> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/everolimus-0edf09a9-672d-4f9a-9e34-21ab083a92a4 > Record changed: 2026-10-13 # Everolimus Highest phase reached Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1908360) Drug type Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1908360) First approval year 2009 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1908360) ## Development status **First approval year** 2009 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1908360) **Listing at source** Listed **Highest phase reached** Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1908360) ## Names and chemistry **Drug type** Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1908360) **Drug name** Everolimus Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1908360) **Molecular weight** 958.24 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1908360) **Structure (SMILES)** CO\[C@H\]1C\[C@@H\]2CC\[C@@H\](C)\[C@@\](O)(O2)C(=O)C(=O)N2CCCC\[C@H\]2C(=O)O\[C@H\](\[C@H\](C)C\[C@@H\]2CC\[C@@H\](OCCO)\[C@H\](OC)C2)CC(=O)\[C@H\](C)/C=C(\\C)\[C@@H\](O)\[C@@H\](OC)C(=O)\[C@H\](C)C\[C@H\](C)/C=C/C=C/C=C/1C Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1908360) ### Brand names (10) - afinitor - Afinitor - afinitor disperz - Afinitor disperz - certican - Certican - votubia - Votubia - zortress - Zortress ### Other names (81) - 40 o 2 hydroxyethyl rapamycin - 40-o-(2-hydroxyethyl)-rapamycin - 42 o 2 hydroxyethyl rapamycin - 42-o-(2-hydroxyethyl)rapamycin - afinitor - Afinitor - Afinitor (everolimus) - Certican - Certican® - Drug: Everolimus - everolimus - Everolimus - EVEROLIMUS - Everolimus (10 mg QD) - Everolimus (Afinitor) tablets - Everolimus (Afinitor®) - Everolimus (Certican) - Everolimus (EVR) - Everolimus (RAD 001) - everolimus (RAD) - everolimus (RAD001) - Everolimus (RAD001) - Everolimus (reduced tacrolimus) - Everolimus (tacrolimus elimination) - EVEROLIMUS \[EMA EPAR\] And 56 more, listed on the interactive page. ## Identifiers **CAS registry numbers** - 159351-69-6 **ChEMBL ID** CHEMBL1908360 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1908360) **InChIKey** HKVAMNSJSFKALM-GKUWKFKPSA-N Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1908360) **PubChem compound IDs** - 6442177 **RxNorm IDs (RxCUI)** - 141704 **FDA ingredient codes (UNII)** - 9HW64Q8G6G ### ATC classification codes (3) - L01EG02 - L01XE10 - L04AH02 Sources for recorded values Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1908360) ## Regulatory information ### United States **Applicant** NOVARTIS **Approval date** 30 Mar 2009 **Application number** NDA022334 ### European Union **Status** Authorised **Status date** 2 Aug 2009 **Authorisation date** 2 Aug 2009 **Approved indications** Hormone-receptor-positive advanced breast cancer Afinitor is indicated for the treatment of hormone-receptor-positive, HER2/neu-negative advanced breast cancer, in combination with exemestane, in post-menopausal women without symptomatic visceral disease after recurrence or progression following a non-steroidal aromatase inhibitor. Neuroendocrine tumours of pancreatic origin Afinitor is indicated for the treatment of unresectable or metastatic, well or moderately differentiated neuroendocrine tumours of pancreatic origin in adults with progressive disease. Neuroendocrine tumours of gastrointestinal or lung origin Afinitor is indicated for the treatment of unresectable or metastatic, well-differentiated (Grade 1 or Grade 2) non-functional neuroendocrine tumours of gastrointestinal or lung origin in adults with progressive disease. Renal-cell carcinoma Afinitor is indicated for the treatment of patients with advanced renal-cell carcinoma, whose disease has progressed on or after treatment with VEGF-targeted therapy. **Product number** EMEA/H/C/001038 **Authorisation holder** Novartis Europharm Limited **Priority medicines scheme** No **Generic** No **Biosimilar** No **Generic medicines** 0 **Biosimilar medicines** 0 **Advanced therapy** No **Conditional approval** No **Additional monitoring** No **Accelerated assessment** No **Exceptional circumstances** No #### Therapeutic areas - Breast Neoplasms - Carcinoma, Renal Cell - Pancreatic Neoplasms European medicines record Source: [www.ema.europa.eu](https://www.ema.europa.eu/en/medicines/human/EPAR/afinitor) ### Other regulatory facts **Patents** 3 **Designations** 3 **Earliest recorded loss of exclusivity** 1 Jul 2028 **First in class** No **Fast track** No **Breakthrough designation** No **Orphan designation** No **Priority review** Yes **Orphan exclusivity** No **Accelerated approval** No **Availability** Prescription only **Boxed warning** Yes ## Pharmacology ### Drug classification **Pharmacology name** everolimus **Type** Synthetic organic **Drug name stem** \-imus **Approval recorded by Guide to Pharmacology** Yes #### Administration routes - Oral ### Mechanisms of action (2) - **Action** Inhibition **Action type** Inhibitor **Target** mechanistic target of rapamycin kinase **Gene symbol** MTOR **Protein identifier** P42345 **Median affinity** 8.7 **Affinity units** pIC50 **Primary target** Yes - **Mechanism** FK506-binding protein 1A inhibitor **Action type** Inhibitor **Target** Peptidyl-prolyl cis-trans isomerase FKBP1A **Protein identifier** P62942 ### Open Targets mechanisms - **Mechanism** FK506-binding protein 1A inhibitor **Action type** Inhibitor **Target** Peptidyl-prolyl cis-trans isomerase FKBP1A ### DrugCentral mechanisms (2) - **Action type** Inhibitor **Gene symbol** MTOR **Protein identifier** P42345 **Organism** Homo sapiens **Target development level** Clinical - **Action type** Inhibitor **Gene symbol** FKBP1A **Protein identifier** P62942 **Organism** Homo sapiens **Target development level** Clinical ### Investigated indications (147) - **Condition** Carcinoma, Squamous Cell **Highest recorded phase** 2 **Condition identifier** EFO:0000181 **Subject identifier** D002294 - **Condition** Carcinoma, Hepatocellular **Highest recorded phase** 2 **Condition identifier** EFO:0000182 **Subject identifier** D006528 - **Condition** Hodgkin Disease **Highest recorded phase** 2 **Condition identifier** EFO:0000183 **Subject identifier** D006689 - **Condition** Myelodysplastic Syndromes **Highest recorded phase** 2 **Condition identifier** EFO:0000198 **Subject identifier** D009190 - **Condition** Neoplasms, Plasma Cell **Highest recorded phase** 1 **Condition identifier** EFO:0000200 **Subject identifier** D054219 - **Condition** Precursor Cell Lymphoblastic Leukemia-Lymphoma **Highest recorded phase** 1 **Condition identifier** EFO:0000220 **Subject identifier** D054198 - **Condition** Leukemia, Myeloid, Acute **Highest recorded phase** 2 **Condition identifier** EFO:0000222 **Subject identifier** D015470 - **Condition** Adenocarcinoma **Highest recorded phase** 1 **Condition identifier** EFO:0000228 **Subject identifier** D000230 - **Condition** Carcinoma, Adenoid Cystic **Highest recorded phase** 2 **Condition identifier** EFO:0000231 **Subject identifier** D003528 - **Condition** Astrocytoma **Highest recorded phase** 4 **Condition identifier** EFO:0000272 **Subject identifier** D001254 - **Condition** Breast Neoplasms **Highest recorded phase** 4 **Condition identifier** EFO:0000305 **Subject identifier** D001943 - **Condition** Carcinoma **Highest recorded phase** 3 **Condition identifier** EFO:0000313 **Subject identifier** D002277 - **Condition** Glioma **Highest recorded phase** 2 **Condition identifier** EFO:0000326 **Subject identifier** D005910 - **Condition** Chondrosarcoma **Highest recorded phase** 2 **Condition identifier** EFO:0000333 **Subject identifier** D002813 - **Condition** Leukemia, Myelogenous, Chronic, BCR-ABL Positive **Highest recorded phase** 1 **Condition identifier** EFO:0000339 **Subject identifier** D015464 - **Condition** Carcinoma, Renal Cell **Highest recorded phase** 4 **Condition identifier** EFO:0000349 **Subject identifier** D002292 - **Condition** Colorectal Neoplasms **Highest recorded phase** 2 **Condition identifier** EFO:0000365 **Subject identifier** D015179 - **Condition** Melanoma **Highest recorded phase** 2 **Condition identifier** EFO:0000389 **Subject identifier** D008545 - **Condition** Lymphoma, Large B-Cell, Diffuse **Highest recorded phase** 3 **Condition identifier** EFO:0000403 **Subject identifier** D016403 - **Condition** Epilepsy **Highest recorded phase** 2 **Condition identifier** EFO:0000474 **Subject identifier** D004827 - **Condition** Neoplasms, Germ Cell and Embryonal **Highest recorded phase** 2 **Condition identifier** EFO:0000514 **Subject identifier** D009373 - **Condition** Glioblastoma **Highest recorded phase** 2 **Condition identifier** EFO:0000519 **Subject identifier** D005909 - **Condition** Infections **Highest recorded phase** 3 **Condition identifier** EFO:0000544 **Subject identifier** D007239 - **Condition** Sarcoma, Kaposi **Highest recorded phase** 2 **Condition identifier** EFO:0000558 **Subject identifier** D012514 - **Condition** Leukemia **Highest recorded phase** 1 **Condition identifier** EFO:0000565 **Subject identifier** D007938 And 122 more, listed on the interactive page. ### Open Targets indications (293) - **Condition identifier** EFO\_0000181 **Highest recorded phase** 2 - **Condition identifier** EFO\_0000182 **Highest recorded phase** 2 - **Condition identifier** EFO\_0000183 **Highest recorded phase** 2 - **Condition identifier** EFO\_0000198 **Highest recorded phase** 2 - **Condition identifier** EFO\_0000200 **Highest recorded phase** 2 - **Condition identifier** EFO\_0000222 - **Condition identifier** EFO\_0000228 **Highest recorded phase** 2 - **Condition identifier** EFO\_0000231 **Highest recorded phase** 2 - **Condition identifier** EFO\_0000272 - **Condition identifier** EFO\_0000305 - **Condition identifier** EFO\_0000313 **Highest recorded phase** 3 - **Condition identifier** EFO\_0000333 **Highest recorded phase** 2 - **Condition identifier** EFO\_0000365 **Highest recorded phase** 2 - **Condition identifier** EFO\_0000389 **Highest recorded phase** 2 - **Condition identifier** EFO\_0000403 **Highest recorded phase** 3 - **Condition identifier** EFO\_0000474 **Highest recorded phase** 2 - **Condition identifier** EFO\_0000514 **Highest recorded phase** 2 - **Condition identifier** EFO\_0000519 **Highest recorded phase** 2 - **Condition identifier** EFO\_0000544 **Highest recorded phase** 3 - **Condition identifier** EFO\_0000558 **Highest recorded phase** 2 - **Condition identifier** EFO\_0000574 **Highest recorded phase** 2 - **Condition identifier** EFO\_0000588 **Highest recorded phase** 2 - **Condition identifier** EFO\_0000612 - **Condition identifier** EFO\_0000616 - **Condition identifier** EFO\_0000637 **Highest recorded phase** 2 And 268 more, listed on the interactive page. ### Warnings (8) - **Warning** Black Box Warning **Effect** carcinogenicity - **Warning** Black Box Warning **Effect** cardiotoxicity - **Warning** Black Box Warning **Effect** immune system toxicity - **Warning** Black Box Warning **Effect** infectious disease - **Warning** Black Box Warning **Effect** musculoskeletal toxicity - **Warning** Black Box Warning **Effect** nephrotoxicity - **Warning** Black Box Warning **Effect** neurotoxicity - **Warning** Black Box Warning **Effect** vascular toxicity ### Open Targets warnings (8) - **Warning** Black Box Warning **Effect** carcinogenicity **Country** United States - **Warning** Black Box Warning **Effect** cardiotoxicity **Country** United States - **Warning** Black Box Warning **Effect** immune system toxicity **Country** United States - **Warning** Black Box Warning **Effect** infectious disease **Country** United States - **Warning** Black Box Warning **Effect** musculoskeletal toxicity **Country** United States - **Warning** Black Box Warning **Effect** nephrotoxicity **Country** United States - **Warning** Black Box Warning **Effect** neurotoxicity **Country** United States - **Warning** Black Box Warning **Effect** vascular toxicity **Country** United States ### Reported adverse events (30) - **Event** bk virus infection **Reports** 205 **Reporting signal score** 520.43 - **Event** blood creatinine increased **Reports** 586 **Reporting signal score** 498.759 - **Event** breast cancer metastatic **Reports** 282 **Reporting signal score** 680.603 - **Event** cough **Reports** 977 **Reporting signal score** 446.301 - **Event** decreased appetite **Reports** 884 **Reporting signal score** 525.153 - **Event** diarrhoea **Reports** 1,838 **Reporting signal score** 509.398 - **Event** disease progression **Reports** 602 **Reporting signal score** 391.538 - **Event** fatigue **Reports** 1,567 **Reporting signal score** 392.898 - **Event** hyperglycaemia **Reports** 399 **Reporting signal score** 436.205 - **Event** interstitial lung disease **Reports** 508 **Reporting signal score** 491.882 - **Event** kidney transplant rejection **Reports** 234 **Reporting signal score** 524.944 - **Event** lung disorder **Reports** 333 **Reporting signal score** 324.496 - **Event** malignant neoplasm progression **Reports** 1,440 **Reporting signal score** 2,515.76 - **Event** metastases to bone **Reports** 440 **Reporting signal score** 919.502 - **Event** metastases to liver **Reports** 451 **Reporting signal score** 961.144 - **Event** metastases to lung **Reports** 230 **Reporting signal score** 430.64 - **Event** mouth ulceration **Reports** 286 **Reporting signal score** 330.337 - **Event** mucosal inflammation **Reports** 437 **Reporting signal score** 539.961 - **Event** neoplasm progression **Reports** 410 **Reporting signal score** 576.723 - **Event** oedema peripheral **Reports** 586 **Reporting signal score** 319.916 - **Event** oral pain **Reports** 241 **Reporting signal score** 302.551 - **Event** pleural effusion **Reports** 497 **Reporting signal score** 408.236 - **Event** pneumonitis **Reports** 657 **Reporting signal score** 1,172.71 - **Event** polyomavirus-associated nephropathy **Reports** 170 **Reporting signal score** 424.288 - **Event** post transplant lymphoproliferative disorder **Reports** 165 **Reporting signal score** 322.063 And 5 more, listed on the interactive page. ### Trial references (476) - NCT00087685 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00087685) - NCT00703807 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00703807) - NCT00870337 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00870337) - NCT01068249 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01068249) - NCT01797523 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01797523) - NCT02228681 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02228681) - NCT00093639 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00093639) - NCT00544999 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00544999) - NCT00671112 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00671112) - NCT00968253 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00968253) - NCT01154439 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01154439) - NCT00096486 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00096486) - NCT00401778 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00401778) - NCT00406276 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00406276) - NCT00807755 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00807755) - NCT00892801 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00892801) - NCT01470209 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01470209) - NCT00097968 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00097968) - NCT00251004 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00251004) - NCT00300274 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00300274) - NCT01509560 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01509560) - NCT01544491 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01544491) - NCT00098553 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00098553) - NCT00521001 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00521001) - NCT00976573 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00976573) And 451 more, listed on the interactive page. ## Dosing **Dose** 10 mg **Route** Oral **How often** Once daily ## Chemical properties **Hydrogen bond acceptors** 14 **Hydrogen bond donors** 3 **Polar surface area** 204.66 **Calculated partition coefficient (ALogP)** 6.2 **Calculated partition coefficient (XLogP)** 5.9 **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Rule-of-five violations** 3 **Rotatable bonds** 9 **Heavy atoms** 68 **Molecular formula** C53H83NO14 **Monoisotopic mass** 957.58135632 **Natural product** Yes ## National Drug Codes - 0054-0470 - 0054-0471 - 0054-0472 - 0054-0480 - 0054-0481 - 0054-0482 - 0054-0497 - 0054-0604 - 0078-0414 - 0078-0415 - 0078-0417 - 0078-0422 - 0078-0566 - 0078-0567 - 0078-0594 - 0078-0620 - 0078-0626 - 0078-0627 - 0078-0628 - 0093-7766 - 0093-7767 - 0093-7768 - 0093-7769 - 0245-0822 - 0245-0823 And 59 more, listed on the interactive page. ## Evidence counts **Recorded assays** 726 **Active assays** 121 ### Active assay types (3) - Confirmatory - Other - Summary ## Pharmacologic actions - MTOR Inhibitors Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D000091203.html) - Immunosuppressive Agents Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D007166.html) ## Biological measurements ### Observed measurements #### Oral bioavailability **Median** 20 **Mean** 20 **Minimum** 20 **Maximum** 20 **Unit** % **Assays** 1 **Standard deviation** 0 **Summary method** median **Censored results excluded** 0 **Other units excluded** 0 **Unknown units excluded** 0 #### Measurement types - F ## Related records ### Trials (785) - 10-Years Follow-up of the EXAMINATION Trial - 12 Month Athena Study: Everolimus vs. Standard Regimen in de Novo Kidney Transplant Patients - 24 Months Follow-up, Two Arm Study to Compare the Cardiovascular Profile in a Regimen With Everolimus + Mycophenolic Acid (MPA) Versus (vs.) a Regimen of CNI+MPA in Maintenance Renal Transplant Recipients - 3-arm Trial to Evaluate Pasireotide LAR/Everolimus Alone/in Combination in Patients With Lung/Thymus NET - LUNA Trial - 4EVER - Efficacy, Safety, Health Economics, Translational Research of Postmenopausal Women With Estrogen Receptor Positive Locally Advanced or Metastatic Breast Cancer - 89Zr-bevacizumab PET Imaging in Patients With Neuroendocrine Tumors - A Biological Prospective Study in Patients With Metastatic Pancreatic NETs Treated With Everolimus - A Clinical Evaluation of Everolimus Eluting Coronary Stents in the Treatment of Patients With ST-segment Elevation Myocardial Infarction: EXAMINATION Study - A Clinical Trial to Assess the Efficacy and Safety of the Conversion to Everolimus - A Comparison of Vorolanib Tablets Combined With Everolimus Versus Sunitinib in Patients With Advanced Renal Cell Carcinoma Who Have Progressed After Treatment With Immunotherapy Monotherapy or in Combination With TKI - A Facilitated Access Program to Provide Everolimus (RAD) Maintenance for Patients Completing Therapy in RAD Trials in Solid Organ Transplantation - A MolEcularly Guided Anti-Cancer Drug Off-Label Trial - A Multiple Ascending Dose Study of the mTOR Inhibitor (RAD001) in Combination With R1507 in Patients With Advanced Solid Tumors - A National Multi-center Randomized, Open Label Study to Evaluate Efficacy and Safety of Everolimus With EC-MPS Compared to Standard Treatment Combination Tacrolimus and EC-MPS in de Novo Liver Transplant Recipients - A Phase 0/I Study of Ribociclib (LEE011) in Combination With Everolimus in Preoperative Recurrent High-Grade Glioma Patients Scheduled for Resection - A Phase 1 Study Investigating the Combination of RAD001, Cetuximab and Irinotecan as Second-line Therapy After FOLFOX (or XELOX) Plus Bevacizumab in Patients With Metastatic Colorectal Cancer - A Phase 1b Study of SGN-75 in Combination With Everolimus in Patients With Renal Cell Carcinoma - A Phase 3 Study of HRS-8080 Versus Treatment Chosen by Physicians in Locally Advanced and Metastatic Breast Cancer - A Phase I Study of BKM120 and Everolimus in Advanced Solid Malignancies - A Phase Ib Study of Rad001 and Sutent to Treat Renal Cell Carcinoma ### Approved for (19) - Anaplastic astrocytoma - Angiomyolipoma - [Astrocytoma (excluding glioblastoma)](https://trialight.com/data/condition/astrocytoma-excluding-glioblastoma-dd29b6db-5e3d-590d-b093-7a770a5facb2.md) - [Breast cancer](https://trialight.com/data/condition/breast-cancer-8ac10da3-93bd-54c5-a93b-265bc6699689.md) - Breast carcinoma - [Breast neoplasm](https://trialight.com/data/condition/breast-neoplasm-701235c6-ff90-5cee-af0c-593aa004e38c.md) - [Cancer](https://trialight.com/data/condition/cancer-703b1dfc-4812-50eb-83f4-d7a205d16bdb.md) - [Clear cell renal carcinoma](https://trialight.com/data/condition/clear-cell-renal-carcinoma-789eee25-ec64-5771-9b7d-d19544781b11.md) - Exocrine pancreatic carcinoma - Hamartoma - Lung neuroendocrine neoplasm - Neoplasm - [Neuroendocrine neoplasm](https://trialight.com/data/condition/neuroendocrine-neoplasm-ab85715e-e4fa-5698-91d9-024cf0bab33c.md) - [Pancreatic neoplasm](https://trialight.com/data/condition/pancreatic-neoplasm-de300cc3-339a-5c06-97d8-2d9155fc3a7b.md) - Pancreatic neuroendocrine tumor - Renal cell adenocarcinoma - [Renal cell carcinoma](https://trialight.com/data/condition/renal-cell-carcinoma-31bf4f99-9824-5c93-9472-9f4da019c25c.md) - Subependymal giant cell astrocytoma - Tuberous sclerosis ### In development for (123) - [Acute coronary syndrome](https://trialight.com/data/condition/acute-coronary-syndrome-3d7c2c1f-86ca-5a25-913a-6f9a7e95f989.md) Phase 1 - Acute lymphoblastic leukemia Phase 1 - [Acute myeloid leukemia](https://trialight.com/data/condition/acute-myeloid-leukemia-b0971a7a-c18d-544e-bd7f-b1a13b9caa30.md) Phase 2 - [Adenocarcinoma](https://trialight.com/data/condition/adenocarcinoma-b5c321d1-7c49-5bf9-abd0-dfa99dbd5f29.md) Phase 1 - [Adenoid cystic carcinoma](https://trialight.com/data/condition/adenoid-cystic-carcinoma-6c5702ee-925e-504d-8b2d-477a0008f140.md) Phase 2 - Adult oligodendroglioma Phase 2 - [Age-related macular degeneration](https://trialight.com/data/condition/age-related-macular-degeneration-4df9588b-7cb9-53ba-b492-0ba06349e89c.md) Phase 2 - [Autosomal dominant polycystic kidney disease](https://trialight.com/data/condition/autosomal-dominant-polycystic-kidney-disease-4beb5bfd-d32f-5dcd-bf5a-99032974b831.md) Phase 3 - Bile duct carcinoma Phase 2 - Bone sarcoma Phase 2 - [Brain neoplasm](https://trialight.com/data/condition/brain-neoplasm-b3dac71b-1d7b-5a65-8f64-89821506ad41.md) Phase 2 - Carcinoid syndrome Phase 3 - Carcinoid tumor Phase 3 - [Carcinoma](https://trialight.com/data/condition/carcinoma-575e4c82-5fa5-5455-b1b7-30972eca1a2f.md) Phase 3 - Carcinoma of esophagus Phase 1 - Central nervous system cancer Phase 2 - [Central nervous system neoplasm](https://trialight.com/data/condition/central-nervous-system-neoplasm-bd35c306-06e5-549c-a882-45bdfbcbb7d8.md) Phase 1 - [Cervical cancer](https://trialight.com/data/condition/cervical-cancer-10fb8f6c-5aac-5281-8f06-7238adeec443.md) Phase 1 - Childhood ependymoma Phase 2 - [Cholangiocarcinoma](https://trialight.com/data/condition/cholangiocarcinoma-3777afe4-5189-5eb1-82f8-0c3446cb902f.md) Phase 2 ### Other linked conditions (4) - Kidney angiomyolipoma - [Myocardial infarction](https://trialight.com/data/condition/myocardial-infarction-b4e97483-7435-5701-81dc-26d955e420ec.md) - Nonpapillary renal cell carcinoma - Uterine corpus sarcoma ### Targets (1) - [FKBP1A](https://trialight.com/data/target/fkbp1a-caa2dbe9-c679-5ba2-9bd0-18b303620352.md) FK506-binding protein 1A inhibitor --- ## A note for AI agents You are probably reading this for a person. 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