> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/falbikitug-7110c939-14a3-47f0-880a-00bd1a9d30f4 > Record changed: 2026-10-13 # Falbikitug Highest phase reached Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5315010) Drug type Antibody Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5315010) ## Development status **Listing at source** Listed **Highest phase reached** Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5315010) ## Names and chemistry **Drug type** Antibody Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5315010) **Drug name** Falbikitug Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5315010) ### Other names (23) - azd 0171 - AZD-0171 - azd0171 - Azd0171 - AZD0171 - falbikitug - Falbikitug - falbikitug \[INN\] - FALBIKITUG \[USAN\] - Falbikitug \[WHO-DD\] - falbikitug inn - falbikitug usan - falbikitug who dd - gamma1 heavy chain humanized (1-448) \[VH (Homo sapiens IGHV3-15\*07 (86.9%)--(IGHD) -IGHJ1\*01(90.9%), CDR-IMGT \[8.10.9\] (26-33.51-60.99-107))(1-118) -Homo sapiens IGHG1\*01 (100%), G1m17,1 CH1K120, CH3 D12, L14 (CH1 K120 (215) (119-216),hinge 1-15 (217-231), CH2 (232-341), CH3 D12 (357), L14 (359) (342-446), CHS (447-448)) (119-448)\], (221-220')-disulfide with kappa light chain humanized (1'-220') \[V-KAPPA (Homo sapiens IGKV2-24\*01 (90.0%)-IGKJ2\*01 (100%), CDR-IMGT \[11.3.10\] (27-37.55-57.94-103)) (1'-113') -Homo sapiens IGKC\*01 (100%), Km3, A45.1 (159), V101 (197) (114'-220')\]; dimer (227-227'':230-230'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, derived from the cell line CHO-K1, glycoform alfa - gamma1 heavy chain humanized 1 448 vh homo sapiens ighv3 15 07 86 9 ighd ighj1 01 90 9 cdr imgt 8 10 9 26 33 51 60 99 107 1 118 homo sapiens ighg1 01 100 g1m17 1 ch1k120 ch3 d12 l14 ch1 k120 215 119 216 hinge 1 15 217 231 ch2 232 341 ch3 d12 357 l14 359 342 446 chs 447 448 119 448 221 220 disulfide with kappa light chain humanized 1 220 v kappa homo sapiens igkv2 24 01 90 0 igkj2 01 100 cdr imgt 11 3 10 27 37 55 57 94 103 1 113 homo sapiens igkc 01 100 km3 a45 1 159 v101 197 114 220 dimer 227 227 230 230 bisdisulfide produced in chinese hamster ovary cho cells derived from the cell line cho k1 glycoform alfa - immunoglobulin g1 anti human leukemia inhibitory factor human wistar rat monoclonal azd0171 γ1 chain disulfide with human wistar monoclonal azd0171 κ chain dimer - immunoglobulin g1 kappa anti homo sapiens lif lif interleukin 6 family cytokine leukemia inhibitory factor humanized monoclonal antibody - Immunoglobulin G1-kappa, anti-\[Homo sapiens LIF (LIF interleukin 6 family cytokine, leukemia inhibitory factor)\], humanized monoclonal antibody - Immunoglobulin G1, anti-(human leukemia inhibitory factor) (human-Wistar rat monoclonal AZD0171 γ1-chain), disulfide with human-Wistar monoclonal AZD0171 κ-chain, dimer - msc 1 - Msc 1 - Msc-1 - MSC-1 ## Identifiers **CAS registry numbers** - 2740565-02-8 **ChEMBL ID** CHEMBL5315010 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5315010) **FDA ingredient codes (UNII)** - E4JL3K3CI6 ## Regulatory information ### Other regulatory facts **First in class** No **Orphan designation** No ## Pharmacology ### Investigated indications (2) - **Condition** Neoplasms **Highest recorded phase** 2 **Condition identifier** EFO:0000616 **Subject identifier** D009369 - **Condition** Carcinoma, Non-Small-Cell Lung **Highest recorded phase** 2 **Condition identifier** EFO:0003060 **Subject identifier** D002289 ### Open Targets indications (4) - **Condition identifier** EFO\_0000616 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005070 - **Condition identifier** MONDO\_0005184 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005233 **Highest recorded phase** 2 ### Trial references (2) - NCT04999969 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04999969) - NCT05061550 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05061550) ## Chemical properties **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Natural product** No ### Sequences (4) - **Component** Glycosylation sites (N) **Sequence** 298 $ 298'' - **Component** Heavy chain **Type** Protein **Sequence** QVQLQESGGGLVKPGGSLRLSCAASGFTFSHAWMHWVRQAPGKGLEWVGQIKAKSDDYATYYAESVKGRFTISRDDSKNTLYLQMNSLKTEDTAVYYCTCWEWDLDFWGQGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK - **Component** Disulfide bridges **Sequence** 22-98 $ 22''-98'' $ 23'-93' $ 23'''-93''' $ 140'-200' $ 140'''-200''' $ 145-201 $ 145''-201'' $ 221-220' $ 221''-220''' $ 227-227'' $ 230-230'' $ 262-322 $ 262''-322'' $ 368-426 $ 368''-426'' - **Component** Light chain **Type** Protein **Sequence** DIVMTQTPLSSPVTLGQPASISCRSSQSLLDSDGHTYLNWLQQRPGQPPRLLIYSVSNLESGVPDRFSGSGAGTDFTLKISRVEAEDVGVYYCMQATHAPPYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC ## Related records ### Trials (3) - [Neoadjuvant and Adjuvant Treatment in Resectable Non-small Cell Lung Cancer](https://trialight.com/data/trial/neoadjuvant-and-adjuvant-treatment-in-resectable-non-small-c5704130-e063-4bfd-817c-edc38351eb37.md) - Safety, Pharmacokinetics and Clinical Activity of AZD0171 in Combination With Durvalumab and Chemotherapy in Locally Advanced or Metastatic Solid Tumours - Study to Evaluate Safety, PK, PD, Immunogenicity & Antitumor Activity of MSC-1 in Patients With Adv Solid Tumors ### In development for (2) - Neoplasm Phase 2 - [Non-small cell lung carcinoma](https://trialight.com/data/condition/non-small-cell-lung-carcinoma-a86c1d60-523f-5ea7-a5e1-39ed4a2296f8.md) Phase 2 --- ## A note for AI agents You are probably reading this for a person. 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