **Condition identifier**  
HP\_0025569

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0001660

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0003005
- **Condition identifier**  
MONDO\_0003005

**Highest recorded phase**  
4
- **Condition identifier**  
MONDO\_0004728

**Highest recorded phase**  
4
- **Condition identifier**  
MONDO\_0005150

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0005266
- **Condition identifier**  
MONDO\_0005417

**Highest recorded phase**  
4
- **Condition identifier**  
MONDO\_0005552

**Highest recorded phase**  
4
- **Condition identifier**  
MONDO\_0006951

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0007935
- **Condition identifier**  
MONDO\_0007935

**Highest recorded phase**  
4
- **Condition identifier**  
MONDO\_0810000

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0810000

**Highest recorded phase**  
3

### Reported adverse events (77)

- **Event**  
anaemic retinopathy

**Reports**  
1

**Reporting signal score**

7.94152
- **Event**  
anterior chamber cell

**Reports**  
3

**Reporting signal score**

9.40842
- **Event**  
anterior chamber flare

**Reports**  
5

**Reporting signal score**

23.7243
- **Event**  
anterior chamber inflammation

**Reports**  
25

**Reporting signal score**

134.453
- **Event**  
bacterial endophthalmitis

**Reports**  
3

**Reporting signal score**

15.7777
- **Event**  
blindness

**Reports**  
49

**Reporting signal score**

134.171
- **Event**  
cerebral infarction

**Reports**  
16

**Reporting signal score**

25.42
- **Event**  
chorioretinitis

**Reports**  
8

**Reporting signal score**

35.8496
- **Event**  
choroidal detachment

**Reports**  
3

**Reporting signal score**

9.8985
- **Event**  
choroidal haemorrhage

**Reports**  
5

**Reporting signal score**

24.3726
- **Event**  
corneal endotheliitis

**Reports**  
2

**Reporting signal score**

9.33691
- **Event**  
detachment of retinal pigment epithelium

**Reports**  
5

**Reporting signal score**

16.3999
- **Event**  
dyspnoea

**Reports**  
2

**Reporting signal score**

13.9132
- **Event**  
endophthalmitis

**Reports**  
49

**Reporting signal score**

196.268
- **Event**  
eye abrasion

**Reports**  
1

**Reporting signal score**

7.94152
- **Event**  
eye haemorrhage

**Reports**  
5

**Reporting signal score**

8.12743
- **Event**  
eye inflammation

**Reports**  
49

**Reporting signal score**

206.879
- **Event**  
eye pain

**Reports**  
18

**Reporting signal score**

32.184
- **Event**  
fatigue

**Reports**  
1

**Reporting signal score**

20.9266
- **Event**  
haemorrhagic occlusive retinal vasculitis

**Reports**  
2

**Reporting signal score**

13.1127
- **Event**  
headache

**Reports**  
5

**Reporting signal score**

8.57055
- **Event**  
hypopyon

**Reports**  
5

**Reporting signal score**

17.1301
- **Event**  
idiopathic orbital inflammation

**Reports**  
2

**Reporting signal score**

9.29966
- **Event**  
immune-mediated adverse reaction

**Reports**  
3

**Reporting signal score**

9.03756
- **Event**  
inflammation

**Reports**  
10

**Reporting signal score**

9.63738

And 52 more, listed on the interactive page.

### Trial references (7)

- NCT01941082  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01941082)
- NCT02484690  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02484690)
- NCT03038880  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03038880)
- NCT04777201  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04777201)
- NCT05904028  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05904028)
- NCT03823287  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03823287)
- NCT03823300  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03823300)

## Dosing

**Dose**

6 mg

**Route**

Intravitreal

**How often**

Every 4 weeks for the first 4 doses, then evaluate; possible additional 4-week dosing after initial 4 doses

### Conditions of use (4)

- Administered by a qualified physician
- Eliminate air bubbles before administration
- Inspect visually prior to use, do not use if damaged, expired, or particulates present
- Single eye treatment per syringe or vial

## Chemical properties

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Natural product**

No

### Sequences (7)

- **Component**  
Heavy chain: anti-VEGFA

**Type**  
Protein

**Sequence**  
EVQLVESGGGLVQPGGSLRLSCAASGYDFTHYGMNWVRQAPGKGLEWVGWINTYTGEPTYAADFKRRFTFSLDTSKSTAYLQMNSLRAEDTAVYYCAKYPYYYGTSHWYFDVWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMASRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLAQDWLNGKEYKCKVSNKALGAPIEKTISKAKGQPREPQVYTLPPCRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNAYTQKSLSLSPGK
- **Component**  
Heavy chain: anti-ANGPT2

**Type**  
Protein

**Sequence**  
QVQLVQSGAEVKKPGASVKVSCKASGYTFTGYYMHWVRQAPGQGLEWMGWINPNSGGTNYAQKFQGRVTMTRDTSISTAYMELSRLRSDDTAVYYCARSPNPYYYDSSGYYYPGAFDIWGQGTMVTVSSASVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMASRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLAQDWLNGKEYKCKVSNKALGAPIEKTISKAKGQPREPQVCTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNAYTQKSLSLSPGK
- **Component**  
Glycosylation sites (N)

**Sequence**  
Asn-303 $ Asn-313''''
- **Component**  
Glycosylation sites (N)

**Sequence**  
Asn-303 $ Asn-313''
- **Component**  
Disulfide bridges

**Sequence**  
22'''-87''' $ 22-96 $ 22''-96'' $ 23'-88' $ 134'-194' $ 137'''-193''' $ 150-206 $ 156''-216'' $ 213'''-236' $ 214'-226 $ 232-242'' $ 235-245'' $ 267-327 $ 277''-337'' $ 360-365'' $ 373-431 $ 383''-441''
- **Component**  
Light chain: anti-ANGPT2

**Type**  
Protein

**Sequence**  
SYVLTQPPSVSVAPGQTARITCGGNNIGSKSVHWYQQKPGQAPVLVVYDDSDRPSGIPERFSGSNSGNTATLTISRVEAGDEADYYCQVWDSSSDHWVFGGGTKLTVLSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC
- **Component**  
Light chain

**Type**  
Protein

**Sequence**  
DIQLTQSPSSLSASVGDRVTITCSASQDISNYLNWYQQKPGKAPKVLIYFTSSLHSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYSTVPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC

## National Drug Codes

- 50242-096

## Related records

### Trials (52)

- [A Phase 1b Study to Assess the Safety, Tolerability, Pharmacokinetics, and Exploratory Efficacy of Intravitreal OLN324](https://trialight.com/data/trial/a-phase-1b-study-to-assess-the-safety-tolerability-88c39e5d-c96a-470d-8fb1-844fe0024875.md)
- A Proof-of-Concept Study of Faricimab (RO6867461) in Participants With Choroidal Neovascularization (CNV) Secondary to Age-Related Macular Degeneration (AMD)
- A Prospective Longitudinal Analysis of Faricimab (Vabysmo 6mg) For Choroidal Neovascularization in Presumed Ocular Histoplasmosis Syndrome
- A Real-World Study to Gain Clinical Insights Into Faricimab (FaReal Study)
- A Real-World Study to Gain Clinical Insights Into Roche Ophthalmology Products
- A Study in Patients With Neovascular Age-Related Macular Degeneration or Diabetic Macular Edema to Evaluate the Safety of the Faricimab Prefilled Syringe
- A Study of Faricimab (RO6867461) in Participants With Center-Involving Diabetic Macular Edema
- A Study of RO6867461 Administered in Single- and Multiple-Ascending Doses in Patients With Wet Age-Related Macular Degeneration
- A Study to Determine the Efficacy, Safety, and Durability of Faricimab in Participants With Neovascular Age-Related Macular Degeneration
- A Study to Evaluate the Efficacy and Safety of Faricimab (RO6867461) in Participants With Diabetic Macular Edema
- A Study to Evaluate the Efficacy and Safety of Faricimab (RO6867461) in Participants With Diabetic Macular Edema (YOSEMITE)
- A Study to Evaluate the Efficacy and Safety of Faricimab in Participants With Macular Edema Secondary to Branch Retinal Vein Occlusion
- A Study to Evaluate the Efficacy and Safety of Faricimab in Participants With Macular Edema Secondary to Central Retinal or Hemiretinal Vein Occlusion
- A Study to Evaluate the Efficacy and Safety of Faricimab in Participants With Neovascular Age-Related Macular Degeneration (LUCERNE)
- A Study to Evaluate the Efficacy and Safety of Faricimab in Participants With Neovascular Age-Related Macular Degeneration (TENAYA)
- A Study to Evaluate the Efficacy and Safety of Faricimab in Patients With Choroidal Neovascularization Secondary to Pathologic Myopia
- A Study to Evaluate the Efficacy and Safety of IBI302 inSubjects With Diabetic Macular Edema（DME）
- A Study to Evaluate the Long-Term Safety and Tolerability of Faricimab in Participants With Diabetic Macular Edema
- A Study to Evaluate the Long-Term Safety and Tolerability of Faricimab in Participants With Neovascular Age-Related Macular Degeneration
- A Study to Evaluate the Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of RO7823653 in Participants With Diabetic Macular Edema (DME)

### Approved for (4)

- Cystoid macular edema
- [Macular retinal edema](https://trialight.com/data/condition/macular-retinal-edema-893472dc-a81c-5efb-b457-9a4c0884e5e5.md)
- Ocular vascular disorder
- [Wet macular degeneration](https://trialight.com/data/condition/wet-macular-degeneration-fce04054-9f5d-5a0b-8ba9-fb08ba7393ba.md)

### In development for (4)

- [Age-related macular degeneration](https://trialight.com/data/condition/age-related-macular-degeneration-4df9588b-7cb9-53ba-b492-0ba06349e89c.md) Phase 3
- [Choroidal neovascularization](https://trialight.com/data/condition/choroidal-neovascularization-5e4d725e-9e65-52d5-8a90-0001a1196b7f.md) Phase 2
- Eye disorder Phase 1
- [Macular degeneration](https://trialight.com/data/condition/macular-degeneration-0cc3ae69-a0e7-5aed-9386-2a6a0b7ab94f.md) Phase 3

### Other linked conditions (1)

- [Diabetic macular edema](https://trialight.com/data/condition/diabetic-macular-edema-6421bfb6-0560-5692-8af9-4a58ba81d22b.md)

### Targets (2)

- [ANGPT2](https://trialight.com/data/target/angpt2-0da1d20a-ff23-5742-83b2-f27f1c4e3930.md) Angiopoietin-2 inhibitor
- [VEGFA](https://trialight.com/data/target/vegfa-d5a98392-6ee9-5b71-b7a2-9a73ce1575d2.md) Vascular endothelial growth factor A inhibitor

---

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